How to get from La Serena to Santiago, RM

Compare Buses and Flights with one click and find the best one for you
Compare & Save Millions of buses in one click. Save up to 70%!
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

What is the best way to travel from La Serena to Santiago, RM?

Looking for a trip? Compare all the available Buses and Flights for the journey to Santiago, RM from La Serena. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 13 available companies to find your perfect trip!
Bus is the cheapest, while Flight is the fastest way on this route
Transport type
Travel time
Cheapest price
Average price
Daily departures
Bus
6h 0m
$9
$12
318
Flight
0h 57m
$22
$102
12

What is the cheapest way to reach Santiago, RM from La Serena?

You can get to Santiago, RM with just $9 by taking a Bus from Cikbus Elité, but you can find many more cheap offers: we have selected the best ones for next few days here for you.

Friday
from $13
Saturday
from $10
Sunday
from $11
Monday
from $10
Tuesday
from $10
Wednesday
from $9
Thursday
from $9

    Cheapest Buses Friday

  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cikbus Elité
    6h 0m
    0
    8:30 AM
    La Serena
    Central Bus Station
    2:30 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $14
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Central Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $15
  • Cormar Bus
    6h 40m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:55 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $16
  • Pullman Bus
    6h 30m
    0
    5:30 AM
    La Serena
    El Sto, 1060
    12:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    $16
  • Cheapest Flights Friday

  • JetSmart
    0h 59m
    0
    1:08 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:07 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $62
  • LAN Airlines
    0h 57m
    0
    10:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:22 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $80
  • LAN Airlines
    0h 57m
    0
    10:51 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:48 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $80
  • Sky Airline
    1h 4m
    0
    6:16 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:20 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $88
  • LAN Perú
    0h 58m
    0
    12:34 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:32 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $93

    Cheapest Buses Saturday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • FlixBus
    6h 5m
    0
    11:00 AM
    La Serena
    Central Bus Station
    5:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $12
  • Cormar Bus
    6h 10m
    0
    1:20 PM
    La Serena
    Central Bus Station
    7:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    First Class
    $14
  • Condor Bus
    6h 15m
    0
    4:50 PM
    La Serena
    Central Bus Station
    11:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $15
  • Cikbus Elité
    6h 0m
    0
    11:00 AM
    La Serena
    Central Bus Station
    5:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    First Class
    $15
  • Cheapest Flights Saturday

  • JetSmart
    0h 59m
    0
    10:27 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:26 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $99
  • Sky Airline
    1h 4m
    0
    11:11 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:15 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $103
  • LAN Perú
    0h 58m
    0
    9:46 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:44 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $110
  • LAN Perú
    0h 57m
    0
    7:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:42 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $110

    Cheapest Buses Sunday

  • Buses Romani
    6h 0m
    0
    9:00 AM
    La Serena
    Central Bus Station
    3:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    $11
  • FlixBus
    6h 5m
    0
    3:30 PM
    La Serena
    Central Bus Station
    9:35 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $12
  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cikbus Elité
    6h 30m
    0
    2:00 AM
    La Serena
    Central Bus Station
    8:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $14
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Central Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $15
  • Cheapest Flights Sunday

  • Sky Airline
    1h 4m
    0
    11:01 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $61
  • JetSmart
    0h 59m
    0
    10:44 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:43 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $63
  • LAN Perú
    0h 58m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $64
  • LAN Airlines
    0h 57m
    0
    2:00 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:57 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $71
  • LAN Airlines
    0h 57m
    0
    3:40 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:37 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $77

    Cheapest Buses Monday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Turbus
    6h 15m
    0
    2:30 AM
    La Serena
    Avda. Fco de Aguirre Station
    8:45 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $14
  • Cormar Bus
    6h 10m
    0
    1:20 PM
    La Serena
    Central Bus Station
    7:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    First Class
    $15
  • Cheapest Flights Monday

  • JetSmart
    0h 59m
    0
    12:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:34 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $101
  • Sky Airline
    1h 4m
    0
    12:19 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:23 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $150
  • LAN Airlines
    0h 58m
    0
    1:32 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $154
  • LAN Perú
    0h 57m
    0
    8:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:32 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $157
  • LAN Airlines
    0h 57m
    0
    4:58 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:55 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $160

    Cheapest Buses Tuesday

  • Buses Romani
    6h 0m
    0
    9:00 AM
    La Serena
    Central Bus Station
    3:00 PM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Turbus
    6h 5m
    0
    6:55 AM
    La Serena
    Avda. Fco de Aguirre Station
    1:00 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cormar Bus
    6h 10m
    0
    11:50 PM
    La Serena
    Central Bus Station
    6:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $11
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $14
  • Condor Bus
    6h 15m
    0
    4:50 PM
    La Serena
    Central Bus Station
    11:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $15
  • Cheapest Flights Tuesday

  • LAN Perú
    0h 57m
    0
    8:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:42 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $104
  • JetSmart
    0h 59m
    0
    10:30 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:29 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $136
  • Sky Airline
    1h 4m
    0
    11:41 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:45 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $148
  • Sky Airline
    1h 4m
    0
    1:20 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:24 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $148
  • LAN Airlines
    0h 57m
    0
    6:31 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:28 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $159

    Cheapest Buses Wednesday

  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Condor Bus
    6h 30m
    0
    3:15 AM
    La Serena
    Central Bus Station
    9:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $11
  • Turbus
    6h 30m
    0
    3:15 AM
    La Serena
    Avda. Fco de Aguirre Station
    9:45 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cormar Bus
    6h 20m
    0
    11:50 AM
    La Serena
    Central Bus Station
    6:10 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $11
  • Cheapest Flights Wednesday

  • Sky Airline
    1h 4m
    0
    10:47 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:51 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $91
  • LAN Perú
    0h 58m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $110
  • LAN Perú
    0h 58m
    0
    12:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:07 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $135
  • LAN Airlines
    0h 57m
    0
    3:32 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:29 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $153
  • Sky Airline
    1h 4m
    0
    9:34 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $185

    Cheapest Buses Thursday

  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Condor Bus
    7h 10m
    0
    9:45 PM
    La Serena
    Central Bus Station
    4:55 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $11
  • Turbus
    6h 40m
    0
    9:20 PM
    La Serena
    Avda. Fco de Aguirre Station
    4:00 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cormar Bus
    6h 10m
    0
    11:50 PM
    La Serena
    Central Bus Station
    6:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $11
  • Cheapest Flights Thursday

  • JetSmart
    0h 58m
    0
    1:40 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:38 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $22
  • Sky Airline
    1h 4m
    0
    7:36 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:40 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $36
  • JetSmart
    0h 59m
    0
    10:03 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:02 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $39
  • Sky Airline
    1h 4m
    0
    11:11 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:15 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $49
  • LAN Perú
    0h 58m
    0
    1:14 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:12 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $64

What are the fastest trips from La Serena to Santiago, RM?

You can get to Santiago, RM from La Serena in just 0h 57m with a Flight from LAN Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.

Friday
from 0h 57m
Saturday
from 0h 57m
Sunday
from 0h 57m
Monday
from 0h 57m
Tuesday
from 0h 57m
Wednesday
from 0h 57m
Thursday
from 0h 58m

    Fastest Flights Friday

  • LAN Airlines
    0h 57m
    0
    10:25 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:22 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $80
  • LAN Airlines
    0h 57m
    0
    10:51 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:48 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $80
  • LAN Perú
    0h 58m
    0
    12:34 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:32 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $93
  • JetSmart
    0h 59m
    0
    1:08 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:07 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $62
  • Sky Airline
    1h 4m
    0
    6:16 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:20 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $88
  • Fastest Buses Friday

  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cikbus Elité
    6h 0m
    0
    8:30 AM
    La Serena
    Central Bus Station
    2:30 PM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $14
  • FlixBus
    6h 5m
    0
    6:00 AM
    La Serena
    Central Bus Station
    12:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Premium Economy
    $15
  • Pullman Bus
    6h 30m
    0
    5:30 AM
    La Serena
    El Sto, 1060
    12:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Pullman Bus
    First Class
    $16
  • Cormar Bus
    6h 40m
    0
    12:15 AM
    La Serena
    Central Bus Station
    6:55 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $16

    Fastest Flights Saturday

  • LAN Perú
    0h 57m
    0
    7:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:42 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $110
  • LAN Perú
    0h 58m
    0
    9:46 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:44 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $110
  • JetSmart
    0h 59m
    0
    10:27 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:26 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $99
  • Sky Airline
    1h 4m
    0
    11:11 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:15 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $103
  • Fastest Buses Saturday

  • Cikbus Elité
    6h 0m
    0
    11:00 AM
    La Serena
    Central Bus Station
    5:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    First Class
    $15
  • FlixBus
    6h 5m
    0
    11:00 AM
    La Serena
    Central Bus Station
    5:05 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $12
  • Cormar Bus
    6h 10m
    0
    1:20 PM
    La Serena
    Central Bus Station
    7:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    First Class
    $14
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Condor Bus
    6h 15m
    0
    4:50 PM
    La Serena
    Central Bus Station
    11:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $15

    Fastest Flights Sunday

  • LAN Airlines
    0h 57m
    0
    2:00 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:57 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $71
  • LAN Airlines
    0h 57m
    0
    3:40 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:37 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $77
  • LAN Perú
    0h 58m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $64
  • JetSmart
    0h 59m
    0
    10:44 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:43 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $63
  • Sky Airline
    1h 4m
    0
    11:01 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:05 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $61
  • Fastest Buses Sunday

  • Buses Romani
    6h 0m
    0
    9:00 AM
    La Serena
    Central Bus Station
    3:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Buses Romani
    Business
    $11
  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • FlixBus
    6h 5m
    0
    3:30 PM
    La Serena
    Central Bus Station
    9:35 PM
    Santiago, RM
    Terminal San Borja
    0
    FlixBus
    Economy
    $12
  • Condor Bus
    6h 15m
    0
    1:45 AM
    La Serena
    Central Bus Station
    8:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $15
  • Cikbus Elité
    6h 30m
    0
    2:00 AM
    La Serena
    Central Bus Station
    8:30 AM
    Santiago, RM
    Sur Bus Station
    0
    Cikbus Elité
    Premium Economy
    $14

    Fastest Flights Monday

  • LAN Perú
    0h 57m
    0
    8:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:32 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $157
  • LAN Airlines
    0h 57m
    0
    4:58 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    5:55 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $160
  • LAN Airlines
    0h 58m
    0
    1:32 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:30 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $154
  • JetSmart
    0h 59m
    0
    12:35 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:34 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $101
  • Sky Airline
    1h 4m
    0
    12:19 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:23 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $150
  • Fastest Buses Monday

  • Serena Mar
    6h 0m
    0
    10:00 AM
    La Serena
    Central Bus Station
    4:00 PM
    Santiago, RM
    Terminal San Borja
    0
    Serena Mar
    First Class
    $13
  • Cormar Bus
    6h 10m
    0
    1:20 PM
    La Serena
    Central Bus Station
    7:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    First Class
    $15
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Turbus
    6h 15m
    0
    2:30 AM
    La Serena
    Avda. Fco de Aguirre Station
    8:45 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $14

    Fastest Flights Tuesday

  • LAN Perú
    0h 57m
    0
    8:45 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    9:42 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $104
  • LAN Airlines
    0h 57m
    0
    6:31 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    7:28 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $159
  • JetSmart
    0h 59m
    0
    10:30 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:29 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $136
  • Sky Airline
    1h 4m
    0
    11:41 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:45 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $148
  • Sky Airline
    1h 4m
    0
    1:20 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:24 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $148
  • Fastest Buses Tuesday

  • Buses Romani
    6h 0m
    0
    9:00 AM
    La Serena
    Central Bus Station
    3:00 PM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Turbus
    6h 5m
    0
    6:55 AM
    La Serena
    Avda. Fco de Aguirre Station
    1:00 PM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cormar Bus
    6h 10m
    0
    11:50 PM
    La Serena
    Central Bus Station
    6:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $11
  • Condor Bus
    6h 15m
    0
    4:50 PM
    La Serena
    Central Bus Station
    11:05 PM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $15
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $14

    Fastest Flights Wednesday

  • LAN Airlines
    0h 57m
    0
    3:32 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    4:29 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Airlines
    Economy
    from $153
  • LAN Perú
    0h 58m
    0
    9:40 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $110
  • LAN Perú
    0h 58m
    0
    12:09 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    1:07 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $135
  • Sky Airline
    1h 4m
    0
    10:47 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:51 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $91
  • Sky Airline
    1h 4m
    0
    9:34 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    10:38 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $185
  • Fastest Buses Wednesday

  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Cormar Bus
    6h 20m
    0
    11:50 AM
    La Serena
    Central Bus Station
    6:10 PM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $11
  • Condor Bus
    6h 30m
    0
    3:15 AM
    La Serena
    Central Bus Station
    9:45 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $11
  • Turbus
    6h 30m
    0
    3:15 AM
    La Serena
    Avda. Fco de Aguirre Station
    9:45 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9

    Fastest Flights Thursday

  • JetSmart
    0h 58m
    0
    1:40 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:38 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $22
  • LAN Perú
    0h 58m
    0
    1:14 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    2:12 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    LAN Perú
    Economy
    from $64
  • JetSmart
    0h 59m
    0
    10:03 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    11:02 AM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    JetSmart
    Economy
    from $39
  • Sky Airline
    1h 4m
    0
    7:36 PM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    8:40 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $36
  • Sky Airline
    1h 4m
    0
    11:11 AM
    La Florida, La Serena Airport
    La Florida, La Serena Airport
    12:15 PM
    Santiago de Chile Airport
    Santiago de Chile Airport
    0
    Sky Airline
    Economy
    from $49
  • Fastest Buses Thursday

  • Cormar Bus
    6h 10m
    0
    11:50 PM
    La Serena
    Central Bus Station
    6:00 AM
    Santiago, RM
    Terminal San Borja
    0
    Cormar Bus
    Premium Economy
    $11
  • Buses Romani
    6h 15m
    0
    12:45 AM
    La Serena
    Central Bus Station
    7:00 AM
    Santiago, RM
    Sur Bus Station
    0
    Buses Romani
    Premium Economy
    $10
  • Turbus
    6h 40m
    0
    9:20 PM
    La Serena
    Avda. Fco de Aguirre Station
    4:00 AM
    Santiago, RM
    Terminal Alameda
    0
    Turbus
    Premium Economy
    $11
  • Cikbus Elité
    7h 0m
    0
    9:30 AM
    La Serena
    Central Bus Station
    4:30 PM
    Santiago, RM
    Terminal San Borja
    0
    Cikbus Elité
    Business
    $9
  • Condor Bus
    7h 10m
    0
    9:45 PM
    La Serena
    Central Bus Station
    4:55 AM
    Santiago, RM
    Sur Bus Station
    0
    Condor Bus
    Premium Economy
    $11
Here you will find all operators and timetables for a Bus from La Serena to Santiago, RM

What are the most popular stations in La Serena and Santiago, RM?

In La Serena, you will usually depart from Avda. Fco de Aguirre Station, Central Bus Station or El Sto, 1060, while in Santiago, RM you will be arriving at Terminal Alameda, Terminal San Borja or Sur Bus Station, but there are many more stops to explore in both locations.

How do I decide? Some tips and tricks from our experience

Are you having trouble deciding on how to get to Santiago, RM from La Serena? With 9 connections between 13 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.

Look for the lowest price

Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between La Serena and Santiago, RM, you can pay as low as $9 with a Bus from Cikbus Elité.

Travel duration

Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from LAN Airlines: you will get to Santiago, RM in just 0h 57m.

Comfort makes all the difference

You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting La Serena and Santiago, RM are Sky Airline, LAN Perú and LAN Airlines, but be sure to check what they have to offer!

Save money with deals, and always compare

One last tip? Even if you live in La Serena and Santiago, RM is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from La Florida, La Serena Airport or to Lo Prado, and look at flights from La Florida, La Serena Airport, and landing at Santiago de Chile Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!

Which companies offer a trip from La Serena to Santiago, RM?

The most popular companies between La Serena and Santiago, RM, are Sky Airline, LAN Perú and LAN Airlines. Be sure to check their seat class offers and the amenities that they provide.

Bus companies: Cikbus Elité, Cormar Bus, Buses Romani and 5 more.

Airlines: Sky Airline, LAN Perú, LAN Airlines and 1 more.

All you need to know when you travel from La Serena to Santiago, RM

Check all information on comfort and services on all modes of transports from La Serena to Santiago, RM. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.

FAQs about the trip from La Serena to Santiago, RM

How can I reach Santiago, RM from La Serena?

Every day, there are on average 9 connections between Bus and Flight, with which you can get to Santiago, RM from La Serena.

How far is Santiago, RM from La Serena?

The distance between La Serena and Santiago, RM is 247.0 miles.

What is the most ecofriendly mode of transport between La Serena and Santiago, RM?

Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance. On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 14 kgs, a car 68 kgs, and a flight 98 kgs.

What is the cheapest mode of transport from La Serena to Santiago, RM?

You can get to Santiago, RM with just $9 by taking a Bus from Cikbus Elité.

What is the fastest way to get from La Serena to Santiago, RM?

While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Santiago, RM in just 0h 57m with a Flight from LAN Airlines.

More routes to La Serena and to Santiago, RM

Looking for more options? Here you can see the most popular routes to La Serena and to Santiago, RM. Simply click on a connection, and you’ll find all the details about the route!

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.