Which bus from San Diego to Tupelo, MS is the cheapest?

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Compare all timetables for the bus from San Diego to Tupelo, MS

Here is a selection of the cheapest bus trips from the schedule from San Diego to Tupelo, MS from various bus operators like FlixBus or Greyhound US for the next days.

today
$224
tomorrow
$228
Monday
$236
Tuesday
$223
Wednesday
$223
Thursday
$240
Friday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 59h 40m 9:25 AM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $224
FlixBus 59h 15m 9:50 AM San Diego La Jolla Village 11:05 PM Tupelo, MS Bus Stop  Economy $228
Greyhound US 49h 30m 7:35 PM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $234
Greyhound US 46h 50m 9:50 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $236
FlixBus 49h 5m 7:35 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $240
  • Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $86? You can find the corresponding connections below.
    • FlixBus
      55h 55m
      0
      1:10 PM
      San Diego
      Seaport Village
      11:55 AM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $122
      • Waiting Time 9h 25m
    • Greyhound US
      1h 45m
      0
      9:20 PM
      Memphis
      Airways Transit Center
      11:05 PM
      Tupelo, MS
      Bus Stop
      0
      Greyhound US
      Economy
      $16
    Travel time is 7h 5m longer, but you will save $86

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 59h 40m 9:25 AM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $228
FlixBus 59h 15m 9:50 AM San Diego La Jolla Village 11:05 PM Tupelo, MS Bus Stop  Economy $228
Greyhound US 46h 50m 9:50 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $236
FlixBus 48h 45m 7:55 AM San Diego La Jolla Village 10:40 AM Tupelo, MS Bus Stop  Economy $250
Greyhound US 49h 30m 7:35 PM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $250
  • Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $90? You can find the corresponding connections below.
    • FlixBus
      55h 55m
      0
      1:10 PM
      San Diego
      Seaport Village
      11:55 AM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $122
      • Waiting Time 9h 25m
    • Greyhound US
      1h 45m
      0
      9:20 PM
      Memphis
      Airways Transit Center
      11:05 PM
      Tupelo, MS
      Bus Stop
      0
      Greyhound US
      Economy
      $16
    Travel time is 7h 5m longer, but you will save $90

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 46h 50m 9:50 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $236
FlixBus 49h 5m 7:35 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $237
Greyhound US 49h 30m 7:35 PM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $256
FlixBus 59h 40m 9:25 AM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $258
  • Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $98? You can find the corresponding connections below.
    • FlixBus
      55h 55m
      0
      1:10 PM
      San Diego
      Seaport Village
      11:55 AM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $122
      • Waiting Time 9h 25m
    • Greyhound US
      1h 45m
      0
      9:20 PM
      Memphis
      Airways Transit Center
      11:05 PM
      Tupelo, MS
      Bus Stop
      0
      Greyhound US
      Economy
      $16
    Travel time is 7h 5m longer, but you will save $98

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 49h 55m 6:45 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $223
Greyhound US 49h 30m 7:35 PM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $230
FlixBus 59h 40m 9:25 AM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $230
FlixBus 49h 5m 7:35 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $245
  • Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $85? You can find the corresponding connections below.
    • FlixBus
      55h 55m
      0
      1:10 PM
      San Diego
      Seaport Village
      11:55 AM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $122
      • Waiting Time 9h 25m
    • Greyhound US
      1h 45m
      0
      9:20 PM
      Memphis
      Airways Transit Center
      11:05 PM
      Tupelo, MS
      Bus Stop
      0
      Greyhound US
      Economy
      $16
    Travel time is 4h 50m longer, but you will save $85

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 49h 55m 6:45 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $223
Greyhound US 49h 30m 7:35 PM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $240
FlixBus 59h 40m 9:25 AM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $241
FlixBus 49h 5m 7:35 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $259
  • Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $85? You can find the corresponding connections below.
    • FlixBus
      55h 55m
      0
      1:10 PM
      San Diego
      Seaport Village
      11:55 AM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $122
      • Waiting Time 9h 25m
    • Greyhound US
      1h 45m
      0
      9:20 PM
      Memphis
      Airways Transit Center
      11:05 PM
      Tupelo, MS
      Bus Stop
      0
      Greyhound US
      Economy
      $16
    Travel time is 4h 50m longer, but you will save $85

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 59h 40m 9:25 AM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $240
FlixBus 59h 15m 9:50 AM San Diego La Jolla Village 11:05 PM Tupelo, MS Bus Stop  Economy $246
Greyhound US 49h 30m 7:35 PM San Diego Old Town Transit Center 11:05 PM Tupelo, MS Bus Stop  Economy $246
Greyhound US 46h 50m 9:50 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $268
FlixBus 49h 5m 7:35 AM San Diego Old Town Transit Center 10:40 AM Tupelo, MS Bus Stop  Economy $283
  • Did you know that if you travel from San Diego to Tupelo, MS via Memphis, you can save more than $102? You can find the corresponding connections below.
    • FlixBus
      55h 55m
      0
      1:10 PM
      San Diego
      Seaport Village
      11:55 AM
      Memphis
      Airways Transit Center
      0
      FlixBus
      Economy
      $122
      • Waiting Time 9h 25m
    • Greyhound US
      1h 45m
      0
      9:20 PM
      Memphis
      Airways Transit Center
      11:05 PM
      Tupelo, MS
      Bus Stop
      0
      Greyhound US
      Economy
      $16
    Travel time is 7h 5m longer, but you will save $102

Best Price Offer: The price for the cheapest bus from San Diego to Tupelo, MS is $218 on 5/12/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between San Diego and Tupelo, MS

See here how frequent the connections between San Diego and Tupelo, MS are, during different times and days of the week.
Thursday is the busiest day, with more than 10 daily buses from San Diego to Tupelo, MS. Monday has instead the fewest connections, with only 4 daily coaches between San Diego and Tupelo, MS.
The busiest time of the day is the Morning, with 30 buses from San Diego to Tupelo, MS, while Evening sees the fewest connections between San Diego and Tupelo, MS, with 8 offers.

Facts about the bus from San Diego to Tupelo, MS

Compare all providers like FlixBus and Greyhound US that travel 6 times every day by bus from San Diego to Tupelo, MS in one click! Book your bus ticket from San Diego to Tupelo, MS starting from $218!

Cheapest Bus $218
Fastest Bus 48h 50m
Earliest Bus 7:35 AM
Latest Bus 7:35 PM
Daily Bus Routes 6 Ø
Distance 1,637.9 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from San Diego to Tupelo, MS

Every day, 6 buses from 2 bus companies leave San Diego for Tupelo, MS: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/16/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 05/10
Monday 05/11
Tuesday 05/12
Wednesday 05/13
Thursday 05/14
Friday 05/15
Saturday 05/16
$224
Sunday 05/17
$228
Monday 05/18
$236
Tuesday 05/19
$223
Wednesday 05/20
$223
Thursday 05/21
$240
Friday 05/22
Saturday 05/23
$246
Sunday 05/24
$238
Monday 05/25
$234
Tuesday 05/26
$218
Wednesday 05/27
Thursday 05/28
$225
Friday 05/29
$230
Saturday 05/30
$225
Sunday 05/31
Monday 06/01
Tuesday 06/02
$218
Wednesday 06/03
Thursday 06/04
$225
Friday 06/05
$229
Saturday 06/06

The cheapest time to travel from San Diego to Tupelo, MS

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Tupelo, MS, for the next 30 days.
With a price starting from $218, Tuesday is the cheapest day for a bus from San Diego to Tupelo, MS. Sunday instead is the most expensive day with prices starting from $226.
Morning is the cheapest day time for bus tickets from San Diego to Tupelo, MS, with $223. Evening is the most expensive time of the day with prices starting from $230.

How to save money travelling from San Diego to Tupelo, MS

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Tupelo, MS in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Tupelo, MS, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Tupelo, MS are also emptier.

Beloved bus companies from San Diego to Tupelo, MS

These are the most booked bus companies between San Diego to Tupelo, MS from our users.

FlixBus from San Diego to Tupelo, MS

FlixBus

Here you will find the key facts about the FlixBus bus route San Diego to Tupelo, MS:

Cheapest Price $224
Fastest Bus 50h 45m
Earliest Bus 7:35 AM
Last Bus 9:50 AM
Daily Connections 3 Ø
Found on 4/21/2026

Greyhound US from San Diego to Tupelo, MS

Greyhound US

Here you will find the key facts about the Greyhound US bus route San Diego to Tupelo, MS:

Cheapest Price $223
Fastest Bus 48h 50m
Earliest Bus 9:50 AM
Last Bus 7:35 PM
Daily Connections 2 Ø
Found on 4/21/2026

All bus stations and stops in San Diego and Tupelo, MS

In the map below, you can see where to find all bus stations in San Diego and Tupelo, MS.

Service and Comfort on the bus from San Diego to Tupelo, MS

Want to know which seat classes are available on the buses from San Diego to Tupelo, MS? Or which bus companies serve the route San Diego to Tupelo, MS? Below you will find answers to your questions.

FAQs about the San Diego to Tupelo, MS bus

How much does a San Diego Tupelo, MS bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $218 and takes 51h 55m to reach Tupelo, MS. Compare offers to save money!

How much could I save by comparing buses from San Diego to Tupelo, MS?

This route is offered by 2 companies with a range of ticket prices between $218 and $287. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Tupelo, MS.

On average, how many connections are available from San Diego to Tupelo, MS each day?

Every day, the San Diego to Tupelo, MS bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Tupelo, MS take?

The fastest bus from San Diego to Tupelo, MS is offered by Greyhound US and takes 48h 50m. Bus tickets for this connection cost $240. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Tupelo, MS?

The earliest bus arriving in Tupelo, MS from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Tupelo, MS?

The latest bus trip departing from San Diego for Tupelo, MS starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Tupelo, MS route?

When traveling by bus from San Diego to Tupelo, MS, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Tupelo, MS?

You can check all the direct connections between San Diego and Tupelo, MS by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Tupelo, MS bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Tupelo, MS bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Tupelo, MS bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Tupelo, MS on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Tupelo, MS?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between San Diego and Tupelo, MS. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Tupelo, MS?

Prices and availability for 6 trips between San Diego and Tupelo, MS change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Tupelo, MS

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Tupelo, MS

Here’s an overview of the most popular bus routes to San Diego and to Tupelo, MS. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Bus to Tupelo, MS from Owensboro, KY Bus to Tupelo, MS from Owensboro, KY
Bus Flint, MI to Tupelo, MS Bus Flint, MI to Tupelo, MS
Bus to Tupelo, MS from Cincinnati Bus to Tupelo, MS from Cincinnati
From Mobile, AL to Tupelo, MS bus From Mobile, AL to Tupelo, MS bus
Popular Airport Shuttles to San Diego and to Tupelo, MS
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