Bus San Diego to Tupelo, MS - Compare all Companies

Compare all timetables for the bus from San Diego to Tupelo, MS

Here is a selection of the cheapest bus trips from the schedule from San Diego to Tupelo, MS from various bus operators like FlixBus or Greyhound US for the next days.

today

$225

tomorrow

$229

Saturday

$248

Sunday

$226

Monday

$225

Tuesday

$223

Wednesday

$225

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$225	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/4/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/6/2026 11:05:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 59h 40m
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$226	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/4/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/6/2026 11:05:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 49h 30m
Greyhound US	46h 50m	9:50 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$238	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/4/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/6/2026 10:40:00 AM. 50 Economy ticket for $238 per person are available. Travel duration is 46h 50m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$240	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/4/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/6/2026 10:40:00 AM. 50 Economy ticket for $240 per person are available. Travel duration is 49h 5m

Did you know that if you travel from San Diego to Tupelo, MS via Phoenix, AZ, you can save more than $36? You can find the corresponding connections below.
- Greyhound US
  
  59h 50m
  
  0
  
  9:15 AM
  
  San Diego
  San Ysidro Transit Center
  
  5:15 PM
  
  Phoenix, AZ
  Bus Station
  
  0
  
  Economy
  
  $43
  
  A Bus from Greyhound US goes from San Ysidro Transit Center, San Diego (USA) at 6/5/2026 9:15:00 AM to Bus Station, Phoenix, AZ (USA) arriving at 6/5/2026 5:15:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 8h 0m
- Greyhound US
  
  37h 15m
  
  0
  
  7:50 AM
  
  Phoenix, AZ
  Bus Station
  
  11:05 PM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $145
  
  A Bus from Greyhound US goes from Bus Station, Phoenix, AZ (USA) at 6/6/2026 7:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/7/2026 11:05:00 PM. 50 Economy ticket for $145 per person are available. Travel duration is 37h 15m
Travel time is 11h 0m longer, but you will save $36

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$229	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/5/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/7/2026 11:05:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 59h 40m
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$230	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/5/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/7/2026 11:05:00 PM. 50 Economy ticket for $230 per person are available. Travel duration is 49h 30m
FlixBus	59h 15m	9:50 AM	San Diego	La Jolla Village	11:05 PM	Tupelo, MS	Bus Stop	Economy	$234	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/5/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/7/2026 11:05:00 PM. 50 Economy ticket for $234 per person are available. Travel duration is 59h 15m
Greyhound US	46h 50m	9:50 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$237	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/5/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/7/2026 10:40:00 AM. 50 Economy ticket for $237 per person are available. Travel duration is 46h 50m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$248	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/5/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/7/2026 10:40:00 AM. 50 Economy ticket for $248 per person are available. Travel duration is 49h 5m

Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $55? You can find the corresponding connections below.
- FlixBus
  
  55h 55m
  
  0
  
  1:10 PM
  
  San Diego
  Seaport Village
  
  11:59 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $153
  
  A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/6/2026 1:10:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/8/2026 11:59:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 44h 49m
- Greyhound US
  
  1h 45m
  
  0
  
  9:20 PM
  
  Memphis
  Airways Transit Center
  
  11:05 PM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $20
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/8/2026 9:20:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/8/2026 11:05:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 1h 45m
Travel time is 7h 5m longer, but you will save $55

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$248	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/6/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/8/2026 11:05:00 PM. 50 Economy ticket for $248 per person are available. Travel duration is 49h 30m
Greyhound US	46h 50m	9:50 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$249	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/6/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/8/2026 10:40:00 AM. 50 Economy ticket for $249 per person are available. Travel duration is 46h 50m
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$251	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/6/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/8/2026 11:05:00 PM. 50 Economy ticket for $251 per person are available. Travel duration is 59h 40m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$264	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/6/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/8/2026 10:40:00 AM. 50 Economy ticket for $264 per person are available. Travel duration is 49h 5m

Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $82? You can find the corresponding connections below.
- FlixBus
  
  67h 30m
  
  0
  
  1:10 PM
  
  San Diego
  Seaport Village
  
  11:59 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $149
  
  A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/7/2026 1:10:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/9/2026 11:59:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 44h 49m
- Greyhound US
  
  1h 40m
  
  0
  
  9:00 AM
  
  Memphis
  Airways Transit Center
  
  10:40 AM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/10/2026 9:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 40m
Travel time is 18h 40m longer, but you will save $82

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$226	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/7/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/9/2026 11:05:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 59h 40m
FlixBus	59h 15m	9:50 AM	San Diego	La Jolla Village	11:05 PM	Tupelo, MS	Bus Stop	Economy	$227	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/7/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/9/2026 11:05:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 59h 15m
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$230	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/7/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/9/2026 11:05:00 PM. 50 Economy ticket for $230 per person are available. Travel duration is 49h 30m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$249	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/7/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/9/2026 10:40:00 AM. 50 Economy ticket for $249 per person are available. Travel duration is 49h 5m
Greyhound US	46h 50m	9:50 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$249	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/7/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/9/2026 10:40:00 AM. 50 Economy ticket for $249 per person are available. Travel duration is 46h 50m

Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $60? You can find the corresponding connections below.
- FlixBus
  
  67h 30m
  
  0
  
  1:10 PM
  
  San Diego
  Seaport Village
  
  11:59 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $149
  
  A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/7/2026 1:10:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/9/2026 11:59:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 44h 49m
- Greyhound US
  
  1h 40m
  
  0
  
  9:00 AM
  
  Memphis
  Airways Transit Center
  
  10:40 AM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/10/2026 9:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 40m
Travel time is 18h 40m longer, but you will save $60

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$225	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/8/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 11:05:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 59h 40m
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$226	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/8/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 11:05:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 49h 30m
FlixBus	59h 15m	9:50 AM	San Diego	La Jolla Village	11:05 PM	Tupelo, MS	Bus Stop	Economy	$231	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/8/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 11:05:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 59h 15m
Greyhound US	46h 50m	9:50 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$236	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/8/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $236 per person are available. Travel duration is 46h 50m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$239	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/8/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $239 per person are available. Travel duration is 49h 5m

Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $59? You can find the corresponding connections below.
- FlixBus
  
  67h 30m
  
  0
  
  1:10 PM
  
  San Diego
  Seaport Village
  
  11:59 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $149
  
  A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/7/2026 1:10:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/9/2026 11:59:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 44h 49m
- Greyhound US
  
  1h 40m
  
  0
  
  9:00 AM
  
  Memphis
  Airways Transit Center
  
  10:40 AM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/10/2026 9:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 40m
Travel time is 18h 40m longer, but you will save $59

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 55m	6:45 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$223	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/9/2026 6:45:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/11/2026 10:40:00 AM. 50 Economy ticket for $223 per person are available. Travel duration is 49h 55m
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$229	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/9/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/11/2026 11:05:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 59h 40m
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$230	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/9/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/11/2026 11:05:00 PM. 50 Economy ticket for $230 per person are available. Travel duration is 49h 30m
FlixBus	59h 15m	9:50 AM	San Diego	La Jolla Village	11:05 PM	Tupelo, MS	Bus Stop	Economy	$231	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/9/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/11/2026 11:05:00 PM. 50 Economy ticket for $231 per person are available. Travel duration is 59h 15m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$239	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/9/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/11/2026 10:40:00 AM. 50 Economy ticket for $239 per person are available. Travel duration is 49h 5m

Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $57? You can find the corresponding connections below.
- FlixBus
  
  67h 30m
  
  0
  
  1:10 PM
  
  San Diego
  Seaport Village
  
  11:59 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $149
  
  A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/7/2026 1:10:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/9/2026 11:59:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 44h 49m
- Greyhound US
  
  1h 40m
  
  0
  
  9:00 AM
  
  Memphis
  Airways Transit Center
  
  10:40 AM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/10/2026 9:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 40m
Travel time is 16h 25m longer, but you will save $57

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 30m	7:35 PM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$225	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/10/2026 7:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/12/2026 11:05:00 PM. 50 Economy ticket for $225 per person are available. Travel duration is 49h 30m
FlixBus	59h 40m	9:25 AM	San Diego	Old Town Transit Center	11:05 PM	Tupelo, MS	Bus Stop	Economy	$226	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/10/2026 9:25:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/12/2026 11:05:00 PM. 50 Economy ticket for $226 per person are available. Travel duration is 59h 40m
Greyhound US	49h 55m	6:45 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$227	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/10/2026 6:45:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/12/2026 10:40:00 AM. 50 Economy ticket for $227 per person are available. Travel duration is 49h 55m
FlixBus	59h 15m	9:50 AM	San Diego	La Jolla Village	11:05 PM	Tupelo, MS	Bus Stop	Economy	$227	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/10/2026 9:50:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/12/2026 11:05:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 59h 15m
FlixBus	49h 5m	7:35 AM	San Diego	Old Town Transit Center	10:40 AM	Tupelo, MS	Bus Stop	Economy	$243	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/10/2026 7:35:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/12/2026 10:40:00 AM. 50 Economy ticket for $243 per person are available. Travel duration is 49h 5m

Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $59? You can find the corresponding connections below.
- FlixBus
  
  67h 30m
  
  0
  
  1:10 PM
  
  San Diego
  Seaport Village
  
  11:59 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $149
  
  A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/7/2026 1:10:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/9/2026 11:59:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 44h 49m
- Greyhound US
  
  1h 40m
  
  0
  
  9:00 AM
  
  Memphis
  Airways Transit Center
  
  10:40 AM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/10/2026 9:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/10/2026 10:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 40m
Travel time is 16h 25m longer, but you will save $59

Best Price Offer: The price for the cheapest bus from San Diego to Tupelo, MS is $216 on 6/22/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Tupelo, MS

See here how frequent the connections between San Diego and Tupelo, MS are, during different times and days of the week.

Monday is the busiest day, with more than 10 daily buses from San Diego to Tupelo, MS. Thursday has instead the fewest connections, with only 4 daily coaches between San Diego and Tupelo, MS.

The busiest time of the day is the Morning, with 40 buses from San Diego to Tupelo, MS, while Evening sees the fewest connections between San Diego and Tupelo, MS, with 10 offers.

Facts about the bus from San Diego to Tupelo, MS

Compare all providers like FlixBus and Greyhound US that travel 7 times every day by bus from San Diego to Tupelo, MS in one click! Book your bus ticket from San Diego to Tupelo, MS starting from $216!

Cheapest Bus	$216
Fastest Bus	48h 50m
Earliest Bus	7:35 AM
Latest Bus	7:35 PM
Daily Bus Routes	7 Ø
Distance	1,637.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Tupelo, MS

Every day, 7 buses from 2 bus companies leave San Diego for Tupelo, MS: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/04/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/31

Monday 06/01

Tuesday 06/02

Wednesday 06/03

Thursday 06/04

$225

Friday 06/05

$229

Saturday 06/06

$248

Sunday 06/07

$226

Monday 06/08

$225

Tuesday 06/09

$223

Wednesday 06/10

$225

Thursday 06/11

Friday 06/12

Saturday 06/13

$222

Sunday 06/14

Monday 06/15

$220

Tuesday 06/16

$218

Wednesday 06/17

$218

Thursday 06/18

$224

Friday 06/19

Saturday 06/20

$220

Sunday 06/21

$220

Monday 06/22

$216

Tuesday 06/23

$216

Wednesday 06/24

$216

Thursday 06/25

$216

Friday 06/26

$218

Saturday 06/27

The cheapest time to travel from San Diego to Tupelo, MS

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Tupelo, MS, for the next 30 days.

With a price starting from $216, Sunday is the cheapest day for a bus from San Diego to Tupelo, MS. Friday instead is the most expensive day with prices starting from $218.

Morning is the cheapest day time for bus tickets from San Diego to Tupelo, MS, with $223. Evening is the most expensive time of the day with prices starting from $225.

How to save money travelling from San Diego to Tupelo, MS

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Tupelo, MS in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Tupelo, MS, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Tupelo, MS are also emptier.

Beloved bus companies from San Diego to Tupelo, MS

These are the most booked bus companies between San Diego to Tupelo, MS from our users.

FlixBus from San Diego to Tupelo, MS

Here you will find the key facts about the FlixBus bus route San Diego to Tupelo, MS:

Cheapest Price	$225
Fastest Bus	50h 45m
Earliest Bus	7:35 AM
Last Bus	9:50 AM
Daily Connections	4 Ø
Found on	5/11/2026

Greyhound US from San Diego to Tupelo, MS

Here you will find the key facts about the Greyhound US bus route San Diego to Tupelo, MS:

Cheapest Price	$223
Fastest Bus	48h 50m
Earliest Bus	9:50 AM
Last Bus	7:35 PM
Daily Connections	2 Ø
Found on	5/11/2026

All bus stations and stops in San Diego and Tupelo, MS

In the map below, you can see where to find all bus stations in San Diego and Tupelo, MS.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Bus Stop

S Eason Blvd 2831

Service and Comfort on the bus from San Diego to Tupelo, MS

Want to know which seat classes are available on the buses from San Diego to Tupelo, MS? Or which bus companies serve the route San Diego to Tupelo, MS? Below you will find answers to your questions.

FAQs about the San Diego to Tupelo, MS bus

How much does a San Diego Tupelo, MS bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $216 and takes 51h 55m to reach Tupelo, MS. Compare offers to save money!

How much could I save by comparing buses from San Diego to Tupelo, MS?

This route is offered by 2 companies with a range of ticket prices between $216 and $264. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Tupelo, MS.

On average, how many connections are available from San Diego to Tupelo, MS each day?

Every day, the San Diego to Tupelo, MS bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Tupelo, MS take?

The fastest bus from San Diego to Tupelo, MS is offered by Greyhound US and takes 48h 50m. Bus tickets for this connection cost $238. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Tupelo, MS?

The earliest bus arriving in Tupelo, MS from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Tupelo, MS?

The latest bus trip departing from San Diego for Tupelo, MS starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Tupelo, MS route?

When traveling by bus from San Diego to Tupelo, MS, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Tupelo, MS?

You can check all the direct connections between San Diego and Tupelo, MS by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Tupelo, MS bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Tupelo, MS bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Tupelo, MS bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Tupelo, MS on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Tupelo, MS?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between San Diego and Tupelo, MS. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Tupelo, MS?

Prices and availability for 7 trips between San Diego and Tupelo, MS change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Tupelo, MS

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Tupelo, MS

Here’s an overview of the most popular bus routes to San Diego and to Tupelo, MS. Simply click on the connection of your choice, and you will find all the details about your bus route!