Bus Santiago, RM to Santa Cruz, LI: Compare prices and save money

Compare all timetables for the bus from Santiago, RM to Santa Cruz, LI

Here is a selection of the cheapest bus trips from the schedule from Santiago, RM to Santa Cruz, LI from various bus operators like FlixBus or Nueva Andimar Vip for the next days.

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tomorrow

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Friday

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Sunday

Monday

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/8/2026 8:55:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/8/2026 11:39:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/8/2026 12:39:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
FlixBus	3h 5m	6:30 AM	Santiago, RM	Terminal San Borja	9:35 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/8/2026 6:30:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/8/2026 9:35:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 5m
FlixBus	3h 5m	11:30 AM	Santiago, RM	Terminal San Borja	2:35 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/8/2026 11:30:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/8/2026 2:35:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 5m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Nueva Andimar Vip	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/9/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/9/2026 8:55:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/9/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/9/2026 11:39:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/9/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/9/2026 12:39:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
FlixBus	3h 5m	11:30 AM	Santiago, RM	Terminal San Borja	2:35 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/9/2026 11:30:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/9/2026 2:35:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 5m
FlixBus	3h 5m	6:30 PM	Santiago, RM	Terminal San Borja	9:35 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/9/2026 6:30:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/9/2026 9:35:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 3h 5m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	3h 5m	6:30 AM	Santiago, RM	Terminal San Borja	9:35 AM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/10/2026 6:30:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/10/2026 9:35:00 AM. 50 Economy ticket for $8 per person are available. Travel duration is 3h 5m
FlixBus	3h 5m	11:30 AM	Santiago, RM	Terminal San Borja	2:35 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/10/2026 11:30:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/10/2026 2:35:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 3h 5m
FlixBus	3h 5m	6:30 PM	Santiago, RM	Terminal San Borja	9:35 PM	Santa Cruz, LI	Central Bus Station	Economy	$8	A Bus from FlixBus goes from Terminal San Borja, Santiago, RM (Chile) at 5/10/2026 6:30:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/10/2026 9:35:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 3h 5m
Nueva Andimar Vip	2h 40m	1:59 PM	Santiago, RM	Sur Bus Station	4:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/10/2026 1:59:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/10/2026 4:39:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 40m
Nueva Andimar Vip	2h 45m	4:59 PM	Santiago, RM	Sur Bus Station	7:44 PM	Santa Cruz, LI	Central Bus Station	Economy	$9	A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/10/2026 4:59:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/10/2026 7:44:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 2h 45m

Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than $2? You can find the corresponding connections below.
- Nueva Andimar Vip
  
  2h 36m
  
  0
  
  11:59 AM
  
  Santiago, RM
  Sur Bus Station
  
  1:44 PM
  
  San Fernando, LI
  Central Bus Station
  
  0
  
  Economy
  
  $4
  
  A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/8/2026 11:59:00 AM to Central Bus Station, San Fernando, LI (Chile) arriving at 5/8/2026 1:44:00 PM. 50 Economy ticket for $4 per person are available. Travel duration is 1h 45m
- FlixBus
  
  0h 50m
  
  0
  
  1:45 PM
  
  San Fernando, LI
  Central Bus Station
  
  2:35 PM
  
  Santa Cruz, LI
  Central Bus Station
  
  0
  
  Economy
  
  $2
  
  A Bus from FlixBus goes from Central Bus Station, San Fernando, LI (Chile) at 5/8/2026 1:45:00 PM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/8/2026 2:35:00 PM. 50 Economy ticket for $2 per person are available. Travel duration is 0h 50m
Travel Time is 0h 4m shorter, and you will save $2

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	2h 40m	6:15 AM	Santiago, RM	Sur Bus Station	8:55 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 6:15:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/11/2026 8:55:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	8:59 AM	Santiago, RM	Sur Bus Station	11:39 AM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 8:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/11/2026 11:39:00 AM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	9:59 AM	Santiago, RM	Sur Bus Station	12:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 9:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/11/2026 12:39:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	10:59 AM	Santiago, RM	Sur Bus Station	1:39 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 10:59:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/11/2026 1:39:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m
FlixBus	2h 40m	11:29 AM	Santiago, RM	Sur Bus Station	2:09 PM	Santa Cruz, LI	Central Bus Station	Economy	$6	A Bus from FlixBus goes from Sur Bus Station, Santiago, RM (Chile) at 5/11/2026 11:29:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/11/2026 2:09:00 PM. 50 Economy ticket for $6 per person are available. Travel duration is 2h 40m

Did you know that if you travel from Santiago, RM to Santa Cruz, LI via San Fernando, LI, you can save more than $1? You can find the corresponding connections below.
- Nueva Andimar Vip
  
  2h 40m
  
  0
  
  6:15 AM
  
  Santiago, RM
  Sur Bus Station
  
  8:00 AM
  
  San Fernando, LI
  Central Bus Station
  
  0
  
  Economy
  
  $4
  
  A Bus from Nueva Andimar Vip goes from Sur Bus Station, Santiago, RM (Chile) at 5/13/2026 6:15:00 AM to Central Bus Station, San Fernando, LI (Chile) arriving at 5/13/2026 8:00:00 AM. 50 Economy ticket for $4 per person are available. Travel duration is 1h 45m
- Nueva Andimar Vip
  
  0h 50m
  
  0
  
  8:05 AM
  
  San Fernando, LI
  Central Bus Station
  
  8:55 AM
  
  Santa Cruz, LI
  Central Bus Station
  
  0
  
  Economy
  
  $1
  
  A Bus from Nueva Andimar Vip goes from Central Bus Station, San Fernando, LI (Chile) at 5/13/2026 8:05:00 AM to Central Bus Station, Santa Cruz, LI (Chile) arriving at 5/13/2026 8:55:00 AM. 50 Economy ticket for $1 per person are available. Travel duration is 0h 50m
Travel time is the same as the direct connection, but you will save $1

Best Price Offer: The price for the cheapest bus from Santiago, RM to Santa Cruz, LI is $2 on 5/12/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Santiago, RM and Santa Cruz, LI

See here how frequent the connections between Santiago, RM and Santa Cruz, LI are, during different times and days of the week.

Friday is the busiest day, with more than 31 daily buses from Santiago, RM to Santa Cruz, LI. Monday has instead the fewest connections, with only 14 daily coaches between Santiago, RM and Santa Cruz, LI.

The busiest time of the day is the Morning, with 35 buses from Santiago, RM to Santa Cruz, LI, while Afternoon sees the fewest connections between Santiago, RM and Santa Cruz, LI, with 26 offers.

Facts about the bus from Santiago, RM to Santa Cruz, LI

Compare all providers like FlixBus and Nueva Andimar Vip that travel 23 times every day by bus from Santiago, RM to Santa Cruz, LI in one click! Book your bus ticket from Santiago, RM to Santa Cruz, LI starting from $2!

Cheapest Bus	$2
Fastest Bus	2h 40m
Earliest Bus	6:15 AM
Latest Bus	8:59 PM
Daily Bus Routes	23 Ø
Distance	91.0 miles
Bus Companies	FlixBus and Nueva Andimar Vip

Cheapest bus connections from Santiago, RM to Santa Cruz, LI

Every day, 23 buses from 2 bus companies leave Santiago, RM for Santa Cruz, LI: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/05/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

Saturday 05/09

Sunday 05/10

Monday 05/11

Tuesday 05/12

Wednesday 05/13

Thursday 05/14

Friday 05/15

Saturday 05/16

Sunday 05/17

Monday 05/18

Tuesday 05/19

Wednesday 05/20

Thursday 05/21

Friday 05/22

Saturday 05/23

Sunday 05/24

Monday 05/25

Tuesday 05/26

Wednesday 05/27

Thursday 05/28

Friday 05/29

Saturday 05/30

The cheapest time to travel from Santiago, RM to Santa Cruz, LI

See here on which day and which time of the day you can find the cheapest bus ticket from Santiago, RM to Santa Cruz, LI, for the next 30 days.

With a price starting from $6, Friday is the cheapest day for a bus from Santiago, RM to Santa Cruz, LI. Saturday instead is the most expensive day with prices starting from $6.

Morning is the cheapest day time for bus tickets from Santiago, RM to Santa Cruz, LI, with $6. Afternoon is the most expensive time of the day with prices starting from $6.

How to save money travelling from Santiago, RM to Santa Cruz, LI

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santiago, RM to Santa Cruz, LI in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santiago, RM to Santa Cruz, LI, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santiago, RM to Santa Cruz, LI are also emptier.

Beloved bus companies from Santiago, RM to Santa Cruz, LI

These are the most booked bus companies between Santiago, RM to Santa Cruz, LI from our users.

FlixBus from Santiago, RM to Santa Cruz, LI

Here you will find the key facts about the FlixBus bus route Santiago, RM to Santa Cruz, LI:

Cheapest Price	$6
Fastest Bus	2h 40m
Earliest Bus	6:15 AM
Last Bus	8:59 PM
Daily Connections	14 Ø
Found on	4/11/2026

All bus stations and stops in Santiago, RM and Santa Cruz, LI

In the map below, you can see where to find all bus stations in Santiago, RM and Santa Cruz, LI.

Terminal Pajaritos

Av. Gral. Óscar Bonilla 5935-5939

Baquedano

Pl. Baquedano

Los Héroes Station

Tucapel Jiménez 22

Porto Seguro Bus Station

Sur Bus Station

Av Libertador Bernardo O'Higgins 3850

Central Bus Station

Av. Rafael Casanova 504

Bimodal

Shell Gas Station

Hospital

La Gloria

Service and Comfort on the bus from Santiago, RM to Santa Cruz, LI

Want to know which seat classes are available on the buses from Santiago, RM to Santa Cruz, LI? Or which bus companies serve the route Santiago, RM to Santa Cruz, LI? Below you will find answers to your questions.

FAQs about the Santiago, RM to Santa Cruz, LI bus

How much does a Santiago, RM Santa Cruz, LI bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $2 and takes 2h 40m to reach Santa Cruz, LI. Compare offers to save money!

How much could I save by comparing buses from Santiago, RM to Santa Cruz, LI?

This route is offered by 2 companies with a range of ticket prices between $2 and $9. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santa Cruz, LI.

On average, how many connections are available from Santiago, RM to Santa Cruz, LI each day?

Every day, the Santiago, RM to Santa Cruz, LI bus route is served by approximately 23 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santiago, RM to Santa Cruz, LI take?

The fastest bus from Santiago, RM to Santa Cruz, LI is offered by Nueva Andimar Vip and takes 2h 40m. Bus tickets for this connection cost $6. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santiago, RM to Santa Cruz, LI?

The earliest bus arriving in Santa Cruz, LI from Santiago, RM starts at 6:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santiago, RM to Santa Cruz, LI?

The latest bus trip departing from Santiago, RM for Santa Cruz, LI starts at 8:59 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santiago, RM Santa Cruz, LI route?

When traveling by bus from Santiago, RM to Santa Cruz, LI, passengers can travel with FlixBus and Nueva Andimar Vip. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santiago, RM and Santa Cruz, LI?

You can check all the direct connections between Santiago, RM and Santa Cruz, LI by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Nueva Andimar Vip.

What can I take with me on the Santiago, RM to Santa Cruz, LI bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santiago, RM Santa Cruz, LI bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santiago, RM Santa Cruz, LI bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santiago, RM to Santa Cruz, LI on your planned travel date.

How does CheckMyBus find the best bus deals from Santiago, RM to Santa Cruz, LI?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 23 daily trips between Santiago, RM and Santa Cruz, LI. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santiago, RM to Santa Cruz, LI?

Prices and availability for 23 trips between Santiago, RM and Santa Cruz, LI change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santiago, RM to Santa Cruz, LI

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santiago, RM and to Santa Cruz, LI

Here’s an overview of the most popular bus routes to Santiago, RM and to Santa Cruz, LI. Simply click on the connection of your choice, and you will find all the details about your bus route!