Bus Tupelo, MS to Indianapolis: Compare prices and save money

Compare all timetables for the bus from Tupelo, MS to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to Indianapolis from various bus operators like Greyhound US for the next days.

today

tomorrow

Monday

Tuesday

$103

Wednesday

Thursday

Friday

$133

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 0m	10:55 AM	Tupelo, MS	Bus Stop	9:55 AM	Indianapolis	Central Bus Station	Economy	$103	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/16/2025 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/17/2025 9:55:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 0m
Greyhound US	13h 30m	9:35 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$103	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/16/2025 9:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/17/2025 12:05:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 13h 30m
Greyhound US	21h 30m	5:35 AM	Tupelo, MS	Bus Stop	4:05 AM	Indianapolis	Central Bus Station	Economy	$104	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/16/2025 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/17/2025 4:05:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 21h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Washington / Delaware	Economy	$106	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/16/2025 11:15:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/17/2025 9:25:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 21h 10m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Washington / Delaware	Economy	$129	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/16/2025 10:55:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/17/2025 8:25:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 20h 30m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	22h 0m	10:55 AM	Tupelo, MS	Bus Stop	9:55 AM	Indianapolis	Central Bus Station	Economy	$133	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/19/2025 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/20/2025 9:55:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 22h 0m
Greyhound US	13h 30m	9:35 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$141	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/19/2025 9:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/20/2025 12:05:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 13h 30m
Greyhound US	21h 30m	5:35 AM	Tupelo, MS	Bus Stop	4:05 AM	Indianapolis	Central Bus Station	Economy	$144	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/19/2025 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/20/2025 4:05:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 21h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Washington / Delaware	Economy	$153	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/19/2025 11:15:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/20/2025 9:25:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 21h 10m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Washington / Delaware	Economy	$155	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 12/19/2025 10:55:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/20/2025 8:25:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 20h 30m

Did you know that if you travel from Tupelo, MS to Indianapolis via Memphis, you can save more than $21? You can find the corresponding connections below.
- FlixBus
  
  13h 30m
  
  0
  
  9:35 PM
  
  Tupelo, MS
  Bus Stop
  
  11:25 PM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $21
  
  A Bus from FlixBus goes from Bus Stop, Tupelo, MS (USA) at 12/15/2025 9:35:00 PM to Airways Transit Center, Memphis (USA) arriving at 12/15/2025 11:25:00 PM. 50 Economy ticket for $21 per person are available. Travel duration is 1h 50m
- FlixBus
  
  10h 30m
  
  0
  
  12:35 AM
  
  Memphis
  Airways Transit Center
  
  12:05 PM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $91
  
  A Bus from FlixBus goes from Airways Transit Center, Memphis (USA) at 12/16/2025 12:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/16/2025 12:05:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 10h 30m
Travel Time is 1h 0m shorter, and you will save $21

Best Price Offer: The price for the cheapest bus from Tupelo, MS to Indianapolis is $92 on 12/8/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Tupelo, MS and Indianapolis

See here how frequent the connections between Tupelo, MS and Indianapolis are, during different times and days of the week.

Tuesday is the busiest day, with more than 5 daily buses from Tupelo, MS to Indianapolis. Tuesday has instead the fewest connections, with only 5 daily coaches between Tupelo, MS and Indianapolis.

The busiest time of the day is the Morning, with 4 buses from Tupelo, MS to Indianapolis, while Night sees the fewest connections between Tupelo, MS and Indianapolis, with 2 offers.

Facts about the bus from Tupelo, MS to Indianapolis

Compare all providers like Greyhound US that travel 5 times every day by bus from Tupelo, MS to Indianapolis in one click! Book your bus ticket from Tupelo, MS to Indianapolis starting from $92!

Cheapest Bus	$92
Fastest Bus	14h 30m
Earliest Bus	5:35 AM
Latest Bus	11:15 PM
Daily Bus Routes	5 Ø
Distance	405.9 miles
Bus Companies	Greyhound US

Cheapest bus connections from Tupelo, MS to Indianapolis

Every day, 5 buses from 1 bus companies leave Tupelo, MS for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/13/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

$103

Wednesday 12/17

Thursday 12/18

Friday 12/19

$133

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

The cheapest time to travel from Tupelo, MS to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Tupelo, MS to Indianapolis, for the next 30 days.

With a price starting from $103, Tuesday is the cheapest day for a bus from Tupelo, MS to Indianapolis. Friday instead is the most expensive day with prices starting from $133.

Morning is the cheapest day time for bus tickets from Tupelo, MS to Indianapolis, with $103. Evening is the most expensive time of the day with prices starting from $103.

How to save money travelling from Tupelo, MS to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to Indianapolis are also emptier.

All bus stations and stops in Tupelo, MS and Indianapolis

In the map below, you can see where to find all bus stations in Tupelo, MS and Indianapolis.

Bus Stop

S Eason Blvd 2831

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Tupelo, MS to Indianapolis

Want to know which seat classes are available on the buses from Tupelo, MS to Indianapolis? Or which bus companies serve the route Tupelo, MS to Indianapolis? Below you will find answers to your questions.

FAQs about the Tupelo, MS to Indianapolis bus

How much does a Tupelo, MS Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 23h 0m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $92 and $155. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Tupelo, MS to Indianapolis each day?

Every day, the Tupelo, MS to Indianapolis bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to Indianapolis take?

The fastest bus from Tupelo, MS to Indianapolis is offered by Greyhound US and takes 14h 30m. Bus tickets for this connection cost $103. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to Indianapolis?

The earliest bus arriving in Indianapolis from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to Indianapolis?

The latest bus trip departing from Tupelo, MS for Indianapolis starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS Indianapolis route?

When traveling by bus from Tupelo, MS to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and Indianapolis?

You can check all the direct connections between Tupelo, MS and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route Tupelo, MS to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to Indianapolis

Here’s an overview of the most popular bus routes to Tupelo, MS and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!