Bus Salisbury, NC to Chicago: Compare prices and save money

Compare all timetables for the bus from Salisbury, NC to Chicago

Here is a selection of the cheapest bus trips from the schedule from Salisbury, NC to Chicago from various bus operators like Greyhound US for the next days.

today

$110

tomorrow

$114

Wednesday

$116

Thursday

Friday

$106

Saturday

$115

Sunday

$106

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 45m	6:15 AM	Salisbury, NC	Greyhound bus station	10:00 AM	Chicago	Downtown Bus Station	Economy	$110	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/20/2026 6:15:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/21/2026 10:00:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 28h 45m
Greyhound US	25h 25m	11:05 AM	Salisbury, NC	Greyhound bus station	11:30 AM	Chicago	Downtown Bus Station	Economy	$111	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/20/2026 11:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/21/2026 11:30:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 25h 25m
Greyhound US	26h 25m	6:45 PM	Salisbury, NC	Greyhound bus station	8:10 PM	Chicago	Downtown Bus Station	Economy	$111	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/20/2026 6:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/21/2026 8:10:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 26h 25m
Greyhound US	28h 5m	11:05 AM	Salisbury, NC	Greyhound bus station	2:10 PM	Chicago	Union Station	Economy	$112	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/20/2026 11:05:00 AM to Union Station, Chicago (USA) arriving at 4/21/2026 2:10:00 PM. 50 Economy ticket for $112 per person are available. Travel duration is 28h 5m
Greyhound US	38h 15m	6:45 PM	Salisbury, NC	Greyhound bus station	8:00 AM	Chicago	Union Station	Economy	$114	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/20/2026 6:45:00 PM to Union Station, Chicago (USA) arriving at 4/22/2026 8:00:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 38h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 45m	6:15 AM	Salisbury, NC	Greyhound bus station	10:00 AM	Chicago	Downtown Bus Station	Economy	$114	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/21/2026 6:15:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 10:00:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 28h 45m
Greyhound US	26h 25m	6:45 PM	Salisbury, NC	Greyhound bus station	8:10 PM	Chicago	Downtown Bus Station	Economy	$114	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/21/2026 6:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 8:10:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 26h 25m
Greyhound US	28h 5m	11:05 AM	Salisbury, NC	Greyhound bus station	2:10 PM	Chicago	Union Station	Economy	$115	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/21/2026 11:05:00 AM to Union Station, Chicago (USA) arriving at 4/22/2026 2:10:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 28h 5m
Greyhound US	25h 25m	11:05 AM	Salisbury, NC	Greyhound bus station	11:30 AM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/21/2026 11:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/22/2026 11:30:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 25h 25m
Greyhound US	38h 15m	6:45 PM	Salisbury, NC	Greyhound bus station	8:00 AM	Chicago	Union Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/21/2026 6:45:00 PM to Union Station, Chicago (USA) arriving at 4/23/2026 8:00:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 38h 15m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 45m	6:15 AM	Salisbury, NC	Greyhound bus station	10:00 AM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/22/2026 6:15:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/23/2026 10:00:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 28h 45m
Greyhound US	25h 25m	11:05 AM	Salisbury, NC	Greyhound bus station	11:30 AM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/22/2026 11:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/23/2026 11:30:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 25h 25m
Greyhound US	26h 25m	6:45 PM	Salisbury, NC	Greyhound bus station	8:10 PM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/22/2026 6:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/23/2026 8:10:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 26h 25m
Greyhound US	28h 5m	11:05 AM	Salisbury, NC	Greyhound bus station	2:10 PM	Chicago	Union Station	Economy	$117	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/22/2026 11:05:00 AM to Union Station, Chicago (USA) arriving at 4/23/2026 2:10:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 28h 5m
Greyhound US	38h 15m	6:45 PM	Salisbury, NC	Greyhound bus station	8:00 AM	Chicago	Union Station	Economy	$119	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/22/2026 6:45:00 PM to Union Station, Chicago (USA) arriving at 4/24/2026 8:00:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 38h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 45m	6:15 AM	Salisbury, NC	Greyhound bus station	10:00 AM	Chicago	Downtown Bus Station	Economy	$106	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/24/2026 6:15:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/25/2026 10:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 28h 45m
Greyhound US	25h 25m	11:05 AM	Salisbury, NC	Greyhound bus station	11:30 AM	Chicago	Downtown Bus Station	Economy	$107	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/24/2026 11:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/25/2026 11:30:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 25h 25m
Greyhound US	26h 25m	6:45 PM	Salisbury, NC	Greyhound bus station	8:10 PM	Chicago	Downtown Bus Station	Economy	$107	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/24/2026 6:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/25/2026 8:10:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 26h 25m
Greyhound US	28h 5m	11:05 AM	Salisbury, NC	Greyhound bus station	2:10 PM	Chicago	Union Station	Economy	$108	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/24/2026 11:05:00 AM to Union Station, Chicago (USA) arriving at 4/25/2026 2:10:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 28h 5m
Greyhound US	38h 15m	6:45 PM	Salisbury, NC	Greyhound bus station	8:00 AM	Chicago	Union Station	Economy	$110	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/24/2026 6:45:00 PM to Union Station, Chicago (USA) arriving at 4/26/2026 8:00:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 38h 15m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 45m	6:15 AM	Salisbury, NC	Greyhound bus station	10:00 AM	Chicago	Downtown Bus Station	Economy	$115	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/25/2026 6:15:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/26/2026 10:00:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 28h 45m
Greyhound US	25h 25m	11:05 AM	Salisbury, NC	Greyhound bus station	11:30 AM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/25/2026 11:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/26/2026 11:30:00 AM. 50 Economy ticket for $116 per person are available. Travel duration is 25h 25m
Greyhound US	26h 25m	6:45 PM	Salisbury, NC	Greyhound bus station	8:10 PM	Chicago	Downtown Bus Station	Economy	$116	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/25/2026 6:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/26/2026 8:10:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 26h 25m
Greyhound US	28h 5m	11:05 AM	Salisbury, NC	Greyhound bus station	2:10 PM	Chicago	Canal & Van Buren	Economy	$117	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/25/2026 11:05:00 AM to Canal & Van Buren, Chicago (USA) arriving at 4/26/2026 2:10:00 PM. 50 Economy ticket for $117 per person are available. Travel duration is 28h 5m
Greyhound US	38h 15m	6:45 PM	Salisbury, NC	Greyhound bus station	8:00 AM	Chicago	Canal & Van Buren	Economy	$118	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/25/2026 6:45:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/27/2026 8:00:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 38h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	28h 45m	6:15 AM	Salisbury, NC	Greyhound bus station	10:00 AM	Chicago	Downtown Bus Station	Economy	$106	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/26/2026 6:15:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/27/2026 10:00:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 28h 45m
Greyhound US	25h 25m	11:05 AM	Salisbury, NC	Greyhound bus station	11:30 AM	Chicago	Downtown Bus Station	Economy	$106	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/26/2026 11:05:00 AM to Downtown Bus Station, Chicago (USA) arriving at 4/27/2026 11:30:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 25h 25m
Greyhound US	26h 25m	6:45 PM	Salisbury, NC	Greyhound bus station	8:10 PM	Chicago	Downtown Bus Station	Economy	$106	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/26/2026 6:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 4/27/2026 8:10:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 26h 25m
Greyhound US	28h 5m	11:05 AM	Salisbury, NC	Greyhound bus station	2:10 PM	Chicago	Canal & Van Buren	Economy	$107	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/26/2026 11:05:00 AM to Canal & Van Buren, Chicago (USA) arriving at 4/27/2026 2:10:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 28h 5m
Greyhound US	38h 15m	6:45 PM	Salisbury, NC	Greyhound bus station	8:00 AM	Chicago	Canal & Van Buren	Economy	$109	A Bus from Greyhound US goes from Greyhound bus station, Salisbury, NC (USA) at 4/26/2026 6:45:00 PM to Canal & Van Buren, Chicago (USA) arriving at 4/28/2026 8:00:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 38h 15m

Best Price Offer: The price for the cheapest bus from Salisbury, NC to Chicago is $103 on 5/15/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Salisbury, NC and Chicago

See here how frequent the connections between Salisbury, NC and Chicago are, during different times and days of the week.

Saturday is the busiest day, with more than 12 daily buses from Salisbury, NC to Chicago. Monday has instead the fewest connections, with only 5 daily coaches between Salisbury, NC and Chicago.

The busiest time of the day is the Morning, with 25 buses from Salisbury, NC to Chicago, while Evening sees the fewest connections between Salisbury, NC and Chicago, with 18 offers.

Facts about the bus from Salisbury, NC to Chicago

Compare all providers like Greyhound US that travel 7 times every day by bus from Salisbury, NC to Chicago in one click! Book your bus ticket from Salisbury, NC to Chicago starting from $103!

Cheapest Bus	$103
Fastest Bus	24h 0m
Earliest Bus	6:15 AM
Latest Bus	6:45 PM
Daily Bus Routes	7 Ø
Distance	576.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Salisbury, NC to Chicago

Every day, 7 buses from 1 bus companies leave Salisbury, NC for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$110

Tuesday 04/21

$122

Wednesday 04/22

$116

Thursday 04/23

Friday 04/24

$106

Saturday 04/25

$115

Sunday 04/26

$106

Monday 04/27

$104

Tuesday 04/28

$122

Wednesday 04/29

$122

Thursday 04/30

$106

Friday 05/01

$106

Saturday 05/02

$119

Sunday 05/03

$111

Monday 05/04

$109

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$106

Saturday 05/09

$123

Sunday 05/10

Monday 05/11

$122

Tuesday 05/12

$107

Wednesday 05/13

$106

Thursday 05/14

Friday 05/15

$103

Saturday 05/16

The cheapest time to travel from Salisbury, NC to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from Salisbury, NC to Chicago, for the next 30 days.

With a price starting from $103, Friday is the cheapest day for a bus from Salisbury, NC to Chicago. Saturday instead is the most expensive day with prices starting from $115.

Morning is the cheapest day time for bus tickets from Salisbury, NC to Chicago, with $106. Evening is the most expensive time of the day with prices starting from $106.

How to save money travelling from Salisbury, NC to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Salisbury, NC to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Salisbury, NC to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Salisbury, NC to Chicago are also emptier.

All bus stations and stops in Salisbury, NC and Chicago

In the map below, you can see where to find all bus stations in Salisbury, NC and Chicago.

Greyhound bus station

Andrews St 100

Stokes Ferry Rd

Stokes Ferry Rd 1510

La Alcancia

S Main St 3023

South Salisbury Blvd

South Salisbury Blvd 1147

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from Salisbury, NC to Chicago

Want to know which seat classes are available on the buses from Salisbury, NC to Chicago? Or which bus companies serve the route Salisbury, NC to Chicago? Below you will find answers to your questions.

FAQs about the Salisbury, NC to Chicago bus

How much does a Salisbury, NC Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $103 and takes 27h 45m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from Salisbury, NC to Chicago?

This route is offered by 1 companies with a range of ticket prices between $103 and $123. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from Salisbury, NC to Chicago each day?

Every day, the Salisbury, NC to Chicago bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Salisbury, NC to Chicago take?

The fastest bus from Salisbury, NC to Chicago is offered by Greyhound US and takes 24h 0m. Bus tickets for this connection cost $122. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Salisbury, NC to Chicago?

The earliest bus arriving in Chicago from Salisbury, NC starts at 6:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Salisbury, NC to Chicago?

The latest bus trip departing from Salisbury, NC for Chicago starts at 6:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Salisbury, NC Chicago route?

When traveling by bus from Salisbury, NC to Chicago, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Salisbury, NC and Chicago?

You can check all the direct connections between Salisbury, NC and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Salisbury, NC to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Salisbury, NC Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Salisbury, NC Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Salisbury, NC to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from Salisbury, NC to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Salisbury, NC and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Salisbury, NC to Chicago?

Prices and availability for 7 trips between Salisbury, NC and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Salisbury, NC to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Salisbury, NC and to Chicago

Here’s an overview of the most popular bus routes to Salisbury, NC and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!