Compare all timetables for the bus from La Serena to Santiago, RM
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 1:45 AM | La Serena | Central Bus Station | 8:00 AM | Santiago, RM | Sur Bus Station | First Class | $3 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/22/2026 1:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/22/2026 8:00:00 AM. 50 First Class ticket for $3 per person are available. Travel duration is 6h 15m
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| Cikbus Elité | 7h 45m | 9:45 PM | La Serena | Central Bus Station | 5:30 AM | Santiago, RM | Sur Bus Station | Premium Economy | $13 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 6/22/2026 9:45:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/23/2026 5:30:00 AM. 50 Premium Economy ticket for $13 per person are available. Travel duration is 7h 45m
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| Pluss Chile | 6h 30m | 12:05 AM | La Serena | Central Bus Station | 6:35 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/22/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/22/2026 6:35:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
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| Cormar Bus | 6h 10m | 11:50 PM | La Serena | Central Bus Station | 6:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $14 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/22/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/23/2026 6:00:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
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| Pullman San Andres | 6h 10m | 11:50 AM | La Serena | Central Bus Station | 6:00 PM | Santiago, RM | Terminal San Borja | Premium Economy | $17 |
A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 6/22/2026 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/22/2026 6:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 12:45 AM | La Serena | Central Bus Station | 7:00 AM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/23/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/23/2026 7:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
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| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/23/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/23/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
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| Condor Bus | 6h 15m | 4:50 PM | La Serena | Central Bus Station | 11:05 PM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Condor Bus goes from Central Bus Station, La Serena (Chile) at 6/23/2026 4:50:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/23/2026 11:05:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 15m
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| Cormar Bus | 6h 10m | 11:50 PM | La Serena | Central Bus Station | 6:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $14 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/23/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/24/2026 6:00:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
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| Cikbus Elité | 7h 5m | 9:55 AM | La Serena | Central Bus Station | 5:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $17 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 6/23/2026 9:55:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/23/2026 5:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 7h 5m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 12:45 AM | La Serena | Central Bus Station | 7:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $12 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/24/2026 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/24/2026 7:00:00 AM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 15m
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| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/24/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/24/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
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| Turbus | 6h 35m | 12:45 AM | La Serena | Avda. Fco de Aguirre Station | 7:20 AM | Santiago, RM | Terminal San Borja | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 6/24/2026 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/24/2026 7:20:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 35m
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| Cormar Bus | 6h 10m | 11:50 PM | La Serena | Central Bus Station | 6:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $14 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/24/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/25/2026 6:00:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
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| Pullman San Andres | 6h 45m | 10:00 AM | La Serena | Central Bus Station | 4:45 PM | Santiago, RM | Terminal San Borja | Business | $17 |
A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 6/24/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/24/2026 4:45:00 PM. 50 Business ticket for $17 per person are available. Travel duration is 6h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 12:45 AM | La Serena | Central Bus Station | 7:00 AM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/25/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/25/2026 7:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
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| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/25/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/25/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
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| Cormar Bus | 6h 10m | 11:50 PM | La Serena | Central Bus Station | 6:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $14 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/25/2026 11:50:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/26/2026 6:00:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 10m
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| Cikbus Elité | 7h 5m | 9:55 AM | La Serena | Central Bus Station | 5:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $17 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 6/25/2026 9:55:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/25/2026 5:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 7h 5m
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| Serena Mar | 6h 0m | 10:00 AM | La Serena | Central Bus Station | 4:00 PM | Santiago, RM | Terminal San Borja | First Class | $18 |
A Bus from Serena Mar goes from Central Bus Station, La Serena (Chile) at 6/25/2026 10:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/25/2026 4:00:00 PM. 50 First Class ticket for $18 per person are available. Travel duration is 6h 0m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 12:45 AM | La Serena | Central Bus Station | 7:00 AM | Santiago, RM | Terminal San Borja | Premium Economy | $12 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/26/2026 12:45:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/26/2026 7:00:00 AM. 50 Premium Economy ticket for $12 per person are available. Travel duration is 6h 15m
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| Pluss Chile | 6h 40m | 12:05 AM | La Serena | Central Bus Station | 6:45 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/26/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/26/2026 6:45:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 40m
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| Cormar Bus | 6h 35m | 12:15 AM | La Serena | Central Bus Station | 6:50 AM | Santiago, RM | Terminal San Borja | Premium Economy | $15 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/26/2026 12:15:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/26/2026 6:50:00 AM. 50 Premium Economy ticket for $15 per person are available. Travel duration is 6h 35m
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| Cikbus Elité | 7h 5m | 9:55 AM | La Serena | Central Bus Station | 5:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $17 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 6/26/2026 9:55:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/26/2026 5:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 7h 5m
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| Pullman San Andres | 6h 10m | 11:50 AM | La Serena | Central Bus Station | 6:00 PM | Santiago, RM | Terminal San Borja | Premium Economy | $17 |
A Bus from Pullman San Andres goes from Central Bus Station, La Serena (Chile) at 6/26/2026 11:50:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/26/2026 6:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 10m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 15m | 12:45 AM | La Serena | Central Bus Station | 7:00 AM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/27/2026 12:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/27/2026 7:00:00 AM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 15m
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| Pluss Chile | 6h 30m | 12:05 AM | La Serena | Central Bus Station | 6:35 AM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/27/2026 12:05:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/27/2026 6:35:00 AM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
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| Turbus | 6h 35m | 4:35 PM | La Serena | Avda. Fco de Aguirre Station | 11:10 PM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 6/27/2026 4:35:00 PM to Terminal Alameda, Santiago, RM (Chile) arriving at 6/27/2026 11:10:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 35m
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| Cikbus Elité | 7h 5m | 9:55 AM | La Serena | Central Bus Station | 5:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $17 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 6/27/2026 9:55:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/27/2026 5:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 7h 5m
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| Cormar Bus | 6h 30m | 2:00 AM | La Serena | Central Bus Station | 8:30 AM | Santiago, RM | Terminal San Borja | Premium Economy | $17 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/27/2026 2:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/27/2026 8:30:00 AM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 30m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Buses Romani | 6h 0m | 9:00 AM | La Serena | Central Bus Station | 3:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $11 |
A Bus from Buses Romani goes from Central Bus Station, La Serena (Chile) at 6/28/2026 9:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/28/2026 3:00:00 PM. 50 Premium Economy ticket for $11 per person are available. Travel duration is 6h 0m
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| Pluss Chile | 6h 30m | 3:00 PM | La Serena | Central Bus Station | 9:30 PM | Santiago, RM | Sur Bus Station | Premium Economy | $14 |
A Bus from Pluss Chile goes from Central Bus Station, La Serena (Chile) at 6/28/2026 3:00:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/28/2026 9:30:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 6h 30m
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| Turbus | 7h 15m | 8:20 AM | La Serena | Avda. Fco de Aguirre Station | 3:35 PM | Santiago, RM | Terminal Alameda | Premium Economy | $14 |
A Bus from Turbus goes from Avda. Fco de Aguirre Station, La Serena (Chile) at 6/28/2026 8:20:00 AM to Terminal Alameda, Santiago, RM (Chile) arriving at 6/28/2026 3:35:00 PM. 50 Premium Economy ticket for $14 per person are available. Travel duration is 7h 15m
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| Cormar Bus | 6h 30m | 2:00 AM | La Serena | Central Bus Station | 8:30 AM | Santiago, RM | Terminal San Borja | Premium Economy | $17 |
A Bus from Cormar Bus goes from Central Bus Station, La Serena (Chile) at 6/28/2026 2:00:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 6/28/2026 8:30:00 AM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 6h 30m
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| Cikbus Elité | 7h 5m | 9:55 AM | La Serena | Central Bus Station | 5:00 PM | Santiago, RM | Sur Bus Station | Premium Economy | $17 |
A Bus from Cikbus Elité goes from Central Bus Station, La Serena (Chile) at 6/28/2026 9:55:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 6/28/2026 5:00:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 7h 5m
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Best Price Offer: The price for the cheapest bus from La Serena to Santiago, RM is $3 on 6/22/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between La Serena and Santiago, RM
Facts about the bus from La Serena to Santiago, RM
Compare all providers like Pullman Bus, Cikbus Elité and Pluss Chile that travel 279 times every day by bus from La Serena to Santiago, RM in one click! Book your bus ticket from La Serena to Santiago, RM starting from $3!
| Cheapest Bus | $3 |
| Fastest Bus | 5h 40m |
| Earliest Bus | 12:05 AM |
| Latest Bus | 11:59 PM |
| Daily Bus Routes | 279 Ø |
| Distance | 247.0 miles |
| Bus Companies | Pullman Bus, Cikbus Elité, Pluss Chile, FlixBus, Pullman San Andres, Turbus, Cormar Bus, Buses Romani, Nueva Andimar Vip, Condor Bus and 2 more. |
Cheapest bus connections from La Serena to Santiago, RM
Every day, 279 buses from 12 bus companies leave La Serena for Santiago, RM: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.
The cheapest time to travel from La Serena to Santiago, RM
How to save money travelling from La Serena to Santiago, RM
Book the ticket from La Serena to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Santiago, RM are also emptier.Beloved bus companies from La Serena to Santiago, RM
Pluss Chile from La Serena to Santiago, RM
Here you will find the key facts about the Pluss Chile bus route La Serena to Santiago, RM:
| Cheapest Price | $14 |
| Fastest Bus | 6h 30m |
| Earliest Bus | 12:05 AM |
| Last Bus | 11:59 PM |
| Daily Connections | 34 Ø |
| Found on | 6/21/2026 |
Cikbus Elité from La Serena to Santiago, RM
Here you will find the key facts about the Cikbus Elité bus route La Serena to Santiago, RM:
| Cheapest Price | $13 |
| Fastest Bus | 5h 45m |
| Earliest Bus | 12:50 AM |
| Last Bus | 11:59 PM |
| Daily Connections | 40 Ø |
| Found on | 6/22/2026 |
Cormar Bus from La Serena to Santiago, RM
Here you will find the key facts about the Cormar Bus bus route La Serena to Santiago, RM:
| Cheapest Price | $14 |
| Fastest Bus | 5h 40m |
| Earliest Bus | 12:15 AM |
| Last Bus | 11:50 PM |
| Daily Connections | 20 Ø |
| Found on | 6/22/2026 |
Latest reviews for bus companies on the route La Serena - Santiago, RM
All bus stations and stops in La Serena and Santiago, RM
In the map below, you can see where to find all bus stations in La Serena and Santiago, RM.
Service and Comfort on the bus from La Serena to Santiago, RM
FAQs about the La Serena to Santiago, RM bus
How much does a La Serena Santiago, RM bus trip cost?
How much could I save by comparing buses from La Serena to Santiago, RM?
On average, how many connections are available from La Serena to Santiago, RM each day?
How long does a bus journey from La Serena to Santiago, RM take?
What time is the first bus from La Serena to Santiago, RM?
What time is the last bus from La Serena to Santiago, RM?
Which bus companies operate the La Serena Santiago, RM route?
Is there a direct bus between La Serena and Santiago, RM?
What can I take with me on the La Serena to Santiago, RM bus route?
What equipment is available for the La Serena Santiago, RM bus route?
How does CheckMyBus find the best bus deals from La Serena to Santiago, RM?
How does CheckMyBus technology work for trips from La Serena to Santiago, RM?
Available seat classes which are offered on the bus route La Serena to Santiago, RM
A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.
Comfortable seating, food and drink service, accompanied generally by ticket flexibility.
Best of the best: you will find the most comfortable accommodation to work or relax during your travel.
More bus routes to La Serena and to Santiago, RM
- Bus Routes to La Serena
- Bus Calama - La Serena
- Buses Chillán to La Serena
- Bus Concepción to La Serena
- Curicó to La Serena bus
- Buses to La Serena from Diego de Almagro
- Bus to La Serena from Iquique
- Bus Los Vilos - La Serena
- Buses to La Serena from Mendoza
- From Ovalle to La Serena bus
- Bus from San Juan, SJ to La Serena
- Bus to La Serena from Tocopilla
- Buses to La Serena from Valdivia
- Bus Vallenar - La Serena
- Buses Valparaíso (CL) to La Serena
- Buses Viña del Mar to La Serena
- Bus Routes to Santiago, RM
- Bus from Ancud to Santiago, RM
- Buses Bariloche to Santiago, RM
- Buses Buenos Aires to Santiago, RM
- Buses Calama - Santiago, RM
- Buses Concepción - Santiago, RM
- Buses Iquique to Santiago, RM
- Bus from Labranza to Santiago, RM
- Buses Loncura to Santiago, RM
- Buses Longaví to Santiago, RM
- Bus Lonquimay to Santiago, RM
- Buses from Pichilemu to Santiago, RM
- Buses Pucón, AR to Santiago, RM
- Bus to Santiago, RM from Puerto Montt
- Buses Rio de Janeiro - Santiago, RM
- Buses to Santiago, RM from San Antonio, VS
- Bus from San Carlos, BI to Santiago, RM
- From Sierra Gorda to Santiago, RM bus
- Buses to Santiago, RM from Talca, ML
- Bus Vallenar - Santiago, RM
- Buses Viña del Mar to Santiago, RM
