What is the best way to travel from La Serena to Santiago, RM?
Looking for a trip? Compare all the available Flights and Buses for the journey to Santiago, RM from La Serena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 15 available companies to find your perfect trip!
What is the cheapest way to reach Santiago, RM from La Serena?
You can get to Santiago, RM with just $12 by taking a Bus from Pullman San Andres, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Pullman San Andres6h 10m06:50 AMLa SerenaCentral Bus Station1:00 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 2/6/2026 6:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 1:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 30m02:30 PMLa SerenaEl Sto, 10609:00 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 2/6/2026 2:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 9:00:00 PM. 50 First Class ticket for $13 per person are available. Travel duration is 6h 30m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/6/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/6/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 30m01:50 AMLa SerenaCentral Bus Station8:20 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/6/2026 1:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 8:20:00 AM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/6/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
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Sky Airline1h 4m09:41 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:45 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 9:41:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 10:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 4m
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LAN Perú0h 56m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:23 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 1:23:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m010:53 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:52 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 10:53:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 11:52:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 54m010:25 PMLa Florida, La Serena AirportLa Florida, La Serena Airport11:19 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 10:25:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 11:19:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 0h 54m
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LATAM Brasil0h 56m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:23 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 1:23:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 0h 56m
Cheapest Buses Friday
Cheapest Flights Friday
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Pullman Bus6h 30m011:30 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0BusinessA Bus from Pullman Bus goes from Central Bus Station, La Serena (Chile) at 2/7/2026 11:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 6:00:00 AM. 50 Business ticket for $14 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m012:15 AMLa SerenaCentral Bus Station6:50 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/7/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/7/2026 6:50:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 35m
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/7/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/7/2026 11:45:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 30m012:05 AMLa SerenaCentral Bus Station6:35 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 2/7/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/7/2026 6:35:00 AM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 6h 30m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 2/7/2026 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/7/2026 4:30:00 PM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 7h 0m
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Sky Airline1h 4m011:01 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:05 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/7/2026 11:01:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/7/2026 12:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/7/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/7/2026 1:26:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 0h 59m
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LATAM Brasil0h 55m09:50 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:45 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/7/2026 9:50:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/7/2026 10:45:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 0h 55m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Cormar Bus6h 20m011:50 AMLa SerenaCentral Bus Station6:10 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/8/2026 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 6:10:00 PM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 20m
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Pullman Bus7h 10m08:15 AMLa SerenaEl Sto, 10603:25 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 2/8/2026 8:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 3:25:00 PM. 50 First Class ticket for $19 per person are available. Travel duration is 7h 10m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 2/8/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 4:00:00 PM. 50 Business ticket for $20 per person are available. Travel duration is 6h 0m
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Pluss Chile6h 30m02:16 AMLa SerenaCentral Bus Station8:46 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 2/8/2026 2:16:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/8/2026 8:46:00 AM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 6h 30m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 2/8/2026 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/8/2026 4:30:00 PM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 7h 0m
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LATAM Brasil0h 56m01:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:50 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 1:54:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 2:50:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 0h 56m
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LAN Airlines0h 56m01:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:50 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 1:54:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 2:50:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 0h 56m
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Sky Airline1h 4m01:53 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:57 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 1:53:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 2:57:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m011:14 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:13 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 11:14:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 12:13:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 0h 59m
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LAN Perú0h 55m09:50 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:45 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 9:50:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 10:45:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 0h 55m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Turbus6h 25m09:20 PMLa SerenaAvda. Fco de Aguirre Station3:45 AMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 2/9/2026 9:20:00 PM to Terminal Alameda, Santiago, RM (Chile) arriving at 2/10/2026 3:45:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 25m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/9/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/9/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 20m011:50 AMLa SerenaCentral Bus Station6:10 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/9/2026 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/9/2026 6:10:00 PM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 20m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/9/2026 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/9/2026 12:05:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 6h 5m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 2/9/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/9/2026 4:00:00 PM. 50 Business ticket for $20 per person are available. Travel duration is 6h 0m
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LATAM Brasil0h 56m012:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:48 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 12:52:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 1:48:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m012:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:48 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 12:52:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 1:48:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 1:26:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 56m01:34 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:30 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 1:34:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 2:30:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 0h 56m
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Sky Airline5h 16m06:00 PMLa Florida, La Serena AirportLa Florida, La Serena Airport11:16 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 6:00:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 11:16:00 PM. 50 Economy ticket for $300 per person are available. Travel duration is 5h 16m
Cheapest Buses Monday
Cheapest Flights Monday
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Cormar Bus6h 35m012:15 AMLa SerenaCentral Bus Station6:50 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/10/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/10/2026 6:50:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 35m
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/10/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/10/2026 11:45:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 6h 30m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/10/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/10/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/10/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/10/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 2/10/2026 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/10/2026 4:30:00 PM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 7h 0m
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Sky Airline1h 4m08:34 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:38 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 8:34:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 9:38:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 4m
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LATAM Brasil0h 54m05:47 PMLa Florida, La Serena AirportLa Florida, La Serena Airport6:41 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 5:47:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 6:41:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 0h 54m
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LAN Airlines0h 56m01:37 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:33 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 1:37:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 2:33:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 0h 56m
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LAN Perú0h 54m08:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:39 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 8:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 9:39:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 0h 54m
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JetSmart0h 59m05:29 PMLa Florida, La Serena AirportLa Florida, La Serena Airport6:28 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 5:29:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 6:28:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 0h 59m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/11/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/11/2026 11:45:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 30m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/11/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/11/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 30m01:50 AMLa SerenaCentral Bus Station8:20 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/11/2026 1:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/11/2026 8:20:00 AM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/11/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/11/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
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Pluss Chile6h 40m012:05 AMLa SerenaCentral Bus Station6:45 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 2/11/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/11/2026 6:45:00 AM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 6h 40m
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LATAM Brasil0h 55m010:20 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:15 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 10:20:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 11:15:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m010:20 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:15 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 10:20:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 11:15:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m011:14 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:13 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 11:14:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 12:13:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:33 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:37 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 11:33:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 12:37:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 4m
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LAN Airlines0h 55m09:43 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 9:43:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 10:38:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 0h 55m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/12/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 11:45:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m012:15 AMLa SerenaCentral Bus Station6:50 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/12/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 6:50:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 35m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/12/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/12/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/12/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 2/12/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 4:00:00 PM. 50 First Class ticket for $21 per person are available. Travel duration is 6h 0m
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LATAM Brasil0h 55m09:45 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:40 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 9:45:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 10:40:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 0h 55m
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Sky Airline1h 4m012:30 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:34 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 12:30:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 1:34:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 1h 4m
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LAN Perú0h 55m09:45 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:40 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 9:45:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 10:40:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 54m04:37 PMLa Florida, La Serena AirportLa Florida, La Serena Airport5:31 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 4:37:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 5:31:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 0h 54m
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JetSmart14h 40m06:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:34 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 6:54:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/13/2026 9:34:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 14h 40m
Cheapest Buses Thursday
Cheapest Flights Thursday
What are the fastest trips from La Serena to Santiago, RM?
You can get to Santiago, RM from La Serena in just 0h 54m with a Flight from LAN Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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LAN Airlines0h 54m010:25 PMLa Florida, La Serena AirportLa Florida, La Serena Airport11:19 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 10:25:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 11:19:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 0h 54m
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LAN Perú0h 56m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:23 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 1:23:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 0h 56m
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LATAM Brasil0h 56m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:23 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 1:23:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m010:53 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:52 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 10:53:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 11:52:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m09:41 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:45 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/6/2026 9:41:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/6/2026 10:45:00 AM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/6/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/6/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Pullman San Andres6h 10m06:50 AMLa SerenaCentral Bus Station1:00 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 2/6/2026 6:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 1:00:00 PM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 30m02:30 PMLa SerenaEl Sto, 10609:00 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 2/6/2026 2:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 9:00:00 PM. 50 First Class ticket for $13 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 30m01:50 AMLa SerenaCentral Bus Station8:20 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/6/2026 1:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 8:20:00 AM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/6/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/6/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
Fastest Flights Friday
Fastest Buses Friday
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LATAM Brasil0h 55m09:50 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:45 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/7/2026 9:50:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/7/2026 10:45:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/7/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/7/2026 1:26:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:01 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:05 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/7/2026 11:01:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/7/2026 12:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 1h 4m
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Pullman Bus6h 30m011:30 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0BusinessA Bus from Pullman Bus goes from Central Bus Station, La Serena (Chile) at 2/7/2026 11:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 6:00:00 AM. 50 Business ticket for $14 per person are available. Travel duration is 6h 30m
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/7/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/7/2026 11:45:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 6h 30m
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Pluss Chile6h 30m012:05 AMLa SerenaCentral Bus Station6:35 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 2/7/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/7/2026 6:35:00 AM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m012:15 AMLa SerenaCentral Bus Station6:50 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/7/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/7/2026 6:50:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 35m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 2/7/2026 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/7/2026 4:30:00 PM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 7h 0m
Fastest Flights Saturday
Fastest Buses Saturday
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LAN Perú0h 55m09:50 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:45 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 9:50:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 10:45:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 0h 55m
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LATAM Brasil0h 56m01:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:50 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 1:54:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 2:50:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 0h 56m
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LAN Airlines0h 56m01:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:50 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 1:54:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 2:50:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m011:14 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:13 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 11:14:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 12:13:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m01:53 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:57 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/8/2026 1:53:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/8/2026 2:57:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 1h 4m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 2/8/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 4:00:00 PM. 50 Business ticket for $20 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 20m011:50 AMLa SerenaCentral Bus Station6:10 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/8/2026 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 6:10:00 PM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 20m
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Pluss Chile6h 30m02:16 AMLa SerenaCentral Bus Station8:46 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 2/8/2026 2:16:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/8/2026 8:46:00 AM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 6h 30m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 2/8/2026 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/8/2026 4:30:00 PM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 7h 0m
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Pullman Bus7h 10m08:15 AMLa SerenaEl Sto, 10603:25 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 2/8/2026 8:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/8/2026 3:25:00 PM. 50 First Class ticket for $19 per person are available. Travel duration is 7h 10m
Fastest Flights Sunday
Fastest Buses Sunday
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LATAM Brasil0h 56m012:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:48 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 12:52:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 1:48:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 0h 56m
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LAN Perú0h 56m012:52 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:48 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 12:52:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 1:48:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 0h 56m
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LAN Airlines0h 56m01:34 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:30 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 1:34:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 2:30:00 PM. 50 Economy ticket for $119 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m012:27 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 12:27:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 1:26:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 0h 59m
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Sky Airline5h 16m06:00 PMLa Florida, La Serena AirportLa Florida, La Serena Airport11:16 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/9/2026 6:00:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/9/2026 11:16:00 PM. 50 Economy ticket for $300 per person are available. Travel duration is 5h 16m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/9/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/9/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 2/9/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/9/2026 4:00:00 PM. 50 Business ticket for $20 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/9/2026 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/9/2026 12:05:00 PM. 50 Economy ticket for $18 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 20m011:50 AMLa SerenaCentral Bus Station6:10 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/9/2026 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/9/2026 6:10:00 PM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 20m
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Turbus6h 25m09:20 PMLa SerenaAvda. Fco de Aguirre Station3:45 AMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 2/9/2026 9:20:00 PM to Terminal Alameda, Santiago, RM (Chile) arriving at 2/10/2026 3:45:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 6h 25m
Fastest Flights Monday
Fastest Buses Monday
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LATAM Brasil0h 54m05:47 PMLa Florida, La Serena AirportLa Florida, La Serena Airport6:41 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 5:47:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 6:41:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 0h 54m
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LAN Perú0h 54m08:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:39 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 8:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 9:39:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 0h 54m
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LAN Airlines0h 56m01:37 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:33 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 1:37:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 2:33:00 PM. 50 Economy ticket for $66 per person are available. Travel duration is 0h 56m
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JetSmart0h 59m05:29 PMLa Florida, La Serena AirportLa Florida, La Serena Airport6:28 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 5:29:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 6:28:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m08:34 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:38 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/10/2026 8:34:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/10/2026 9:38:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/10/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/10/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/10/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/10/2026 11:45:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m012:15 AMLa SerenaCentral Bus Station6:50 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/10/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/10/2026 6:50:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 35m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/10/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/10/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 2/10/2026 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/10/2026 4:30:00 PM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 7h 0m
Fastest Flights Tuesday
Fastest Buses Tuesday
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LATAM Brasil0h 55m010:20 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:15 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 10:20:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 11:15:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m010:20 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:15 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 10:20:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 11:15:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 0h 55m
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LAN Airlines0h 55m09:43 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 9:43:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 10:38:00 AM. 50 Economy ticket for $59 per person are available. Travel duration is 0h 55m
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JetSmart0h 59m011:14 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:13 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 11:14:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 12:13:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:33 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:37 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/11/2026 11:33:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/11/2026 12:37:00 PM. 50 Economy ticket for $58 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/11/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/11/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/11/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/11/2026 11:45:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 30m01:50 AMLa SerenaCentral Bus Station8:20 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/11/2026 1:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/11/2026 8:20:00 AM. 50 Premium Economy ticket for $18 per person are available. Travel duration is 6h 30m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/11/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/11/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
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Pluss Chile6h 40m012:05 AMLa SerenaCentral Bus Station6:45 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 2/11/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/11/2026 6:45:00 AM. 50 Premium Economy ticket for $22 per person are available. Travel duration is 6h 40m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Airlines0h 54m04:37 PMLa Florida, La Serena AirportLa Florida, La Serena Airport5:31 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 4:37:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 5:31:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 0h 54m
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LATAM Brasil0h 55m09:45 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:40 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 9:45:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 10:40:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 0h 55m
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LAN Perú0h 55m09:45 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:40 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 9:45:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 10:40:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 0h 55m
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Sky Airline1h 4m012:30 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:34 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 12:30:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/12/2026 1:34:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 1h 4m
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JetSmart14h 40m06:54 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:34 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 2/12/2026 6:54:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 2/13/2026 9:34:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 14h 40m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 2/12/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 2/12/2026 3:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 0m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0First ClassA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 2/12/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 4:00:00 PM. 50 First Class ticket for $21 per person are available. Travel duration is 6h 0m
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FlixBus6h 30m05:15 PMLa SerenaCentral Bus Station11:45 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 2/12/2026 5:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 11:45:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 30m
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Cormar Bus6h 35m012:15 AMLa SerenaCentral Bus Station6:50 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 2/12/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 6:50:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 35m
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Buses Paravias6h 40m04:30 PMLa SerenaCentral Bus Station11:10 PMSantiago, RMTerminal San Borja0EconomyA Bus from Buses Paravias goes from Central Bus Station, La Serena (Chile) at 2/12/2026 4:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 2/12/2026 11:10:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 6h 40m
Fastest Flights Thursday
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from La Serena to Santiago, RM
What are the most popular stations in La Serena and Santiago, RM?
In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Bus Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 10 connections between 15 Flight and Bus operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as $12 with a Bus from Pullman San Andres.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Airlines: you will get to Santiago, RM in just 0h 54m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are Sky Airline, JetSmart and Cormar Bus, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from La Serena to Santiago, RM?
The most popular companies between La Serena and Santiago, RM, are Sky Airline, JetSmart and Cormar Bus. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Cormar Bus, Buses Romani, FlixBus and 7 more.
Airlines: Sky Airline, JetSmart, LATAM Brasil and 2 more.
All you need to know when you travel from La Serena to Santiago, RM
Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from La Serena to Santiago, RM
How can I reach Santiago, RM from La Serena?
Every day, there are on average 10 connections between Flight and Bus, with which you can get to Santiago, RM from La Serena.
How far is Santiago, RM from La Serena?
The distance between La Serena and Santiago, RM is 247.0 miles.
What is the most ecofriendly mode of transport between La Serena and Santiago, RM?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from La Serena to Santiago, RM?
You can get to Santiago, RM with just $12 by taking a Bus from Pullman San Andres.
What is the fastest way to get from La Serena to Santiago, RM?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 54m with a Flight from LAN Airlines.
More routes to La Serena and to Santiago, RM
Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!
- Trips to La Serena
- Antofagasta to La Serena
- Arica, AP to La Serena
- Calama to La Serena
- Concepción to La Serena
- Iquique to La Serena
- Mendoza to La Serena
- San Juan, SJ to La Serena
- Santiago, RM to La Serena
- Trips to Santiago, RM
- Alto Hospicio to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Bariloche to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Iquique to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Pitrufquén to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Valparaíso (CL) to Santiago, RM
- Viña del Mar to Santiago, RM
