Bus Greenville, SC to Indianapolis - Compare all Companies

Compare all timetables for the bus from Greenville, SC to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

Monday

$87

Tuesday

$124

Wednesday

$139

Thursday

Friday

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 25m	1:20 PM	Greenville, SC	Woodruff Rd	4:45 AM	Indianapolis	Central Bus Station	Economy	$87	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/9/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/10/2026 4:45:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 25m
FlixBus	16h 25m	7:40 PM	Greenville, SC	Woodruff Rd	12:05 PM	Indianapolis	Central Bus Station	Economy	$87	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/9/2026 7:40:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/10/2026 12:05:00 PM. 50 Economy ticket for $87 per person are available. Travel duration is 16h 25m
Greyhound US	16h 10m	5:45 PM	Greenville, SC	Woodruff Rd	9:55 AM	Indianapolis	Central Bus Station	Economy	$87	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 2/9/2026 5:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/10/2026 9:55:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 16h 10m
FlixBus	20h 40m	10:00 PM	Greenville, SC	Woodruff Rd	6:40 PM	Indianapolis	Central Bus Station	Economy	$88	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/9/2026 10:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/10/2026 6:40:00 PM. 50 Economy ticket for $88 per person are available. Travel duration is 20h 40m
Greyhound US	17h 40m	2:45 PM	Greenville, SC	Woodruff Rd	8:25 AM	Indianapolis	Washington / Delaware	Economy	$88	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 2/9/2026 2:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 2/10/2026 8:25:00 AM. 50 Economy ticket for $88 per person are available. Travel duration is 17h 40m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 40m	2:45 PM	Greenville, SC	Woodruff Rd	8:25 AM	Indianapolis	Washington / Delaware	Economy	$124	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 2/10/2026 2:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 2/11/2026 8:25:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 17h 40m
FlixBus	20h 40m	10:00 PM	Greenville, SC	Woodruff Rd	6:40 PM	Indianapolis	Central Bus Station	Economy	$126	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/10/2026 10:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/11/2026 6:40:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 20h 40m
FlixBus	15h 25m	1:20 PM	Greenville, SC	Woodruff Rd	4:45 AM	Indianapolis	Central Bus Station	Economy	$127	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/10/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/11/2026 4:45:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 15h 25m
Greyhound US	19h 10m	2:45 PM	Greenville, SC	Woodruff Rd	9:55 AM	Indianapolis	Central Bus Station	Economy	$127	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 2/10/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/11/2026 9:55:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 19h 10m

Did you know that if you travel from Greenville, SC to Indianapolis via Nashville, you can save more than $16? You can find the corresponding connections below.
- Busbud
  
  15h 25m
  
  0
  
  1:20 PM
  
  Greenville, SC
  Woodruff Rd
  
  9:10 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $64
  
  A Bus from Busbud goes from Woodruff Rd, Greenville, SC (USA) at 2/12/2026 1:20:00 PM to 5th Ave South Station, Nashville (USA) arriving at 2/12/2026 9:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 8h 50m
- Busbud
  
  5h 30m
  
  0
  
  10:15 PM
  
  Nashville
  5th Ave South Station
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $44
  
  A Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 2/12/2026 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/13/2026 4:45:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 30m
Travel time is the same as the direct connection, but you will save $16

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	19h 10m	2:45 PM	Greenville, SC	Woodruff Rd	9:55 AM	Indianapolis	Central Bus Station	Economy	$139	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 2/11/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/12/2026 9:55:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 19h 10m
Greyhound US	17h 40m	2:45 PM	Greenville, SC	Woodruff Rd	8:25 AM	Indianapolis	Washington / Delaware	Economy	$139	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 2/11/2026 2:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 2/12/2026 8:25:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 17h 40m
FlixBus	20h 40m	10:00 PM	Greenville, SC	Woodruff Rd	6:40 PM	Indianapolis	Central Bus Station	Economy	$141	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/11/2026 10:00:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/12/2026 6:40:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 20h 40m
FlixBus	15h 25m	1:20 PM	Greenville, SC	Woodruff Rd	4:45 AM	Indianapolis	Central Bus Station	Economy	$158	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 2/11/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/12/2026 4:45:00 AM. 50 Economy ticket for $158 per person are available. Travel duration is 15h 25m

Did you know that if you travel from Greenville, SC to Indianapolis via Nashville, you can save more than $31? You can find the corresponding connections below.
- Busbud
  
  15h 25m
  
  0
  
  1:20 PM
  
  Greenville, SC
  Woodruff Rd
  
  9:10 PM
  
  Nashville
  5th Ave South Station
  
  0
  
  Economy
  
  $64
  
  A Bus from Busbud goes from Woodruff Rd, Greenville, SC (USA) at 2/12/2026 1:20:00 PM to 5th Ave South Station, Nashville (USA) arriving at 2/12/2026 9:10:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 8h 50m
- Busbud
  
  5h 30m
  
  0
  
  10:15 PM
  
  Nashville
  5th Ave South Station
  
  4:45 AM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $44
  
  A Bus from Busbud goes from 5th Ave South Station, Nashville (USA) at 2/12/2026 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 2/13/2026 4:45:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 30m
Travel time is the same as the direct connection, but you will save $31

Best Price Offer: The price for the cheapest bus from Greenville, SC to Indianapolis is $81 on 2/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Indianapolis

See here how frequent the connections between Greenville, SC and Indianapolis are, during different times and days of the week.

Monday is the busiest day, with more than 12 daily buses from Greenville, SC to Indianapolis. Tuesday has instead the fewest connections, with only 4 daily coaches between Greenville, SC and Indianapolis.

The busiest time of the day is the Afternoon, with 12 buses from Greenville, SC to Indianapolis, while Evening sees the fewest connections between Greenville, SC and Indianapolis, with 8 offers.

Facts about the bus from Greenville, SC to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 6 times every day by bus from Greenville, SC to Indianapolis in one click! Book your bus ticket from Greenville, SC to Indianapolis starting from $81!

Cheapest Bus	$81
Fastest Bus	15h 25m
Earliest Bus	1:20 PM
Latest Bus	10:00 PM
Daily Bus Routes	6 Ø
Distance	397.5 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Indianapolis

Every day, 6 buses from 2 bus companies leave Greenville, SC for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/07/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/01

Monday 02/02

Tuesday 02/03

Wednesday 02/04

Thursday 02/05

Friday 02/06

Saturday 02/07

Sunday 02/08

Monday 02/09

$87

Tuesday 02/10

$124

Wednesday 02/11

$139

Thursday 02/12

Friday 02/13

Saturday 02/14

$134

Sunday 02/15

Monday 02/16

Tuesday 02/17

Wednesday 02/18

Thursday 02/19

Friday 02/20

Saturday 02/21

Sunday 02/22

$82

Monday 02/23

Tuesday 02/24

Wednesday 02/25

Thursday 02/26

Friday 02/27

Saturday 02/28

The cheapest time to travel from Greenville, SC to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Indianapolis, for the next 30 days.

With a price starting from $87, Monday is the cheapest day for a bus from Greenville, SC to Indianapolis. Wednesday instead is the most expensive day with prices starting from $139.

Afternoon is the cheapest day time for bus tickets from Greenville, SC to Indianapolis, with $87. Afternoon is the most expensive time of the day with prices starting from $87.

How to save money travelling from Greenville, SC to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Indianapolis are also emptier.

All bus stations and stops in Greenville, SC and Indianapolis

In the map below, you can see where to find all bus stations in Greenville, SC and Indianapolis.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Guadalajara Supermarket

White Horse Rd 2803

Greyhound Bus Station

Hendrix Dr 9

N Church St

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Greenville, SC to Indianapolis

Want to know which seat classes are available on the buses from Greenville, SC to Indianapolis? Or which bus companies serve the route Greenville, SC to Indianapolis? Below you will find answers to your questions.

FAQs about the Greenville, SC to Indianapolis bus

How much does a Greenville, SC Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $81 and takes 15h 25m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $81 and $158. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Greenville, SC to Indianapolis each day?

Every day, the Greenville, SC to Indianapolis bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Indianapolis take?

The fastest bus from Greenville, SC to Indianapolis is offered by FlixBus and takes 15h 25m. Bus tickets for this connection cost $87. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Indianapolis?

The earliest bus arriving in Indianapolis from Greenville, SC starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Indianapolis?

The latest bus trip departing from Greenville, SC for Indianapolis starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Indianapolis route?

When traveling by bus from Greenville, SC to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Indianapolis?

You can check all the direct connections between Greenville, SC and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Greenville, SC and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Indianapolis?

Prices and availability for 6 trips between Greenville, SC and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Indianapolis

Here’s an overview of the most popular bus routes to Greenville, SC and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!