What is the best way to travel from St. Louis, MO to Chicago?
Looking for a trip? Compare all the available Buses and Flights for the journey to Chicago from St. Louis, MO. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach Chicago from St. Louis, MO?
You can get to Chicago with just $34 by taking a Bus from FlixBus, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/5/2025 4:30:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 7h 0m
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FlixBus5h 50m04:00 PMSt. Louis, MOGateway Station9:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 4:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 9:50:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 5h 50m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 3:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 25m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/5/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/5/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
Cheapest Buses Friday
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 4:30:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 7h 0m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/6/2025 3:55:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 6h 25m
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FlixBus6h 15m04:00 PMSt. Louis, MOGateway Station10:15 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 10:15:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 6h 15m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/6/2025 2:10:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/6/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
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Frontier Airlines15h 25m07:43 PMSt. Louis Lambert AirportSt. Louis Lambert Airport11:08 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 7:43:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 12/7/2025 11:08:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 25m
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Skyscanner1h 29m06:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 6:30:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 7:59:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 29m
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Skyscanner1h 29m08:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport9:29 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 8:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 9:29:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 29m
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Skyscanner1h 30m01:00 PMSt. Louis Lambert AirportSt. Louis Lambert Airport2:30 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 1:00:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 2:30:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 30m
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United Airlines1h 23m05:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 5:27:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 6:50:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 23m
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Frontier Airlines25h 57m03:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport5:27 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 3:30:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 12/7/2025 5:27:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 25h 57m
Cheapest Buses Saturday
Cheapest Flights Saturday
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/7/2025 4:30:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 7h 0m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/7/2025 3:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 25m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/7/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/7/2025 2:10:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 10m
Cheapest Buses Sunday
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 4:30:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 7h 0m
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FlixBus6h 15m04:00 PMSt. Louis, MOGateway Station10:15 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 10:15:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 3:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 25m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 12h 10m
Cheapest Buses Monday
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Greyhound US9h 5m01:55 PMSt. Louis, MOGateway Station11:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/10/2025 11:00:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 9h 5m
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Greyhound US11h 40m02:00 AMSt. Louis, MOGateway Station1:40 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/10/2025 1:40:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 11h 40m
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Greyhound US13h 40m08:45 AMSt. Louis, MOGateway Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 8:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/10/2025 10:25:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 13h 40m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/10/2025 2:10:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 10m
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Greyhound US12h 35m02:00 AMSt. Louis, MOGateway Station2:35 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 2:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/10/2025 2:35:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 35m
Cheapest Buses Wednesday
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Greyhound US9h 5m01:55 PMSt. Louis, MOGateway Station11:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 1:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:00:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 9h 5m
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/11/2025 4:30:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 7h 0m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 3:55:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 6h 25m
Cheapest Buses Thursday
What are the fastest trips from St. Louis, MO to Chicago?
You can get to Chicago from St. Louis, MO in just 1h 23m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus5h 50m04:00 PMSt. Louis, MOGateway Station9:50 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 4:00:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 9:50:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 5h 50m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/5/2025 3:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/5/2025 4:30:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/5/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/5/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/5/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
Fastest Buses Friday
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United Airlines1h 23m05:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport6:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from United Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 5:27:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 6:50:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 23m
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Skyscanner1h 29m06:30 AMSt. Louis Lambert AirportSt. Louis Lambert Airport7:59 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 6:30:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 7:59:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 29m
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Skyscanner1h 29m08:00 AMSt. Louis Lambert AirportSt. Louis Lambert Airport9:29 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 8:00:00 AM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 9:29:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 29m
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Skyscanner1h 30m01:00 PMSt. Louis Lambert AirportSt. Louis Lambert Airport2:30 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center0EconomyA Flight from Skyscanner goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 1:00:00 PM to Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) arriving at 12/6/2025 2:30:00 PM. 50 Economy ticket for $85 per person are available. Travel duration is 1h 30m
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Frontier Airlines15h 25m07:43 PMSt. Louis Lambert AirportSt. Louis Lambert Airport11:08 AMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 7:43:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 12/7/2025 11:08:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 15h 25m
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Frontier Airlines25h 57m03:30 PMSt. Louis Lambert AirportSt. Louis Lambert Airport5:27 PMChicago Midway AirportChicago Midway Airport0EconomyA Flight from Frontier Airlines goes from St. Louis Lambert Airport, St. Louis Lambert Airport (USA) at 12/6/2025 3:30:00 PM to Chicago Midway Airport, Chicago Midway Airport (USA) arriving at 12/7/2025 5:27:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 25h 57m
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FlixBus6h 15m04:00 PMSt. Louis, MOGateway Station10:15 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 10:15:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/6/2025 3:55:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/6/2025 4:30:00 PM. 50 Economy ticket for $34 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/6/2025 2:10:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/6/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/6/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
Fastest Flights Saturday
Fastest Buses Saturday
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/7/2025 3:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/7/2025 4:30:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/7/2025 2:10:00 PM. 50 Economy ticket for $55 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/7/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/7/2025 2:10:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 10m
Fastest Buses Sunday
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FlixBus6h 15m04:00 PMSt. Louis, MOGateway Station10:15 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 4:00:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 10:15:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 6h 15m
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/8/2025 3:55:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/8/2025 4:30:00 PM. 50 Economy ticket for $35 per person are available. Travel duration is 7h 0m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoCanal & Van Buren0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 2:00:00 AM to Canal & Van Buren, Chicago (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 12h 10m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/8/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/8/2025 2:10:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 12h 10m
Fastest Buses Monday
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Greyhound US9h 5m01:55 PMSt. Louis, MOGateway Station11:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 1:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/10/2025 11:00:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 9h 5m
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Greyhound US11h 40m02:00 AMSt. Louis, MOGateway Station1:40 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 2:00:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/10/2025 1:40:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 11h 40m
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Greyhound US12h 10m02:00 AMSt. Louis, MOGateway Station2:10 PMChicagoUnion Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 2:00:00 AM to Union Station, Chicago (USA) arriving at 12/10/2025 2:10:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 10m
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Greyhound US12h 35m02:00 AMSt. Louis, MOGateway Station2:35 PMChicagoDowntown Bus Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 2:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/10/2025 2:35:00 PM. 50 Economy ticket for $56 per person are available. Travel duration is 12h 35m
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Greyhound US13h 40m08:45 AMSt. Louis, MOGateway Station10:25 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 8:45:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/10/2025 10:25:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 13h 40m
Fastest Buses Wednesday
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FlixBus6h 25m09:30 AMSt. Louis, MOGateway Station3:55 PMChicago95th Red Line Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 9:30:00 AM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 3:55:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 6h 25m
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FlixBus7h 0m09:30 AMSt. Louis, MOGateway Station4:30 PMChicagoDowntown Bus Station0EconomyA Bus from FlixBus goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 9:30:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/11/2025 4:30:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 7h 0m
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Greyhound US9h 5m01:55 PMSt. Louis, MOGateway Station11:00 PMChicago95th Red Line Station0EconomyA Bus from Greyhound US goes from Gateway Station, St. Louis, MO (USA) at 12/11/2025 1:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 12/11/2025 11:00:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 9h 5m
Fastest Buses Thursday
Here you will find all operators and timetables for a
Bus from St. Louis, MO to Chicago
What are the most popular stations in St. Louis, MO and Chicago?
In St. Louis, MO, you will usually depart from Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, while in Chicago you will be arriving at California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to Chicago from St. Louis, MO? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between St. Louis, MO and Chicago, you can pay as low as $34 with a Bus from FlixBus.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to Chicago in just 1h 23m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting St. Louis, MO and Chicago are FlixBus, Greyhound US and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in St. Louis, MO and Chicago is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Sauget, IL or to Cicero, IL, and look at flights from St. Louis Lambert Airport, and landing at Chicago Midway Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from St. Louis, MO to Chicago?
The most popular companies between St. Louis, MO and Chicago, are FlixBus, Greyhound US and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: FlixBus and Greyhound US
Airlines: Skyscanner, Frontier Airlines and United Airlines
All you need to know when you travel from St. Louis, MO to Chicago
Check all information on comfort and services on all modes of transports from St. Louis, MO to Chicago. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from St. Louis, MO to Chicago
How can I reach Chicago from St. Louis, MO?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to Chicago from St. Louis, MO.
How far is Chicago from St. Louis, MO?
The distance between St. Louis, MO and Chicago is 262.3 miles.
What is the most ecofriendly mode of transport between St. Louis, MO and Chicago?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 15 kgs, a car 72 kgs, and a flight 104 kgs.
What is the cheapest mode of transport from St. Louis, MO to Chicago?
You can get to Chicago with just $34 by taking a Bus from FlixBus.
What is the fastest way to get from St. Louis, MO to Chicago?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to Chicago in just 1h 23m with a Flight from United Airlines.
More routes to St. Louis, MO and to Chicago
Looking for more options? Here you can see the most popular routes to St. Louis, MO and to Chicago. Simply click on a connection, and you’ll find all the details about the route!
- Trips to St. Louis, MO
- Atlanta, GA to St. Louis, MO
- Ciudad Juárez to St. Louis, MO
- Dallas to St. Louis, MO
- Mexico City to St. Louis, MO
- Monterrey, NL to St. Louis, MO
- Trips to Chicago
- Aguascalientes to Chicago
- Atlanta, GA to Chicago
- Buffalo, NY to Chicago
- Dallas to Chicago
- El Paso, TX to Chicago
- Guadalajara, JC to Chicago
- Houston to Chicago
- Louisville, KY to Chicago
- McAllen, TX to Chicago
- Memphis to Chicago
- Mexico City to Chicago
- Mississauga, ON to Chicago
- Monterrey, NL to Chicago
- Nashville to Chicago
- New York to Chicago
- Oklahoma City, OK to Chicago
- Pearson Toronto Airport to Chicago
- Phoenix, AZ to Chicago
- Pittsburgh to Chicago
- San Antonio, TX to Chicago
- San Luis Potosí to Chicago
- Santiago de Queretaro to Chicago
- Toronto, ON to Chicago

