Compare all timetables for the bus from Santiago, RM to La Serena
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 AM | Santiago, RM | Sur Bus Station | 5:00 PM | La Serena | Central Bus Station | Premium Economy | $10 |
A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 12/14/2025 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/14/2025 5:00:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 30m | 12:00 PM | Santiago, RM | Terminal San Borja | 6:30 PM | La Serena | Central Bus Station | Premium Economy | $14 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/14/2025 12:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/14/2025 6:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
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| Turbus | 6h 40m | 11:15 AM | Santiago, RM | Terminal Alameda | 5:55 PM | La Serena | Avda. Fco de Aguirre Station | Premium Economy | $16 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 12/14/2025 11:15:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 12/14/2025 5:55:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 40m
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| FlixBus | 6h 5m | 6:15 AM | Santiago, RM | Terminal San Borja | 12:20 PM | La Serena | Central Bus Station | Economy | $16 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/14/2025 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/14/2025 12:20:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 6h 5m
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| Pullman Bus | 6h 20m | 11:00 AM | Santiago, RM | Terminal San Borja | 5:20 PM | La Serena | El Sto, 1060 | First Class | $16 |
A Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/14/2025 11:00:00 AM to El Sto, 1060, La Serena (Chile) arriving at 12/14/2025 5:20:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cormar Bus | 6h 10m | 1:00 PM | Santiago, RM | Terminal San Borja | 7:10 PM | La Serena | Central Bus Station | Premium Economy | $11 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/15/2025 1:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/15/2025 7:10:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
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| Buses Romani | 6h 30m | 10:30 AM | Santiago, RM | Terminal San Borja | 5:00 PM | La Serena | Central Bus Station | Business | $11 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 12/15/2025 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/15/2025 5:00:00 PM. 50 Business ticket for $11 per person are available. Travel duration is 6h 30m
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| FlixBus | 6h 10m | 6:15 AM | Santiago, RM | Terminal San Borja | 12:25 PM | La Serena | Central Bus Station | Economy | $13 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/15/2025 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/15/2025 12:25:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 10m
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| Cikbus Elité | 7h 10m | 1:30 PM | Santiago, RM | Terminal San Borja | 8:40 PM | La Serena | Central Bus Station | Business | $17 |
A Bus from Cikbus Elité goes from Terminal San Borja, Santiago, RM (Chile) at 12/15/2025 1:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/15/2025 8:40:00 PM. 50 Business ticket for $17 per person are available. Travel duration is 7h 10m
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| Turbus | 7h 10m | 6:55 AM | Santiago, RM | Terminal Alameda | 2:05 PM | La Serena | Avda. Fco de Aguirre Station | Premium Economy | $18 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 12/15/2025 6:55:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 12/15/2025 2:05:00 PM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 7h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 AM | Santiago, RM | Sur Bus Station | 5:00 PM | La Serena | Central Bus Station | Premium Economy | $10 |
A Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 12/16/2025 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/16/2025 5:00:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 10m | 1:00 PM | Santiago, RM | Terminal San Borja | 7:10 PM | La Serena | Central Bus Station | Premium Economy | $11 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/16/2025 1:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/16/2025 7:10:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
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| FlixBus | 6h 10m | 6:15 AM | Santiago, RM | Terminal San Borja | 12:25 PM | La Serena | Central Bus Station | Economy | $12 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/16/2025 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/16/2025 12:25:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 6h 10m
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| Nueva Andimar Vip | 6h 0m | 7:50 AM | Santiago, RM | Terminal San Borja | 1:50 PM | La Serena | Central Bus Station | Economy | $17 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 12/16/2025 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/16/2025 1:50:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 0m
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| Buses Paravias | 6h 20m | 12:30 PM | Santiago, RM | Sur Bus Station | 6:50 PM | La Serena | Central Bus Station | First Class | $17 |
A Bus from Buses Paravias goes from Sur Bus Station, Santiago, RM (Chile) at 12/16/2025 12:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/16/2025 6:50:00 PM. 50 First Class ticket for $17 per person are available. Travel duration is 6h 20m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 10:30 AM | Santiago, RM | Terminal San Borja | 5:00 PM | La Serena | Central Bus Station | Business | $11 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 12/17/2025 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/17/2025 5:00:00 PM. 50 Business ticket for $11 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 10m | 1:00 PM | Santiago, RM | Terminal San Borja | 7:10 PM | La Serena | Central Bus Station | Premium Economy | $11 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/17/2025 1:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/17/2025 7:10:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
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| FlixBus | 6h 10m | 6:15 AM | Santiago, RM | Terminal San Borja | 12:25 PM | La Serena | Central Bus Station | Economy | $12 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/17/2025 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/17/2025 12:25:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 6h 10m
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| Turbus | 5h 55m | 1:50 PM | Santiago, RM | Terminal Alameda | 7:45 PM | La Serena | Avda. Fco de Aguirre Station | Premium Economy | $17 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 12/17/2025 1:50:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 12/17/2025 7:45:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 5h 55m
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| Cikbus Elité | 7h 15m | 7:30 AM | Santiago, RM | Terminal San Borja | 2:45 PM | La Serena | Central Bus Station | Business | $17 |
A Bus from Cikbus Elité goes from Terminal San Borja, Santiago, RM (Chile) at 12/17/2025 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/17/2025 2:45:00 PM. 50 Business ticket for $17 per person are available. Travel duration is 7h 15m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Turbus | 6h 20m | 6:10 AM | Santiago, RM | Terminal Alameda | 12:30 PM | La Serena | Avda. Fco de Aguirre Station | Premium Economy | $11 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 12/18/2025 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 12/18/2025 12:30:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 20m
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| Buses Romani | 6h 30m | 10:30 AM | Santiago, RM | Terminal San Borja | 5:00 PM | La Serena | Central Bus Station | Business | $11 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 12/18/2025 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/18/2025 5:00:00 PM. 50 Business ticket for $11 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 10m | 1:00 PM | Santiago, RM | Terminal San Borja | 7:10 PM | La Serena | Central Bus Station | Premium Economy | $11 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/18/2025 1:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/18/2025 7:10:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
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| FlixBus | 6h 10m | 6:15 AM | Santiago, RM | Terminal San Borja | 12:25 PM | La Serena | Central Bus Station | Economy | $12 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/18/2025 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/18/2025 12:25:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 6h 10m
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| Nueva Andimar Vip | 6h 0m | 7:50 AM | Santiago, RM | Terminal San Borja | 1:50 PM | La Serena | Central Bus Station | Economy | $17 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 12/18/2025 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/18/2025 1:50:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 0m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Turbus | 6h 25m | 7:20 AM | Santiago, RM | Terminal Alameda | 1:45 PM | La Serena | Avda. Fco de Aguirre Station | Premium Economy | $11 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 12/19/2025 7:20:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 12/19/2025 1:45:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 25m
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| Cormar Bus | 6h 30m | 5:30 PM | Santiago, RM | Terminal San Borja | 12:00 AM | La Serena | Central Bus Station | Premium Economy | $11 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/19/2025 5:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/20/2025 12:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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| Buses Romani | 6h 30m | 10:30 AM | Santiago, RM | Terminal San Borja | 5:00 PM | La Serena | Central Bus Station | Business | $11 |
A Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 12/19/2025 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/19/2025 5:00:00 PM. 50 Business ticket for $11 per person are available. Travel duration is 6h 30m
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| FlixBus | 6h 10m | 6:15 AM | Santiago, RM | Terminal San Borja | 12:25 PM | La Serena | Central Bus Station | Economy | $13 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/19/2025 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/19/2025 12:25:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 10m
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| Nueva Andimar Vip | 6h 0m | 7:50 AM | Santiago, RM | Terminal San Borja | 1:50 PM | La Serena | Central Bus Station | Economy | $17 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 12/19/2025 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/19/2025 1:50:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 0m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Turbus | 6h 10m | 6:30 PM | Santiago, RM | Terminal Alameda | 12:40 AM | La Serena | Avda. Fco de Aguirre Station | Premium Economy | $11 |
A Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 12/20/2025 6:30:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 12/21/2025 12:40:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 10m
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| FlixBus | 6h 10m | 6:10 PM | Santiago, RM | Terminal San Borja | 12:20 AM | La Serena | Central Bus Station | Premium Economy | $12 |
A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 12/20/2025 6:10:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/21/2025 12:20:00 AM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 10m
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| Cormar Bus | 6h 30m | 8:30 AM | Santiago, RM | Terminal San Borja | 3:00 PM | La Serena | Central Bus Station | First Class | $17 |
A Bus from Cormar Bus goes from Terminal San Borja, Santiago, RM (Chile) at 12/20/2025 8:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/20/2025 3:00:00 PM. 50 First Class ticket for $17 per person are available. Travel duration is 6h 30m
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| Nueva Andimar Vip | 6h 0m | 7:50 AM | Santiago, RM | Terminal San Borja | 1:50 PM | La Serena | Central Bus Station | Economy | $17 |
A Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 12/20/2025 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 12/20/2025 1:50:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 0m
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| Pullman San Andres | 6h 15m | 3:30 PM | Santiago, RM | Terminal San Borja | 9:45 PM | La Serena | Central Bus Station | Premium Economy | $18 |
A Bus from Pullman San Andres goes from Terminal San Borja, Santiago, RM (Chile) at 12/20/2025 3:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/20/2025 9:45:00 PM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 15m
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Best Price Offer: The price for the cheapest bus from Santiago, RM to La Serena is $10 on 12/22/2025. Flexible travelers save on ticket prices.
Frequency of bus connections between Santiago, RM and La Serena
Facts about the bus from Santiago, RM to La Serena
Compare all providers like FlixBus, Pullman Bus and Turbus that travel 261 times every day by bus from Santiago, RM to La Serena in one click! Book your bus ticket from Santiago, RM to La Serena starting from $10!
| Cheapest Bus | $10 |
| Fastest Bus | 5h 30m |
| Earliest Bus | 6:10 AM |
| Latest Bus | 11:59 PM |
| Daily Bus Routes | 261 Ø |
| Distance | 247.0 miles |
| Bus Companies | FlixBus, Pullman Bus, Turbus, Pullman San Andres, Cikbus Elité, Pluss Chile, Cormar Bus, Condor Bus, Nueva Andimar Vip, Buses Romani and 4 more. |
Cheapest bus connections from Santiago, RM to La Serena
Every day, 261 buses from 14 bus companies leave Santiago, RM for La Serena: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/14/2025 and for the following days.
The cheapest time to travel from Santiago, RM to La Serena
How to save money travelling from Santiago, RM to La Serena
Book the ticket from Santiago, RM to La Serena in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to La Serena, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santiago, RM to La Serena are also emptier.Beloved bus companies from Santiago, RM to La Serena
Turbus from Santiago, RM to La Serena
Here you will find the key facts about the Turbus bus route Santiago, RM to La Serena:
| Cheapest Price | $11 |
| Fastest Bus | 5h 30m |
| Earliest Bus | 6:10 AM |
| Last Bus | 11:50 PM |
| Daily Connections | 37 Ø |
| Found on | 12/14/2025 |
FlixBus from Santiago, RM to La Serena
Here you will find the key facts about the FlixBus bus route Santiago, RM to La Serena:
| Cheapest Price | $12 |
| Fastest Bus | 5h 35m |
| Earliest Bus | 6:15 AM |
| Last Bus | 11:59 PM |
| Daily Connections | 46 Ø |
| Found on | 12/14/2025 |
Nueva Andimar Vip from Santiago, RM to La Serena
Here you will find the key facts about the Nueva Andimar Vip bus route Santiago, RM to La Serena:
| Cheapest Price | $17 |
| Fastest Bus | 6h 0m |
| Earliest Bus | 7:50 AM |
| Last Bus | 11:30 PM |
| Daily Connections | 13 Ø |
| Found on | 12/14/2025 |
Latest reviews for bus companies on the route Santiago, RM - La Serena
All bus stations and stops in Santiago, RM and La Serena
In the map below, you can see where to find all bus stations in Santiago, RM and La Serena.
Compare the bus with other modes of transport
Service and Comfort on the bus from Santiago, RM to La Serena
FAQs about the Santiago, RM to La Serena bus
How much does a Santiago, RM La Serena bus trip cost?
How much could I save by comparing buses from Santiago, RM to La Serena?
On average, how many connections are available from Santiago, RM to La Serena each day?
How long does a bus journey from Santiago, RM to La Serena take?
What time is the first bus from Santiago, RM to La Serena?
What time is the last bus from Santiago, RM to La Serena?
Which bus companies operate the Santiago, RM La Serena route?
Is there a direct bus between Santiago, RM and La Serena?
What can I take with me on the Santiago, RM to La Serena bus route?
What equipment is available for the Santiago, RM La Serena bus route?
Available seat classes which are offered on the bus route Santiago, RM to La Serena
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
Comfortable seating, food and drink service, accompanied generally by ticket flexibility.
Best of the best: you will find the most comfortable accommodation to work or relax during your travel.
More bus routes to Santiago, RM and to La Serena
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- Bus from Molina to Santiago, RM
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- Pucón, AR to Santiago, RM bus
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- Tongoy, CO to Santiago, RM bus
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- Bus Routes to La Serena
- Bus to La Serena from Alto Hospicio
- Bus Antofagasta to La Serena
- Buses Arica, AP - La Serena
- Concepción to La Serena bus
- Buses Copiapó to La Serena
- Buses Diego de Almagro to La Serena
- Bus Iquique - La Serena
- Bus from La Calera to La Serena
- Bus Los Vilos to La Serena
- From Mendoza to La Serena bus
- Buses to La Serena from Ovalle
- Bus to La Serena from Pozo Almonte
- Quilpué to La Serena bus
- Buses Rancagua to La Serena
- Buses to La Serena from San Juan, SJ
- From Sierra Gorda to La Serena bus
- Bus to La Serena from Talca, ML
- Bus Temuco to La Serena
- Buses Tocopilla - La Serena
- Buses to La Serena from Valdivia

