Bus San Francisco to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Francisco to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Francisco to Indianapolis from various bus operators like Greyhound US for the next days.

today

$139

tomorrow

Saturday

$122

Sunday

Monday

Tuesday

Wednesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	54h 45m	1:30 PM	San Francisco	Bus Station Transbay	11:15 PM	Indianapolis	Washington / Delaware	Economy	$139	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/3/2026 1:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/5/2026 11:15:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 54h 45m
Greyhound US	51h 0m	1:30 PM	San Francisco	Bus Station Transbay	7:30 PM	Indianapolis	Central Bus Station	Economy	$149	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/3/2026 1:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/5/2026 7:30:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 51h 0m
Greyhound US	68h 15m	10:30 PM	San Francisco	Bus Station Transbay	9:45 PM	Indianapolis	Washington / Delaware	Economy	$218	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/3/2026 10:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/6/2026 9:45:00 PM. 50 Economy ticket for $218 per person are available. Travel duration is 68h 15m
Greyhound US	61h 0m	10:30 PM	San Francisco	Bus Station Transbay	2:30 PM	Indianapolis	Central Bus Station	Economy	$251	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/3/2026 10:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/6/2026 2:30:00 PM. 50 Economy ticket for $251 per person are available. Travel duration is 61h 0m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	51h 0m	1:30 PM	San Francisco	Bus Station Transbay	7:30 PM	Indianapolis	Central Bus Station	Economy	$122	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/5/2026 1:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/7/2026 7:30:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 51h 0m
Greyhound US	54h 45m	1:30 PM	San Francisco	Bus Station Transbay	11:15 PM	Indianapolis	Washington / Delaware	Economy	$133	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/5/2026 1:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/7/2026 11:15:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 54h 45m
Greyhound US	68h 15m	10:30 PM	San Francisco	Bus Station Transbay	9:45 PM	Indianapolis	Washington / Delaware	Economy	$186	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/5/2026 10:30:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/8/2026 9:45:00 PM. 50 Economy ticket for $186 per person are available. Travel duration is 68h 15m
Greyhound US	61h 0m	10:30 PM	San Francisco	Bus Station Transbay	2:30 PM	Indianapolis	Central Bus Station	Economy	$190	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 9/5/2026 10:30:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/8/2026 2:30:00 PM. 50 Economy ticket for $190 per person are available. Travel duration is 61h 0m

Best Price Offer: The price for the cheapest bus from San Francisco to Indianapolis is $122 on 9/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Francisco and Indianapolis

See here how frequent the connections between San Francisco and Indianapolis are, during different times and days of the week.

Thursday is the busiest day, with more than 4 daily buses from San Francisco to Indianapolis. Thursday has instead the fewest connections, with only 4 daily coaches between San Francisco and Indianapolis.

The busiest time of the day is the Afternoon, with 4 buses from San Francisco to Indianapolis, while Afternoon sees the fewest connections between San Francisco and Indianapolis, with 4 offers.

Facts about the bus from San Francisco to Indianapolis

Compare all providers like Greyhound US that travel 4 times every day by bus from San Francisco to Indianapolis in one click! Book your bus ticket from San Francisco to Indianapolis starting from $122!

Cheapest Bus	$122
Fastest Bus	54h 0m
Earliest Bus	1:30 PM
Latest Bus	10:30 PM
Daily Bus Routes	4 Ø
Distance	1,944.5 miles
Bus Companies	Greyhound US

Cheapest bus connections from San Francisco to Indianapolis

Every day, 4 buses from 1 bus companies leave San Francisco for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/03/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/30

Monday 08/31

Tuesday 09/01

Wednesday 09/02

Thursday 09/03

$139

Friday 09/04

Saturday 09/05

$122

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

Thursday 09/10

Friday 09/11

Saturday 09/12

$132

Sunday 09/13

$147

Monday 09/14

Tuesday 09/15

Wednesday 09/16

Thursday 09/17

Friday 09/18

Saturday 09/19

$148

Sunday 09/20

$180

Monday 09/21

Tuesday 09/22

Wednesday 09/23

$139

Thursday 09/24

Friday 09/25

$165

Saturday 09/26

The cheapest time to travel from San Francisco to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Francisco to Indianapolis, for the next 30 days.

With a price starting from $122, Saturday is the cheapest day for a bus from San Francisco to Indianapolis. Thursday instead is the most expensive day with prices starting from $139.

Afternoon is the cheapest day time for bus tickets from San Francisco to Indianapolis, with $122. Evening is the most expensive time of the day with prices starting from $186.

How to save money travelling from San Francisco to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Francisco to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Francisco to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Francisco to Indianapolis are also emptier.

All bus stations and stops in San Francisco and Indianapolis

In the map below, you can see where to find all bus stations in San Francisco and Indianapolis.

South Van Ness Ave & Market St

5th/Townsend

Townsend St 400

Bus Station Transbay

Folsom Street 200

Union Square

Post St 470

Beach St & Hyde St

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Francisco to Indianapolis

Want to know which seat classes are available on the buses from San Francisco to Indianapolis? Or which bus companies serve the route San Francisco to Indianapolis? Below you will find answers to your questions.

FAQs about the San Francisco to Indianapolis bus

How much does a San Francisco Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $122 and takes 54h 0m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Francisco to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $122 and $251. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Francisco to Indianapolis each day?

Every day, the San Francisco to Indianapolis bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Francisco to Indianapolis take?

The fastest bus from San Francisco to Indianapolis is offered by Greyhound US and takes 54h 0m. Bus tickets for this connection cost $149. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Francisco to Indianapolis?

The earliest bus arriving in Indianapolis from San Francisco starts at 1:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Francisco to Indianapolis?

The latest bus trip departing from San Francisco for Indianapolis starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Francisco Indianapolis route?

When traveling by bus from San Francisco to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Francisco and Indianapolis?

You can check all the direct connections between San Francisco and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the San Francisco to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Francisco Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Francisco Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Francisco to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from San Francisco to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between San Francisco and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Francisco to Indianapolis?

Prices and availability for 4 trips between San Francisco and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Francisco to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Francisco and to Indianapolis

Here’s an overview of the most popular bus routes to San Francisco and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!