How to get from La Serena to Santiago, RM

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What is the best way to travel from La Serena to Santiago, RM?

Looking for a trip? Compare all the available Flights and Buses for the journey to Santiago, RM from La Serena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 14 available companies to find your perfect trip!
Bus is the cheapest, while Flight is the fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
6h 0m
$10
$12
340
Flight
0h 55m
$32
$47
25

What is the cheapest way to reach Santiago, RM from La Serena?

You can get to Santiago, RM with just $10 by taking a Bus from Buses Romani, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

Sunday
from $11
Monday
from $10
Tuesday
from $10
Wednesday
from $10
Thursday
from $10
Friday
from $11
Saturday
from $11

    Cheapest Buses Sunday

  • Pluss Chile
    7h 15m
    0
    9:50 AM
    La Serena
    Central Bus Station
    5:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Buses Romani
    6h 0m
    0
    9:00 AM
    La Serena
    Central Bus Station
    3:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Premium Economy
    $12
  • Serena Mar
    6h 20m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:20 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    Business
    $14
  • Cormar Bus
    6h 30m
    0
    2:15 PM
    La Serena
    Central Bus Station
    8:45 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Business
    $14
  • Cikbus Elité
    7h 5m
    0
    2:55 PM
    La Serena
    Central Bus Station
    10:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $15
  • Cheapest Flights Sunday

  • LAN Perú
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $50
  • Sky Airline
    1h 4m
    0
    8:48 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:52 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $52
  • LATAM Brasil
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $57
  • LAN Airlines
    0h 55m
    0
    2:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $61
  • JetSmart
    0h 59m
    0
    3:37 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:36 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $62

    Cheapest Buses Monday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Pluss Chile
    6h 30m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Cormar Bus
    6h 35m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:50 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Serena Mar
    6h 20m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:20 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Condor Bus
    6h 15m
    0
    4:50 PM
    La Serena
    Central Bus Station
    11:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $16
  • Cheapest Flights Monday

  • Sky Airline
    1h 4m
    0
    12:21 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $65
  • LAN Perú
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $72
  • LATAM Brasil
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $73
  • LAN Airlines
    0h 55m
    0
    1:04 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:59 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $77

    Cheapest Buses Tuesday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 35m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:50 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • FlixBus
    6h 5m
    0
    3:15 PM
    La Serena
    Central Bus Station
    9:20 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $14
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $15
  • Buses Paravias
    6h 40m
    0
    11:30 PM
    La Serena
    Central Bus Station
    6:10 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Paravias
    First Class
    $15
  • Cheapest Flights Tuesday

  • Sky Airline
    1h 4m
    0
    10:28 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:32 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $32
  • JetSmart
    0h 59m
    0
    9:47 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:46 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $41
  • LAN Perú
    0h 55m
    0
    9:45 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $42
  • LAN Airlines
    0h 55m
    0
    1:38 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LATAM Brasil
    0h 55m
    0
    1:38 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $43

    Cheapest Buses Wednesday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Cormar Bus
    6h 30m
    0
    1:50 AM
    La Serena
    Central Bus Station
    8:20 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $13
  • FlixBus
    6h 5m
    0
    3:15 PM
    La Serena
    Central Bus Station
    9:20 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $13
  • Cheapest Flights Wednesday

  • Sky Airline
    1h 4m
    0
    10:25 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:29 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $32
  • JetSmart
    0h 59m
    0
    12:48 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:47 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $42
  • LAN Perú
    0h 55m
    0
    9:41 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:36 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $42
  • LATAM Brasil
    0h 55m
    0
    9:41 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:36 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $43
  • LAN Airlines
    0h 55m
    0
    3:49 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:44 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $58

    Cheapest Buses Thursday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Cormar Bus
    6h 30m
    0
    1:50 AM
    La Serena
    Central Bus Station
    8:20 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Serena Mar
    6h 20m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:20 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $14
  • Cheapest Flights Thursday

  • Sky Airline
    1h 4m
    0
    1:52 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:56 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $35
  • JetSmart
    0h 59m
    0
    7:38 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:37 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $42
  • LAN Airlines
    0h 55m
    0
    3:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:04 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LATAM Brasil
    0h 55m
    0
    3:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:04 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $44
  • LAN Perú
    0h 56m
    0
    8:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:41 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $44

    Cheapest Buses Friday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    $11
  • Turbus
    6h 5m
    0
    6:55 AM
    La Serena
    Avda. Fco de Aguirre Station
    1:00 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cormar Bus
    6h 35m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:50 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $14
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Central Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $15
  • Cheapest Flights Friday

  • JetSmart
    0h 59m
    0
    4:31 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $36
  • LAN Airlines
    0h 56m
    0
    10:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:21 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LAN Perú
    0h 56m
    0
    9:30 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:26 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $44
  • LATAM Brasil
    0h 56m
    0
    9:30 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:26 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $45
  • Sky Airline
    1h 4m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:44 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $53

    Cheapest Buses Saturday

  • Pluss Chile
    6h 30m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    $11
  • Turbus
    6h 35m
    0
    4:35 PM
    La Serena
    Avda. Fco de Aguirre Station
    11:10 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cormar Bus
    6h 30m
    0
    1:50 AM
    La Serena
    Central Bus Station
    8:20 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $14
  • Cheapest Flights Saturday

  • JetSmart
    0h 59m
    0
    12:41 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:40 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $38
  • Sky Airline
    1h 4m
    0
    9:30 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:34 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $39
  • JetSmart
    0h 59m
    0
    10:45 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:44 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $40
  • LAN Perú
    0h 55m
    0
    9:42 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $40
  • LAN Perú
    0h 55m
    0
    12:17 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:12 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $40

What are the fastest trips from La Serena to Santiago, RM?

You can get to Santiago, RM from La Serena in just 0h 55m with a Flight from LAN Perú. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

Sunday
from 0h 55m
Monday
from 0h 55m
Tuesday
from 0h 55m
Wednesday
from 0h 55m
Thursday
from 0h 55m
Friday
from 0h 56m
Saturday
from 0h 55m

    Fastest Flights Sunday

  • LAN Perú
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $50
  • LATAM Brasil
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $57
  • LAN Airlines
    0h 55m
    0
    2:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    3:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $61
  • JetSmart
    0h 59m
    0
    3:37 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:36 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $62
  • Sky Airline
    1h 4m
    0
    8:48 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:52 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $52
  • Fastest Buses Sunday

  • Buses Romani
    6h 0m
    0
    9:00 AM
    La Serena
    Central Bus Station
    3:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Premium Economy
    $12
  • Serena Mar
    6h 20m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:20 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    Business
    $14
  • Cormar Bus
    6h 30m
    0
    2:15 PM
    La Serena
    Central Bus Station
    8:45 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Business
    $14
  • Cikbus Elité
    7h 5m
    0
    2:55 PM
    La Serena
    Central Bus Station
    10:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $15
  • Pluss Chile
    7h 15m
    0
    9:50 AM
    La Serena
    Central Bus Station
    5:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11

    Fastest Flights Monday

  • LAN Perú
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $72
  • LATAM Brasil
    0h 55m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:35 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $73
  • LAN Airlines
    0h 55m
    0
    1:04 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:59 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $77
  • Sky Airline
    1h 4m
    0
    12:21 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:25 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $65
  • Fastest Buses Monday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Condor Bus
    6h 15m
    0
    4:50 PM
    La Serena
    Central Bus Station
    11:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $16
  • Serena Mar
    6h 20m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:20 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Pluss Chile
    6h 30m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Cormar Bus
    6h 35m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:50 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12

    Fastest Flights Tuesday

  • LAN Perú
    0h 55m
    0
    9:45 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:40 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $42
  • LAN Airlines
    0h 55m
    0
    1:38 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LATAM Brasil
    0h 55m
    0
    1:38 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:33 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $43
  • JetSmart
    0h 59m
    0
    9:47 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:46 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $41
  • Sky Airline
    1h 4m
    0
    10:28 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:32 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $32
  • Fastest Buses Tuesday

  • FlixBus
    6h 5m
    0
    3:15 PM
    La Serena
    Central Bus Station
    9:20 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $14
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 35m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:50 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Buses Paravias
    6h 40m
    0
    11:30 PM
    La Serena
    Central Bus Station
    6:10 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Paravias
    First Class
    $15
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $15

    Fastest Flights Wednesday

  • LAN Perú
    0h 55m
    0
    9:41 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:36 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $42
  • LATAM Brasil
    0h 55m
    0
    9:41 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:36 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $43
  • LAN Airlines
    0h 55m
    0
    3:49 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:44 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $58
  • JetSmart
    0h 59m
    0
    12:48 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:47 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $42
  • Sky Airline
    1h 4m
    0
    10:25 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:29 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $32
  • Fastest Buses Wednesday

  • FlixBus
    6h 5m
    0
    3:15 PM
    La Serena
    Central Bus Station
    9:20 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $13
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 30m
    0
    1:50 AM
    La Serena
    Central Bus Station
    8:20 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $13

    Fastest Flights Thursday

  • LAN Airlines
    0h 55m
    0
    3:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:04 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LATAM Brasil
    0h 55m
    0
    3:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:04 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $44
  • LAN Perú
    0h 56m
    0
    8:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:41 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $44
  • JetSmart
    0h 59m
    0
    7:38 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:37 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $42
  • Sky Airline
    1h 4m
    0
    1:52 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:56 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $35
  • Fastest Buses Thursday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Serena Mar
    6h 20m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:20 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cormar Bus
    6h 30m
    0
    1:50 AM
    La Serena
    Central Bus Station
    8:20 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Pluss Chile
    6h 40m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $14

    Fastest Flights Friday

  • LAN Airlines
    0h 56m
    0
    10:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:21 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $42
  • LAN Perú
    0h 56m
    0
    9:30 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:26 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $44
  • LATAM Brasil
    0h 56m
    0
    9:30 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:26 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LATAM Brasil
    Economy
    from $45
  • JetSmart
    0h 59m
    0
    4:31 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $36
  • Sky Airline
    1h 4m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:44 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $53
  • Fastest Buses Friday

  • Turbus
    6h 5m
    0
    6:55 AM
    La Serena
    Avda. Fco de Aguirre Station
    1:00 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Central Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $15
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    $11
  • Cormar Bus
    6h 35m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:50 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $14

    Fastest Flights Saturday

  • LAN Perú
    0h 55m
    0
    9:42 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:37 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $40
  • LAN Perú
    0h 55m
    0
    12:17 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:12 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $40
  • JetSmart
    0h 59m
    0
    12:41 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:40 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $38
  • JetSmart
    0h 59m
    0
    10:45 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:44 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $40
  • Sky Airline
    1h 4m
    0
    9:30 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:34 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $39
  • Fastest Buses Saturday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    $11
  • Pluss Chile
    6h 30m
    0
    12:05 AM
    La Serena
    Central Bus Station
    6:35 AM
    Santiago, RM
    Sur Bus Station
    0
    Pluss Chile
    Premium Economy
    $11
  • Cormar Bus
    6h 30m
    0
    1:50 AM
    La Serena
    Central Bus Station
    8:20 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $12
  • Turbus
    6h 35m
    0
    4:35 PM
    La Serena
    Avda. Fco de Aguirre Station
    11:10 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Nueva Andimar Vip
    7h 15m
    0
    11:50 AM
    La Serena
    Central Bus Station
    7:05 PM
    Santiago, RM
    Terminal San Borja
    0
    Nueva Andimar Vip
    Economy
    $14
Here you will find all operators and timetables for a Bus from La Serena to Santiago, RM

What are the most popular stations in La Serena and Santiago, RM?

In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Bus Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 10 connections between 14 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as $10 with a Bus from Buses Romani.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Perú: you will get to Santiago, RM in just 0h 55m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are LAN Perú, Sky Airline and Buses Romani, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from La Serena to Santiago, RM?

The most popular companies between La Serena and Santiago, RM, are LAN Perú, Sky Airline and Buses Romani. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: Buses Romani, Cormar Bus, Pluss Chile and 7 more.

Airlines: LAN Perú, Sky Airline, JetSmart and 2 more.

All you need to know when you travel from La Serena to Santiago, RM

Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from La Serena to Santiago, RM

How can I reach Santiago, RM from La Serena?

Every day, there are on average 10 connections between Flight and Bus, with which you can get to Santiago, RM from La Serena.

How far is Santiago, RM from La Serena?

The distance between La Serena and Santiago, RM is 247.0 miles.

What is the most ecofriendly mode of transport between La Serena and Santiago, RM?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.

What is the cheapest mode of transport from La Serena to Santiago, RM?

You can get to Santiago, RM with just $10 by taking a Bus from Buses Romani.

What is the fastest way to get from La Serena to Santiago, RM?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 55m with a Flight from LAN Perú.

More routes to La Serena and to Santiago, RM

Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!

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