Bus San Antonio, TX to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Antonio, TX to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Indianapolis from various bus operators like FlixBus, Greyhound Lines Mexico or Greyhound US for the next days.

today

tomorrow

$124

Wednesday

$96

Thursday

$126

Friday

Saturday

$134

Sunday

$130

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	29h 55m	1:30 AM	San Antonio, TX	Bus Station	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$124	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/26/2026 1:30:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 5/27/2026 8:25:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 29h 55m
Greyhound Lines Mexico	26h 15m	1:30 AM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$124	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/26/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 5/27/2026 4:45:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 26h 15m
FlixBus	33h 30m	9:55 PM	San Antonio, TX	Bus Station	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$124	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/26/2026 9:55:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 5/28/2026 8:25:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 33h 30m
FlixBus	29h 50m	9:55 PM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$124	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/26/2026 9:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 5/28/2026 4:45:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 29h 50m
Greyhound US	31h 50m	12:35 PM	San Antonio, TX	Bus Station	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$125	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/26/2026 12:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 5/27/2026 9:25:00 PM. 50 Economy ticket for $125 per person are available. Travel duration is 31h 50m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	26h 15m	1:30 AM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$96	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/27/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 5/28/2026 4:45:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 26h 15m
Greyhound Lines Mexico	29h 15m	5:50 AM	San Antonio, TX	Bus Station	12:05 PM	Indianapolis	Central Bus Station	Economy	$96	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/27/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 5/28/2026 12:05:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 29h 15m
Greyhound US	31h 50m	12:35 PM	San Antonio, TX	Bus Station	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$96	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/27/2026 12:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 5/28/2026 9:25:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 31h 50m
Greyhound US	27h 0m	12:35 PM	San Antonio, TX	Bus Station	4:35 PM	Indianapolis	Central Bus Station	Economy	$96	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/27/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 5/28/2026 4:35:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 27h 0m
Valley Transit	30h 30m	9:15 PM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$96	A Bus from Valley Transit goes from Bus Station, San Antonio, TX (USA) at 5/27/2026 9:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 5/29/2026 4:45:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 30h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	29h 55m	1:30 AM	San Antonio, TX	Bus Station	8:25 AM	Indianapolis	Washington / Delaware	Economy	$126	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/28/2026 1:30:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 5/29/2026 8:25:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 29h 55m
Greyhound US	31h 50m	12:35 PM	San Antonio, TX	Bus Station	9:25 PM	Indianapolis	Washington / Delaware	Economy	$126	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/28/2026 12:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 5/29/2026 9:25:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 31h 50m
FlixBus	34h 10m	9:15 PM	San Antonio, TX	Bus Station	8:25 AM	Indianapolis	Washington / Delaware	Economy	$126	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/28/2026 9:15:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 5/30/2026 8:25:00 AM. 50 Economy ticket for $126 per person are available. Travel duration is 34h 10m
Greyhound Lines Mexico	26h 15m	1:30 AM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$127	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/28/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 5/29/2026 4:45:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 26h 15m
Greyhound US	27h 0m	12:35 PM	San Antonio, TX	Bus Station	4:35 PM	Indianapolis	Central Bus Station	Economy	$127	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/28/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 5/29/2026 4:35:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 27h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	26h 15m	1:30 AM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$134	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/30/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 5/31/2026 4:45:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 26h 15m
Greyhound Lines Mexico	29h 15m	5:50 AM	San Antonio, TX	Bus Station	12:05 PM	Indianapolis	Central Bus Station	Economy	$134	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/30/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 5/31/2026 12:05:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 29h 15m
Greyhound US	31h 50m	12:35 PM	San Antonio, TX	Bus Station	9:25 PM	Indianapolis	Washington / Delaware	Economy	$134	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/30/2026 12:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 5/31/2026 9:25:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 31h 50m
Greyhound US	27h 0m	12:35 PM	San Antonio, TX	Bus Station	4:35 PM	Indianapolis	Central Bus Station	Economy	$134	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/30/2026 12:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 5/31/2026 4:35:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 27h 0m
FlixBus	29h 50m	9:55 PM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$134	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/30/2026 9:55:00 PM to Central Bus Station, Indianapolis (USA) arriving at 6/1/2026 4:45:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 29h 50m

Did you know that if you travel from San Antonio, TX to Indianapolis via Austin, you can save more than $18? You can find the corresponding connections below.
- Greyhound US
  
  26h 15m
  
  0
  
  1:30 AM
  
  San Antonio, TX
  Bus Station
  
  3:00 AM
  
  Austin
  5119 Eastside Bus Plaza
  
  0
  
  Economy
  
  $13
  
  A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/1/2026 1:30:00 AM to 5119 Eastside Bus Plaza, Austin (USA) arriving at 6/1/2026 3:00:00 AM. 50 Economy ticket for $13 per person are available. Travel duration is 1h 30m
- Greyhound Lines Mexico
  
  24h 40m
  
  0
  
  3:05 AM
  
  Austin
  5119 Eastside Bus Plaza
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $102
  
  A Bus from Greyhound Lines Mexico goes from 5119 Eastside Bus Plaza, Austin (USA) at 6/1/2026 3:05:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/2/2026 4:45:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 24h 40m
Travel Time is 1h 0m shorter, and you will save $18

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	26h 15m	1:30 AM	San Antonio, TX	Bus Station	4:45 AM	Indianapolis	Central Bus Station	Economy	$130	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/31/2026 1:30:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/1/2026 4:45:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 26h 15m
Greyhound Lines Mexico	29h 15m	5:50 AM	San Antonio, TX	Bus Station	12:05 PM	Indianapolis	Central Bus Station	Economy	$130	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 5/31/2026 5:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/1/2026 12:05:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 29h 15m
FlixBus	33h 30m	9:55 PM	San Antonio, TX	Bus Station	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$131	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 5/31/2026 9:55:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 6/2/2026 8:25:00 AM. 50 Economy ticket for $131 per person are available. Travel duration is 33h 30m
FlixBus	38h 35m	7:45 AM	San Antonio, TX	Pearl District	11:20 PM	Indianapolis	Downtown Transit Center	Economy	$131	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 5/31/2026 7:45:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 6/1/2026 11:20:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 38h 35m
Greyhound US	31h 50m	12:35 PM	San Antonio, TX	Bus Station	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$137	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 5/31/2026 12:35:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 6/1/2026 9:25:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 31h 50m

Did you know that if you travel from San Antonio, TX to Indianapolis via Austin, you can save more than $16? You can find the corresponding connections below.
- Greyhound US
  
  29h 15m
  
  0
  
  5:50 AM
  
  San Antonio, TX
  Bus Station
  
  7:25 AM
  
  Austin
  5119 Eastside Bus Plaza
  
  0
  
  Economy
  
  $12
  
  A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/1/2026 5:50:00 AM to 5119 Eastside Bus Plaza, Austin (USA) arriving at 6/1/2026 7:25:00 AM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 35m
- Greyhound Lines Mexico
  
  27h 10m
  
  0
  
  7:55 AM
  
  Austin
  5119 Eastside Bus Plaza
  
  12:05 PM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $102
  
  A Bus from Greyhound Lines Mexico goes from 5119 Eastside Bus Plaza, Austin (USA) at 6/1/2026 7:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/2/2026 12:05:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 27h 10m
Travel time is 2h 0m longer, but you will save $16

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Indianapolis is $96 on 5/27/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Indianapolis

See here how frequent the connections between San Antonio, TX and Indianapolis are, during different times and days of the week.

Sunday is the busiest day, with more than 20 daily buses from San Antonio, TX to Indianapolis. Tuesday has instead the fewest connections, with only 7 daily coaches between San Antonio, TX and Indianapolis.

The busiest time of the day is the Night, with 18 buses from San Antonio, TX to Indianapolis, while Afternoon sees the fewest connections between San Antonio, TX and Indianapolis, with 12 offers.

Facts about the bus from San Antonio, TX to Indianapolis

Compare all providers like FlixBus, Greyhound Lines Mexico and Greyhound US that travel 11 times every day by bus from San Antonio, TX to Indianapolis in one click! Book your bus ticket from San Antonio, TX to Indianapolis starting from $96!

Cheapest Bus	$96
Fastest Bus	27h 15m
Earliest Bus	1:30 AM
Latest Bus	9:55 PM
Daily Bus Routes	11 Ø
Distance	999.5 miles
Bus Companies	FlixBus, Greyhound Lines Mexico, Greyhound US and Valley Transit

Cheapest bus connections from San Antonio, TX to Indianapolis

Every day, 11 buses from 4 bus companies leave San Antonio, TX for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/25/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/24

Monday 05/25

Tuesday 05/26

$124

Wednesday 05/27

$96

Thursday 05/28

$126

Friday 05/29

Saturday 05/30

$134

Sunday 05/31

$134

Monday 06/01

$114

Tuesday 06/02

$124

Wednesday 06/03

$142

Thursday 06/04

$129

Friday 06/05

$128

Saturday 06/06

$127

Sunday 06/07

$120

Monday 06/08

$132

Tuesday 06/09

$134

Wednesday 06/10

$147

Thursday 06/11

$135

Friday 06/12

$139

Saturday 06/13

Sunday 06/14

$140

Monday 06/15

Tuesday 06/16

$133

Wednesday 06/17

$153

Thursday 06/18

$144

Friday 06/19

$138

Saturday 06/20

The cheapest time to travel from San Antonio, TX to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Indianapolis, for the next 30 days.

With a price starting from $96, Wednesday is the cheapest day for a bus from San Antonio, TX to Indianapolis. Saturday instead is the most expensive day with prices starting from $127.

Afternoon is the cheapest day time for bus tickets from San Antonio, TX to Indianapolis, with $96. Morning is the most expensive time of the day with prices starting from $97.

How to save money travelling from San Antonio, TX to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Indianapolis are also emptier.

Beloved bus companies from San Antonio, TX to Indianapolis

These are the most booked bus companies between San Antonio, TX to Indianapolis from our users.

FlixBus from San Antonio, TX to Indianapolis

Here you will find the key facts about the FlixBus bus route San Antonio, TX to Indianapolis:

Cheapest Price	$97
Fastest Bus	30h 45m
Earliest Bus	9:55 PM
Last Bus	9:55 PM
Daily Connections	4 Ø
Found on	5/1/2026

Valley Transit from San Antonio, TX to Indianapolis

Here you will find the key facts about the Valley Transit bus route San Antonio, TX to Indianapolis:

Cheapest Price	$96
Fastest Bus	31h 30m
Earliest Bus	9:15 PM
Last Bus	9:15 PM
Daily Connections	2 Ø
Found on	4/27/2026

All bus stations and stops in San Antonio, TX and Indianapolis

In the map below, you can see where to find all bus stations in San Antonio, TX and Indianapolis.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Antonio, TX to Indianapolis

Want to know which seat classes are available on the buses from San Antonio, TX to Indianapolis? Or which bus companies serve the route San Antonio, TX to Indianapolis? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Indianapolis bus

How much does a San Antonio, TX Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $96 and takes 28h 0m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Indianapolis?

This route is offered by 4 companies with a range of ticket prices between $96 and $156. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Antonio, TX to Indianapolis each day?

Every day, the San Antonio, TX to Indianapolis bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Indianapolis take?

The fastest bus from San Antonio, TX to Indianapolis is offered by Greyhound Lines Mexico and takes 27h 15m. Bus tickets for this connection cost $124. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Indianapolis?

The earliest bus arriving in Indianapolis from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Indianapolis?

The latest bus trip departing from San Antonio, TX for Indianapolis starts at 9:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Indianapolis route?

When traveling by bus from San Antonio, TX to Indianapolis, passengers can travel with FlixBus, Greyhound Lines Mexico and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Indianapolis?

You can check all the direct connections between San Antonio, TX and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Greyhound Lines Mexico and Greyhound US.

What can I take with me on the San Antonio, TX to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 11 daily trips between San Antonio, TX and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Indianapolis?

Prices and availability for 11 trips between San Antonio, TX and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Indianapolis

Here’s an overview of the most popular bus routes to San Antonio, TX and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!