What is the best way to travel from La Serena to Santiago, RM?
Looking for a trip? Compare all the available Buses and Flights for the journey to Santiago, RM from La Serena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 13 available companies to find your perfect trip!
What is the cheapest way to reach Santiago, RM from La Serena?
You can get to Santiago, RM with just $10 by taking a Bus from Buses Romani, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/17/2025 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/17/2025 3:00:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m011:00 AMLa SerenaCentral Bus Station5:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/17/2025 11:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/17/2025 5:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/17/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/17/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 10m011:50 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/17/2025 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 6:00:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 30m07:45 AMLa SerenaCentral Bus Station2:15 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 12/17/2025 7:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/17/2025 2:15:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 30m
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LAN Perú0h 58m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 10:38:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 0h 58m
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Sky Airline1h 4m011:28 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:32 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 11:28:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 12:32:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 1h 4m
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LAN Airlines0h 57m03:51 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:48 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 3:51:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 4:48:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 57m03:50 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:47 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 3:50:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 4:47:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 0h 57m
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JetSmart9h 54m03:03 PMLa Florida, La Serena AirportLa Florida, La Serena Airport12:57 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 3:03:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 12:57:00 AM. 50 Economy ticket for $180 per person are available. Travel duration is 9h 54m
Cheapest Buses Wednesday
Cheapest Flights Wednesday
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/18/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/18/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 12/18/2025 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/18/2025 4:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 0m
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FlixBus6h 50m02:00 PMLa SerenaCentral Bus Station8:50 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/18/2025 2:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 8:50:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 50m
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Cormar Bus6h 10m01:20 PMLa SerenaCentral Bus Station7:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/18/2025 1:20:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 7:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 0m012:45 AMLa SerenaEl Sto, 10606:45 AMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/18/2025 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 6:45:00 AM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Sky Airline1h 4m02:11 PMLa Florida, La Serena AirportLa Florida, La Serena Airport3:15 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 2:11:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 3:15:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m09:45 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:44 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 9:45:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 10:44:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 57m04:39 PMLa Florida, La Serena AirportLa Florida, La Serena Airport5:36 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 4:39:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 5:36:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 0h 57m
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LAN Perú0h 58m012:03 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:01 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 12:03:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 1:01:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 0h 58m
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LATAM Brasil0h 57m03:38 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:35 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 3:38:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 4:35:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 0h 57m
Cheapest Buses Thursday
Cheapest Flights Thursday
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/19/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/19/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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Condor Bus6h 50m03:15 AMLa SerenaCentral Bus Station10:05 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 12/19/2025 3:15:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/19/2025 10:05:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 50m
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Turbus6h 30m03:15 AMLa SerenaAvda. Fco de Aguirre Station9:45 AMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/19/2025 3:15:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 12/19/2025 9:45:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/19/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/19/2025 12:05:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 5m
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Cikbus Elité7h 0m07:00 AMLa SerenaCentral Bus Station2:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 12/19/2025 7:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/19/2025 2:00:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 7h 0m
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Sky Airline1h 4m09:40 PMLa Florida, La Serena AirportLa Florida, La Serena Airport10:44 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 9:40:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 10:44:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 4m
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LAN Airlines0h 57m010:25 PMLa Florida, La Serena AirportLa Florida, La Serena Airport11:22 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 10:25:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 11:22:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 0h 57m
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JetSmart0h 59m01:08 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:07 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 1:08:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 2:07:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 0h 59m
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LATAM Brasil0h 57m09:33 PMLa Florida, La Serena AirportLa Florida, La Serena Airport10:30 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 9:33:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 10:30:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m09:33 PMLa Florida, La Serena AirportLa Florida, La Serena Airport10:30 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 9:33:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 10:30:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 0h 57m
Cheapest Buses Friday
Cheapest Flights Friday
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/20/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/20/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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Condor Bus7h 10m09:45 PMLa SerenaCentral Bus Station4:55 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 12/20/2025 9:45:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/21/2025 4:55:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 7h 10m
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FlixBus5h 59m06:00 PMLa SerenaCentral Bus Station11:59 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/20/2025 6:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/20/2025 11:59:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 5h 59m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/20/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/20/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Turbus6h 35m04:35 PMLa SerenaAvda. Fco de Aguirre Station11:10 PMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/20/2025 4:35:00 PM to Terminal Alameda, Santiago, RM (Chile) arriving at 12/20/2025 11:10:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 35m
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JetSmart0h 59m010:47 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:46 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 10:47:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 11:46:00 AM. 50 Economy ticket for $37 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:06 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:10 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 11:06:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 12:10:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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LAN Perú0h 58m09:46 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:44 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 9:46:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 10:44:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 0h 58m
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LATAM Brasil0h 57m07:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport8:42 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 7:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 8:42:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 0h 57m
Cheapest Buses Saturday
Cheapest Flights Saturday
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/21/2025 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/21/2025 3:00:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 0m
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Turbus6h 15m01:45 AMLa SerenaAvda. Fco de Aguirre Station8:00 AMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/21/2025 1:45:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 12/21/2025 8:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/21/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/21/2025 12:05:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m011:50 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/21/2025 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 6:00:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/21/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/21/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Sky Airline1h 4m02:11 PMLa Florida, La Serena AirportLa Florida, La Serena Airport3:15 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 2:11:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 3:15:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m010:39 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 10:39:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 11:38:00 AM. 50 Economy ticket for $36 per person are available. Travel duration is 0h 59m
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LATAM Brasil0h 58m012:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 12:28:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 1:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m012:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 12:28:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 1:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 57m04:19 PMLa Florida, La Serena AirportLa Florida, La Serena Airport5:16 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 4:19:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 5:16:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 0h 57m
Cheapest Buses Sunday
Cheapest Flights Sunday
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/22/2025 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 7:00:00 AM. 50 Business ticket for $11 per person are available. Travel duration is 6h 15m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMTerminal San Borja0BusinessA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 12/22/2025 9:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 4:30:00 PM. 50 Business ticket for $13 per person are available. Travel duration is 7h 0m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/22/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 12/22/2025 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 4:00:00 PM. 50 Business ticket for $14 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 20m011:50 AMLa SerenaCentral Bus Station6:10 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/22/2025 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 6:10:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 20m
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LAN Perú0h 57m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:37 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 10:37:00 AM. 50 Economy ticket for $32 per person are available. Travel duration is 0h 57m
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JetSmart0h 59m09:38 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:37 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 9:38:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 10:37:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 58m01:29 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:27 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 1:29:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 2:27:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 0h 58m
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LAN Perú0h 57m08:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:42 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 8:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 9:42:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 57m05:07 PMLa Florida, La Serena AirportLa Florida, La Serena Airport6:04 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 5:07:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 6:04:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 0h 57m
Cheapest Buses Monday
Cheapest Flights Monday
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/23/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/23/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/23/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/23/2025 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m011:50 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/23/2025 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/24/2025 6:00:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 10m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/23/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/23/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Nueva Andimar Vip7h 15m010:20 AMLa SerenaCentral Bus Station5:35 PMSantiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 12/23/2025 10:20:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/23/2025 5:35:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 7h 15m
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LATAM Brasil0h 58m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 10:38:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 10:38:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 0h 58m
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Sky Airline1h 4m010:38 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:42 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 10:38:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 11:42:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 1h 4m
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JetSmart0h 59m03:25 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:24 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 3:25:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 4:24:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 0h 59m
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LAN Airlines0h 58m01:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:43 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 1:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 2:43:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 0h 58m
Cheapest Buses Tuesday
Cheapest Flights Tuesday
What are the fastest trips from La Serena to Santiago, RM?
You can get to Santiago, RM from La Serena in just 0h 57m with a Flight from LAN Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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LAN Airlines0h 57m03:51 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:48 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 3:51:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 4:48:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 57m03:50 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:47 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 3:50:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 4:47:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 0h 57m
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LAN Perú0h 58m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 10:38:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 0h 58m
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Sky Airline1h 4m011:28 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:32 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 11:28:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/17/2025 12:32:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 1h 4m
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JetSmart9h 54m03:03 PMLa Florida, La Serena AirportLa Florida, La Serena Airport12:57 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/17/2025 3:03:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 12:57:00 AM. 50 Economy ticket for $180 per person are available. Travel duration is 9h 54m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/17/2025 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/17/2025 3:00:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 0m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/17/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/17/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m011:00 AMLa SerenaCentral Bus Station5:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/17/2025 11:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/17/2025 5:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m011:50 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/17/2025 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 6:00:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 10m
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Pluss Chile6h 30m07:45 AMLa SerenaCentral Bus Station2:15 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 12/17/2025 7:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/17/2025 2:15:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 30m
Fastest Flights Wednesday
Fastest Buses Wednesday
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LAN Airlines0h 57m04:39 PMLa Florida, La Serena AirportLa Florida, La Serena Airport5:36 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 4:39:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 5:36:00 PM. 50 Economy ticket for $82 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 57m03:38 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:35 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 3:38:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 4:35:00 PM. 50 Economy ticket for $94 per person are available. Travel duration is 0h 57m
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LAN Perú0h 58m012:03 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:01 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 12:03:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 1:01:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m09:45 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:44 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 9:45:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 10:44:00 AM. 50 Economy ticket for $71 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m02:11 PMLa Florida, La Serena AirportLa Florida, La Serena Airport3:15 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/18/2025 2:11:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/18/2025 3:15:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 1h 4m
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Pullman Bus6h 0m012:45 AMLa SerenaEl Sto, 10606:45 AMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/18/2025 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 6:45:00 AM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Cormar Bus6h 10m01:20 PMLa SerenaCentral Bus Station7:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/18/2025 1:20:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 7:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 10m
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/18/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/18/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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FlixBus6h 50m02:00 PMLa SerenaCentral Bus Station8:50 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/18/2025 2:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/18/2025 8:50:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 50m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 12/18/2025 9:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/18/2025 4:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 0m
Fastest Flights Thursday
Fastest Buses Thursday
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LAN Airlines0h 57m010:25 PMLa Florida, La Serena AirportLa Florida, La Serena Airport11:22 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 10:25:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 11:22:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 57m09:33 PMLa Florida, La Serena AirportLa Florida, La Serena Airport10:30 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 9:33:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 10:30:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m09:33 PMLa Florida, La Serena AirportLa Florida, La Serena Airport10:30 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 9:33:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 10:30:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 0h 57m
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JetSmart0h 59m01:08 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:07 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 1:08:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 2:07:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m09:40 PMLa Florida, La Serena AirportLa Florida, La Serena Airport10:44 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/19/2025 9:40:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/19/2025 10:44:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 1h 4m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/19/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/19/2025 12:05:00 PM. 50 Economy ticket for $14 per person are available. Travel duration is 6h 5m
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/19/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/19/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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Turbus6h 30m03:15 AMLa SerenaAvda. Fco de Aguirre Station9:45 AMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/19/2025 3:15:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 12/19/2025 9:45:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
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Condor Bus6h 50m03:15 AMLa SerenaCentral Bus Station10:05 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 12/19/2025 3:15:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/19/2025 10:05:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 50m
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Cikbus Elité7h 0m07:00 AMLa SerenaCentral Bus Station2:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 12/19/2025 7:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/19/2025 2:00:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 7h 0m
Fastest Flights Friday
Fastest Buses Friday
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LATAM Brasil0h 57m07:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport8:42 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 7:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 8:42:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 0h 57m
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LAN Perú0h 58m09:46 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:44 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 9:46:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 10:44:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m010:47 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:46 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 10:47:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 11:46:00 AM. 50 Economy ticket for $37 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m011:06 AMLa Florida, La Serena AirportLa Florida, La Serena Airport12:10 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/20/2025 11:06:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/20/2025 12:10:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 1h 4m
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FlixBus5h 59m06:00 PMLa SerenaCentral Bus Station11:59 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/20/2025 6:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/20/2025 11:59:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 5h 59m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/20/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/20/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/20/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/20/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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Turbus6h 35m04:35 PMLa SerenaAvda. Fco de Aguirre Station11:10 PMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/20/2025 4:35:00 PM to Terminal Alameda, Santiago, RM (Chile) arriving at 12/20/2025 11:10:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 35m
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Condor Bus7h 10m09:45 PMLa SerenaCentral Bus Station4:55 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 12/20/2025 9:45:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/21/2025 4:55:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 7h 10m
Fastest Flights Saturday
Fastest Buses Saturday
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LAN Airlines0h 57m04:19 PMLa Florida, La Serena AirportLa Florida, La Serena Airport5:16 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 4:19:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 5:16:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 0h 57m
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LATAM Brasil0h 58m012:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 12:28:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 1:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m012:28 PMLa Florida, La Serena AirportLa Florida, La Serena Airport1:26 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 12:28:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 1:26:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m010:39 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 10:39:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 11:38:00 AM. 50 Economy ticket for $36 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m02:11 PMLa Florida, La Serena AirportLa Florida, La Serena Airport3:15 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/21/2025 2:11:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/21/2025 3:15:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 1h 4m
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Buses Romani6h 0m09:00 AMLa SerenaCentral Bus Station3:00 PMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/21/2025 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/21/2025 3:00:00 PM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 0m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/21/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/21/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/21/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/21/2025 12:05:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m011:50 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/21/2025 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 6:00:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 10m
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Turbus6h 15m01:45 AMLa SerenaAvda. Fco de Aguirre Station8:00 AMSantiago, RMTerminal Alameda0Premium EconomyA Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 12/21/2025 1:45:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 12/21/2025 8:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
Fastest Flights Sunday
Fastest Buses Sunday
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LAN Perú0h 57m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:37 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 10:37:00 AM. 50 Economy ticket for $32 per person are available. Travel duration is 0h 57m
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LAN Perú0h 57m08:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport9:42 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 8:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 9:42:00 PM. 50 Economy ticket for $47 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 57m05:07 PMLa Florida, La Serena AirportLa Florida, La Serena Airport6:04 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 5:07:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 6:04:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 0h 57m
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LAN Airlines0h 58m01:29 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:27 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 1:29:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 2:27:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m09:38 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:37 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/22/2025 9:38:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/22/2025 10:37:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 0h 59m
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Serena Mar6h 0m010:00 AMLa SerenaCentral Bus Station4:00 PMSantiago, RMTerminal San Borja0BusinessA Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 12/22/2025 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 4:00:00 PM. 50 Business ticket for $14 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/22/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMTerminal San Borja0BusinessA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/22/2025 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 7:00:00 AM. 50 Business ticket for $11 per person are available. Travel duration is 6h 15m
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Cormar Bus6h 20m011:50 AMLa SerenaCentral Bus Station6:10 PMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/22/2025 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 6:10:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 20m
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Cikbus Elité7h 0m09:30 AMLa SerenaCentral Bus Station4:30 PMSantiago, RMTerminal San Borja0BusinessA Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 12/22/2025 9:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/22/2025 4:30:00 PM. 50 Business ticket for $13 per person are available. Travel duration is 7h 0m
Fastest Flights Monday
Fastest Buses Monday
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LATAM Brasil0h 58m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LATAM Brasil goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 10:38:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 0h 58m
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LAN Perú0h 58m09:40 AMLa Florida, La Serena AirportLa Florida, La Serena Airport10:38 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Perú goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 9:40:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 10:38:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 0h 58m
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LAN Airlines0h 58m01:45 PMLa Florida, La Serena AirportLa Florida, La Serena Airport2:43 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from LAN Airlines goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 1:45:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 2:43:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 0h 58m
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JetSmart0h 59m03:25 PMLa Florida, La Serena AirportLa Florida, La Serena Airport4:24 PMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from JetSmart goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 3:25:00 PM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 4:24:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 0h 59m
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Sky Airline1h 4m010:38 AMLa Florida, La Serena AirportLa Florida, La Serena Airport11:42 AMSantiago de Chile AirportSantiago de Chile Airport0EconomyA Flight from Sky Airline goes from La Florida, La Serena Airport, La Florida, La Serena Airport (Chile) at 12/23/2025 10:38:00 AM to Santiago de Chile Airport, Santiago de Chile Airport (Chile) arriving at 12/23/2025 11:42:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 1h 4m
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Pullman Bus6h 0m08:30 AMLa SerenaEl Sto, 10602:30 PMSantiago, RMTerminal San Borja0First ClassA Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 12/23/2025 8:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/23/2025 2:30:00 PM. 50 First Class ticket for $16 per person are available. Travel duration is 6h 0m
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FlixBus6h 5m06:00 AMLa SerenaCentral Bus Station12:05 PMSantiago, RMTerminal San Borja0EconomyA Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 12/23/2025 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/23/2025 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
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Cormar Bus6h 10m011:50 PMLa SerenaCentral Bus Station6:00 AMSantiago, RMTerminal San Borja0Premium EconomyA Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 12/23/2025 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/24/2025 6:00:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 10m
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Buses Romani6h 15m012:45 AMLa SerenaCentral Bus Station7:00 AMSantiago, RMSur Bus Station0Premium EconomyA Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 12/23/2025 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/23/2025 7:00:00 AM. 50 Premium Economy ticket for $10 per person are available. Travel duration is 6h 15m
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Nueva Andimar Vip7h 15m010:20 AMLa SerenaCentral Bus Station5:35 PMSantiago, RMTerminal San Borja0EconomyA Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 12/23/2025 10:20:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 12/23/2025 5:35:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 7h 15m
Fastest Flights Tuesday
Fastest Buses Tuesday
Here you will find all operators and timetables for a
Bus from La Serena to Santiago, RM
What are the most popular stations in La Serena and Santiago, RM?
In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Bus Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 10 connections between 13 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as $10 with a Bus from Buses Romani.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Airlines: you will get to Santiago, RM in just 0h 57m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are LAN Perú, JetSmart and Buses Romani, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from La Serena to Santiago, RM?
The most popular companies between La Serena and Santiago, RM, are LAN Perú, JetSmart and Buses Romani. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Buses Romani, FlixBus, Pullman Bus and 7 more.
Airlines: LAN Perú, JetSmart, LAN Airlines and 2 more.
All you need to know when you travel from La Serena to Santiago, RM
Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from La Serena to Santiago, RM
How can I reach Santiago, RM from La Serena?
Every day, there are on average 10 connections between Bus and Flight, with which you can get to Santiago, RM from La Serena.
How far is Santiago, RM from La Serena?
The distance between La Serena and Santiago, RM is 247.0 miles.
What is the most ecofriendly mode of transport between La Serena and Santiago, RM?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.
What is the cheapest mode of transport from La Serena to Santiago, RM?
You can get to Santiago, RM with just $10 by taking a Bus from Buses Romani.
What is the fastest way to get from La Serena to Santiago, RM?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 57m with a Flight from LAN Airlines.
More routes to La Serena and to Santiago, RM
Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!
- Trips to La Serena
- Antofagasta to La Serena
- Arica, AP to La Serena
- Calama to La Serena
- Concepción to La Serena
- Iquique to La Serena
- Mendoza to La Serena
- San Juan, SJ to La Serena
- Santiago, RM to La Serena
- Trips to Santiago, RM
- Antofagasta to Santiago, RM
- Arica, AP to Santiago, RM
- Buenos Aires to Santiago, RM
- Calama to Santiago, RM
- Castro to Santiago, RM
- Concepción to Santiago, RM
- Copiapó to Santiago, RM
- Coquimbo to Santiago, RM
- Coronel to Santiago, RM
- Freire to Santiago, RM
- Iquique to Santiago, RM
- Los Ángeles, BI to Santiago, RM
- Mendoza to Santiago, RM
- Osorno, LL to Santiago, RM
- Porto Alegre, RS to Santiago, RM
- Puerto Montt to Santiago, RM
- Puerto Varas to Santiago, RM
- Temuco to Santiago, RM
- Valdivia to Santiago, RM
- Valparaíso (CL) to Santiago, RM
- Viña del Mar to Santiago, RM

