How to get from Santiago, RM to La Serena

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What is the best way to travel from Santiago, RM to La Serena?

Looking for a trip? Compare all the available Buses and Flights for the journey to La Serena from Santiago, RM. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 17 available companies to find your perfect trip!
Bus is the cheapest, while Flight is the fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
5h 55m
$10
$14
316
Flight
1h 8m
$33
$73
11

What is the cheapest way to reach La Serena from Santiago, RM?

You can get to La Serena with just $10 by taking a Bus from Buses Romani, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

Sunday
from $10
Monday
from $11
Tuesday
from $10
Wednesday
from $11
Thursday
from $11
Friday
from $11
Saturday
from $11

    Cheapest Buses Sunday

  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Sur Bus Station
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 30m
    0
    12:00 PM
    Santiago, RM
    Terminal San Borja
    6:30 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $14
  • Turbus
    6h 40m
    0
    11:15 AM
    Santiago, RM
    Terminal Alameda
    5:55 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $16
  • FlixBus
    6h 5m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:20 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $16
  • Pullman Bus
    6h 20m
    0
    11:00 AM
    Santiago, RM
    Terminal San Borja
    5:20 PM
    La Serena
    El Sto, 1060
    0
    Pullman Bus
    First Class
    $16
  • Cheapest Flights Sunday

  • JetSmart
    1h 10m
    0
    7:51 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:01 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $39
  • Sky Airline
    1h 11m
    0
    9:15 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    10:26 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $61
  • Sky Airline
    1h 11m
    0
    2:03 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    3:14 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $69
  • LAN Airlines
    1h 10m
    0
    1:41 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    2:51 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $71
  • JetSmart
    1h 10m
    0
    11:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $72

    Cheapest Buses Monday

  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $13
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cikbus Elité
    7h 10m
    0
    1:30 PM
    Santiago, RM
    Terminal San Borja
    8:40 PM
    La Serena
    Central Bus Station
    0
    Cikbus Elité
    Business
    $17
  • Cheapest Flights Monday

  • Sky Airline
    1h 11m
    0
    1:00 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    2:11 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $117
  • JetSmart
    1h 10m
    0
    7:12 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:22 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $119
  • Sky Airline
    1h 11m
    0
    5:45 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $133
  • LAN Airlines
    1h 10m
    0
    11:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $134
  • LAN Airlines
    1h 10m
    0
    11:43 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:53 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $134

    Cheapest Buses Tuesday

  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Sur Bus Station
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $12
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Buses Paravias
    6h 20m
    0
    12:30 PM
    Santiago, RM
    Sur Bus Station
    6:50 PM
    La Serena
    Central Bus Station
    0
    Buses Paravias
    First Class
    $17
  • Cheapest Flights Tuesday

  • Sky Airline
    1h 11m
    0
    5:40 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:51 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $38
  • JetSmart
    1h 10m
    0
    7:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:15 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $45
  • LAN Perú
    1h 8m
    0
    6:52 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:00 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $49
  • JetSmart
    1h 10m
    0
    8:00 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:10 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $80
  • LAN Airlines
    1h 10m
    0
    11:48 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:58 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $94

    Cheapest Buses Wednesday

  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $12
  • Turbus
    5h 55m
    0
    1:50 PM
    Santiago, RM
    Terminal Alameda
    7:45 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $17
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cheapest Flights Wednesday

  • LAN Airlines
    1h 8m
    0
    2:01 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    3:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $44
  • Sky Airline
    1h 11m
    0
    11:22 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:33 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $47
  • Sky Airline
    1h 11m
    0
    10:41 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    11:52 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $48
  • LAN Airlines
    1h 8m
    0
    3:03 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    4:11 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $49
  • LAN Perú
    1h 10m
    0
    7:45 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:55 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $62

    Cheapest Buses Thursday

  • Turbus
    6h 20m
    0
    6:10 AM
    Santiago, RM
    Terminal Alameda
    12:30 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $11
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $12
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cheapest Flights Thursday

  • JetSmart
    1h 10m
    0
    8:17 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:27 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $33
  • LAN Perú
    1h 15m
    0
    7:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:55 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $42
  • Sky Airline
    1h 11m
    0
    12:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    1:36 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $45
  • LAN Perú
    1h 13m
    0
    5:43 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $48
  • LAN Airlines
    1h 10m
    0
    1:42 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    2:52 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $48

    Cheapest Buses Friday

  • Turbus
    6h 25m
    0
    7:20 AM
    Santiago, RM
    Terminal Alameda
    1:45 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $11
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $13
  • Cormar Bus
    6h 30m
    0
    12:00 PM
    Santiago, RM
    Terminal San Borja
    6:30 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $14
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cheapest Flights Friday

  • Sky Airline
    1h 11m
    0
    6:03 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    7:14 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $75
  • LAN Perú
    1h 13m
    0
    2:26 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    3:39 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $94
  • LAN Perú
    1h 13m
    0
    7:34 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:47 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $94
  • LAN Airlines
    1h 13m
    0
    8:27 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:40 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $97
  • JetSmart
    1h 10m
    0
    4:22 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    5:32 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $118

    Cheapest Buses Saturday

  • Turbus
    6h 10m
    0
    6:30 PM
    Santiago, RM
    Terminal Alameda
    12:40 AM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:10 PM
    Santiago, RM
    Terminal San Borja
    12:20 AM
    La Serena
    Central Bus Station
    0
    FlixBus
    Premium Economy
    $12
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cormar Bus
    6h 10m
    0
    10:50 PM
    Santiago, RM
    Terminal San Borja
    5:00 AM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Business
    $17
  • Pullman San Andres
    6h 15m
    0
    3:30 PM
    Santiago, RM
    Terminal San Borja
    9:45 PM
    La Serena
    Central Bus Station
    0
    Pullman San Andres
    Premium Economy
    $18
  • Cheapest Flights Saturday

  • Sky Airline
    1h 11m
    0
    9:20 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    10:31 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $51
  • LAN Perú
    1h 15m
    0
    7:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:55 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $54
  • LAN Perú
    1h 10m
    0
    10:26 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    11:36 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $84
  • JetSmart
    1h 10m
    0
    5:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $101

What are the fastest trips from Santiago, RM to La Serena?

You can get to La Serena from Santiago, RM in just 1h 8m with a Flight from LAN Perú. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

Sunday
from 1h 10m
Monday
from 1h 10m
Tuesday
from 1h 8m
Wednesday
from 1h 8m
Thursday
from 1h 10m
Friday
from 1h 10m
Saturday
from 1h 10m

    Fastest Flights Sunday

  • JetSmart
    1h 10m
    0
    7:51 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:01 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $39
  • LAN Airlines
    1h 10m
    0
    1:41 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    2:51 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $71
  • JetSmart
    1h 10m
    0
    11:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $72
  • Sky Airline
    1h 11m
    0
    9:15 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    10:26 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $61
  • Sky Airline
    1h 11m
    0
    2:03 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    3:14 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $69
  • Fastest Buses Sunday

  • FlixBus
    6h 5m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:20 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $16
  • Pullman Bus
    6h 20m
    0
    11:00 AM
    Santiago, RM
    Terminal San Borja
    5:20 PM
    La Serena
    El Sto, 1060
    0
    Pullman Bus
    First Class
    $16
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Sur Bus Station
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 30m
    0
    12:00 PM
    Santiago, RM
    Terminal San Borja
    6:30 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $14
  • Turbus
    6h 40m
    0
    11:15 AM
    Santiago, RM
    Terminal Alameda
    5:55 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $16

    Fastest Flights Monday

  • JetSmart
    1h 10m
    0
    7:12 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:22 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $119
  • LAN Airlines
    1h 10m
    0
    11:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $134
  • LAN Airlines
    1h 10m
    0
    11:43 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:53 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $134
  • Sky Airline
    1h 11m
    0
    1:00 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    2:11 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $117
  • Sky Airline
    1h 11m
    0
    5:45 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $133
  • Fastest Buses Monday

  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $13
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11
  • Cikbus Elité
    7h 10m
    0
    1:30 PM
    Santiago, RM
    Terminal San Borja
    8:40 PM
    La Serena
    Central Bus Station
    0
    Cikbus Elité
    Business
    $17

    Fastest Flights Tuesday

  • LAN Perú
    1h 8m
    0
    6:52 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:00 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $49
  • JetSmart
    1h 10m
    0
    7:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:15 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $45
  • JetSmart
    1h 10m
    0
    8:00 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:10 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $80
  • LAN Airlines
    1h 10m
    0
    11:48 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:58 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $94
  • Sky Airline
    1h 11m
    0
    5:40 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:51 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $38
  • Fastest Buses Tuesday

  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $12
  • Buses Paravias
    6h 20m
    0
    12:30 PM
    Santiago, RM
    Sur Bus Station
    6:50 PM
    La Serena
    Central Bus Station
    0
    Buses Paravias
    First Class
    $17
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Sur Bus Station
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Premium Economy
    $10

    Fastest Flights Wednesday

  • LAN Airlines
    1h 8m
    0
    2:01 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    3:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $44
  • LAN Airlines
    1h 8m
    0
    3:03 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    4:11 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $49
  • LAN Perú
    1h 10m
    0
    7:45 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:55 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $62
  • Sky Airline
    1h 11m
    0
    11:22 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    12:33 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $47
  • Sky Airline
    1h 11m
    0
    10:41 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    11:52 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $48
  • Fastest Buses Wednesday

  • Turbus
    5h 55m
    0
    1:50 PM
    Santiago, RM
    Terminal Alameda
    7:45 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $17
  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $12
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11

    Fastest Flights Thursday

  • JetSmart
    1h 10m
    0
    8:17 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:27 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $33
  • LAN Airlines
    1h 10m
    0
    1:42 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    2:52 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $48
  • Sky Airline
    1h 11m
    0
    12:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    1:36 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $45
  • LAN Perú
    1h 13m
    0
    5:43 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:56 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $48
  • LAN Perú
    1h 15m
    0
    7:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:55 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $42
  • Fastest Buses Thursday

  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Cormar Bus
    6h 10m
    0
    1:00 PM
    Santiago, RM
    Terminal San Borja
    7:10 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $12
  • Turbus
    6h 20m
    0
    6:10 AM
    Santiago, RM
    Terminal Alameda
    12:30 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $11
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11

    Fastest Flights Friday

  • JetSmart
    1h 10m
    0
    4:22 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    5:32 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $118
  • Sky Airline
    1h 11m
    0
    6:03 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    7:14 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $75
  • LAN Perú
    1h 13m
    0
    2:26 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    3:39 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $94
  • LAN Perú
    1h 13m
    0
    7:34 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:47 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $94
  • LAN Airlines
    1h 13m
    0
    8:27 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    9:40 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Airlines
    Economy
    from $97
  • Fastest Buses Friday

  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • FlixBus
    6h 10m
    0
    6:15 AM
    Santiago, RM
    Terminal San Borja
    12:25 PM
    La Serena
    Central Bus Station
    0
    FlixBus
    Economy
    $13
  • Turbus
    6h 25m
    0
    7:20 AM
    Santiago, RM
    Terminal Alameda
    1:45 PM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $11
  • Buses Romani
    6h 30m
    0
    10:30 AM
    Santiago, RM
    Terminal San Borja
    5:00 PM
    La Serena
    Central Bus Station
    0
    Buses Romani
    Business
    $11
  • Cormar Bus
    6h 30m
    0
    12:00 PM
    Santiago, RM
    Terminal San Borja
    6:30 PM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Premium Economy
    $14

    Fastest Flights Saturday

  • LAN Perú
    1h 10m
    0
    10:26 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    11:36 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $84
  • JetSmart
    1h 10m
    0
    5:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    6:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    JetSmart
    Economy
    from $101
  • Sky Airline
    1h 11m
    0
    9:20 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    10:31 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    Sky Airline
    Economy
    from $51
  • LAN Perú
    1h 15m
    0
    7:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    8:55 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    0
    LAN Perú
    Economy
    from $54
  • Fastest Buses Saturday

  • Nueva Andimar Vip
    6h 0m
    0
    7:50 AM
    Santiago, RM
    Terminal San Borja
    1:50 PM
    La Serena
    Central Bus Station
    0
    Nueva Andimar Vip
    Economy
    $17
  • Turbus
    6h 10m
    0
    6:30 PM
    Santiago, RM
    Terminal Alameda
    12:40 AM
    La Serena
    Avda. Fco de Aguirre Station
    0
    Turbus
    Premium Economy
    $11
  • FlixBus
    6h 10m
    0
    6:10 PM
    Santiago, RM
    Terminal San Borja
    12:20 AM
    La Serena
    Central Bus Station
    0
    FlixBus
    Premium Economy
    $12
  • Cormar Bus
    6h 10m
    0
    10:50 PM
    Santiago, RM
    Terminal San Borja
    5:00 AM
    La Serena
    Central Bus Station
    0
    Cormar Bus
    Business
    $17
  • Pullman San Andres
    6h 15m
    0
    3:30 PM
    Santiago, RM
    Terminal San Borja
    9:45 PM
    La Serena
    Central Bus Station
    0
    Pullman San Andres
    Premium Economy
    $18
Here you will find all operators and timetables for a Bus from Santiago, RM to La Serena

What are the most popular stations in Santiago, RM and La Serena?

In Santiago, RM, you will usually depart from Terminal Alameda, Terminal San Borja or Sur Bus Station, while in La Serena you will be arriving at Avda. Fco de Aguirre Station, Central Bus Station or El Sto, 1060, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to La Serena from Santiago, RM? With 9 connections between 17 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Santiago, RM and La Serena, you can pay as low as $10 with a Bus from Buses Romani.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Perú: you will get to La Serena in just 1h 8m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Santiago, RM and La Serena are Sky Airline, JetSmart and LAN Airlines, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in Santiago, RM and La Serena is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Lo Prado or to La Florida, La Serena Airport, and look at flights from Santiago de Chile Airport, and landing at La Florida, La Serena Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from Santiago, RM to La Serena?

The most popular companies between Santiago, RM and La Serena, are Sky Airline, JetSmart and LAN Airlines. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: Cormar Bus, FlixBus, Buses Romani and 6 more.

Airlines: Sky Airline, JetSmart, LAN Airlines and 1 more.

All you need to know when you travel from Santiago, RM to La Serena

Check all information on comfort and services on all modes of transports from Santiago, RM to La Serena. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from Santiago, RM to La Serena

How can I reach La Serena from Santiago, RM?

Every day, there are on average 9 connections between Bus and Flight, with which you can get to La Serena from Santiago, RM.

How far is La Serena from Santiago, RM?

The distance between Santiago, RM and La Serena is 247.0 miles.

What is the most ecofriendly mode of transport between Santiago, RM and La Serena?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.

What is the cheapest mode of transport from Santiago, RM to La Serena?

You can get to La Serena with just $10 by taking a Bus from Buses Romani.

What is the fastest way to get from Santiago, RM to La Serena?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to La Serena in just 1h 8m with a Flight from LAN Perú.

More routes to Santiago, RM and to La Serena

Looking for more options? Here you can see the most popular routes to Santiago, RM and to La Serena. Simply click on a connection, and you’ll find all the details about the route!

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