Bus from San Diego to Mesa, AZ from $53

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from San Diego to Mesa, AZ

Here is a selection of the cheapest bus trips from the schedule from San Diego to Mesa, AZ from various bus operators like FlixBus or Greyhound US for the next days.

today
tomorrow
$53
Wednesday
Thursday
Friday
Saturday
Sunday
$61

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 13h 35m 1:10 PM San Diego Seaport Village 3:45 AM Mesa, AZ Greyhound  Economy $53
FlixBus 10h 35m 7:35 AM San Diego Old Town Transit Center 7:10 PM Mesa, AZ Greyhound  Economy $54
FlixBus 17h 20m 9:25 AM San Diego Old Town Transit Center 3:45 AM Mesa, AZ Greyhound  Economy $54
Greyhound US 12h 5m 7:35 PM San Diego Old Town Transit Center 8:40 AM Mesa, AZ Greyhound  Economy $54

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 13h 10m 1:35 PM San Diego La Jolla Village 3:45 AM Mesa, AZ Greyhound  Economy $61
FlixBus 10h 35m 7:35 AM San Diego Old Town Transit Center 7:10 PM Mesa, AZ Greyhound  Economy $62
FlixBus 14h 30m 12:15 PM San Diego Old Town Transit Center 3:45 AM Mesa, AZ Greyhound  Economy $62
Greyhound US 8h 10m 10:00 AM San Diego Old Town Transit Center 7:10 PM Mesa, AZ Greyhound  Economy $62
Greyhound US 12h 5m 7:35 PM San Diego Old Town Transit Center 8:40 AM Mesa, AZ Greyhound  Economy $62

Best Price Offer: The price for the cheapest bus from San Diego to Mesa, AZ is $53 on 1/27/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between San Diego and Mesa, AZ

See here how frequent the connections between San Diego and Mesa, AZ are, during different times and days of the week.
Sunday is the busiest day, with more than 9 daily buses from San Diego to Mesa, AZ. Tuesday has instead the fewest connections, with only 6 daily coaches between San Diego and Mesa, AZ.
The busiest time of the day is the Afternoon, with 7 buses from San Diego to Mesa, AZ, while Evening sees the fewest connections between San Diego and Mesa, AZ, with 2 offers.

Facts about the bus from San Diego to Mesa, AZ

Compare all providers like FlixBus and Greyhound US that travel 7 times every day by bus from San Diego to Mesa, AZ in one click! Book your bus ticket from San Diego to Mesa, AZ starting from $53!

Cheapest Bus $53
Fastest Bus 9h 10m
Earliest Bus 7:35 AM
Latest Bus 7:35 PM
Daily Bus Routes 7 Ø
Distance 311.8 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from San Diego to Mesa, AZ

Every day, 7 buses from 2 bus companies leave San Diego for Mesa, AZ: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 01/26/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 01/25
Monday 01/26
Tuesday 01/27
$53
Wednesday 01/28
Thursday 01/29
Friday 01/30
Saturday 01/31
Sunday 02/01
$61
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
Sunday 02/08
Monday 02/09
Tuesday 02/10
Wednesday 02/11
Thursday 02/12
Friday 02/13
Saturday 02/14
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21

The cheapest time to travel from San Diego to Mesa, AZ

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Mesa, AZ, for the next 30 days.
With a price starting from $53, Tuesday is the cheapest day for a bus from San Diego to Mesa, AZ. Sunday instead is the most expensive day with prices starting from $61.
Afternoon is the cheapest day time for bus tickets from San Diego to Mesa, AZ, with $53. Evening is the most expensive time of the day with prices starting from $54.

How to save money travelling from San Diego to Mesa, AZ

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Mesa, AZ in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Mesa, AZ, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Mesa, AZ are also emptier.

Beloved bus companies from San Diego to Mesa, AZ

These are the most booked bus companies between San Diego to Mesa, AZ from our users.

FlixBus from San Diego to Mesa, AZ

FlixBus

Here you will find the key facts about the FlixBus bus route San Diego to Mesa, AZ:

Cheapest Price $53
Fastest Bus 11h 15m
Earliest Bus 7:35 AM
Last Bus 4:15 PM
Daily Connections 6 Ø
Found on 1/24/2026

All bus stations and stops in San Diego and Mesa, AZ

In the map below, you can see where to find all bus stations in San Diego and Mesa, AZ.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from San Diego to Mesa, AZ? Compare all modes of transports from San Diego to Mesa, AZ.

Service and Comfort on the bus from San Diego to Mesa, AZ

Want to know which seat classes are available on the buses from San Diego to Mesa, AZ? Or which bus companies serve the route San Diego to Mesa, AZ? Below you will find answers to your questions.

FAQs about the San Diego to Mesa, AZ bus

How much does a San Diego Mesa, AZ bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $53 and takes 14h 35m to reach Mesa, AZ. Compare offers to save money!

How much could I save by comparing buses from San Diego to Mesa, AZ?

This route is offered by 2 companies with a range of ticket prices between $53 and $66. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Mesa, AZ.

On average, how many connections are available from San Diego to Mesa, AZ each day?

Every day, the San Diego to Mesa, AZ bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Mesa, AZ take?

The fastest bus from San Diego to Mesa, AZ is offered by Greyhound US and takes 9h 10m. Bus tickets for this connection cost $62. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Mesa, AZ?

The earliest bus arriving in Mesa, AZ from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Mesa, AZ?

The latest bus trip departing from San Diego for Mesa, AZ starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Mesa, AZ route?

When traveling by bus from San Diego to Mesa, AZ, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Mesa, AZ?

You can check all the direct connections between San Diego and Mesa, AZ by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Mesa, AZ bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Mesa, AZ bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Mesa, AZ bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Mesa, AZ on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Mesa, AZ?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between San Diego and Mesa, AZ. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Mesa, AZ?

Prices and availability for 7 trips between San Diego and Mesa, AZ change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Mesa, AZ

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Mesa, AZ

Here’s an overview of the most popular bus routes to San Diego and to Mesa, AZ. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Santa Ana, CA - San Diego Bus Santa Ana, CA - San Diego
Bus New York - San Diego Bus New York - San Diego
Bus Dallas to San Diego Bus Dallas to San Diego
Bus from Fresno, CA to San Diego Bus from Fresno, CA to San Diego
Buses Los Angeles - Mesa, AZ Buses Los Angeles - Mesa, AZ
Buses Milwaukee - Mesa, AZ Buses Milwaukee - Mesa, AZ
Bus to Mesa, AZ from Oceanside, CA Bus to Mesa, AZ from Oceanside, CA
Buses Nogales, AZ to Mesa, AZ Buses Nogales, AZ to Mesa, AZ
Popular Airport Shuttles to San Diego and to Mesa, AZ
CheckMyBus › Buses in USA › Bus to San Diego › Bus to Mesa, AZ

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.