Bus from Santiago, RM to Santa Cruz, LI from $5

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Compare all timetables for the bus from Santiago, RM to Santa Cruz, LI

Here is a selection of the cheapest bus trips from the schedule from Santiago, RM to Santa Cruz, LI from various bus operators like FlixBus or Nueva Andimar Vip for the next days.

today
$8
tomorrow
Tuesday
$8
Wednesday
$6
Thursday
Friday
$6
Saturday
$8

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 6:59 PM Santiago, RM Sur Bus Station 9:39 PM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 7:29 PM Santiago, RM Sur Bus Station 10:09 PM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 7:59 PM Santiago, RM Sur Bus Station 10:39 PM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 8:59 PM Santiago, RM Sur Bus Station 11:39 PM Santa Cruz, LI Central Bus Station  Economy $8
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than $1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59 AM
      Santiago, RM
      Sur Bus Station
      1:44 PM
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      $4
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      1:45 PM
      San Fernando, LI
      Central Bus Station
      2:35 PM
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      $3
    Travel Time is 0h 4m shorter, and you will save $1

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 3h 5m 5:30 AM Santiago, RM Terminal San Borja 8:35 AM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 3h 5m 11:30 AM Santiago, RM Terminal San Borja 2:35 PM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 3h 5m 6:30 PM Santiago, RM Terminal San Borja 9:35 PM Santa Cruz, LI Central Bus Station  Economy $8
Nueva Andimar Vip 2h 40m 6:15 AM Santiago, RM Sur Bus Station 8:55 AM Santa Cruz, LI Central Bus Station  Economy $8
Nueva Andimar Vip 2h 40m 8:59 AM Santiago, RM Sur Bus Station 11:39 AM Santa Cruz, LI Central Bus Station  Economy $8
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than $1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59 AM
      Santiago, RM
      Sur Bus Station
      1:44 PM
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      $4
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      1:45 PM
      San Fernando, LI
      Central Bus Station
      2:35 PM
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      $3
    Travel Time is 0h 4m shorter, and you will save $1

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Nueva Andimar Vip 2h 40m 6:15 AM Santiago, RM Sur Bus Station 8:55 AM Santa Cruz, LI Central Bus Station  Economy $6
Nueva Andimar Vip 2h 40m 8:59 AM Santiago, RM Sur Bus Station 11:39 AM Santa Cruz, LI Central Bus Station  Economy $6
Nueva Andimar Vip 2h 40m 9:59 AM Santiago, RM Sur Bus Station 12:39 PM Santa Cruz, LI Central Bus Station  Economy $6
FlixBus 3h 5m 6:30 AM Santiago, RM Terminal San Borja 9:35 AM Santa Cruz, LI Central Bus Station  Economy $6
FlixBus 3h 5m 11:30 AM Santiago, RM Terminal San Borja 2:35 PM Santa Cruz, LI Central Bus Station  Economy $6

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 6:15 AM Santiago, RM Sur Bus Station 8:55 AM Santa Cruz, LI Central Bus Station  Economy $6
FlixBus 2h 40m 8:59 AM Santiago, RM Sur Bus Station 11:39 AM Santa Cruz, LI Central Bus Station  Economy $6
FlixBus 2h 40m 9:59 AM Santiago, RM Sur Bus Station 12:39 PM Santa Cruz, LI Central Bus Station  Economy $6
FlixBus 2h 40m 10:59 AM Santiago, RM Sur Bus Station 1:39 PM Santa Cruz, LI Central Bus Station  Economy $7
FlixBus 2h 40m 11:29 AM Santiago, RM Sur Bus Station 2:09 PM Santa Cruz, LI Central Bus Station  Economy $7

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 2h 40m 6:15 AM Santiago, RM Sur Bus Station 8:55 AM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 8:59 AM Santiago, RM Sur Bus Station 11:39 AM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 9:59 AM Santiago, RM Sur Bus Station 12:39 PM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 10:59 AM Santiago, RM Sur Bus Station 1:39 PM Santa Cruz, LI Central Bus Station  Economy $8
FlixBus 2h 40m 11:29 AM Santiago, RM Sur Bus Station 2:09 PM Santa Cruz, LI Central Bus Station  Economy $8
  • Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than $1? You can find the corresponding connections below.
    • Nueva Andimar Vip
      2h 36m
      0
      11:59 AM
      Santiago, RM
      Sur Bus Station
      1:44 PM
      San Fernando, LI
      Central Bus Station
      0
      Nueva Andimar Vip
      Economy
      $4
      • Waiting Time 0h 1m
    • FlixBus
      0h 50m
      0
      1:45 PM
      San Fernando, LI
      Central Bus Station
      2:35 PM
      Santa Cruz, LI
      Central Bus Station
      0
      FlixBus
      Economy
      $3
    Travel Time is 0h 4m shorter, and you will save $1

Best Price Offer: The price for the cheapest bus from Santiago, RM to Santa Cruz, LI is $5 on 3/25/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Santiago, RM and Santa Cruz, LI

See here how frequent the connections between Santiago, RM and Santa Cruz, LI are, during different times and days of the week.
Wednesday is the busiest day, with more than 31 daily buses from Santiago, RM to Santa Cruz, LI. Sunday has instead the fewest connections, with only 4 daily coaches between Santiago, RM and Santa Cruz, LI.
The busiest time of the day is the Morning, with 33 buses from Santiago, RM to Santa Cruz, LI, while Night sees the fewest connections between Santiago, RM and Santa Cruz, LI, with 1 offers.

Facts about the bus from Santiago, RM to Santa Cruz, LI

Compare all providers like FlixBus and Nueva Andimar Vip that travel 16 times every day by bus from Santiago, RM to Santa Cruz, LI in one click! Book your bus ticket from Santiago, RM to Santa Cruz, LI starting from $5!

Cheapest Bus $5
Fastest Bus 2h 40m
Earliest Bus 6:59 PM
Latest Bus 8:59 PM
Daily Bus Routes 16 Ø
Distance 91.0 miles
Bus Companies FlixBus and Nueva Andimar Vip

Cheapest bus connections from Santiago, RM to Santa Cruz, LI

Every day, 16 buses from 2 bus companies leave Santiago, RM for Santa Cruz, LI: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 03/22
$6
Monday 03/23
Tuesday 03/24
$8
Wednesday 03/25
$5
Thursday 03/26
Friday 03/27
$7
Saturday 03/28
$8
Sunday 03/29
Monday 03/30
$6
Tuesday 03/31
$8
Wednesday 04/01
Thursday 04/02
$9
Friday 04/03
$7
Saturday 04/04
$8
Sunday 04/05
$8
Monday 04/06
$6
Tuesday 04/07
$6
Wednesday 04/08
$8
Thursday 04/09
$6
Friday 04/10
$7
Saturday 04/11
$8
Sunday 04/12
$6
Monday 04/13
$6
Tuesday 04/14
$6
Wednesday 04/15
$8
Thursday 04/16
$6
Friday 04/17
$7
Saturday 04/18

The cheapest time to travel from Santiago, RM to Santa Cruz, LI

See here on which day and which time of the day you can find the cheapest bus ticket from Santiago, RM to Santa Cruz, LI, for the next 30 days.
With a price starting from $5, Wednesday is the cheapest day for a bus from Santiago, RM to Santa Cruz, LI. Saturday instead is the most expensive day with prices starting from $8.
Night is the cheapest day time for bus tickets from Santiago, RM to Santa Cruz, LI, with $5. Morning is the most expensive time of the day with prices starting from $6.

How to save money travelling from Santiago, RM to Santa Cruz, LI

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santiago, RM to Santa Cruz, LI in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to Santa Cruz, LI, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santiago, RM to Santa Cruz, LI are also emptier.

Beloved bus companies from Santiago, RM to Santa Cruz, LI

These are the most booked bus companies between Santiago, RM to Santa Cruz, LI from our users.

FlixBus from Santiago, RM to Santa Cruz, LI

FlixBus

Here you will find the key facts about the FlixBus bus route Santiago, RM to Santa Cruz, LI:

Cheapest Price $6
Fastest Bus 2h 40m
Earliest Bus 6:59 PM
Last Bus 8:59 PM
Daily Connections 10 Ø
Found on 3/22/2026

All bus stations and stops in Santiago, RM and Santa Cruz, LI

In the map below, you can see where to find all bus stations in Santiago, RM and Santa Cruz, LI.

Service and Comfort on the bus from Santiago, RM to Santa Cruz, LI

Want to know which seat classes are available on the buses from Santiago, RM to Santa Cruz, LI? Or which bus companies serve the route Santiago, RM to Santa Cruz, LI? Below you will find answers to your questions.

FAQs about the Santiago, RM to Santa Cruz, LI bus

How much does a Santiago, RM Santa Cruz, LI bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $5 and takes 2h 40m to reach Santa Cruz, LI. Compare offers to save money!

How much could I save by comparing buses from Santiago, RM to Santa Cruz, LI?

This route is offered by 2 companies with a range of ticket prices between $5 and $8. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Cruz, LI.

On average, how many connections are available from Santiago, RM to Santa Cruz, LI each day?

Every day, the Santiago, RM to Santa Cruz, LI bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santiago, RM to Santa Cruz, LI take?

The fastest bus from Santiago, RM to Santa Cruz, LI is offered by FlixBus and takes 2h 40m. Bus tickets for this connection cost $8. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santiago, RM to Santa Cruz, LI?

The earliest bus arriving in Santa Cruz, LI from Santiago, RM starts at 6:59 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santiago, RM to Santa Cruz, LI?

The latest bus trip departing from Santiago, RM for Santa Cruz, LI starts at 8:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santiago, RM Santa Cruz, LI route?

When traveling by bus from Santiago, RM to Santa Cruz, LI, passengers can travel with FlixBus and Nueva Andimar Vip. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santiago, RM and Santa Cruz, LI?

You can check all the direct connections between Santiago, RM and Santa Cruz, LI by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Nueva Andimar Vip.

What can I take with me on the Santiago, RM to Santa Cruz, LI bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santiago, RM Santa Cruz, LI bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santiago, RM Santa Cruz, LI bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santiago, RM to Santa Cruz, LI on your planned travel date.

How does CheckMyBus find the best bus deals from Santiago, RM to Santa Cruz, LI?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between Santiago, RM and Santa Cruz, LI. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santiago, RM to Santa Cruz, LI?

Prices and availability for 16 trips between Santiago, RM and Santa Cruz, LI change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santiago, RM to Santa Cruz, LI

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santiago, RM and to Santa Cruz, LI

Here’s an overview of the most popular bus routes to Santiago, RM and to Santa Cruz, LI. Simply click on the connection of your choice, and you will find all the details about your bus route!
From Pichilemu to Santa Cruz, LI bus From Pichilemu to Santa Cruz, LI bus
Buses Buenos Aires - Santa Cruz, LI Buses Buenos Aires - Santa Cruz, LI
Bus Mejillones - Santiago, RM Bus Mejillones - Santiago, RM
Buses from Lota to Santiago, RM Buses from Lota to Santiago, RM
Bus Requínoa to Santiago, RM Bus Requínoa to Santiago, RM
Buses Talcahuano - Santiago, RM Buses Talcahuano - Santiago, RM
Buses from Coronel to Santiago, RM Buses from Coronel to Santiago, RM
Buses to Santiago, RM from Angol Buses to Santiago, RM from Angol
Buses Longaví - Santiago, RM Buses Longaví - Santiago, RM
Buses from Pozo Almonte to Santiago, RM Buses from Pozo Almonte to Santiago, RM
From Saavedra to Santiago, RM bus From Saavedra to Santiago, RM bus
Bus Pichicuy to Santiago, RM Bus Pichicuy to Santiago, RM
Buses to Santiago, RM from La Serena Buses to Santiago, RM from La Serena
Bus Bariloche to Santiago, RM Bus Bariloche to Santiago, RM
Bus from Pucón, AR to Santiago, RM Bus from Pucón, AR to Santiago, RM
San Antonio, VS to Santiago, RM bus San Antonio, VS to Santiago, RM bus
From Viña del Mar to Santiago, RM bus From Viña del Mar to Santiago, RM bus
From Buenos Aires to Santiago, RM bus From Buenos Aires to Santiago, RM bus
Buses to Santiago, RM from Mendoza Buses to Santiago, RM from Mendoza
Bus Valparaíso (CL) to Santiago, RM Bus Valparaíso (CL) to Santiago, RM
Buses Vallenar - Santiago, RM Buses Vallenar - Santiago, RM
Buses to Santiago, RM from Los Ángeles, BI Buses to Santiago, RM from Los Ángeles, BI
Buses to Santiago, RM from Coquimbo Buses to Santiago, RM from Coquimbo
Buses to Santiago, RM from Maitencillo Buses to Santiago, RM from Maitencillo
Popular Airport Shuttles to Santiago, RM and to Santa Cruz, LI
CheckMyBus › Buses in Chile › Bus to Santiago, RM › Bus to Santa Cruz, LI

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