Bus from Milan to Brindisi from $21

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Compare all timetables for the bus from Milan to Brindisi

Here is a selection of the cheapest bus trips from the schedule from Milan to Brindisi from various bus operators like Itabus, MarinoBus or FlixBus for the next days.

today
$70
tomorrow
$62
Friday
$76
Saturday
$70
Sunday
$76
Monday
$83
Tuesday
$64

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 13h 50m 8:10 PM Milan San Donato Bus Station 10:00 AM Brindisi Tribunale Bus Stop  Premium Economy $70
Itabus 14h 35m 7:25 PM Milan Lampugnano Bus Station 10:00 AM Brindisi Tribunale Bus Stop  Premium Economy $76
MarinoBus 13h 45m 8:25 AM Milan Lampugnano Bus Station 10:10 PM Brindisi Tribunale Bus Stop  Basic $90
MarinoBus 13h 0m 9:10 AM Milan San Donato Bus Station 10:10 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Basic $90
FlixBus 15h 35m 9:50 PM Milan Lampugnano Bus Station 1:25 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $124
  • Did you know that if you travel from Milan to Brindisi via Bologna, you can save more than $13? You can find the corresponding connections below.
    • Distribusion
      16h 35m
      0
      6:50 AM
      Milan
      San Donato Bus Station
      9:35 AM
      Bologna
      Piazza XX Settembre Bus Station
      0
      Distribusion
      Premium Economy
      $8
      • Waiting Time 0h 55m
    • Distribusion
      12h 55m
      0
      10:30 AM
      Bologna
      Piazza XX Settembre Bus Station
      11:25 PM
      Brindisi
      Tribunale Bus Stop
      0
      Distribusion
      Premium Economy
      $49
    Travel time is 3h 35m longer, but you will save $13

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 19h 0m 9:35 PM Milan San Donato Bus Station 4:35 PM Brindisi Tribunale Bus Stop  Premium Economy $62
Itabus 16h 35m 6:50 AM Milan San Donato Bus Station 11:25 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Premium Economy $70
MarinoBus 13h 0m 9:10 AM Milan San Donato Bus Station 10:10 PM Brindisi Tribunale Bus Stop  Basic $95
MarinoBus 13h 45m 8:25 AM Milan Lampugnano Bus Station 10:10 PM Brindisi Tribunale Bus Stop  Basic $95
FlixBus 18h 0m 10:45 PM Milan Lampugnano Bus Station 4:45 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $141

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 19h 5m 1:25 PM Milan San Donato Bus Station 8:30 AM Brindisi Via Giuseppe Maria Galanti Bus Stop  Premium Economy $76
Itabus 13h 50m 8:10 PM Milan San Donato Bus Station 10:00 AM Brindisi Tribunale Bus Stop  Premium Economy $76
MarinoBus 13h 45m 8:25 AM Milan Lampugnano Bus Station 10:10 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Basic $122
MarinoBus 13h 0m 9:10 AM Milan San Donato Bus Station 10:10 PM Brindisi Tribunale Bus Stop  Basic $122
FlixBus 14h 25m 7:15 AM Milan Lampugnano Bus Station 9:40 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $145
  • Did you know that if you travel from Milan to Brindisi via San Donato Milanese, you can save more than $-37? You will find the corresponding connections below.
    • 13h 50m
      Milan
      6 mi
      8:10 PM
      San Donato Milanese
      Bus Stop
      10:00 AM
      Brindisi
      Via Giuseppe Maria Galanti Bus Stop
      0 mi
      Economy
      $113
  • Did you know that if you travel from Milan to Brindisi via Bologna, you can save more than $19? You can find the corresponding connections below.
    • Distribusion
      16h 35m
      0
      6:50 AM
      Milan
      San Donato Bus Station
      9:35 AM
      Bologna
      Piazza XX Settembre Bus Station
      0
      Distribusion
      Premium Economy
      $8
      • Waiting Time 0h 55m
    • Distribusion
      12h 55m
      0
      10:30 AM
      Bologna
      Piazza XX Settembre Bus Station
      11:25 PM
      Brindisi
      Tribunale Bus Stop
      0
      Distribusion
      Premium Economy
      $49
    Travel time is 3h 35m longer, but you will save $19

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 19h 5m 1:25 PM Milan San Donato Bus Station 8:30 AM Brindisi Tribunale Bus Stop  Premium Economy $70
Itabus 19h 30m 1:00 PM Milan Lampugnano Bus Station 8:30 AM Brindisi Tribunale Bus Stop  Premium Economy $70
MarinoBus 12h 50m 7:35 PM Milan San Donato Bus Station 8:25 AM Brindisi Tribunale Bus Stop  Basic $122
MarinoBus 13h 35m 6:50 PM Milan Lampugnano Bus Station 8:25 AM Brindisi Tribunale Bus Stop  Basic $122
FlixBus 14h 25m 7:15 AM Milan Lampugnano Bus Station 9:40 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $155
  • Did you know that if you travel from Milan to Brindisi via Bologna, you can save more than $13? You can find the corresponding connections below.
    • Distribusion
      16h 35m
      0
      6:50 AM
      Milan
      San Donato Bus Station
      9:35 AM
      Bologna
      Piazza XX Settembre Bus Station
      0
      Distribusion
      Premium Economy
      $8
      • Waiting Time 0h 55m
    • Distribusion
      12h 55m
      0
      10:30 AM
      Bologna
      Piazza XX Settembre Bus Station
      11:25 PM
      Brindisi
      Tribunale Bus Stop
      0
      Distribusion
      Premium Economy
      $49
    Travel time is 3h 45m longer, but you will save $13

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 14h 35m 7:25 PM Milan Lampugnano Bus Station 10:00 AM Brindisi Tribunale Bus Stop  Premium Economy $76
Itabus 13h 50m 8:10 PM Milan San Donato Bus Station 10:00 AM Brindisi Tribunale Bus Stop  Premium Economy $76
MarinoBus 13h 45m 8:25 AM Milan Lampugnano Bus Station 10:10 PM Brindisi Tribunale Bus Stop  Basic $122
MarinoBus 13h 35m 6:50 PM Milan Lampugnano Bus Station 8:25 AM Brindisi Via Giuseppe Maria Galanti Bus Stop  Basic $122
FlixBus 14h 25m 7:15 AM Milan Lampugnano Bus Station 9:40 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $142
  • Did you know that if you travel from Milan to Brindisi via San Donato Milanese, you can save more than $-11? You will find the corresponding connections below.
    • 13h 50m
      Milan
      6 mi
      8:10 PM
      San Donato Milanese
      Bus Stop
      10:00 AM
      Brindisi
      Via Giuseppe Maria Galanti Bus Stop
      0 mi
      Economy
      $87
  • Did you know that if you travel from Milan to Brindisi via Bologna, you can save more than $19? You can find the corresponding connections below.
    • Distribusion
      16h 35m
      0
      6:50 AM
      Milan
      San Donato Bus Station
      9:35 AM
      Bologna
      Piazza XX Settembre Bus Station
      0
      Distribusion
      Premium Economy
      $8
      • Waiting Time 0h 55m
    • Distribusion
      12h 55m
      0
      10:30 AM
      Bologna
      Piazza XX Settembre Bus Station
      11:25 PM
      Brindisi
      Tribunale Bus Stop
      0
      Distribusion
      Premium Economy
      $49
    Travel time is 3h 0m longer, but you will save $19

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 14h 35m 7:25 PM Milan Lampugnano Bus Station 10:00 AM Brindisi Via Giuseppe Maria Galanti Bus Stop  Premium Economy $83
Itabus 13h 50m 8:10 PM Milan San Donato Bus Station 10:00 AM Brindisi Via Giuseppe Maria Galanti Bus Stop  Premium Economy $83
MarinoBus 13h 45m 8:25 AM Milan Lampugnano Bus Station 10:10 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $106
MarinoBus 13h 0m 9:10 AM Milan San Donato Bus Station 10:10 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $106
FlixBus 14h 25m 7:15 AM Milan Lampugnano Bus Station 9:40 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $142
  • Did you know that if you travel from Milan to Brindisi via San Donato Milanese, you can save more than $-4? You will find the corresponding connections below.
    • 13h 50m
      Milan
      6 mi
      8:10 PM
      San Donato Milanese
      Bus Stop
      10:00 AM
      Brindisi
      Via Giuseppe Maria Galanti Bus Stop
      0 mi
      Economy
      $87
  • Did you know that if you travel from Milan to Brindisi via Bologna, you can save more than $26? You can find the corresponding connections below.
    • Distribusion
      16h 35m
      0
      6:50 AM
      Milan
      San Donato Bus Station
      9:35 AM
      Bologna
      Piazza XX Settembre Bus Station
      0
      Distribusion
      Premium Economy
      $8
      • Waiting Time 0h 55m
    • Distribusion
      12h 55m
      0
      10:30 AM
      Bologna
      Piazza XX Settembre Bus Station
      11:25 PM
      Brindisi
      Tribunale Bus Stop
      0
      Distribusion
      Premium Economy
      $49
    Travel time is 3h 35m longer, but you will save $26

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Itabus 19h 5m 1:25 PM Milan San Donato Bus Station 8:30 AM Brindisi Via Giuseppe Maria Galanti Bus Stop  Basic $64
Itabus 19h 30m 1:00 PM Milan Lampugnano Bus Station 8:30 AM Brindisi Via Giuseppe Maria Galanti Bus Stop  Basic $71
MarinoBus 13h 45m 8:25 AM Milan Lampugnano Bus Station 10:10 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $114
MarinoBus 13h 0m 9:10 AM Milan San Donato Bus Station 10:10 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $114
FlixBus 14h 25m 7:15 AM Milan Lampugnano Bus Station 9:40 PM Brindisi Via Giuseppe Maria Galanti Bus Stop  Economy $155
  • Did you know that if you travel from Milan to Brindisi via Bologna, you can save more than $11? You can find the corresponding connections below.
    • FlixBus
      13h 35m
      0
      8:05 AM
      Milan
      San Donato Bus Station
      10:30 AM
      Bologna
      Piazza XX Settembre Bus Station
      0
      FlixBus
      Economy
      $7
      • Waiting Time 0h 10m
    • FlixBus
      11h 0m
      0
      10:40 AM
      Bologna
      Piazza XX Settembre Bus Station
      9:40 PM
      Brindisi
      Via Giuseppe Maria Galanti Bus Stop
      0
      FlixBus
      Economy
      $46
    Travel time is 0h 35m longer, but you will save $11

Best Price Offer: The price for the cheapest bus from Milan to Brindisi is $21 on 1/9/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Milan and Brindisi

See here how frequent the connections between Milan and Brindisi are, during different times and days of the week.
Monday is the busiest day, with more than 83 daily buses from Milan to Brindisi. Wednesday has instead the fewest connections, with only 38 daily coaches between Milan and Brindisi.
The busiest time of the day is the Evening, with 255 buses from Milan to Brindisi, while Night sees the fewest connections between Milan and Brindisi, with 16 offers.

Facts about the bus from Milan to Brindisi

Compare all providers like Itabus, MarinoBus and FlixBus that travel 61 times every day by bus from Milan to Brindisi in one click! Book your bus ticket from Milan to Brindisi starting from $21!

Cheapest Bus $21
Fastest Bus 12h 40m
Earliest Bus 8:25 AM
Latest Bus 11:20 PM
Daily Bus Routes 61 Ø
Distance 553.7 miles
Bus Companies Itabus, MarinoBus and FlixBus

Cheapest bus connections from Milan to Brindisi

Every day, 61 buses from 3 bus companies leave Milan for Brindisi: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/17/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 12/14
Monday 12/15
Tuesday 12/16
Wednesday 12/17
$70
Thursday 12/18
$57
Friday 12/19
$96
Saturday 12/20
$64
Sunday 12/21
$76
Monday 12/22
$74
Tuesday 12/23
$69
Wednesday 12/24
$43
Thursday 12/25
$41
Friday 12/26
$76
Saturday 12/27
$41
Sunday 12/28
$49
Monday 12/29
$50
Tuesday 12/30
$56
Wednesday 12/31
$23
Thursday 01/01
$70
Friday 01/02
$50
Saturday 01/03
$40
Sunday 01/04
$40
Monday 01/05
$39
Tuesday 01/06
$37
Wednesday 01/07
$27
Thursday 01/08
$30
Friday 01/09
$21
Saturday 01/10

The cheapest time to travel from Milan to Brindisi

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Brindisi, for the next 30 days.
With a price starting from $21, Friday is the cheapest day for a bus from Milan to Brindisi. Tuesday instead is the most expensive day with prices starting from $37.
Night is the cheapest day time for bus tickets from Milan to Brindisi, with $21. Morning is the most expensive time of the day with prices starting from $70.

How to save money travelling from Milan to Brindisi

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Brindisi in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Brindisi, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Brindisi are also emptier.

All bus stations and stops in Milan and Brindisi

In the map below, you can see where to find all bus stations in Milan and Brindisi.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Milan to Brindisi? Compare all modes of transports from Milan to Brindisi.

Service and Comfort on the bus from Milan to Brindisi

Want to know which seat classes are available on the buses from Milan to Brindisi? Or which bus companies serve the route Milan to Brindisi? Below you will find answers to your questions.

FAQs about the Milan to Brindisi bus

How much does a Milan Brindisi bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $21 and takes 19h 0m to reach Brindisi. Compare offers to save money!

How much could I save by comparing buses from Milan to Brindisi?

This route is offered by 3 companies with a range of ticket prices between $21 and $212. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Brindisi.

On average, how many connections are available from Milan to Brindisi each day?

Every day, the Milan to Brindisi bus route is served by approximately 61 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Brindisi take?

The fastest bus from Milan to Brindisi is offered by MarinoBus and takes 12h 40m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Brindisi?

The earliest bus arriving in Brindisi from Milan starts at 8:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Brindisi?

The latest bus trip departing from Milan for Brindisi starts at 11:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Brindisi route?

When traveling by bus from Milan to Brindisi, passengers can travel with Itabus, MarinoBus and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Brindisi?

You can check all the direct connections between Milan and Brindisi by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Itabus, MarinoBus and FlixBus.

What can I take with me on the Milan to Brindisi bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Brindisi bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Brindisi bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Brindisi on your planned travel date.

How does CheckMyBus find the best bus deals from Milan to Brindisi?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 61 daily trips between Milan and Brindisi. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Milan to Brindisi?

Prices and availability for 61 trips between Milan and Brindisi change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Milan to Brindisi

Basic
Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Milan and to Brindisi

Here’s an overview of the most popular bus routes to Milan and to Brindisi. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Florence to Milan bus Florence to Milan bus
From Amsterdam to Milan bus From Amsterdam to Milan bus
From Turin to Milan bus From Turin to Milan bus
From Ostuni to Brindisi bus From Ostuni to Brindisi bus
Bus Otranto to Brindisi Bus Otranto to Brindisi
Bus Gallipoli - Brindisi Bus Gallipoli - Brindisi
From Alberobello to Brindisi bus From Alberobello to Brindisi bus
Popular Airport Shuttles to Milan and to Brindisi
CheckMyBus › Buses in Italy › Bus to Milan › Bus to Brindisi

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