Bus Houston to Tupelo, MS - Compare all Companies

Compare all timetables for the bus from Houston to Tupelo, MS

Here is a selection of the cheapest bus trips from the schedule from Houston to Tupelo, MS from various bus operators like Greyhound US, FlixBus or Valley Transit for the next days.

today

$112

tomorrow

$107

Thursday

$89

Friday

$95

Saturday

$90

Sunday

$89

Monday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 35m	10:00 PM	Houston	Harrisburg Blvd Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$112	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/23/2026 10:00:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 9:35:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 23h 35m
FlixBus	27h 30m	7:35 PM	Houston	Downtown Houston	11:05 PM	Tupelo, MS	Bus Stop	Economy	$113	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/23/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 11:05:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 27h 30m
FlixBus	21h 25m	1:15 PM	Houston	Downtown Houston	10:40 AM	Tupelo, MS	Bus Stop	Economy	$114	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/23/2026 1:15:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 10:40:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 21h 25m
Greyhound US	20h 30m	2:10 PM	Houston	Harrisburg Blvd Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$114	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/23/2026 2:10:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 10:40:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 20h 30m

Did you know that if you travel from Houston to Tupelo, MS via Memphis, you can save more than $16? You can find the corresponding connections below.
- Greyhound US
  
  23h 0m
  
  0
  
  12:05 AM
  
  Houston
  Harrisburg Blvd Station
  
  4:20 PM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $80
  
  A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 12:05:00 AM to Airways Transit Center, Memphis (USA) arriving at 6/25/2026 4:20:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 16h 15m
- Greyhound US
  
  1h 45m
  
  0
  
  9:20 PM
  
  Memphis
  Airways Transit Center
  
  11:05 PM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $16
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/25/2026 9:20:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 11:05:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 1h 45m
Travel time is 2h 30m longer, but you will save $16

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 15m	1:50 AM	Houston	Harrisburg Blvd Station	11:05 PM	Tupelo, MS	Bus Stop	Economy	$107	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/24/2026 1:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 11:05:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 21h 15m
Greyhound US	24h 25m	5:00 AM	Houston	Harrisburg Blvd Station	5:25 AM	Tupelo, MS	Bus Stop	Economy	$107	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/24/2026 5:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 5:25:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 24h 25m
Greyhound US	20h 30m	2:10 PM	Houston	Harrisburg Blvd Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$107	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/24/2026 2:10:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 10:40:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 20h 30m
FlixBus	28h 5m	6:35 AM	Houston	SW Agencia Autobuses	10:40 AM	Tupelo, MS	Bus Stop	Economy	$108	A Bus from FlixBus goes from SW Agencia Autobuses, Houston (USA) at 6/24/2026 6:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 10:40:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 28h 5m
FlixBus	22h 45m	10:50 PM	Houston	Downtown Houston	9:35 PM	Tupelo, MS	Bus Stop	Economy	$108	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/24/2026 10:50:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 9:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 22h 45m

Did you know that if you travel from Houston to Tupelo, MS via Memphis, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  23h 0m
  
  0
  
  12:05 AM
  
  Houston
  Harrisburg Blvd Station
  
  4:20 PM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $80
  
  A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 12:05:00 AM to Airways Transit Center, Memphis (USA) arriving at 6/25/2026 4:20:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 16h 15m
- Greyhound US
  
  1h 45m
  
  0
  
  9:20 PM
  
  Memphis
  Airways Transit Center
  
  11:05 PM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $16
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/25/2026 9:20:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 11:05:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 1h 45m
Travel time is 2h 30m longer, but you will save $11

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 30m	12:05 AM	Houston	Harrisburg Blvd Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$89	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 12:05:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/25/2026 9:35:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 30m
Greyhound US	20h 30m	2:10 PM	Houston	Harrisburg Blvd Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$89	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/25/2026 2:10:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/26/2026 10:40:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 20h 30m
Valley Transit	28h 5m	6:35 AM	Houston	SW Agencia Autobuses	10:40 AM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/25/2026 6:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/26/2026 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 28h 5m
FlixBus	23h 30m	11:10 AM	Houston	Downtown Houston	10:40 AM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 11:10:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/26/2026 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 23h 30m
FlixBus	22h 45m	10:50 PM	Houston	Downtown Houston	9:35 PM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/25/2026 10:50:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/26/2026 9:35:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 22h 45m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 30m	12:05 AM	Houston	Harrisburg Blvd Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$95	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 12:05:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/26/2026 9:35:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 21h 30m
Greyhound US	20h 30m	2:10 PM	Houston	Harrisburg Blvd Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$95	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/26/2026 2:10:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/27/2026 10:40:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 20h 30m
FlixBus	21h 25m	1:15 PM	Houston	Downtown Houston	10:40 AM	Tupelo, MS	Bus Stop	Economy	$95	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/26/2026 1:15:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/27/2026 10:40:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 21h 25m
FlixBus	22h 45m	10:50 PM	Houston	Downtown Houston	9:35 PM	Tupelo, MS	Bus Stop	Economy	$95	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/26/2026 10:50:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/27/2026 9:35:00 PM. 50 Economy ticket for $95 per person are available. Travel duration is 22h 45m
Valley Transit	28h 5m	6:35 AM	Houston	SW Agencia Autobuses	10:40 AM	Tupelo, MS	Bus Stop	Economy	$96	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/26/2026 6:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/27/2026 10:40:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 28h 5m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	24h 25m	5:00 AM	Houston	Harrisburg Blvd Station	5:25 AM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/27/2026 5:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/28/2026 5:25:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 24h 25m
Greyhound US	23h 35m	10:00 PM	Houston	Harrisburg Blvd Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/27/2026 10:00:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/28/2026 9:35:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 23h 35m
FlixBus	21h 25m	1:15 PM	Houston	Downtown Houston	10:40 AM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/27/2026 1:15:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/28/2026 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 21h 25m
Valley Transit	28h 5m	6:35 AM	Houston	SW Agencia Autobuses	10:40 AM	Tupelo, MS	Bus Stop	Economy	$91	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/27/2026 6:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/28/2026 10:40:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 28h 5m
FlixBus	22h 45m	10:50 PM	Houston	Downtown Houston	9:35 PM	Tupelo, MS	Bus Stop	Economy	$92	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/27/2026 10:50:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/28/2026 9:35:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 22h 45m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 30m	12:05 AM	Houston	Harrisburg Blvd Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$89	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/28/2026 12:05:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/28/2026 9:35:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 30m
Greyhound US	20h 30m	2:10 PM	Houston	Harrisburg Blvd Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$89	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 6/28/2026 2:10:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/29/2026 10:40:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 20h 30m
FlixBus	21h 25m	1:15 PM	Houston	Downtown Houston	10:40 AM	Tupelo, MS	Bus Stop	Economy	$89	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/28/2026 1:15:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/29/2026 10:40:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 25m
Valley Transit	28h 5m	6:35 AM	Houston	SW Agencia Autobuses	10:40 AM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from Valley Transit goes from SW Agencia Autobuses, Houston (USA) at 6/28/2026 6:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/29/2026 10:40:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 28h 5m
FlixBus	22h 45m	10:50 PM	Houston	Downtown Houston	9:35 PM	Tupelo, MS	Bus Stop	Economy	$90	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 6/28/2026 10:50:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/29/2026 9:35:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 22h 45m

Best Price Offer: The price for the cheapest bus from Houston to Tupelo, MS is $85 on 7/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and Tupelo, MS

See here how frequent the connections between Houston and Tupelo, MS are, during different times and days of the week.

Sunday is the busiest day, with more than 16 daily buses from Houston to Tupelo, MS. Tuesday has instead the fewest connections, with only 8 daily coaches between Houston and Tupelo, MS.

The busiest time of the day is the Night, with 30 buses from Houston to Tupelo, MS, while Morning sees the fewest connections between Houston and Tupelo, MS, with 12 offers.

Facts about the bus from Houston to Tupelo, MS

Compare all providers like Greyhound US, FlixBus and Valley Transit that travel 14 times every day by bus from Houston to Tupelo, MS in one click! Book your bus ticket from Houston to Tupelo, MS starting from $85!

Cheapest Bus	$85
Fastest Bus	20h 30m
Earliest Bus	1:15 PM
Latest Bus	10:50 PM
Daily Bus Routes	14 Ø
Distance	499.6 miles
Bus Companies	Greyhound US, FlixBus and Valley Transit

Cheapest bus connections from Houston to Tupelo, MS

Every day, 14 buses from 3 bus companies leave Houston for Tupelo, MS: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/23/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

Tuesday 06/23

$112

Wednesday 06/24

$107

Thursday 06/25

$93

Friday 06/26

$95

Saturday 06/27

$90

Sunday 06/28

$89

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

$85

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$97

Saturday 07/11

$95

Sunday 07/12

$97

Monday 07/13

$96

Tuesday 07/14

$108

Wednesday 07/15

$109

Thursday 07/16

$98

Friday 07/17

$99

Saturday 07/18

The cheapest time to travel from Houston to Tupelo, MS

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to Tupelo, MS, for the next 30 days.

With a price starting from $85, Sunday is the cheapest day for a bus from Houston to Tupelo, MS. Tuesday instead is the most expensive day with prices starting from $108.

Night is the cheapest day time for bus tickets from Houston to Tupelo, MS, with $85. Evening is the most expensive time of the day with prices starting from $90.

How to save money travelling from Houston to Tupelo, MS

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to Tupelo, MS in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to Tupelo, MS, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to Tupelo, MS are also emptier.

Beloved bus companies from Houston to Tupelo, MS

These are the most booked bus companies between Houston to Tupelo, MS from our users.

FlixBus from Houston to Tupelo, MS

Here you will find the key facts about the FlixBus bus route Houston to Tupelo, MS:

Cheapest Price	$89
Fastest Bus	21h 25m
Earliest Bus	1:15 PM
Last Bus	10:50 PM
Daily Connections	4 Ø
Found on	5/29/2026

All bus stations and stops in Houston and Tupelo, MS

In the map below, you can see where to find all bus stations in Houston and Tupelo, MS.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Chase Bank

Milam Street 212

Uptown/Upper Kirby

Southwest Fwy 2525

Bus Stop

S Eason Blvd 2831

Service and Comfort on the bus from Houston to Tupelo, MS

Want to know which seat classes are available on the buses from Houston to Tupelo, MS? Or which bus companies serve the route Houston to Tupelo, MS? Below you will find answers to your questions.

FAQs about the Houston to Tupelo, MS bus

How much does a Houston Tupelo, MS bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $85 and takes 21h 30m to reach Tupelo, MS. Compare offers to save money!

How much could I save by comparing buses from Houston to Tupelo, MS?

This route is offered by 3 companies with a range of ticket prices between $85 and $118. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Tupelo, MS.

On average, how many connections are available from Houston to Tupelo, MS each day?

Every day, the Houston to Tupelo, MS bus route is served by approximately 14 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to Tupelo, MS take?

The fastest bus from Houston to Tupelo, MS is offered by Greyhound US and takes 20h 30m. Bus tickets for this connection cost $118. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to Tupelo, MS?

The earliest bus arriving in Tupelo, MS from Houston starts at 1:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to Tupelo, MS?

The latest bus trip departing from Houston for Tupelo, MS starts at 10:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston Tupelo, MS route?

When traveling by bus from Houston to Tupelo, MS, passengers can travel with Greyhound US, FlixBus and Valley Transit. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and Tupelo, MS?

You can check all the direct connections between Houston and Tupelo, MS by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US, FlixBus and Valley Transit.

What can I take with me on the Houston to Tupelo, MS bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston Tupelo, MS bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston Tupelo, MS bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to Tupelo, MS on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to Tupelo, MS?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 14 daily trips between Houston and Tupelo, MS. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to Tupelo, MS?

Prices and availability for 14 trips between Houston and Tupelo, MS change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to Tupelo, MS

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to Tupelo, MS

Here’s an overview of the most popular bus routes to Houston and to Tupelo, MS. Simply click on the connection of your choice, and you will find all the details about your bus route!