Bus Santiago, RM to La Serena: Compare prices and save money

Compare all timetables for the bus from Santiago, RM to La Serena

Here is a selection of the cheapest bus trips from the schedule from Santiago, RM to La Serena from various bus operators like Cikbus Elité, Pullman San Andres or Pullman Bus for the next days.

today

$11

tomorrow

$11

Saturday

$11

Sunday

$11

Monday

$11

Tuesday

$11

Wednesday

$12

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	10:30 AM	Santiago, RM	Sur Bus Station	5:00 PM	La Serena	Central Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 5/7/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/7/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Cormar Bus	6h 40m	7:30 PM	Santiago, RM	Terminal San Borja	2:10 AM	La Serena	Central Bus Station	Premium Economy	$13	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 5/7/2026 7:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/8/2026 2:10:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 40m
Pluss Chile	7h 5m	9:30 AM	Santiago, RM	Sur Bus Station	4:35 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 5/7/2026 9:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/7/2026 4:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
Condor Bus	7h 5m	2:30 PM	Santiago, RM	Sur Bus Station	9:35 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 5/7/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/7/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
FlixBus	6h 10m	6:10 PM	Santiago, RM	Terminal San Borja	12:20 AM	La Serena	Central Bus Station	Economy	$15	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/7/2026 6:10:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/8/2026 12:20:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	10:30 AM	Santiago, RM	Sur Bus Station	5:00 PM	La Serena	Central Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/8/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Pluss Chile	6h 20m	7:45 AM	Santiago, RM	Sur Bus Station	2:05 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/8/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
FlixBus	6h 10m	6:15 AM	Santiago, RM	Terminal San Borja	12:25 PM	La Serena	Central Bus Station	Economy	$15	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/8/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/8/2026 12:25:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 10m
Cormar Bus	6h 40m	11:45 PM	Santiago, RM	Terminal San Borja	6:25 AM	La Serena	Central Bus Station	Premium Economy	$16	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 5/8/2026 11:45:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/9/2026 6:25:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 40m
Cikbus Elité	7h 15m	7:30 AM	Santiago, RM	Sur Bus Station	2:45 PM	La Serena	Central Bus Station	Premium Economy	$17	A Bus from Cikbus Elité goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/8/2026 2:45:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 7h 15m

Did you know that if you travel from Coquimbo to Santiago, RM via La Serena, you can save more than $7? You will find the corresponding connections below.
- Save more than 64%
  
  0h 35m
  
  0 mi
  
  1:30 PM
  
  Coquimbo
  Bus Station
  
  2:05 PM
  
  La Serena
  El Sto, 1060
  
  244 mi
  
  Santiago, RM
  
  Premium Economy
  
  $4
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 5/8/2026 1:30:00 PM to El Sto, 1060, La Serena (Chile) arriving at 5/8/2026 2:05:00 PM. 50 Premium Economy ticket for $4 per person are available. Travel duration is 0h 35m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Pluss Chile	6h 20m	2:30 PM	Santiago, RM	Sur Bus Station	8:50 PM	La Serena	Central Bus Station	Premium Economy	$11	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 5/9/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/9/2026 8:50:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 20m
Turbus	6h 10m	6:30 PM	Santiago, RM	Terminal Alameda	12:40 AM	La Serena	Avda. Fco de Aguirre Station	Premium Economy	$14	A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 5/9/2026 6:30:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 5/10/2026 12:40:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
FlixBus	6h 10m	6:15 AM	Santiago, RM	Terminal San Borja	12:25 PM	La Serena	Central Bus Station	Economy	$14	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/9/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/9/2026 12:25:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
Nueva Andimar Vip	6h 50m	1:15 PM	Santiago, RM	Terminal San Borja	8:05 PM	La Serena	Central Bus Station	Economy	$15	A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 5/9/2026 1:15:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/9/2026 8:05:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 50m
Cormar Bus	6h 30m	10:55 PM	Santiago, RM	Terminal San Borja	5:25 AM	La Serena	Central Bus Station	Premium Economy	$16	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 5/9/2026 10:55:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/10/2026 5:25:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 30m

Did you know that if you travel from Coquimbo to Santiago, RM via La Serena, you can save more than $7? You will find the corresponding connections below.
- Save more than 64%
  
  0h 30m
  
  0 mi
  
  11:00 AM
  
  Coquimbo
  Bus Station
  
  11:30 AM
  
  La Serena
  El Sto, 1060
  
  244 mi
  
  Santiago, RM
  
  Premium Economy
  
  $4
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 5/9/2026 11:00:00 AM to El Sto, 1060, La Serena (Chile) arriving at 5/9/2026 11:30:00 AM. 50 Premium Economy ticket for $4 per person are available. Travel duration is 0h 30m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	10:30 AM	Santiago, RM	Sur Bus Station	5:00 PM	La Serena	Central Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 5/10/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/10/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Turbus	7h 20m	6:55 AM	Santiago, RM	Terminal Alameda	2:15 PM	La Serena	Avda. Fco de Aguirre Station	Premium Economy	$14	A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 5/10/2026 6:55:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 5/10/2026 2:15:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 20m
FlixBus	6h 10m	7:30 AM	Santiago, RM	Terminal San Borja	1:40 PM	La Serena	Central Bus Station	Economy	$14	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/10/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/10/2026 1:40:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
Pluss Chile	6h 20m	7:45 AM	Santiago, RM	Sur Bus Station	2:05 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 5/10/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/10/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
Pullman Bus	6h 30m	11:59 PM	Santiago, RM	Terminal San Borja	6:29 AM	La Serena	El Sto, 1060	First Class	$15	A Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 5/10/2026 11:59:00 PM to El Sto, 1060, La Serena (Chile) arriving at 5/11/2026 6:29:00 AM. 50 First Class ticket for $15 per person are available. Travel duration is 6h 30m

Did you know that if you travel from Coquimbo to Santiago, RM via La Serena, you can save more than $7? You will find the corresponding connections below.
- Save more than 64%
  
  0h 35m
  
  0 mi
  
  1:30 PM
  
  Coquimbo
  Bus Station
  
  2:05 PM
  
  La Serena
  El Sto, 1060
  
  244 mi
  
  Santiago, RM
  
  Premium Economy
  
  $4
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 5/10/2026 1:30:00 PM to El Sto, 1060, La Serena (Chile) arriving at 5/10/2026 2:05:00 PM. 50 Premium Economy ticket for $4 per person are available. Travel duration is 0h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	10:30 AM	Santiago, RM	Sur Bus Station	5:00 PM	La Serena	Central Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/11/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Turbus	7h 20m	6:55 AM	Santiago, RM	Terminal Alameda	2:15 PM	La Serena	Avda. Fco de Aguirre Station	Premium Economy	$14	A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 5/11/2026 6:55:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 5/11/2026 2:15:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 20m
FlixBus	6h 10m	6:15 AM	Santiago, RM	Terminal San Borja	12:25 PM	La Serena	Central Bus Station	Economy	$14	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/11/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/11/2026 12:25:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
Pluss Chile	6h 20m	7:45 AM	Santiago, RM	Sur Bus Station	2:05 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/11/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
Condor Bus	7h 5m	2:30 PM	Santiago, RM	Sur Bus Station	9:35 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/11/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	10:30 AM	Santiago, RM	Sur Bus Station	5:00 PM	La Serena	Central Bus Station	Premium Economy	$11	A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 5/12/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/12/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Turbus	6h 25m	7:20 AM	Santiago, RM	Terminal Alameda	1:45 PM	La Serena	Avda. Fco de Aguirre Station	Premium Economy	$14	A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 5/12/2026 7:20:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 5/12/2026 1:45:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 25m
Cormar Bus	6h 10m	1:00 PM	Santiago, RM	Terminal San Borja	7:10 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 5/12/2026 1:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/12/2026 7:10:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
Condor Bus	7h 5m	2:30 PM	Santiago, RM	Sur Bus Station	9:35 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 5/12/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/12/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
FlixBus	6h 10m	7:30 AM	Santiago, RM	Terminal San Borja	1:40 PM	La Serena	Central Bus Station	Economy	$14	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/12/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/12/2026 1:40:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m

Did you know that if you travel from Coquimbo to Santiago, RM via La Serena, you can save more than $7? You will find the corresponding connections below.
- Save more than 64%
  
  0h 35m
  
  0 mi
  
  1:30 PM
  
  Coquimbo
  Bus Station
  
  2:05 PM
  
  La Serena
  El Sto, 1060
  
  244 mi
  
  Santiago, RM
  
  Premium Economy
  
  $4
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 5/12/2026 1:30:00 PM to El Sto, 1060, La Serena (Chile) arriving at 5/12/2026 2:05:00 PM. 50 Premium Economy ticket for $4 per person are available. Travel duration is 0h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Romani	6h 30m	10:30 AM	Santiago, RM	Terminal San Borja	5:00 PM	La Serena	Central Bus Station	Premium Economy	$12	A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 5/13/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/13/2026 5:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 30m
Turbus	6h 20m	6:10 AM	Santiago, RM	Terminal Alameda	12:30 PM	La Serena	Avda. Fco de Aguirre Station	Premium Economy	$14	A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 5/13/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 5/13/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
Pluss Chile	6h 20m	7:45 AM	Santiago, RM	Sur Bus Station	2:05 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 5/13/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/13/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
Cormar Bus	6h 10m	1:00 PM	Santiago, RM	Terminal San Borja	7:10 PM	La Serena	Central Bus Station	Premium Economy	$14	A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 5/13/2026 1:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 5/13/2026 7:10:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
FlixBus	6h 10m	7:30 AM	Santiago, RM	Terminal San Borja	1:40 PM	La Serena	Central Bus Station	Economy	$14	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/13/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 5/13/2026 1:40:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m

Did you know that if you travel from Coquimbo to Santiago, RM via La Serena, you can save more than $8? You will find the corresponding connections below.
- Save more than 67%
  
  0h 35m
  
  0 mi
  
  1:30 PM
  
  Coquimbo
  Bus Station
  
  2:05 PM
  
  La Serena
  El Sto, 1060
  
  244 mi
  
  Santiago, RM
  
  Premium Economy
  
  $4
  
  A Bus from goes from Bus Station, Coquimbo (Chile) at 5/13/2026 1:30:00 PM to El Sto, 1060, La Serena (Chile) arriving at 5/13/2026 2:05:00 PM. 50 Premium Economy ticket for $4 per person are available. Travel duration is 0h 35m

Best Price Offer: The price for the cheapest bus from Santiago, RM to La Serena is $11 on 5/7/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Santiago, RM and La Serena

See here how frequent the connections between Santiago, RM and La Serena are, during different times and days of the week.

Sunday is the busiest day, with more than 358 daily buses from Santiago, RM to La Serena. Wednesday has instead the fewest connections, with only 231 daily coaches between Santiago, RM and La Serena.

The busiest time of the day is the Evening, with 937 buses from Santiago, RM to La Serena, while Night sees the fewest connections between Santiago, RM and La Serena, with 12 offers.

Facts about the bus from Santiago, RM to La Serena

Compare all providers like Cikbus Elité, Pullman San Andres and Pullman Bus that travel 295 times every day by bus from Santiago, RM to La Serena in one click! Book your bus ticket from Santiago, RM to La Serena starting from $11!

Cheapest Bus	$11
Fastest Bus	5h 30m
Earliest Bus	8:30 AM
Latest Bus	11:59 PM
Daily Bus Routes	295 Ø
Distance	247.0 miles
Bus Companies	Cikbus Elité, Pullman San Andres, Pullman Bus, Turbus, FlixBus, Pluss Chile, Cormar Bus, Buses Romani, Condor Bus, Nueva Andimar Vip and 4 more.

Cheapest bus connections from Santiago, RM to La Serena

Every day, 295 buses from 14 bus companies leave Santiago, RM for La Serena: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/07/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

$17

Friday 05/08

$12

Saturday 05/09

$11

Sunday 05/10

$12

Monday 05/11

$14

Tuesday 05/12

$12

Wednesday 05/13

$12

Thursday 05/14

$14

Friday 05/15

$23

Saturday 05/16

$14

Sunday 05/17

$13

Monday 05/18

$11

Tuesday 05/19

$14

Wednesday 05/20

$12

Thursday 05/21

$14

Friday 05/22

$14

Saturday 05/23

$14

Sunday 05/24

$12

Monday 05/25

$14

Tuesday 05/26

$11

Wednesday 05/27

$13

Thursday 05/28

$11

Friday 05/29

$14

Saturday 05/30

The cheapest time to travel from Santiago, RM to La Serena

See here on which day and which time of the day you can find the cheapest bus ticket from Santiago, RM to La Serena, for the next 30 days.

With a price starting from $11, Sunday is the cheapest day for a bus from Santiago, RM to La Serena. Wednesday instead is the most expensive day with prices starting from $12.

Morning is the cheapest day time for bus tickets from Santiago, RM to La Serena, with $11. Evening is the most expensive time of the day with prices starting from $13.

How to save money travelling from Santiago, RM to La Serena

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santiago, RM to La Serena in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to La Serena, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santiago, RM to La Serena are also emptier.

Beloved bus companies from Santiago, RM to La Serena

These are the most booked bus companies between Santiago, RM to La Serena from our users.

Turbus from Santiago, RM to La Serena

Here you will find the key facts about the Turbus bus route Santiago, RM to La Serena:

Cheapest Price	$14
Fastest Bus	5h 30m
Earliest Bus	8:30 AM
Last Bus	11:50 PM
Daily Connections	36 Ø
Found on	5/7/2026

Cormar Bus from Santiago, RM to La Serena

Here you will find the key facts about the Cormar Bus bus route Santiago, RM to La Serena:

Cheapest Price	$13
Fastest Bus	5h 50m
Earliest Bus	9:00 AM
Last Bus	11:59 PM
Daily Connections	20 Ø
Found on	5/7/2026

FlixBus from Santiago, RM to La Serena

Here you will find the key facts about the FlixBus bus route Santiago, RM to La Serena:

Cheapest Price	$14
Fastest Bus	5h 35m
Earliest Bus	2:15 PM
Last Bus	11:59 PM
Daily Connections	34 Ø
Found on	5/7/2026

Latest reviews for bus companies on the route Santiago, RM - La Serena

Javier cortes, 4/18/2026

CANCELAN EL VIAJE A LA HORA DE LA PARTIDA. SE EXCUSAN DICIENDO QUE EL CHIFER NO LLEGÓ (O SEA TAMPOCO HAY CHOFER DE REEMPLAZO?), COSA QUE ES DUDOSA. NO TOMEN NUNCA ESTA LÍNEA DE BUSES

Franco órdenes , 2/18/2026

Pésima primera experiencia con Flixbus. Compramos pasaje para dos adultos y una bebé de 6 meses y solo nos permitió elegir los pasajes de adulto, designando arbitrariamente el asiento de la bebé en el ... Pésima primera experiencia con Flixbus. Compramos pasaje para dos adultos y una bebé de 6 meses y solo nos permitió elegir los pasajes de adulto, designando arbitrariamente el asiento de la bebé en el segundo piso. No nos ofrecieron ninguna solución excusándose que es problema del sistema en línea. No lo recomiendo

jonathan, 9/4/2025

HORRIBLE

Rocío Santana , 11/22/2024

Malísima experiencia con un hombre del personal, a media hora de haber salido del terminal San Borja mi hija necesito usar el baño a lo que respondió que el baño era solo para ruta y que estaban aburr ... Malísima experiencia con un hombre del personal, a media hora de haber salido del terminal San Borja mi hija necesito usar el baño a lo que respondió que el baño era solo para ruta y que estaban aburridos que las personas le hicieran ( del 2) , cosa que entiendo perfectamente, pero fue bastante grosero y retador y con la voz alzada, pésima experiencia no respondí porque estaba con mi hija pero nunca más usaré este servicio.

Camila , 11/7/2024

Pésima experiencia, en bus de verdad tienen un olor demasiado hediondo es insoportable, además no tienen aire acondicionado y hizo mucho frío yo viaje de noche y pase demasiado frío, gente del bus le ... Pésima experiencia, en bus de verdad tienen un olor demasiado hediondo es insoportable, además no tienen aire acondicionado y hizo mucho frío yo viaje de noche y pase demasiado frío, gente del bus le pidió al chofer copiloto subir la temperatura y jamás lo hizo La verdad nunca mas viajo con ellos

Ernesto, 9/12/2024

Viajo regularmente entre Santiago y La Serena y v/v, en Buses salón cama. es la primera vez que tomo esta empresa y en realidad no volvería a tomarla. Las razones: GPS DESCONECTADO por tanto se DESC ... Viajo regularmente entre Santiago y La Serena y v/v, en Buses salón cama. es la primera vez que tomo esta empresa y en realidad no volvería a tomarla. Las razones: GPS DESCONECTADO por tanto se DESCONOCE el nombre del conductor, cuanto tiempo lleva conduciendo y a qué velocidad estamos transitando. Maquina NO SANITIZADA da desconfianza sentarse en los asientos con los apoyacabezas negros de suciedad y sin funda de protección lo mismo pasa con los cinturones de seguridad también muy sucios. Esta máquina salió a las 12:30 PM desde terminal San Borja con destino a Arica, (yo bajo el La Serena)

Sramirez , 9/12/2024

Voy viajando en Salón cama y literal que voy atrapada entre mi asiento y el respaldo del asiento en frente de mi. El nivel de inclinación de los asientos supera lo permitido quedando prácticamente atr ... Voy viajando en Salón cama y literal que voy atrapada entre mi asiento y el respaldo del asiento en frente de mi. El nivel de inclinación de los asientos supera lo permitido quedando prácticamente atrapada, tienes el respaldo de la persona que va delante sobre tus piernas sin poder moverte y eso que soy delgada, imagino a alguien de mayor dimensión o un adulto mayor, además del mal olor en el bus es horrible. No viajo más en esta línea.

All bus stations and stops in Santiago, RM and La Serena

In the map below, you can see where to find all bus stations in Santiago, RM and La Serena.

Los Héroes Station

Tucapel Jiménez 22

Baquedano

Pl. Baquedano

Porto Seguro Bus Station

Sur Bus Station

Av Libertador Bernardo O'Higgins 3850

Terminal Alameda

Av Libertador Bernardo O'Higgins 3750

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Bus Station

Avenida El Santo 1475

terminal de buses covalle bus

Cienfuegos

Corsario

Service and Comfort on the bus from Santiago, RM to La Serena

Want to know which seat classes are available on the buses from Santiago, RM to La Serena? Or which bus companies serve the route Santiago, RM to La Serena? Below you will find answers to your questions.

FAQs about the Santiago, RM to La Serena bus

How much does a Santiago, RM La Serena bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $11 and takes 6h 30m to reach La Serena. Compare offers to save money!

How much could I save by comparing buses from Santiago, RM to La Serena?

This route is offered by 14 companies with a range of ticket prices between $11 and $60. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to La Serena.

On average, how many connections are available from Santiago, RM to La Serena each day?

Every day, the Santiago, RM to La Serena bus route is served by approximately 295 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santiago, RM to La Serena take?

The fastest bus from Santiago, RM to La Serena is offered by Serena Mar and takes 5h 30m. Bus tickets for this connection cost $22. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santiago, RM to La Serena?

The earliest bus arriving in La Serena from Santiago, RM starts at 8:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santiago, RM to La Serena?

The latest bus trip departing from Santiago, RM for La Serena starts at 11:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santiago, RM La Serena route?

When traveling by bus from Santiago, RM to La Serena, passengers can travel with Cikbus Elité, Pullman San Andres and Pullman Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santiago, RM and La Serena?

You can check all the direct connections between Santiago, RM and La Serena by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Cikbus Elité, Pullman San Andres and Pullman Bus.

What can I take with me on the Santiago, RM to La Serena bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santiago, RM La Serena bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santiago, RM La Serena bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santiago, RM to La Serena on your planned travel date.

How does CheckMyBus find the best bus deals from Santiago, RM to La Serena?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 295 daily trips between Santiago, RM and La Serena. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santiago, RM to La Serena?

Prices and availability for 295 trips between Santiago, RM and La Serena change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santiago, RM to La Serena

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

First Class

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to Santiago, RM and to La Serena

Here’s an overview of the most popular bus routes to Santiago, RM and to La Serena. Simply click on the connection of your choice, and you will find all the details about your bus route!