Compare all timetables for the bus from La Serena to Santiago, RM
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 12:45 AM | La Serena | Central Bus Station | 7:15 AM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 8/6/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/6/2026 7:15:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
|
||
| FlixBus | 6h 5m | 6:00 AM | La Serena | Central Bus Station | 12:05 PM | Santiago, RM | Terminal San Borja | Economy | $13 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/6/2026 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/6/2026 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
|
||
| Pluss Chile | 6h 30m | 2:30 AM | La Serena | Central Bus Station | 9:00 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/6/2026 2:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/6/2026 9:00:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
|
||
| Turbus | 6h 15m | 2:30 AM | La Serena | Avda. Fco de Aguirre Station | 8:45 AM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/6/2026 2:30:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/6/2026 8:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
|
||
| Cormar Bus | 6h 10m | 11:50 PM | La Serena | Central Bus Station | 6:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $15 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 8/6/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/7/2026 6:00:00 AM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 6h 10m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 30m | 12:45 AM | La Serena | Central Bus Station | 7:15 AM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 8/7/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/7/2026 7:15:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 30m
|
||
| Pullman Bus | 8h 0m | 1:00 PM | La Serena | El Sto, 1060 | 9:00 PM | Santiago, RM | Terminal San Borja | First Class | $12 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 8/7/2026 1:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/7/2026 9:00:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 8h 0m
|
||
| FlixBus | 6h 5m | 3:15 PM | La Serena | Central Bus Station | 9:20 PM | Santiago, RM | Terminal San Borja | Economy | $13 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/7/2026 3:15:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/7/2026 9:20:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
|
||
| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/7/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/7/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
|
||
| Turbus | 6h 15m | 2:30 AM | La Serena | Avda. Fco de Aguirre Station | 8:45 AM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/7/2026 2:30:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/7/2026 8:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 6h 5m | 6:00 AM | La Serena | Central Bus Station | 12:05 PM | Santiago, RM | Terminal San Borja | Economy | $13 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/8/2026 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/8/2026 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
|
||
| Pluss Chile | 6h 30m | 12:05 AM | La Serena | Central Bus Station | 6:35 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/8/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/8/2026 6:35:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
|
||
| Turbus | 6h 15m | 4:50 AM | La Serena | Avda. Fco de Aguirre Station | 11:05 AM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/8/2026 4:50:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/8/2026 11:05:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
|
||
| Cormar Bus | 6h 45m | 12:30 AM | La Serena | Central Bus Station | 7:15 AM | Santiago, RM | Terminal San Borja | Premium Economy | $16 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 8/8/2026 12:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/8/2026 7:15:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 45m
|
||
| Nueva Andimar Vip | 7h 15m | 10:10 AM | La Serena | Central Bus Station | 5:25 PM | Santiago, RM | Terminal San Borja | Economy | $17 |
A Bus from Nueva Andimar Vip goes from Central Bus Station, La Serena (Chile) at 8/8/2026 10:10:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/8/2026 5:25:00 PM. 50 Economy ticket for $17 per person are available. Travel duration is 7h 15m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pluss Chile | 6h 30m | 2:30 AM | La Serena | Central Bus Station | 9:00 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/9/2026 2:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/9/2026 9:00:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
|
||
| Condor Bus | 6h 30m | 3:15 AM | La Serena | Central Bus Station | 9:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 8/9/2026 3:15:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/9/2026 9:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
|
||
| Turbus | 6h 15m | 2:30 AM | La Serena | Avda. Fco de Aguirre Station | 8:45 AM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/9/2026 2:30:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/9/2026 8:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
|
||
| Cormar Bus | 6h 35m | 12:15 AM | La Serena | Central Bus Station | 6:50 AM | Santiago, RM | Terminal San Borja | Premium Economy | $15 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 8/9/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/9/2026 6:50:00 AM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 6h 35m
|
||
| FlixBus | 6h 5m | 6:00 AM | La Serena | Central Bus Station | 12:05 PM | Santiago, RM | Terminal San Borja | Economy | $15 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/9/2026 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/9/2026 12:05:00 PM. 50 Economy ticket for $15 per person are available. Travel duration is 6h 5m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 12:45 AM | La Serena | Central Bus Station | 7:00 AM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 8/10/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/10/2026 7:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
|
||
| Pullman Bus | 6h 30m | 3:00 PM | La Serena | El Sto, 1060 | 9:30 PM | Santiago, RM | Terminal San Borja | First Class | $12 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 8/10/2026 3:00:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/10/2026 9:30:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 6h 30m
|
||
| FlixBus | 6h 5m | 6:00 AM | La Serena | Central Bus Station | 12:05 PM | Santiago, RM | Terminal San Borja | Economy | $13 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/10/2026 6:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/10/2026 12:05:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 6h 5m
|
||
| Pluss Chile | 6h 30m | 12:05 AM | La Serena | Central Bus Station | 6:35 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/10/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/10/2026 6:35:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
|
||
| Condor Bus | 6h 50m | 3:15 AM | La Serena | Central Bus Station | 10:05 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 8/10/2026 3:15:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/10/2026 10:05:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 50m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pullman Bus | 6h 0m | 12:45 AM | La Serena | El Sto, 1060 | 6:45 AM | Santiago, RM | Terminal San Borja | First Class | $12 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 8/11/2026 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/11/2026 6:45:00 AM. 50 First Class ticket for $12 per person are available. Travel duration is 6h 0m
|
||
| FlixBus | 6h 30m | 8:00 AM | La Serena | Central Bus Station | 2:30 PM | Santiago, RM | Terminal San Borja | Business | $13 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/11/2026 8:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/11/2026 2:30:00 PM. 50 Business ticket for $13 per person are available. Travel duration is 6h 30m
|
||
| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/11/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/11/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
|
||
| Turbus | 6h 15m | 2:30 AM | La Serena | Avda. Fco de Aguirre Station | 8:45 AM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/11/2026 2:30:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/11/2026 8:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
|
||
| Cormar Bus | 6h 45m | 12:30 AM | La Serena | Central Bus Station | 7:15 AM | Santiago, RM | Terminal San Borja | Premium Economy | $16 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 8/11/2026 12:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/11/2026 7:15:00 AM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 6h 45m
|
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pullman Bus | 7h 0m | 7:15 AM | La Serena | El Sto, 1060 | 2:15 PM | Santiago, RM | Terminal San Borja | First Class | $12 |
A Bus from Pullman Bus goes from El Sto, 1060, La Serena (Chile) at 8/12/2026 7:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/12/2026 2:15:00 PM. 50 First Class ticket for $12 per person are available. Travel duration is 7h 0m
|
||
| FlixBus | 6h 30m | 8:00 AM | La Serena | Central Bus Station | 2:30 PM | Santiago, RM | Terminal San Borja | Business | $13 |
A Bus from FlixBus goes from Central Bus Station, La Serena (Chile) at 8/12/2026 8:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 8/12/2026 2:30:00 PM. 50 Business ticket for $13 per person are available. Travel duration is 6h 30m
|
||
| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 8/12/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/12/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
|
||
| Turbus | 6h 15m | 2:30 AM | La Serena | Avda. Fco de Aguirre Station | 8:45 AM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 8/12/2026 2:30:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 8/12/2026 8:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
|
||
| Cikbus Elité | 7h 5m | 9:55 AM | La Serena | Central Bus Station | 5:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $16 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 8/12/2026 9:55:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 8/12/2026 5:00:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 7h 5m
|
Best Price Offer: The price for the cheapest bus from La Serena to Santiago, RM is $9 on 8/17/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between La Serena and Santiago, RM
Facts about the bus from La Serena to Santiago, RM
Compare all providers like Pluss Chile, Turbus and FlixBus that travel 208 times every day by bus from La Serena to Santiago, RM in one click! Book your bus ticket from La Serena to Santiago, RM starting from $9!
| Cheapest Bus | $9 |
| Fastest Bus | 5h 40m |
| Earliest Bus | 12:15 AM |
| Latest Bus | 11:59 PM |
| Daily Bus Routes | 208 Ø |
| Distance | 247.0 miles |
| Bus Companies | Pluss Chile, Turbus, FlixBus, Pullman San Andres, Cikbus Elité, Pullman Bus, Cormar Bus, Nueva Andimar Vip, Condor Bus, Buses Romani and 2 more. |
Cheapest bus connections from La Serena to Santiago, RM
Every day, 208 buses from 12 bus companies leave La Serena for Santiago, RM: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/06/2026 and for the following days.
The cheapest time to travel from La Serena to Santiago, RM
How to save money travelling from La Serena to Santiago, RM
Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Santiago, RM are also emptier.Beloved bus companies from La Serena to Santiago, RM
Cormar Bus from La Serena to Santiago, RM
Here you will find the key facts about the Cormar Bus bus route La Serena to Santiago, RM:
| Cheapest Price | $15 |
| Fastest Bus | 5h 40m |
| Earliest Bus | 12:15 AM |
| Last Bus | 1:00 PM |
| Daily Connections | 12 Ø |
| Found on | 8/6/2026 |
Cikbus Elité from La Serena to Santiago, RM
Here you will find the key facts about the Cikbus Elité bus route La Serena to Santiago, RM:
| Cheapest Price | $16 |
| Fastest Bus | 5h 45m |
| Earliest Bus | 12:50 AM |
| Last Bus | 11:59 PM |
| Daily Connections | 33 Ø |
| Found on | 8/6/2026 |
Pluss Chile from La Serena to Santiago, RM
Here you will find the key facts about the Pluss Chile bus route La Serena to Santiago, RM:
| Cheapest Price | $14 |
| Fastest Bus | 6h 30m |
| Earliest Bus | 12:21 AM |
| Last Bus | 10:20 PM |
| Daily Connections | 34 Ø |
| Found on | 8/6/2026 |
Latest reviews for bus companies on the route La Serena - Santiago, RM
All bus stations and stops in La Serena and Santiago, RM
In the map below, you can see where to find all bus stations in La Serena and Santiago, RM.
Service and Comfort on the bus from La Serena to Santiago, RM
FAQs about the La Serena to Santiago, RM bus
How much does a La Serena Santiago, RM bus trip cost?
How much could I save by comparing buses from La Serena to Santiago, RM?
On average, how many connections are available from La Serena to Santiago, RM each day?
How long does a bus journey from La Serena to Santiago, RM take?
What time is the first bus from La Serena to Santiago, RM?
What time is the last bus from La Serena to Santiago, RM?
Which bus companies operate the La Serena Santiago, RM route?
Is there a direct bus between La Serena and Santiago, RM?
What can I take with me on the La Serena to Santiago, RM bus route?
What equipment is available for the La Serena Santiago, RM bus route?
How does CheckMyBus find the best bus deals from La Serena to Santiago, RM?
How does CheckMyBus technology work for trips from La Serena to Santiago, RM?
Available seat classes which are offered on the bus route La Serena to Santiago, RM
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
Comfortable seating, food and drink service, accompanied generally by ticket flexibility.
Best of the best: you will find the most comfortable accommodation to work or relax during your travel.
More bus routes to La Serena and to Santiago, RM
- Bus Routes to La Serena
- Bus Calama - La Serena
- Buses Chillán to La Serena
- Copiapó to La Serena bus
- Buses to La Serena from Diego de Almagro
- Bus to La Serena from Iquique
- Buses to La Serena from Mendoza
- Bus to La Serena from Pozo Almonte
- From Rancagua to La Serena bus
- Bus from San Juan, SJ to La Serena
- Buses from Sierra Gorda to La Serena
- Bus Talca, ML to La Serena
- Bus to La Serena from Tocopilla
- Buses to La Serena from Valdivia
- Bus Vallenar - La Serena
- Buses Valparaíso (CL) to La Serena
- Buses Viña del Mar to La Serena
- Bus Routes to Santiago, RM
- Buses Bariloche to Santiago, RM
- Buses Buenos Aires to Santiago, RM
- Buses Calama - Santiago, RM
- Buses Concepción - Santiago, RM
- Bus Coronel - Santiago, RM
- Buses to Santiago, RM from Curicó
- Bus from Freire to Santiago, RM
- Buses Iquique to Santiago, RM
- Bus from Labranza to Santiago, RM
- Buses Loncura to Santiago, RM
- Buses Longaví to Santiago, RM
- Ovalle to Santiago, RM bus
- Buses from Pichilemu to Santiago, RM
- Buses from Pozo Almonte to Santiago, RM
- Buses Pucón, AR to Santiago, RM
- Bus to Santiago, RM from Puerto Montt
- Bus Rancagua - Santiago, RM
- Buses to Santiago, RM from San Antonio, VS
- From Talcahuano to Santiago, RM bus
- Buses Viña del Mar to Santiago, RM
