Bus Harrisburg, PA to Indianapolis - Compare all Companies

Compare all timetables for the bus from Harrisburg, PA to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Harrisburg, PA to Indianapolis from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$86

Friday

Saturday

$90

Sunday

Monday

$102

Tuesday

$119

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 0m	7:45 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$86	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/18/2025 7:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/19/2025 9:45:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 14h 0m
Greyhound US	13h 10m	2:50 PM	Harrisburg, PA	Bus Station	4:00 AM	Indianapolis	Central Bus Station	Economy	$89	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/18/2025 2:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/19/2025 4:00:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 13h 10m
FlixBus	12h 20m	2:40 PM	Harrisburg, PA	Bus Station	3:00 AM	Indianapolis	Washington / Delaware	Economy	$92	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/18/2025 2:40:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/19/2025 3:00:00 AM. 50 Economy ticket for $92 per person are available. Travel duration is 12h 20m
Greyhound US	13h 30m	8:15 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$127	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/18/2025 8:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/19/2025 9:45:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 13h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 10m	2:50 PM	Harrisburg, PA	Bus Station	4:00 AM	Indianapolis	Central Bus Station	Economy	$90	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/20/2025 2:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/21/2025 4:00:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 13h 10m
Greyhound US	14h 0m	7:45 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$90	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/20/2025 7:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/21/2025 9:45:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 14h 0m
FlixBus	12h 20m	2:40 PM	Harrisburg, PA	Bus Station	3:00 AM	Indianapolis	Downtown Transit Center	Economy	$93	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/20/2025 2:40:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 12/21/2025 3:00:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 12h 20m
Greyhound US	13h 30m	8:15 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$129	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/20/2025 8:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/21/2025 9:45:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 13h 30m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 10m	2:50 PM	Harrisburg, PA	Bus Station	4:00 AM	Indianapolis	Central Bus Station	Economy	$102	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/22/2025 2:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/23/2025 4:00:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 13h 10m
Greyhound US	14h 0m	7:45 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$115	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/22/2025 7:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/23/2025 9:45:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 14h 0m
FlixBus	12h 20m	2:40 PM	Harrisburg, PA	Bus Station	3:00 AM	Indianapolis	Downtown Transit Center	Economy	$138	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/22/2025 2:40:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 12/23/2025 3:00:00 AM. 50 Economy ticket for $138 per person are available. Travel duration is 12h 20m
Greyhound US	13h 30m	8:15 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$155	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/22/2025 8:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/23/2025 9:45:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 13h 30m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 0m	7:45 PM	Harrisburg, PA	Bus Station	9:45 AM	Indianapolis	Central Bus Station	Economy	$119	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 7:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/24/2025 9:45:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 14h 0m
Greyhound US	13h 10m	2:50 PM	Harrisburg, PA	Bus Station	4:00 AM	Indianapolis	Central Bus Station	Economy	$123	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:50:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/24/2025 4:00:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 13h 10m
FlixBus	12h 20m	2:40 PM	Harrisburg, PA	Bus Station	3:00 AM	Indianapolis	Downtown Transit Center	Economy	$126	A Bus from FlixBus goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:40:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 12/24/2025 3:00:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 12h 20m
Greyhound US	16h 10m	2:30 AM	Harrisburg, PA	Bus Station	6:40 PM	Indianapolis	Central Bus Station	Economy	$142	A Bus from Greyhound US goes from Bus Station, Harrisburg, PA (USA) at 12/23/2025 2:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/23/2025 6:40:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 16h 10m

Did you know that if you travel from Harrisburg, PA to Indianapolis via Pittsburgh, you can save more than $18? You can find the corresponding connections below.
- Busbud
  
  12h 10m
  
  0
  
  2:50 PM
  
  Harrisburg, PA
  Bus Station
  
  7:00 PM
  
  Pittsburgh
  Grant Street Transportation Center
  
  0
  
  Economy
  
  $42
  
  A Bus from Busbud goes from Bus Station, Harrisburg, PA (USA) at 12/18/2025 2:50:00 PM to Grant Street Transportation Center, Pittsburgh (USA) arriving at 12/18/2025 7:00:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 4h 10m
- FlixBus
  
  7h 15m
  
  0
  
  7:45 PM
  
  Pittsburgh
  Grant Street Transportation Center
  
  3:00 AM
  
  Indianapolis
  Washington / Delaware
  
  0
  
  Economy
  
  $59
  
  A Bus from FlixBus goes from Grant Street Transportation Center, Pittsburgh (USA) at 12/18/2025 7:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/19/2025 3:00:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 7h 15m
Travel Time is 0h 10m shorter, and you will save $18

Best Price Offer: The price for the cheapest bus from Harrisburg, PA to Indianapolis is $67 on 12/14/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Harrisburg, PA and Indianapolis

See here how frequent the connections between Harrisburg, PA and Indianapolis are, during different times and days of the week.

Tuesday is the busiest day, with more than 14 daily buses from Harrisburg, PA to Indianapolis. Monday has instead the fewest connections, with only 7 daily coaches between Harrisburg, PA and Indianapolis.

The busiest time of the day is the Evening, with 24 buses from Harrisburg, PA to Indianapolis, while Night sees the fewest connections between Harrisburg, PA and Indianapolis, with 6 offers.

Facts about the bus from Harrisburg, PA to Indianapolis

Compare all providers like Greyhound US and FlixBus that travel 10 times every day by bus from Harrisburg, PA to Indianapolis in one click! Book your bus ticket from Harrisburg, PA to Indianapolis starting from $67!

Cheapest Bus	$67
Fastest Bus	12h 20m
Earliest Bus	2:30 AM
Latest Bus	9:10 PM
Daily Bus Routes	10 Ø
Distance	494.3 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Harrisburg, PA to Indianapolis

Every day, 10 buses from 2 bus companies leave Harrisburg, PA for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/17/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

$99

Friday 12/19

Saturday 12/20

$90

Sunday 12/21

Monday 12/22

$102

Tuesday 12/23

$119

Wednesday 12/24

Thursday 12/25

$115

Friday 12/26

$116

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Harrisburg, PA to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Harrisburg, PA to Indianapolis, for the next 30 days.

With a price starting from $86, Thursday is the cheapest day for a bus from Harrisburg, PA to Indianapolis. Tuesday instead is the most expensive day with prices starting from $119.

Evening is the cheapest day time for bus tickets from Harrisburg, PA to Indianapolis, with $86. Night is the most expensive time of the day with prices starting from $90.

How to save money travelling from Harrisburg, PA to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Harrisburg, PA to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Harrisburg, PA to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Harrisburg, PA to Indianapolis are also emptier.

All bus stations and stops in Harrisburg, PA and Indianapolis

In the map below, you can see where to find all bus stations in Harrisburg, PA and Indianapolis.

Bus Station

Market St 411

S 4th St & Chestnut St

N Cameron St

N Cameron St 2000

Mall Parking Lot

Paxton St 3501

Old Country Buffet

Jonestown Rd 5083

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Harrisburg, PA to Indianapolis

Want to know which seat classes are available on the buses from Harrisburg, PA to Indianapolis? Or which bus companies serve the route Harrisburg, PA to Indianapolis? Below you will find answers to your questions.

FAQs about the Harrisburg, PA to Indianapolis bus

How much does a Harrisburg, PA Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $67 and takes 14h 0m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Harrisburg, PA to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $67 and $245. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Harrisburg, PA to Indianapolis each day?

Every day, the Harrisburg, PA to Indianapolis bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Harrisburg, PA to Indianapolis take?

The fastest bus from Harrisburg, PA to Indianapolis is offered by FlixBus and takes 12h 20m. Bus tickets for this connection cost $92. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Harrisburg, PA to Indianapolis?

The earliest bus arriving in Indianapolis from Harrisburg, PA starts at 2:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Harrisburg, PA to Indianapolis?

The latest bus trip departing from Harrisburg, PA for Indianapolis starts at 9:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Harrisburg, PA Indianapolis route?

When traveling by bus from Harrisburg, PA to Indianapolis, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Harrisburg, PA and Indianapolis?

You can check all the direct connections between Harrisburg, PA and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Harrisburg, PA to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Harrisburg, PA Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Harrisburg, PA Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Harrisburg, PA to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Harrisburg, PA to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between Harrisburg, PA and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Harrisburg, PA to Indianapolis?

Prices and availability for 10 trips between Harrisburg, PA and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Harrisburg, PA to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Harrisburg, PA and to Indianapolis

Here’s an overview of the most popular bus routes to Harrisburg, PA and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!