Bus Mendoza to La Serena: Compare prices and save money

Compare all timetables for the bus from Mendoza to La Serena

Here is a selection of the cheapest bus trips from the schedule from Mendoza to La Serena from various bus operators like CATA Internacional for the next days.

today

tomorrow

$83

Sunday

Monday

Tuesday

Wednesday

Thursday

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	CATA Internacional	11h 45m	8:15 PM	Mendoza	Bus Station	8:00 AM	La Serena	Central Bus Station		Basic	$83	A Bus from CATA Internacional goes from Bus Station, Mendoza (Argentina) at 12/20/2025 8:15:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/21/2025 8:00:00 AM. 50 Basic ticket for $83 per person are available. Travel duration is 11h 45m

Did you know that if you travel from Mendoza to La Serena via Santiago, RM, you can save more than $48? You can find the corresponding connections below.
- Plataforma 10
  
  16h 10m
  
  0
  
  7:45 AM
  
  Mendoza
  Bus Station
  
  2:45 PM
  
  Santiago, RM
  Sur Bus Station
  
  0
  
  Basic
  
  $24
  
  A Bus from Plataforma 10 goes from Bus Station, Mendoza (Argentina) at 12/22/2025 7:45:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 12/22/2025 2:45:00 PM. 50 Basic ticket for $24 per person are available. Travel duration is 7h 0m
- Bookaway
  
  6h 25m
  
  0
  
  5:30 PM
  
  Santiago, RM
  Terminal San Borja
  
  11:55 PM
  
  La Serena
  Central Bus Station
  
  0
  
  Business
  
  $11
  
  A Bus from Bookaway goes from Terminal San Borja, Santiago, RM (Chile) at 12/22/2025 5:30:00 PM to Central Bus Station, La Serena (Chile) arriving at 12/22/2025 11:55:00 PM. 50 Business ticket for $11 per person are available. Travel duration is 6h 25m
Travel time is 4h 25m longer, but you will save $48

Best Price Offer: The price for the cheapest bus from Mendoza to La Serena is $83 on 12/20/2025. Flexible travelers save on ticket prices.

Facts about the bus from Mendoza to La Serena

Compare all providers like CATA Internacional that travel 8 times every day by bus from Mendoza to La Serena in one click! Book your bus ticket from Mendoza to La Serena starting from $83!

Cheapest Bus	$83
Fastest Bus	11h 45m
Earliest Bus	8:15 PM
Latest Bus	8:15 PM
Daily Bus Routes	8 Ø
Distance	250.5 miles
Bus Companies	CATA Internacional

Cheapest bus connections from Mendoza to La Serena

Every day, 8 buses from 1 bus companies leave Mendoza for La Serena: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

$95

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

$95

Sunday 12/28

$95

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

$95

Friday 01/02

Saturday 01/03

$95

Sunday 01/04

Monday 01/05

Tuesday 01/06

$95

Wednesday 01/07

Thursday 01/08

$95

Friday 01/09

Saturday 01/10

How to save money travelling from Mendoza to La Serena

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mendoza to La Serena in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mendoza to La Serena, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mendoza to La Serena are also emptier.

All bus stations and stops in Mendoza and La Serena

In the map below, you can see where to find all bus stations in Mendoza and La Serena.

Bus Station

Juan B. Alberdi s/n

Hotel Internacional

Av. Sarmiento 720

Hotel NH Cordillera

1324 1324

Casa Juri

Centro Informacion Turistica

de Julio 9

Avda. Fco de Aguirre Station

Avenida Francisco de Aguirre 410

Central Bus Station

Avenida El Santo 1475

El Sto, 1060

terminal de buses covalle bus

Rotonda

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Mendoza to La Serena? Compare all modes of transports from Mendoza to La Serena.

Service and Comfort on the bus from Mendoza to La Serena

Want to know which seat classes are available on the buses from Mendoza to La Serena? Or which bus companies serve the route Mendoza to La Serena? Below you will find answers to your questions.

FAQs about the Mendoza to La Serena bus

How much does a Mendoza La Serena bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $83 and takes 11h 45m to reach La Serena. Compare offers to save money!

How much could I save by comparing buses from Mendoza to La Serena?

This route is offered by 1 companies with a range of ticket prices between $83 and $121. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to La Serena.

On average, how many connections are available from Mendoza to La Serena each day?

Every day, the Mendoza to La Serena bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mendoza to La Serena take?

The fastest bus from Mendoza to La Serena is offered by CATA Internacional and takes 11h 45m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mendoza to La Serena?

The earliest bus arriving in La Serena from Mendoza starts at 8:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mendoza to La Serena?

The latest bus trip departing from Mendoza for La Serena starts at 8:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mendoza La Serena route?

When traveling by bus from Mendoza to La Serena, passengers can travel with CATA Internacional. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mendoza and La Serena?

You can check all the direct connections between Mendoza and La Serena by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: CATA Internacional.

What can I take with me on the Mendoza to La Serena bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mendoza La Serena bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mendoza La Serena bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mendoza to La Serena on your planned travel date.

How does CheckMyBus find the best bus deals from Mendoza to La Serena?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Mendoza and La Serena. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mendoza to La Serena?

Prices and availability for 8 trips between Mendoza and La Serena change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mendoza to La Serena

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

More bus routes to Mendoza and to La Serena

Here’s an overview of the most popular bus routes to Mendoza and to La Serena. Simply click on the connection of your choice, and you will find all the details about your bus route!