Bus Jacksonville, FL to Chicago: Compare prices and save money

Compare all timetables for the bus from Jacksonville, FL to Chicago

Here is a selection of the cheapest bus trips from the schedule from Jacksonville, FL to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

$300

tomorrow

$351

Monday

Tuesday

$163

Wednesday

$155

Thursday

Friday

$169

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	26h 35m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	11:00 PM	Chicago	95th Red Line Station	Economy	$300	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/20/2025 9:25:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/21/2025 11:00:00 PM. 50 Economy ticket for $300 per person are available. Travel duration is 26h 35m
FlixBus	28h 35m	11:40 AM	Jacksonville, FL	Downtown Bus Stop	3:15 PM	Chicago	Downtown Bus Station	Economy	$324	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/20/2025 11:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/21/2025 3:15:00 PM. 50 Economy ticket for $324 per person are available. Travel duration is 28h 35m
FlixBus	23h 45m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	8:10 PM	Chicago	Downtown Bus Station	Economy	$334	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/20/2025 9:25:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/21/2025 8:10:00 PM. 50 Economy ticket for $334 per person are available. Travel duration is 23h 45m
FlixBus	35h 20m	10:05 PM	Jacksonville, FL	Amtrak Train Station	8:25 AM	Chicago	Downtown Bus Station	Economy	$359	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/20/2025 10:05:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 8:25:00 AM. 50 Economy ticket for $359 per person are available. Travel duration is 35h 20m
FlixBus	34h 55m	10:05 PM	Jacksonville, FL	Amtrak Train Station	8:00 AM	Chicago	Union Station	Economy	$359	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/20/2025 10:05:00 PM to Union Station, Chicago (USA) arriving at 12/22/2025 8:00:00 AM. 50 Economy ticket for $359 per person are available. Travel duration is 34h 55m

Did you know that if you travel from Jacksonville, FL to Chicago via Atlanta, GA, you can save more than $113? You can find the corresponding connections below.
- Busbud
  
  23h 45m
  
  0
  
  9:25 PM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  4:10 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $62
  
  A Bus from Busbud goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/21/2025 9:25:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/22/2025 4:10:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 6h 45m
- Busbud
  
  16h 5m
  
  0
  
  5:05 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  8:10 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $125
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/22/2025 5:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 8:10:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 16h 5m
Travel time is 1h 0m longer, but you will save $113

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	28h 35m	11:40 AM	Jacksonville, FL	Amtrak Train Station	3:15 PM	Chicago	Downtown Bus Station	Economy	$351	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/21/2025 11:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 3:15:00 PM. 50 Economy ticket for $351 per person are available. Travel duration is 28h 35m
FlixBus	26h 35m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	11:00 PM	Chicago	95th Red Line Station	Economy	$367	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/21/2025 9:25:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/22/2025 11:00:00 PM. 50 Economy ticket for $367 per person are available. Travel duration is 26h 35m
FlixBus	23h 55m	9:05 AM	Jacksonville, FL	Downtown Bus Stop	8:00 AM	Chicago	Canal & Van Buren	Economy	$378	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/21/2025 9:05:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/22/2025 8:00:00 AM. 50 Economy ticket for $378 per person are available. Travel duration is 23h 55m
Greyhound US	27h 0m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	11:30 AM	Chicago	Downtown Bus Station	Economy	$382	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/21/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 11:30:00 AM. 50 Economy ticket for $382 per person are available. Travel duration is 27h 0m
Greyhound US	29h 40m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	2:10 PM	Chicago	Canal & Van Buren	Economy	$397	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/21/2025 9:30:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/22/2025 2:10:00 PM. 50 Economy ticket for $397 per person are available. Travel duration is 29h 40m

Did you know that if you travel from Jacksonville, FL to Chicago via Atlanta, GA, you can save more than $164? You can find the corresponding connections below.
- Busbud
  
  23h 45m
  
  0
  
  9:25 PM
  
  Jacksonville, FL
  Downtown Bus Stop
  
  4:10 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  0
  
  Economy
  
  $62
  
  A Bus from Busbud goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/21/2025 9:25:00 PM to Garnett Transit Station, Atlanta, GA (USA) arriving at 12/22/2025 4:10:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 6h 45m
- Busbud
  
  16h 5m
  
  0
  
  5:05 AM
  
  Atlanta, GA
  Garnett Transit Station
  
  8:10 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $125
  
  A Bus from Busbud goes from Garnett Transit Station, Atlanta, GA (USA) at 12/22/2025 5:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 8:10:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 16h 5m
Travel time is 0h 50m longer, but you will save $164

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	26h 35m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:00 PM	Chicago	95th Red Line Station	Economy	$163	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/23/2025 9:25:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/24/2025 11:00:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 26h 35m
Greyhound US	26h 35m	9:30 AM	Jacksonville, FL	Amtrak Train Station	11:05 AM	Chicago	95th Red Line Station	Economy	$201	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/23/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/24/2025 11:05:00 AM. 50 Economy ticket for $201 per person are available. Travel duration is 26h 35m
FlixBus	25h 45m	9:05 AM	Jacksonville, FL	Amtrak Train Station	9:50 AM	Chicago	95th Red Line Station	Economy	$215	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/23/2025 9:05:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/24/2025 9:50:00 AM. 50 Economy ticket for $215 per person are available. Travel duration is 25h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	26h 35m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	11:00 PM	Chicago	95th Red Line Station	Economy	$155	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/24/2025 9:25:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 11:00:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 26h 35m
Greyhound US	26h 35m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	11:05 AM	Chicago	95th Red Line Station	Economy	$160	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/24/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/25/2025 11:05:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 26h 35m
FlixBus	23h 45m	9:25 PM	Jacksonville, FL	Downtown Bus Stop	8:10 PM	Chicago	Downtown Bus Station	Economy	$177	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/24/2025 9:25:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 8:10:00 PM. 50 Economy ticket for $177 per person are available. Travel duration is 23h 45m
FlixBus	28h 35m	11:40 AM	Jacksonville, FL	Downtown Bus Stop	3:15 PM	Chicago	Downtown Bus Station	Economy	$178	A Bus from FlixBus goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/24/2025 11:40:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 3:15:00 PM. 50 Economy ticket for $178 per person are available. Travel duration is 28h 35m
Greyhound US	29h 40m	9:30 AM	Jacksonville, FL	Downtown Bus Stop	2:10 PM	Chicago	Canal & Van Buren	Economy	$178	A Bus from Greyhound US goes from Downtown Bus Stop, Jacksonville, FL (USA) at 12/24/2025 9:30:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/25/2025 2:10:00 PM. 50 Economy ticket for $178 per person are available. Travel duration is 29h 40m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	26h 35m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:00 PM	Chicago	95th Red Line Station	Economy	$169	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/26/2025 9:25:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/27/2025 11:00:00 PM. 50 Economy ticket for $169 per person are available. Travel duration is 26h 35m
Greyhound US	26h 35m	9:30 AM	Jacksonville, FL	Amtrak Train Station	11:05 AM	Chicago	95th Red Line Station	Economy	$173	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/26/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/27/2025 11:05:00 AM. 50 Economy ticket for $173 per person are available. Travel duration is 26h 35m
FlixBus	23h 45m	9:25 PM	Jacksonville, FL	Amtrak Train Station	8:10 PM	Chicago	Downtown Bus Station	Economy	$195	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/26/2025 9:25:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/27/2025 8:10:00 PM. 50 Economy ticket for $195 per person are available. Travel duration is 23h 45m
Greyhound US	27h 0m	9:30 AM	Jacksonville, FL	Amtrak Train Station	11:30 AM	Chicago	Downtown Bus Station	Economy	$195	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/26/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/27/2025 11:30:00 AM. 50 Economy ticket for $195 per person are available. Travel duration is 27h 0m
Greyhound US	29h 40m	9:30 AM	Jacksonville, FL	Amtrak Train Station	2:10 PM	Chicago	Union Station	Economy	$201	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 12/26/2025 9:30:00 AM to Union Station, Chicago (USA) arriving at 12/27/2025 2:10:00 PM. 50 Economy ticket for $201 per person are available. Travel duration is 29h 40m

Best Price Offer: The price for the cheapest bus from Jacksonville, FL to Chicago is $135 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Jacksonville, FL and Chicago

See here how frequent the connections between Jacksonville, FL and Chicago are, during different times and days of the week.

Sunday is the busiest day, with more than 22 daily buses from Jacksonville, FL to Chicago. Tuesday has instead the fewest connections, with only 3 daily coaches between Jacksonville, FL and Chicago.

The busiest time of the day is the Morning, with 39 buses from Jacksonville, FL to Chicago, while Evening sees the fewest connections between Jacksonville, FL and Chicago, with 29 offers.

Facts about the bus from Jacksonville, FL to Chicago

Compare all providers like FlixBus and Greyhound US that travel 13 times every day by bus from Jacksonville, FL to Chicago in one click! Book your bus ticket from Jacksonville, FL to Chicago starting from $135!

Cheapest Bus	$135
Fastest Bus	22h 45m
Earliest Bus	11:40 AM
Latest Bus	10:05 PM
Daily Bus Routes	13 Ø
Distance	864.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Jacksonville, FL to Chicago

Every day, 13 buses from 2 bus companies leave Jacksonville, FL for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/20/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

$300

Sunday 12/21

$351

Monday 12/22

Tuesday 12/23

$163

Wednesday 12/24

$155

Thursday 12/25

Friday 12/26

$195

Saturday 12/27

Sunday 12/28

$170

Monday 12/29

$155

Tuesday 12/30

Wednesday 12/31

$149

Thursday 01/01

Friday 01/02

Saturday 01/03

$173

Sunday 01/04

Monday 01/05

Tuesday 01/06

$138

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from Jacksonville, FL to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Jacksonville, FL to Chicago, for the next 30 days.

With a price starting from $138, Tuesday is the cheapest day for a bus from Jacksonville, FL to Chicago. Saturday instead is the most expensive day with prices starting from $173.

Evening is the cheapest day time for bus tickets from Jacksonville, FL to Chicago, with $155. Morning is the most expensive time of the day with prices starting from $160.

How to save money travelling from Jacksonville, FL to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Jacksonville, FL to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Jacksonville, FL to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Jacksonville, FL to Chicago are also emptier.

Beloved bus companies from Jacksonville, FL to Chicago

These are the most booked bus companies between Jacksonville, FL to Chicago from our users.

Greyhound US from Jacksonville, FL to Chicago

Here you will find the key facts about the Greyhound US bus route Jacksonville, FL to Chicago:

Cheapest Price	$160
Fastest Bus	25h 35m
Earliest Bus	9:30 AM
Last Bus	9:30 AM
Daily Connections	4 Ø
Found on	12/20/2025

All bus stations and stops in Jacksonville, FL and Chicago

In the map below, you can see where to find all bus stations in Jacksonville, FL and Chicago.

Downtown Bus Stop

West Forsyth Street 1111

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Beaver St. & Ocean St. Bus Stop

Friendship Fountain

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Jacksonville, FL to Chicago

Want to know which seat classes are available on the buses from Jacksonville, FL to Chicago? Or which bus companies serve the route Jacksonville, FL to Chicago? Below you will find answers to your questions.

FAQs about the Jacksonville, FL to Chicago bus

How much does a Jacksonville, FL Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $135 and takes 25h 35m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Jacksonville, FL to Chicago?

This route is offered by 2 companies with a range of ticket prices between $135 and $447. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Jacksonville, FL to Chicago each day?

Every day, the Jacksonville, FL to Chicago bus route is served by approximately 13 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Jacksonville, FL to Chicago take?

The fastest bus from Jacksonville, FL to Chicago is offered by FlixBus and takes 22h 45m. Bus tickets for this connection cost $350. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Jacksonville, FL to Chicago?

The earliest bus arriving in Chicago from Jacksonville, FL starts at 11:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Jacksonville, FL to Chicago?

The latest bus trip departing from Jacksonville, FL for Chicago starts at 10:05 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Jacksonville, FL Chicago route?

When traveling by bus from Jacksonville, FL to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Jacksonville, FL and Chicago?

You can check all the direct connections between Jacksonville, FL and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Jacksonville, FL to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Jacksonville, FL Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Jacksonville, FL Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Jacksonville, FL to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Jacksonville, FL to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 13 daily trips between Jacksonville, FL and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Jacksonville, FL to Chicago?

Prices and availability for 13 trips between Jacksonville, FL and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Jacksonville, FL to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Jacksonville, FL and to Chicago

Here’s an overview of the most popular bus routes to Jacksonville, FL and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!