Bus La Serena to Mendoza - Compare all Companies

Compare all timetables for the bus from La Serena to Mendoza

Here is a selection of the cheapest bus trips from the schedule from La Serena to Mendoza from various bus operators like CATA Internacional for the next days.

today

tomorrow

Saturday

Sunday

$83

Monday

Tuesday

Wednesday

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	CATA Internacional	13h 15m	5:30 PM	La Serena	Avda. Fco de Aguirre Station	6:45 AM	Mendoza	Bus Station		Business	$83	A Bus from CATA Internacional goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/21/2025 5:30:00 PM to Bus Station, Mendoza (Argentina) arriving at 12/22/2025 6:45:00 AM. 50 Business ticket for $83 per person are available. Travel duration is 13h 15m

Did you know that if you travel from La Serena to Mendoza via Santiago, RM, you can save more than $49? You can find the corresponding connections below.
- Recorrido CL
  
  15h 0m
  
  0
  
  12:45 AM
  
  La Serena
  Central Bus Station
  
  7:00 AM
  
  Santiago, RM
  Sur Bus Station
  
  0
  
  Premium Economy
  
  $10
  
  A Bus from Recorrido CL goes from Central Bus Station, La Serena (Chile) at 12/23/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/23/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
- Voyenbus
  
  8h 0m
  
  0
  
  7:45 AM
  
  Santiago, RM
  Los Héroes Station
  
  3:45 PM
  
  Mendoza
  Bus Station
  
  0
  
  Basic
  
  $24
  
  A Bus from Voyenbus goes from Los Héroes Station, Santiago, RM (Chile) at 12/23/2025 7:45:00 AM to Bus Station, Mendoza (Argentina) arriving at 12/23/2025 3:45:00 PM. 50 Basic ticket for $24 per person are available. Travel duration is 8h 0m
Travel time is 1h 45m longer, but you will save $49

Best Price Offer: The price for the cheapest bus from La Serena to Mendoza is $62 on 12/14/2025. Flexible travelers save on ticket prices.

Facts about the bus from La Serena to Mendoza

Compare all providers like CATA Internacional that travel 5 times every day by bus from La Serena to Mendoza in one click! Book your bus ticket from La Serena to Mendoza starting from $62!

Cheapest Bus	$62
Fastest Bus	13h 15m
Earliest Bus	5:30 PM
Latest Bus	5:30 PM
Daily Bus Routes	5 Ø
Distance	250.5 miles
Bus Companies	CATA Internacional

Cheapest bus connections from La Serena to Mendoza

Every day, 5 buses from 1 bus companies leave La Serena for Mendoza: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/18/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

$83

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

$83

Monday 12/29

$83

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

$83

Saturday 01/03

Sunday 01/04

$95

Monday 01/05

Tuesday 01/06

Wednesday 01/07

$83

Thursday 01/08

Friday 01/09

$83

Saturday 01/10

How to save money travelling from La Serena to Mendoza

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from La Serena to Mendoza in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Mendoza, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Mendoza are also emptier.

All bus stations and stops in La Serena and Mendoza

In the map below, you can see where to find all bus stations in La Serena and Mendoza.

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Bus Station

Avenida El Santo 1475

El Sto, 1060

terminal de buses covalle bus

Rotonda

Bus Station

Juan B. Alberdi s/n

Hotel Internacional

Av. Sarmiento 720

Hotel Hyatt

Chile 1124

Hotel NH Cordillera

1324 1324

Casa Juri

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from La Serena to Mendoza? Compare all modes of transports from La Serena to Mendoza.

Service and Comfort on the bus from La Serena to Mendoza

Want to know which seat classes are available on the buses from La Serena to Mendoza? Or which bus companies serve the route La Serena to Mendoza? Below you will find answers to your questions.

FAQs about the La Serena to Mendoza bus

How much does a La Serena Mendoza bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $62 and takes 13h 15m to reach Mendoza. Compare offers to save money!

How much could I save by comparing buses from La Serena to Mendoza?

This route is offered by 1 companies with a range of ticket prices between $62 and $107. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Mendoza.

On average, how many connections are available from La Serena to Mendoza each day?

Every day, the La Serena to Mendoza bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from La Serena to Mendoza take?

The fastest bus from La Serena to Mendoza is offered by CATA Internacional and takes 13h 15m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from La Serena to Mendoza?

The earliest bus arriving in Mendoza from La Serena starts at 5:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from La Serena to Mendoza?

The latest bus trip departing from La Serena for Mendoza starts at 5:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the La Serena Mendoza route?

When traveling by bus from La Serena to Mendoza, passengers can travel with CATA Internacional. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between La Serena and Mendoza?

You can check all the direct connections between La Serena and Mendoza by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: CATA Internacional.

What can I take with me on the La Serena to Mendoza bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the La Serena Mendoza bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Mendoza bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Mendoza on your planned travel date.

How does CheckMyBus find the best bus deals from La Serena to Mendoza?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between La Serena and Mendoza. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from La Serena to Mendoza?

Prices and availability for 5 trips between La Serena and Mendoza change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route La Serena to Mendoza

Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

More bus routes to La Serena and to Mendoza

Here’s an overview of the most popular bus routes to La Serena and to Mendoza. Simply click on the connection of your choice, and you will find all the details about your bus route!