Bus San Francisco to Santa Ana, CA - Compare all Companies

Compare all timetables for the bus from San Francisco to Santa Ana, CA

Here is a selection of the cheapest bus trips from the schedule from San Francisco to Santa Ana, CA from various bus operators like Greyhound US or FlixBus for the next days.

today

$59

tomorrow

$54

Wednesday

$42

Thursday

$60

Friday

$68

Saturday

$57

Sunday

$68

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 30m	6:30 AM	San Francisco	Bus Station Transbay	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$59	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 6/22/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/22/2026 10:00:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 15h 30m
FlixBus	14h 30m	7:30 AM	San Francisco	5th/Townsend	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$59	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 6/22/2026 7:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/22/2026 10:00:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 14h 30m
Greyhound US	11h 30m	10:30 PM	San Francisco	Bus Station Transbay	10:00 AM	Santa Ana, CA	Bus Stop	Economy	$153	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 6/22/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/23/2026 10:00:00 AM. 50 Economy ticket for $153 per person are available. Travel duration is 11h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 30m	6:30 AM	San Francisco	Salesforce Transit Center	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$54	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/23/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/23/2026 10:00:00 PM. 50 Economy ticket for $54 per person are available. Travel duration is 15h 30m
FlixBus	14h 30m	7:30 AM	San Francisco	5th/Townsend	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$55	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 6/23/2026 7:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/23/2026 10:00:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 14h 30m
Greyhound US	11h 30m	10:30 PM	San Francisco	Salesforce Transit Center	10:00 AM	Santa Ana, CA	Bus Stop	Economy	$149	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/23/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/24/2026 10:00:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 11h 30m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 30m	6:30 AM	San Francisco	Salesforce Transit Center	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$42	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/24/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/24/2026 10:00:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 15h 30m
FlixBus	14h 30m	7:30 AM	San Francisco	5th/Townsend	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$43	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 6/24/2026 7:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/24/2026 10:00:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 14h 30m
Greyhound US	10h 50m	10:30 PM	San Francisco	Salesforce Transit Center	9:20 AM	Santa Ana, CA	Bus Stop	Economy	$91	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/24/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/25/2026 9:20:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 10h 50m
Greyhound US	11h 30m	10:30 PM	San Francisco	Bus Station Transbay	10:00 AM	Santa Ana, CA	Bus Stop	Economy	$98	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 6/24/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/25/2026 10:00:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 11h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	14h 30m	7:30 AM	San Francisco	5th/Townsend	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$60	A Bus from FlixBus goes from 5th/Townsend, San Francisco (USA) at 6/25/2026 7:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/25/2026 10:00:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 14h 30m
Greyhound US	15h 30m	6:30 AM	San Francisco	Bus Station Transbay	10:00 PM	Santa Ana, CA	Bus Stop	Economy	$61	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 6/25/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/25/2026 10:00:00 PM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 30m
Greyhound US	11h 30m	10:30 PM	San Francisco	Bus Station Transbay	10:00 AM	Santa Ana, CA	Bus Stop	Economy	$162	A Bus from Greyhound US goes from Bus Station Transbay, San Francisco (USA) at 6/25/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/26/2026 10:00:00 AM. 50 Economy ticket for $162 per person are available. Travel duration is 11h 30m

Cheapest bus trips Friday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	15h 30m	6:30 AM	San Francisco	Salesforce Transit Center	10:00 PM	Santa Ana, CA	Bus Stop		Economy	$68	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/26/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/26/2026 10:00:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 30m
	Greyhound US	11h 30m	10:30 PM	San Francisco	Salesforce Transit Center	10:00 AM	Santa Ana, CA	Bus Stop		Economy	$168	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/26/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/27/2026 10:00:00 AM. 50 Economy ticket for $168 per person are available. Travel duration is 11h 30m

Did you know that if you travel from San Francisco to Santa Ana, CA via Los Angeles, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  15h 30m
  
  0
  
  6:30 AM
  
  San Francisco
  Salesforce Transit Center
  
  7:55 PM
  
  Los Angeles
  Union Station
  
  0
  
  Economy
  
  $45
  
  A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/24/2026 6:30:00 AM to Union Station, Los Angeles (USA) arriving at 6/24/2026 7:55:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 13h 25m
- Greyhound US
  
  1h 40m
  
  0
  
  8:20 PM
  
  Los Angeles
  Union Station
  
  10:00 PM
  
  Santa Ana, CA
  Bus Stop
  
  0
  
  Economy
  
  $12
  
  A Bus from Greyhound US goes from Union Station, Los Angeles (USA) at 6/24/2026 8:20:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/24/2026 10:00:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 40m
Travel time is 4h 0m longer, but you will save $11

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	15h 30m	6:30 AM	San Francisco	Salesforce Transit Center	10:00 PM	Santa Ana, CA	Bus Stop		Economy	$57	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/27/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/27/2026 10:00:00 PM. 50 Economy ticket for $57 per person are available. Travel duration is 15h 30m
	Greyhound US	11h 30m	10:30 PM	San Francisco	Salesforce Transit Center	10:00 AM	Santa Ana, CA	Bus Stop		Economy	$100	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/27/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/28/2026 10:00:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 11h 30m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	15h 30m	6:30 AM	San Francisco	Salesforce Transit Center	10:00 PM	Santa Ana, CA	Bus Stop		Economy	$68	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/28/2026 6:30:00 AM to Bus Stop, Santa Ana, CA (USA) arriving at 6/28/2026 10:00:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 15h 30m
	Greyhound US	11h 30m	10:30 PM	San Francisco	Salesforce Transit Center	10:00 AM	Santa Ana, CA	Bus Stop		Economy	$100	A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/28/2026 10:30:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/29/2026 10:00:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 11h 30m

Did you know that if you travel from San Francisco to Santa Ana, CA via Los Angeles, you can save more than $11? You can find the corresponding connections below.
- Greyhound US
  
  15h 30m
  
  0
  
  6:30 AM
  
  San Francisco
  Salesforce Transit Center
  
  7:55 PM
  
  Los Angeles
  Union Station
  
  0
  
  Economy
  
  $45
  
  A Bus from Greyhound US goes from Salesforce Transit Center, San Francisco (USA) at 6/24/2026 6:30:00 AM to Union Station, Los Angeles (USA) arriving at 6/24/2026 7:55:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 13h 25m
- Greyhound US
  
  1h 40m
  
  0
  
  8:20 PM
  
  Los Angeles
  Union Station
  
  10:00 PM
  
  Santa Ana, CA
  Bus Stop
  
  0
  
  Economy
  
  $12
  
  A Bus from Greyhound US goes from Union Station, Los Angeles (USA) at 6/24/2026 8:20:00 PM to Bus Stop, Santa Ana, CA (USA) arriving at 6/24/2026 10:00:00 PM. 50 Economy ticket for $12 per person are available. Travel duration is 1h 40m
Travel time is 4h 0m longer, but you will save $11

Best Price Offer: The price for the cheapest bus from San Francisco to Santa Ana, CA is $42 on 6/24/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Francisco and Santa Ana, CA

See here how frequent the connections between San Francisco and Santa Ana, CA are, during different times and days of the week.

Tuesday is the busiest day, with more than 6 daily buses from San Francisco to Santa Ana, CA. Saturday has instead the fewest connections, with only 2 daily coaches between San Francisco and Santa Ana, CA.

The busiest time of the day is the Morning, with 17 buses from San Francisco to Santa Ana, CA, while Evening sees the fewest connections between San Francisco and Santa Ana, CA, with 11 offers.

Facts about the bus from San Francisco to Santa Ana, CA

Compare all providers like Greyhound US and FlixBus that travel 4 times every day by bus from San Francisco to Santa Ana, CA in one click! Book your bus ticket from San Francisco to Santa Ana, CA starting from $42!

Cheapest Bus	$42
Fastest Bus	10h 50m
Earliest Bus	6:30 AM
Latest Bus	10:30 PM
Daily Bus Routes	4 Ø
Distance	376.9 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from San Francisco to Santa Ana, CA

Every day, 4 buses from 2 bus companies leave San Francisco for Santa Ana, CA: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

$59

Tuesday 06/23

$54

Wednesday 06/24

$50

Thursday 06/25

$60

Friday 06/26

$68

Saturday 06/27

$57

Sunday 06/28

$68

Monday 06/29

$57

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

$68

Monday 07/06

$59

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$81

Saturday 07/11

$54

Sunday 07/12

$63

Monday 07/13

$56

Tuesday 07/14

$46

Wednesday 07/15

$47

Thursday 07/16

$56

Friday 07/17

$70

Saturday 07/18

The cheapest time to travel from San Francisco to Santa Ana, CA

See here on which day and which time of the day you can find the cheapest bus ticket from San Francisco to Santa Ana, CA, for the next 30 days.

With a price starting from $42, Wednesday is the cheapest day for a bus from San Francisco to Santa Ana, CA. Friday instead is the most expensive day with prices starting from $68.

Morning is the cheapest day time for bus tickets from San Francisco to Santa Ana, CA, with $42. Evening is the most expensive time of the day with prices starting from $91.

How to save money travelling from San Francisco to Santa Ana, CA

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Francisco to Santa Ana, CA in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Francisco to Santa Ana, CA, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Francisco to Santa Ana, CA are also emptier.

All bus stations and stops in San Francisco and Santa Ana, CA

In the map below, you can see where to find all bus stations in San Francisco and Santa Ana, CA.

South Van Ness Ave & Market St

Union Square

Post St 470

Bus Station Transbay

Folsom Street 200

Beach St & Hyde St

One Ferry Building

Passenger Loading Zone in front of Ferry Building on Embarcadero. Bus will stop near Marketbar Cafe.

Bus Stop

1000 E Santa Ana Blvd 105

Service and Comfort on the bus from San Francisco to Santa Ana, CA

Want to know which seat classes are available on the buses from San Francisco to Santa Ana, CA? Or which bus companies serve the route San Francisco to Santa Ana, CA? Below you will find answers to your questions.

FAQs about the San Francisco to Santa Ana, CA bus

How much does a San Francisco Santa Ana, CA bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $42 and takes 15h 30m to reach Santa Ana, CA. Compare offers to save money!

How much could I save by comparing buses from San Francisco to Santa Ana, CA?

This route is offered by 2 companies with a range of ticket prices between $42 and $172. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Ana, CA.

On average, how many connections are available from San Francisco to Santa Ana, CA each day?

Every day, the San Francisco to Santa Ana, CA bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Francisco to Santa Ana, CA take?

The fastest bus from San Francisco to Santa Ana, CA is offered by Greyhound US and takes 10h 50m. Bus tickets for this connection cost $91. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Francisco to Santa Ana, CA?

The earliest bus arriving in Santa Ana, CA from San Francisco starts at 6:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Francisco to Santa Ana, CA?

The latest bus trip departing from San Francisco for Santa Ana, CA starts at 10:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Francisco Santa Ana, CA route?

When traveling by bus from San Francisco to Santa Ana, CA, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Francisco and Santa Ana, CA?

You can check all the direct connections between San Francisco and Santa Ana, CA by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the San Francisco to Santa Ana, CA bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Francisco Santa Ana, CA bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Francisco Santa Ana, CA bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Francisco to Santa Ana, CA on your planned travel date.

How does CheckMyBus find the best bus deals from San Francisco to Santa Ana, CA?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between San Francisco and Santa Ana, CA. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Francisco to Santa Ana, CA?

Prices and availability for 4 trips between San Francisco and Santa Ana, CA change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Francisco to Santa Ana, CA

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Francisco and to Santa Ana, CA

Here’s an overview of the most popular bus routes to San Francisco and to Santa Ana, CA. Simply click on the connection of your choice, and you will find all the details about your bus route!