What is the best way to travel from Santiago, RM to La Serena?
Looking for a trip? Compare all the available Flights and Buses for the journey to La Serena from Santiago, RM. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 15 available companies to find your perfect trip!
What is the cheapest way to reach La Serena from Santiago, RM?
You can get to La Serena with just $8 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus6h 45m011:00 PMSantiago, RMTerminal San Borja5:45 AMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/2/2026 11:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 5:45:00 AM. 50 Economy ticket for $10 per person are available. Travel duration is 6h 45m
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/2/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/2/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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Pullman Bus6h 30m010:30 AMSantiago, RMTerminal San Borja5:00 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/2/2026 10:30:00 AM to El Sto, 1060, La Serena (Chile) arriving at 6/2/2026 5:00:00 PM. 50 First Class ticket for $13 per person are available. Travel duration is 6h 30m
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Nueva Andimar Vip6h 50m012:15 PMSantiago, RMTerminal San Borja7:05 PMLa SerenaCentral Bus Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 6/2/2026 12:15:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/2/2026 7:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 50m
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Turbus5h 45m09:30 PMSantiago, RMTerminal Alameda3:15 AMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/2/2026 9:30:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/3/2026 3:15:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 5h 45m
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Sky Airline1h 11m02:58 PMSantiago de Chile AirportSantiago de Chile Airport4:09 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 2:58:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 4:09:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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JetSmart1h 11m04:17 PMSantiago de Chile AirportSantiago de Chile Airport5:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:17:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 5:28:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 1h 11m
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LAN Perú1h 9m04:52 PMSantiago de Chile AirportSantiago de Chile Airport6:01 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:52:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 6:01:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 1h 9m
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LATAM Brasil1h 9m04:52 PMSantiago de Chile AirportSantiago de Chile Airport6:01 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:52:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 6:01:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 1h 9m
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Air Labrador1h 11m04:17 PMSantiago de Chile AirportSantiago de Chile Airport5:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Air Labrador goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:17:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 5:28:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 11m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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FlixBus6h 10m09:30 AMSantiago, RMTerminal San Borja3:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/3/2026 9:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 3:40:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 10m
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Buses Romani6h 30m010:30 AMSantiago, RMTerminal San Borja5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 6/3/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 5:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 30m
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Turbus6h 20m06:10 AMSantiago, RMTerminal Alameda12:30 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/3/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/3/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/3/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Condor Bus7h 5m02:30 PMSantiago, RMSur Bus Station9:35 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 6/3/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
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Sky Airline1h 11m09:10 AMSantiago de Chile AirportSantiago de Chile Airport10:21 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 9:10:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 10:21:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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JetSmart1h 11m05:43 PMSantiago de Chile AirportSantiago de Chile Airport6:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 5:43:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 6:54:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 1h 11m
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LAN Perú1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 8:55:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 6m
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LATAM Brasil1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 8:55:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 6m
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Air Labrador1h 11m05:43 PMSantiago de Chile AirportSantiago de Chile Airport6:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Air Labrador goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 5:43:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 6:54:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 1h 11m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Buses Romani6h 30m010:30 AMSantiago, RMTerminal San Borja5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 6/4/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/4/2026 5:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 30m
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Turbus7h 20m06:55 AMSantiago, RMTerminal Alameda2:15 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/4/2026 6:55:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/4/2026 2:15:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 20m
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Condor Bus7h 5m02:30 PMSantiago, RMSur Bus Station9:35 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 6/4/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/4/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
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FlixBus6h 10m07:30 AMSantiago, RMTerminal San Borja1:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/4/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/4/2026 1:40:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 35m05:00 PMSantiago, RMTerminal San Borja11:35 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/4/2026 5:00:00 PM to El Sto, 1060, La Serena (Chile) arriving at 6/4/2026 11:35:00 PM. 50 First Class ticket for $15 per person are available. Travel duration is 6h 35m
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JetSmart1h 11m04:06 PMSantiago de Chile AirportSantiago de Chile Airport5:17 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 4:06:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 5:17:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m01:15 PMSantiago de Chile AirportSantiago de Chile Airport2:26 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 1:15:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 2:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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LAN Perú1h 9m02:55 PMSantiago de Chile AirportSantiago de Chile Airport4:04 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 2:55:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 4:04:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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LAN Perú1h 9m04:50 PMSantiago de Chile AirportSantiago de Chile Airport5:59 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 4:50:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 5:59:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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LATAM Brasil1h 9m02:55 PMSantiago de Chile AirportSantiago de Chile Airport4:04 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 2:55:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 4:04:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 9m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus6h 10m07:30 AMSantiago, RMTerminal San Borja1:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/5/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 1:40:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 10m
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Nueva Andimar Vip6h 0m07:50 AMSantiago, RMTerminal San Borja1:50 PMLa SerenaCentral Bus Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 6/5/2026 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 1:50:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 6h 0m
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/5/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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Turbus6h 20m06:10 AMSantiago, RMTerminal Alameda12:30 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/5/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/5/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/5/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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LAN Perú1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 8:55:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 6m
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LATAM Brasil1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 8:55:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 6m
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JetSmart1h 11m03:41 PMSantiago de Chile AirportSantiago de Chile Airport4:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 3:41:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 4:52:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m02:48 PMSantiago de Chile AirportSantiago de Chile Airport3:59 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 2:48:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 3:59:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 1h 11m
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LAN Airlines1h 8m08:32 PMSantiago de Chile AirportSantiago de Chile Airport9:40 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 8:32:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 9:40:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 1h 8m
Cheapest Buses Friday
Cheapest Flights Friday
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FlixBus6h 10m07:30 AMSantiago, RMTerminal San Borja1:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/6/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 1:40:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 10m
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Nueva Andimar Vip6h 0m07:50 AMSantiago, RMTerminal San Borja1:50 PMLa SerenaCentral Bus Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 6/6/2026 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 1:50:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 6h 0m
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Turbus6h 40m011:15 AMSantiago, RMTerminal Alameda5:55 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/6/2026 11:15:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/6/2026 5:55:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
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Condor Bus7h 5m02:30 PMSantiago, RMSur Bus Station9:35 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 6/6/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
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Pullman Bus6h 20m011:00 AMSantiago, RMTerminal San Borja5:20 PMLa SerenaCentral Bus Station0BusinessA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/6/2026 11:00:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 5:20:00 PM. 50 Business ticket for $14 per person are available. Travel duration is 6h 20m
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JetSmart1h 11m012:44 PMSantiago de Chile AirportSantiago de Chile Airport1:55 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 12:44:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 1:55:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m011:15 AMSantiago de Chile AirportSantiago de Chile Airport12:26 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 11:15:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 12:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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LAN Perú1h 9m08:06 AMSantiago de Chile AirportSantiago de Chile Airport9:15 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 8:06:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 9:15:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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LAN Perú1h 9m010:10 AMSantiago de Chile AirportSantiago de Chile Airport11:19 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 10:10:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 11:19:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/7/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/7/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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Pullman Bus6h 20m011:00 AMSantiago, RMTerminal San Borja5:20 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/7/2026 11:00:00 AM to El Sto, 1060, La Serena (Chile) arriving at 6/7/2026 5:20:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 6h 20m
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Turbus6h 20m06:10 AMSantiago, RMTerminal Alameda12:30 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/7/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/7/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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FlixBus6h 10m06:15 AMSantiago, RMTerminal San Borja12:25 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/7/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/7/2026 12:25:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/7/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/7/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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JetSmart1h 11m03:24 PMSantiago de Chile AirportSantiago de Chile Airport4:35 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 3:24:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 4:35:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 1h 11m
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Sky Airline1h 4m03:48 PMSantiago de Chile AirportSantiago de Chile Airport4:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 3:48:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 4:52:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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Sky Airline1h 4m05:34 PMSantiago de Chile AirportSantiago de Chile Airport6:38 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 5:34:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 6:38:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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LATAM Brasil1h 9m01:02 PMSantiago de Chile AirportSantiago de Chile Airport2:11 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 1:02:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 2:11:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 1h 9m
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LATAM Brasil1h 8m08:31 PMSantiago de Chile AirportSantiago de Chile Airport9:39 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 8:31:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 9:39:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 1h 8m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/8/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/8/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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Pullman Bus6h 20m011:00 AMSantiago, RMTerminal San Borja5:20 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/8/2026 11:00:00 AM to El Sto, 1060, La Serena (Chile) arriving at 6/8/2026 5:20:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 6h 20m
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Turbus6h 25m07:20 AMSantiago, RMTerminal Alameda1:45 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/8/2026 7:20:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/8/2026 1:45:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 25m
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FlixBus6h 10m06:15 AMSantiago, RMTerminal San Borja12:25 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/8/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/8/2026 12:25:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/8/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/8/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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JetSmart1h 11m03:47 PMSantiago de Chile AirportSantiago de Chile Airport4:58 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 3:47:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 4:58:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 1h 11m
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Sky Airline1h 4m02:10 PMSantiago de Chile AirportSantiago de Chile Airport3:14 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 2:10:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 3:14:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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Sky Airline1h 4m03:34 PMSantiago de Chile AirportSantiago de Chile Airport4:38 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 3:34:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 4:38:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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JetSmart1h 11m05:35 PMSantiago de Chile AirportSantiago de Chile Airport6:46 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 5:35:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 6:46:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 11m
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LATAM Brasil1h 9m01:38 PMSantiago de Chile AirportSantiago de Chile Airport2:47 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 1:38:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 2:47:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 1h 9m
Cheapest Buses Monday
Cheapest Flights Monday
What are the fastest trips from Santiago, RM to La Serena?
You can get to La Serena from Santiago, RM in just 1h 4m with a Flight from Sky Airline. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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LAN Perú1h 9m04:52 PMSantiago de Chile AirportSantiago de Chile Airport6:01 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:52:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 6:01:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 1h 9m
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LATAM Brasil1h 9m04:52 PMSantiago de Chile AirportSantiago de Chile Airport6:01 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:52:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 6:01:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 1h 9m
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Sky Airline1h 11m02:58 PMSantiago de Chile AirportSantiago de Chile Airport4:09 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 2:58:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 4:09:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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JetSmart1h 11m04:17 PMSantiago de Chile AirportSantiago de Chile Airport5:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:17:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 5:28:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 1h 11m
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Air Labrador1h 11m04:17 PMSantiago de Chile AirportSantiago de Chile Airport5:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Air Labrador goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/2/2026 4:17:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/2/2026 5:28:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 11m
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Turbus5h 45m09:30 PMSantiago, RMTerminal Alameda3:15 AMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/2/2026 9:30:00 PM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/3/2026 3:15:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 5h 45m
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/2/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/2/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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Pullman Bus6h 30m010:30 AMSantiago, RMTerminal San Borja5:00 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/2/2026 10:30:00 AM to El Sto, 1060, La Serena (Chile) arriving at 6/2/2026 5:00:00 PM. 50 First Class ticket for $13 per person are available. Travel duration is 6h 30m
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FlixBus6h 45m011:00 PMSantiago, RMTerminal San Borja5:45 AMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/2/2026 11:00:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 5:45:00 AM. 50 Economy ticket for $10 per person are available. Travel duration is 6h 45m
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Nueva Andimar Vip6h 50m012:15 PMSantiago, RMTerminal San Borja7:05 PMLa SerenaCentral Bus Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 6/2/2026 12:15:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/2/2026 7:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 50m
Fastest Flights Tuesday
Fastest Buses Tuesday
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LAN Perú1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 8:55:00 AM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 6m
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LATAM Brasil1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 8:55:00 AM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 6m
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Sky Airline1h 11m09:10 AMSantiago de Chile AirportSantiago de Chile Airport10:21 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 9:10:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 10:21:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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JetSmart1h 11m05:43 PMSantiago de Chile AirportSantiago de Chile Airport6:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 5:43:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 6:54:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 1h 11m
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Air Labrador1h 11m05:43 PMSantiago de Chile AirportSantiago de Chile Airport6:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Air Labrador goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/3/2026 5:43:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/3/2026 6:54:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m09:30 AMSantiago, RMTerminal San Borja3:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/3/2026 9:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 3:40:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 10m
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Turbus6h 20m06:10 AMSantiago, RMTerminal Alameda12:30 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/3/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/3/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/3/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30 AMSantiago, RMTerminal San Borja5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 6/3/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 5:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 30m
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Condor Bus7h 5m02:30 PMSantiago, RMSur Bus Station9:35 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 6/3/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/3/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Perú1h 9m02:55 PMSantiago de Chile AirportSantiago de Chile Airport4:04 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 2:55:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 4:04:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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LAN Perú1h 9m04:50 PMSantiago de Chile AirportSantiago de Chile Airport5:59 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 4:50:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 5:59:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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LATAM Brasil1h 9m02:55 PMSantiago de Chile AirportSantiago de Chile Airport4:04 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 2:55:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 4:04:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 9m
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JetSmart1h 11m04:06 PMSantiago de Chile AirportSantiago de Chile Airport5:17 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 4:06:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 5:17:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m01:15 PMSantiago de Chile AirportSantiago de Chile Airport2:26 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/4/2026 1:15:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/4/2026 2:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m07:30 AMSantiago, RMTerminal San Borja1:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/4/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/4/2026 1:40:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
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Buses Romani6h 30m010:30 AMSantiago, RMTerminal San Borja5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Terminal San Borja, Santiago, RM (Chile) at 6/4/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/4/2026 5:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 30m
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Pullman Bus6h 35m05:00 PMSantiago, RMTerminal San Borja11:35 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/4/2026 5:00:00 PM to El Sto, 1060, La Serena (Chile) arriving at 6/4/2026 11:35:00 PM. 50 First Class ticket for $15 per person are available. Travel duration is 6h 35m
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Condor Bus7h 5m02:30 PMSantiago, RMSur Bus Station9:35 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 6/4/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/4/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
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Turbus7h 20m06:55 AMSantiago, RMTerminal Alameda2:15 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/4/2026 6:55:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/4/2026 2:15:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 20m
Fastest Flights Thursday
Fastest Buses Thursday
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LAN Perú1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 8:55:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 6m
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LATAM Brasil1h 6m07:49 AMSantiago de Chile AirportSantiago de Chile Airport8:55 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 7:49:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 8:55:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 6m
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LAN Airlines1h 8m08:32 PMSantiago de Chile AirportSantiago de Chile Airport9:40 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Airlines goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 8:32:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 9:40:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 1h 8m
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JetSmart1h 11m03:41 PMSantiago de Chile AirportSantiago de Chile Airport4:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 3:41:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 4:52:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m02:48 PMSantiago de Chile AirportSantiago de Chile Airport3:59 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/5/2026 2:48:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/5/2026 3:59:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 1h 11m
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Nueva Andimar Vip6h 0m07:50 AMSantiago, RMTerminal San Borja1:50 PMLa SerenaCentral Bus Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 6/5/2026 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 1:50:00 PM. 50 Economy ticket for $11 per person are available. Travel duration is 6h 0m
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FlixBus6h 10m07:30 AMSantiago, RMTerminal San Borja1:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/5/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 1:40:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 10m
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Turbus6h 20m06:10 AMSantiago, RMTerminal Alameda12:30 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/5/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/5/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/5/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/5/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/5/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Fastest Flights Friday
Fastest Buses Friday
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LAN Perú1h 9m08:06 AMSantiago de Chile AirportSantiago de Chile Airport9:15 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 8:06:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 9:15:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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LAN Perú1h 9m010:10 AMSantiago de Chile AirportSantiago de Chile Airport11:19 AMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LAN Perú goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 10:10:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 11:19:00 AM. 50 Economy ticket for $39 per person are available. Travel duration is 1h 9m
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JetSmart1h 11m012:44 PMSantiago de Chile AirportSantiago de Chile Airport1:55 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 12:44:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 1:55:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 1h 11m
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Sky Airline1h 11m011:15 AMSantiago de Chile AirportSantiago de Chile Airport12:26 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/6/2026 11:15:00 AM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/6/2026 12:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 11m
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Nueva Andimar Vip6h 0m07:50 AMSantiago, RMTerminal San Borja1:50 PMLa SerenaCentral Bus Station0EconomyA Bus from Nueva Andimar Vip goes from Terminal San Borja, Santiago, RM (Chile) at 6/6/2026 7:50:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 1:50:00 PM. 50 Economy ticket for $10 per person are available. Travel duration is 6h 0m
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FlixBus6h 10m07:30 AMSantiago, RMTerminal San Borja1:40 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/6/2026 7:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 1:40:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 20m011:00 AMSantiago, RMTerminal San Borja5:20 PMLa SerenaCentral Bus Station0BusinessA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/6/2026 11:00:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 5:20:00 PM. 50 Business ticket for $14 per person are available. Travel duration is 6h 20m
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Turbus6h 40m011:15 AMSantiago, RMTerminal Alameda5:55 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/6/2026 11:15:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/6/2026 5:55:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
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Condor Bus7h 5m02:30 PMSantiago, RMSur Bus Station9:35 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Condor Bus goes from Sur Bus Station, Santiago, RM (Chile) at 6/6/2026 2:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 6/6/2026 9:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 5m
Fastest Flights Saturday
Fastest Buses Saturday
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Sky Airline1h 4m03:48 PMSantiago de Chile AirportSantiago de Chile Airport4:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 3:48:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 4:52:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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Sky Airline1h 4m05:34 PMSantiago de Chile AirportSantiago de Chile Airport6:38 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 5:34:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 6:38:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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LATAM Brasil1h 8m08:31 PMSantiago de Chile AirportSantiago de Chile Airport9:39 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 8:31:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 9:39:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 1h 8m
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LATAM Brasil1h 9m01:02 PMSantiago de Chile AirportSantiago de Chile Airport2:11 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 1:02:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 2:11:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 1h 9m
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JetSmart1h 11m03:24 PMSantiago de Chile AirportSantiago de Chile Airport4:35 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/7/2026 3:24:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/7/2026 4:35:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m06:15 AMSantiago, RMTerminal San Borja12:25 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/7/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/7/2026 12:25:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 20m011:00 AMSantiago, RMTerminal San Borja5:20 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/7/2026 11:00:00 AM to El Sto, 1060, La Serena (Chile) arriving at 6/7/2026 5:20:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 6h 20m
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Turbus6h 20m06:10 AMSantiago, RMTerminal Alameda12:30 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/7/2026 6:10:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/7/2026 12:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/7/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/7/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/7/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/7/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Fastest Flights Sunday
Fastest Buses Sunday
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Sky Airline1h 4m02:10 PMSantiago de Chile AirportSantiago de Chile Airport3:14 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 2:10:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 3:14:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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Sky Airline1h 4m03:34 PMSantiago de Chile AirportSantiago de Chile Airport4:38 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from Sky Airline goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 3:34:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 4:38:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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LATAM Brasil1h 9m01:38 PMSantiago de Chile AirportSantiago de Chile Airport2:47 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from LATAM Brasil goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 1:38:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 2:47:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 1h 9m
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JetSmart1h 11m03:47 PMSantiago de Chile AirportSantiago de Chile Airport4:58 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 3:47:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 4:58:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 1h 11m
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JetSmart1h 11m05:35 PMSantiago de Chile AirportSantiago de Chile Airport6:46 PMLa Florida, La Serena AirportLa Florida, La Serena Airport0EconomyA Flight from JetSmart goes from Santiago de Chile Airport, Santiago de Chile Airport (Chile) at 6/8/2026 5:35:00 PM to La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) arriving at 6/8/2026 6:46:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 11m
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FlixBus6h 10m06:15 AMSantiago, RMTerminal San Borja12:25 PMLa SerenaCentral Bus Station0EconomyA Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 6/8/2026 6:15:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/8/2026 12:25:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 20m011:00 AMSantiago, RMTerminal San Borja5:20 PMLa SerenaEl Sto, 10600First ClassA Bus from Pullman Bus goes from Terminal San Borja, Santiago, RM (Chile) at 6/8/2026 11:00:00 AM to El Sto, 1060, La Serena (Chile) arriving at 6/8/2026 5:20:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 20m07:45 AMSantiago, RMSur Bus Station2:05 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Pluss Chile goes from Sur Bus Station, Santiago, RM (Chile) at 6/8/2026 7:45:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/8/2026 2:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 20m
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Turbus6h 25m07:20 AMSantiago, RMTerminal Alameda1:45 PMLa SerenaAvda. Fco de Aguirre Station0Premium EconomyA Bus from Turbus goes from Terminal Alameda, Santiago, RM (Chile) at 6/8/2026 7:20:00 AM to Avda. Fco de Aguirre Station, La Serena (Chile) arriving at 6/8/2026 1:45:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 25m
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Buses Romani6h 30m010:30 AMSantiago, RMSur Bus Station5:00 PMLa SerenaCentral Bus Station0Premium EconomyA Bus from Buses Romani goes from Sur Bus Station, Santiago, RM (Chile) at 6/8/2026 10:30:00 AM to Central Bus Station, La Serena (Chile) arriving at 6/8/2026 5:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
Fastest Flights Monday
Fastest Buses Monday
Here you will find all operators and timetables for a
Bus from Santiago, RM to La Serena
What are the most popular stations in Santiago, RM and La Serena?
In Santiago, RM, you will usually depart from Sur Bus Station, Terminal San Borja or Terminal Alameda, while in La Serena you will be arriving at El Sto, 1060, Central Bus Station or Avda. Fco de Aguirre Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to La Serena from Santiago, RM? With 10 connections between 15 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Santiago, RM and La Serena, you can pay as low as $8 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from Sky Airline: you will get to La Serena in just 1h 4m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Santiago, RM and La Serena are Sky Airline, JetSmart and FlixBus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Santiago, RM and La Serena is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Lo Prado or to La Florida, La Serena Airport, and look at flights from Santiago de Chile Airport, and landing at La Florida, La Serena Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Santiago, RM to La Serena?
The most popular companies between Santiago, RM and La Serena, are Sky Airline, JetSmart and FlixBus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus, Turbus, Buses Romani and 4 more.
Airlines: Sky Airline, JetSmart, LAN Perú and 3 more.
All you need to know when you travel from Santiago, RM to La Serena
Check all information on comfort and services on all modes of transports from Santiago, RM to La Serena. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Santiago, RM to La Serena
How can I reach La Serena from Santiago, RM?
Every day, there are on average 10 connections between Flight and Bus, with which you can get to La Serena from Santiago, RM.
How far is La Serena from Santiago, RM?
The distance between Santiago, RM and La Serena is 247.0 miles.
What is the most ecofriendly mode of transport between Santiago, RM and La Serena?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from Santiago, RM to La Serena?
You can get to La Serena with just $8 by taking a Bus from FlixBus.
What is the fastest way to get from Santiago, RM to La Serena?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to La Serena in just 1h 4m with a Flight from Sky Airline.
More routes to Santiago, RM and to La Serena
Looking for more options? Here you can see the most popular routes to Santiago, RM and to La Serena. Simply click on a connection, and you’ll find all the details about the route!
