Bus Santa Cruz, LI to Santiago, RM - Compare all Companies

Compare all timetables for the bus from Santa Cruz, LI to Santiago, RM

Here is a selection of the cheapest bus trips from the schedule from Santa Cruz, LI to Santiago, RM from various bus operators like FlixBus, Nueva Andimar Vip or Buses Jet Sur for the next days.

today

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Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Buses Transantin	3h 15m	6:10 AM	Santa Cruz, LI	Central Bus Station	9:25 AM	Santiago, RM	Sur Bus Station	Premium Economy	$6	A Bus from Buses Transantin goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/22/2026 6:10:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/22/2026 9:25:00 AM. 50 Premium Economy ticket for $6 per person are available. Travel duration is 3h 15m
Buses Transantin	3h 15m	2:10 PM	Santa Cruz, LI	Central Bus Station	5:25 PM	Santiago, RM	Sur Bus Station	Premium Economy	$6	A Bus from Buses Transantin goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/22/2026 2:10:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/22/2026 5:25:00 PM. 50 Premium Economy ticket for $6 per person are available. Travel duration is 3h 15m
FlixBus	3h 0m	6:30 AM	Santa Cruz, LI	Central Bus Station	9:30 AM	Santiago, RM	Terminal San Borja	Economy	$6	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/22/2026 6:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 3/22/2026 9:30:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 0m
FlixBus	3h 0m	2:30 PM	Santa Cruz, LI	Central Bus Station	5:30 PM	Santiago, RM	Terminal San Borja	Economy	$6	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/22/2026 2:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 3/22/2026 5:30:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 0m
Nueva Andimar Vip	2h 44m	2:00 PM	Santa Cruz, LI	Central Bus Station	4:44 PM	Santiago, RM	Sur Bus Station	Economy	$7	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/22/2026 2:00:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/22/2026 4:44:00 PM. 50 Economy ticket for $7 per person are available. Travel duration is 2h 44m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	2h 44m	5:50 AM	Santa Cruz, LI	Central Bus Station	8:34 AM	Santiago, RM	Sur Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/23/2026 5:50:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/23/2026 8:34:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 44m
Nueva Andimar Vip	2h 44m	6:50 AM	Santa Cruz, LI	Central Bus Station	9:34 AM	Santiago, RM	Sur Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/23/2026 6:50:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/23/2026 9:34:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 44m
Nueva Andimar Vip	2h 44m	7:30 AM	Santa Cruz, LI	Central Bus Station	10:14 AM	Santiago, RM	Sur Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/23/2026 7:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/23/2026 10:14:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 44m
FlixBus	3h 0m	6:30 AM	Santa Cruz, LI	Central Bus Station	9:30 AM	Santiago, RM	Terminal San Borja	Economy	$6	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/23/2026 6:30:00 AM to Terminal San Borja, Santiago, RM (Chile) arriving at 3/23/2026 9:30:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 0m
FlixBus	3h 0m	2:30 PM	Santa Cruz, LI	Central Bus Station	5:30 PM	Santiago, RM	Terminal San Borja	Economy	$6	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/23/2026 2:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 3/23/2026 5:30:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 0m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 44m	5:00 AM	Santa Cruz, LI	Central Bus Station	7:44 AM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/27/2026 5:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/27/2026 7:44:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
FlixBus	2h 44m	5:50 AM	Santa Cruz, LI	Central Bus Station	8:34 AM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/27/2026 5:50:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/27/2026 8:34:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
FlixBus	2h 44m	6:50 AM	Santa Cruz, LI	Central Bus Station	9:34 AM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/27/2026 6:50:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/27/2026 9:34:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
FlixBus	2h 44m	7:30 AM	Santa Cruz, LI	Central Bus Station	10:14 AM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/27/2026 7:30:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/27/2026 10:14:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
FlixBus	2h 44m	8:00 AM	Santa Cruz, LI	Central Bus Station	10:44 AM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/27/2026 8:00:00 AM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/27/2026 10:44:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	2h 44m	2:00 PM	Santa Cruz, LI	Central Bus Station	4:44 PM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/28/2026 2:00:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/28/2026 4:44:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
Nueva Andimar Vip	2h 44m	3:00 PM	Santa Cruz, LI	Central Bus Station	5:44 PM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/28/2026 3:00:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/28/2026 5:44:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
Nueva Andimar Vip	2h 44m	3:30 PM	Santa Cruz, LI	Central Bus Station	6:14 PM	Santiago, RM	Sur Bus Station	Economy	$8	A Bus from Nueva Andimar Vip goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/28/2026 3:30:00 PM to Sur Bus Station, Santiago, RM (Chile) arriving at 3/28/2026 6:14:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 2h 44m
FlixBus	3h 0m	1:30 PM	Santa Cruz, LI	Central Bus Station	4:30 PM	Santiago, RM	Terminal San Borja	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/28/2026 1:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 3/28/2026 4:30:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 3h 0m
FlixBus	3h 0m	8:30 PM	Santa Cruz, LI	Central Bus Station	11:30 PM	Santiago, RM	Terminal San Borja	Economy	$8	A Bus from FlixBus goes from Central Bus Station, Santa Cruz, LI (Chile) at 3/28/2026 8:30:00 PM to Terminal San Borja, Santiago, RM (Chile) arriving at 3/28/2026 11:30:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 3h 0m

Best Price Offer: The price for the cheapest bus from Santa Cruz, LI to Santiago, RM is $2 on 3/22/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Santa Cruz, LI and Santiago, RM

See here how frequent the connections between Santa Cruz, LI and Santiago, RM are, during different times and days of the week.

Sunday is the busiest day, with more than 35 daily buses from Santa Cruz, LI to Santiago, RM. Friday has instead the fewest connections, with only 14 daily coaches between Santa Cruz, LI and Santiago, RM.

The busiest time of the day is the Afternoon, with 47 buses from Santa Cruz, LI to Santiago, RM, while Night sees the fewest connections between Santa Cruz, LI and Santiago, RM, with 8 offers.

Facts about the bus from Santa Cruz, LI to Santiago, RM

Compare all providers like FlixBus, Nueva Andimar Vip and Buses Jet Sur that travel 24 times every day by bus from Santa Cruz, LI to Santiago, RM in one click! Book your bus ticket from Santa Cruz, LI to Santiago, RM starting from $2!

Cheapest Bus	$2
Fastest Bus	2h 0m
Earliest Bus	6:10 AM
Latest Bus	8:30 PM
Daily Bus Routes	24 Ø
Distance	91.0 miles
Bus Companies	FlixBus, Nueva Andimar Vip, Buses Jet Sur and Buses Transantin

Cheapest bus connections from Santa Cruz, LI to Santiago, RM

Every day, 24 buses from 4 bus companies leave Santa Cruz, LI for Santiago, RM: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

Monday 03/23

Tuesday 03/24

Wednesday 03/25

Thursday 03/26

Friday 03/27

Saturday 03/28

Sunday 03/29

Monday 03/30

Tuesday 03/31

Wednesday 04/01

Thursday 04/02

Friday 04/03

Saturday 04/04

Sunday 04/05

Monday 04/06

Tuesday 04/07

Wednesday 04/08

Thursday 04/09

Friday 04/10

Saturday 04/11

Sunday 04/12

Monday 04/13

Tuesday 04/14

Wednesday 04/15

Thursday 04/16

Friday 04/17

Saturday 04/18

The cheapest time to travel from Santa Cruz, LI to Santiago, RM

See here on which day and which time of the day you can find the cheapest bus ticket from Santa Cruz, LI to Santiago, RM, for the next 30 days.

With a price starting from $2, Sunday is the cheapest day for a bus from Santa Cruz, LI to Santiago, RM. Saturday instead is the most expensive day with prices starting from $8.

Night is the cheapest day time for bus tickets from Santa Cruz, LI to Santiago, RM, with $2. Morning is the most expensive time of the day with prices starting from $6.

How to save money travelling from Santa Cruz, LI to Santiago, RM

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santa Cruz, LI to Santiago, RM in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santa Cruz, LI to Santiago, RM, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santa Cruz, LI to Santiago, RM are also emptier.

All bus stations and stops in Santa Cruz, LI and Santiago, RM

In the map below, you can see where to find all bus stations in Santa Cruz, LI and Santiago, RM.

Central Bus Station

Av. Rafael Casanova 504

Bimodal

Shell Gas Station

Hospital

La Gloria

Sur Bus Station

Av Libertador Bernardo O'Higgins 3850

Terminal San Borja

San Francisco de Borja 198-180

Terminal Alameda

Av Libertador Bernardo O'Higgins 3750

Terminal Pajaritos

Av. Gral. Óscar Bonilla 5935-5939

Los Héroes Station

Tucapel Jiménez 22

Service and Comfort on the bus from Santa Cruz, LI to Santiago, RM

Want to know which seat classes are available on the buses from Santa Cruz, LI to Santiago, RM? Or which bus companies serve the route Santa Cruz, LI to Santiago, RM? Below you will find answers to your questions.

FAQs about the Santa Cruz, LI to Santiago, RM bus

How much does a Santa Cruz, LI Santiago, RM bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $2 and takes 2h 44m to reach Santiago, RM. Compare offers to save money!

How much could I save by comparing buses from Santa Cruz, LI to Santiago, RM?

This route is offered by 4 companies with a range of ticket prices between $2 and $9. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago, RM.

On average, how many connections are available from Santa Cruz, LI to Santiago, RM each day?

Every day, the Santa Cruz, LI to Santiago, RM bus route is served by approximately 24 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santa Cruz, LI to Santiago, RM take?

The fastest bus from Santa Cruz, LI to Santiago, RM is offered by Buses Jet Sur and takes 2h 0m. Bus tickets for this connection cost $9. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santa Cruz, LI to Santiago, RM?

The earliest bus arriving in Santiago, RM from Santa Cruz, LI starts at 6:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santa Cruz, LI to Santiago, RM?

The latest bus trip departing from Santa Cruz, LI for Santiago, RM starts at 8:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santa Cruz, LI Santiago, RM route?

When traveling by bus from Santa Cruz, LI to Santiago, RM, passengers can travel with FlixBus, Nueva Andimar Vip and Buses Jet Sur. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santa Cruz, LI and Santiago, RM?

You can check all the direct connections between Santa Cruz, LI and Santiago, RM by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Nueva Andimar Vip and Buses Jet Sur.

What can I take with me on the Santa Cruz, LI to Santiago, RM bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santa Cruz, LI Santiago, RM bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santa Cruz, LI Santiago, RM bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santa Cruz, LI to Santiago, RM on your planned travel date.

How does CheckMyBus find the best bus deals from Santa Cruz, LI to Santiago, RM?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 24 daily trips between Santa Cruz, LI and Santiago, RM. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santa Cruz, LI to Santiago, RM?

Prices and availability for 24 trips between Santa Cruz, LI and Santiago, RM change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santa Cruz, LI to Santiago, RM

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Santa Cruz, LI and to Santiago, RM

Here’s an overview of the most popular bus routes to Santa Cruz, LI and to Santiago, RM. Simply click on the connection of your choice, and you will find all the details about your bus route!