Bus Tupelo, MS to Indianapolis: Compare prices and save money

Compare all timetables for the bus from Tupelo, MS to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to Indianapolis from various bus operators like Greyhound US for the next days.

today

$97

tomorrow

Monday

$97

Tuesday

Wednesday

$99

Thursday

$89

Friday

$97

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 40m	5:35 AM	Tupelo, MS	Bus Stop	4:15 AM	Indianapolis	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/20/2026 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/21/2026 4:15:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 21h 40m
Greyhound US	13h 20m	9:45 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/20/2026 9:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 6/21/2026 12:05:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 13h 20m
Greyhound US	21h 35m	10:55 AM	Tupelo, MS	Bus Stop	9:30 AM	Indianapolis	Central Bus Station	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/20/2026 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/21/2026 9:30:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 35m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/20/2026 10:55:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 6/21/2026 8:25:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/20/2026 11:15:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 6/21/2026 9:25:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 10m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 40m	5:35 AM	Tupelo, MS	Bus Stop	4:15 AM	Indianapolis	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/22/2026 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/23/2026 4:15:00 AM. 50 Economy ticket for $97 per person are available. Travel duration is 21h 40m
Greyhound US	13h 20m	9:45 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/22/2026 9:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 6/23/2026 12:05:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 13h 20m
Greyhound US	21h 35m	10:55 AM	Tupelo, MS	Bus Stop	9:30 AM	Indianapolis	Central Bus Station	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/22/2026 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/23/2026 9:30:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 35m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/22/2026 10:55:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 6/23/2026 8:25:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/22/2026 11:15:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 6/23/2026 9:25:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 10m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 35m	10:55 AM	Tupelo, MS	Bus Stop	9:30 AM	Indianapolis	Central Bus Station	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/24/2026 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/25/2026 9:30:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 35m
Greyhound US	13h 20m	9:45 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/24/2026 9:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 6/25/2026 12:05:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 13h 20m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Washington / Delaware	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/24/2026 10:55:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 6/25/2026 8:25:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Washington / Delaware	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/24/2026 11:15:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 6/25/2026 9:25:00 PM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 10m
Greyhound US	21h 40m	5:35 AM	Tupelo, MS	Bus Stop	4:15 AM	Indianapolis	Central Bus Station	Economy	$112	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/24/2026 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/25/2026 4:15:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 21h 40m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 35m	10:55 AM	Tupelo, MS	Bus Stop	9:30 AM	Indianapolis	Central Bus Station	Economy	$89	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/25/2026 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/26/2026 9:30:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 35m
Greyhound US	13h 20m	9:45 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$89	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/25/2026 9:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 6/26/2026 12:05:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 13h 20m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$89	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/25/2026 10:55:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 6/26/2026 8:25:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 20h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$89	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/25/2026 11:15:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 6/26/2026 9:25:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 10m
Greyhound US	21h 40m	5:35 AM	Tupelo, MS	Bus Stop	4:15 AM	Indianapolis	Central Bus Station	Economy	$99	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/25/2026 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/26/2026 4:15:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 40m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	13h 20m	9:45 PM	Tupelo, MS	Bus Stop	12:05 PM	Indianapolis	Central Bus Station	Economy	$97	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/26/2026 9:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 6/27/2026 12:05:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 13h 20m
Greyhound US	21h 35m	10:55 AM	Tupelo, MS	Bus Stop	9:30 AM	Indianapolis	Central Bus Station	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/26/2026 10:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/27/2026 9:30:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 35m
Greyhound US	20h 30m	10:55 AM	Tupelo, MS	Bus Stop	8:25 AM	Indianapolis	Downtown Transit Center	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/26/2026 10:55:00 AM to Downtown Transit Center, Indianapolis (USA) arriving at 6/27/2026 8:25:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 20h 30m
Greyhound US	21h 10m	11:15 PM	Tupelo, MS	Bus Stop	9:25 PM	Indianapolis	Downtown Transit Center	Economy	$98	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/26/2026 11:15:00 PM to Downtown Transit Center, Indianapolis (USA) arriving at 6/27/2026 9:25:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 10m
Greyhound US	21h 40m	5:35 AM	Tupelo, MS	Bus Stop	4:15 AM	Indianapolis	Central Bus Station	Economy	$110	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 6/26/2026 5:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 6/27/2026 4:15:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 21h 40m

Best Price Offer: The price for the cheapest bus from Tupelo, MS to Indianapolis is $76 on 7/10/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Tupelo, MS and Indianapolis

See here how frequent the connections between Tupelo, MS and Indianapolis are, during different times and days of the week.

Friday is the busiest day, with more than 10 daily buses from Tupelo, MS to Indianapolis. Monday has instead the fewest connections, with only 5 daily coaches between Tupelo, MS and Indianapolis.

The busiest time of the day is the Morning, with 14 buses from Tupelo, MS to Indianapolis, while Night sees the fewest connections between Tupelo, MS and Indianapolis, with 7 offers.

Facts about the bus from Tupelo, MS to Indianapolis

Compare all providers like Greyhound US that travel 7 times every day by bus from Tupelo, MS to Indianapolis in one click! Book your bus ticket from Tupelo, MS to Indianapolis starting from $76!

Cheapest Bus	$76
Fastest Bus	14h 20m
Earliest Bus	5:35 AM
Latest Bus	11:15 PM
Daily Bus Routes	7 Ø
Distance	405.9 miles
Bus Companies	Greyhound US

Cheapest bus connections from Tupelo, MS to Indianapolis

Every day, 7 buses from 1 bus companies leave Tupelo, MS for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

Wednesday 06/17

Thursday 06/18

Friday 06/19

Saturday 06/20

$101

Sunday 06/21

Monday 06/22

$97

Tuesday 06/23

Wednesday 06/24

$99

Thursday 06/25

$89

Friday 06/26

$97

Saturday 06/27

$99

Sunday 06/28

$102

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$76

Saturday 07/11

The cheapest time to travel from Tupelo, MS to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Tupelo, MS to Indianapolis, for the next 30 days.

With a price starting from $72, Saturday is the cheapest day for a bus from Tupelo, MS to Indianapolis. Wednesday instead is the most expensive day with prices starting from $99.

Night is the cheapest day time for bus tickets from Tupelo, MS to Indianapolis, with $72. Morning is the most expensive time of the day with prices starting from $89.

How to save money travelling from Tupelo, MS to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to Indianapolis are also emptier.

All bus stations and stops in Tupelo, MS and Indianapolis

In the map below, you can see where to find all bus stations in Tupelo, MS and Indianapolis.

Bus Stop

S Eason Blvd 2831

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

S Keystone Avenue

S Keystone Avenue 3649

BP Gas Station 70/91

N Post Rd 2102

Central Bus Station

Service and Comfort on the bus from Tupelo, MS to Indianapolis

Want to know which seat classes are available on the buses from Tupelo, MS to Indianapolis? Or which bus companies serve the route Tupelo, MS to Indianapolis? Below you will find answers to your questions.

FAQs about the Tupelo, MS to Indianapolis bus

How much does a Tupelo, MS Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $76 and takes 14h 20m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to Indianapolis?

This route is offered by 1 companies with a range of ticket prices between $76 and $114. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Tupelo, MS to Indianapolis each day?

Every day, the Tupelo, MS to Indianapolis bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to Indianapolis take?

The fastest bus from Tupelo, MS to Indianapolis is offered by Greyhound US and takes 14h 20m. Bus tickets for this connection cost $97. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to Indianapolis?

The earliest bus arriving in Indianapolis from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to Indianapolis?

The latest bus trip departing from Tupelo, MS for Indianapolis starts at 11:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS Indianapolis route?

When traveling by bus from Tupelo, MS to Indianapolis, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and Indianapolis?

You can check all the direct connections between Tupelo, MS and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Tupelo, MS to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Tupelo, MS and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Tupelo, MS to Indianapolis?

Prices and availability for 7 trips between Tupelo, MS and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Tupelo, MS to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to Indianapolis

Here’s an overview of the most popular bus routes to Tupelo, MS and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!