Bus Greenville, SC to Indianapolis - Compare all Companies

Compare all timetables for the bus from Greenville, SC to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Indianapolis from various bus operators like Greyhound US or FlixBus for the next days.

today

$95

tomorrow

$90

Tuesday

$78

Wednesday

$81

Thursday

$83

Friday

Saturday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 35m	1:20 PM	Greenville, SC	Woodruff Rd	4:55 AM	Indianapolis	Central Bus Station	Economy	$95	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/6/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/7/2026 4:55:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 15h 35m
Greyhound US	18h 45m	2:45 PM	Greenville, SC	Woodruff Rd	9:30 AM	Indianapolis	Central Bus Station	Economy	$95	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/6/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/7/2026 9:30:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 18h 45m
Greyhound US	17h 15m	2:45 PM	Greenville, SC	Woodruff Rd	8:00 AM	Indianapolis	Washington / Delaware	Economy	$95	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/6/2026 2:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/7/2026 8:00:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 17h 15m
Greyhound US	15h 50m	8:20 PM	Greenville, SC	Woodruff Rd	12:10 PM	Indianapolis	Central Bus Station	Economy	$96	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/6/2026 8:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/7/2026 12:10:00 PM. 50 Economy ticket for $96 per person are available. Travel duration is 15h 50m
FlixBus	24h 10m	9:35 PM	Greenville, SC	Woodruff Rd	9:45 PM	Indianapolis	Washington / Delaware	Economy	$97	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/6/2026 9:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/7/2026 9:45:00 PM. 50 Economy ticket for $97 per person are available. Travel duration is 24h 10m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 15m	2:45 PM	Greenville, SC	Woodruff Rd	8:00 AM	Indianapolis	Washington / Delaware	Economy	$90	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/7/2026 2:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/8/2026 8:00:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 17h 15m
Greyhound US	15h 50m	8:20 PM	Greenville, SC	Woodruff Rd	12:10 PM	Indianapolis	Central Bus Station	Economy	$91	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/7/2026 8:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/8/2026 12:10:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 15h 50m
FlixBus	20h 55m	9:35 PM	Greenville, SC	Woodruff Rd	6:30 PM	Indianapolis	Central Bus Station	Economy	$92	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/7/2026 9:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/8/2026 6:30:00 PM. 50 Economy ticket for $92 per person are available. Travel duration is 20h 55m
Greyhound US	18h 45m	2:45 PM	Greenville, SC	Woodruff Rd	9:30 AM	Indianapolis	Central Bus Station	Economy	$92	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/7/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/8/2026 9:30:00 AM. 50 Economy ticket for $92 per person are available. Travel duration is 18h 45m
FlixBus	24h 10m	9:35 PM	Greenville, SC	Woodruff Rd	9:45 PM	Indianapolis	Washington / Delaware	Economy	$93	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/7/2026 9:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/8/2026 9:45:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 24h 10m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	18h 45m	2:45 PM	Greenville, SC	Woodruff Rd	9:30 AM	Indianapolis	Central Bus Station	Economy	$78	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/8/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/9/2026 9:30:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 18h 45m
Greyhound US	15h 50m	8:20 PM	Greenville, SC	Woodruff Rd	12:10 PM	Indianapolis	Central Bus Station	Economy	$79	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/8/2026 8:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/9/2026 12:10:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 15h 50m
FlixBus	20h 35m	9:35 PM	Greenville, SC	Woodruff Rd	6:10 PM	Indianapolis	Central Bus Station	Economy	$80	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/8/2026 9:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/9/2026 6:10:00 PM. 50 Economy ticket for $80 per person are available. Travel duration is 20h 35m
FlixBus	15h 35m	1:20 PM	Greenville, SC	Woodruff Rd	4:55 AM	Indianapolis	Central Bus Station	Economy	$86	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/8/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/9/2026 4:55:00 AM. 50 Economy ticket for $86 per person are available. Travel duration is 15h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 35m	9:35 PM	Greenville, SC	Woodruff Rd	6:10 PM	Indianapolis	Central Bus Station	Economy	$81	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/9/2026 9:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/10/2026 6:10:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 20h 35m
Greyhound US	18h 45m	2:45 PM	Greenville, SC	Woodruff Rd	9:30 AM	Indianapolis	Central Bus Station	Economy	$81	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/9/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/10/2026 9:30:00 AM. 50 Economy ticket for $81 per person are available. Travel duration is 18h 45m
Greyhound US	15h 50m	8:20 PM	Greenville, SC	Woodruff Rd	12:10 PM	Indianapolis	Central Bus Station	Economy	$81	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/9/2026 8:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/10/2026 12:10:00 PM. 50 Economy ticket for $81 per person are available. Travel duration is 15h 50m
FlixBus	15h 35m	1:20 PM	Greenville, SC	Woodruff Rd	4:55 AM	Indianapolis	Central Bus Station	Economy	$85	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/9/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/10/2026 4:55:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 15h 35m
Greyhound US	17h 15m	2:45 PM	Greenville, SC	Woodruff Rd	8:00 AM	Indianapolis	Washington / Delaware	Economy	$85	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/9/2026 2:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/10/2026 8:00:00 AM. 50 Economy ticket for $85 per person are available. Travel duration is 17h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	15h 35m	1:20 PM	Greenville, SC	Woodruff Rd	4:55 AM	Indianapolis	Central Bus Station	Economy	$83	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/10/2026 1:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/11/2026 4:55:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 35m
FlixBus	20h 35m	9:35 PM	Greenville, SC	Woodruff Rd	6:10 PM	Indianapolis	Central Bus Station	Economy	$83	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 9/10/2026 9:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/11/2026 6:10:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 20h 35m
Greyhound US	18h 35m	2:45 PM	Greenville, SC	Woodruff Rd	9:20 AM	Indianapolis	Central Bus Station	Economy	$83	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/10/2026 2:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/11/2026 9:20:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 18h 35m
Greyhound US	15h 50m	8:20 PM	Greenville, SC	Woodruff Rd	12:10 PM	Indianapolis	Central Bus Station	Economy	$84	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/10/2026 8:20:00 PM to Central Bus Station, Indianapolis (USA) arriving at 9/11/2026 12:10:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 15h 50m
Greyhound US	26h 55m	8:20 PM	Greenville, SC	Woodruff Rd	11:15 PM	Indianapolis	Washington / Delaware	Economy	$86	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 9/10/2026 8:20:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 9/11/2026 11:15:00 PM. 50 Economy ticket for $86 per person are available. Travel duration is 26h 55m

Best Price Offer: The price for the cheapest bus from Greenville, SC to Indianapolis is $73 on 9/15/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Indianapolis

See here how frequent the connections between Greenville, SC and Indianapolis are, during different times and days of the week.

Thursday is the busiest day, with more than 11 daily buses from Greenville, SC to Indianapolis. Tuesday has instead the fewest connections, with only 4 daily coaches between Greenville, SC and Indianapolis.

The busiest time of the day is the Evening, with 19 buses from Greenville, SC to Indianapolis, while Afternoon sees the fewest connections between Greenville, SC and Indianapolis, with 18 offers.

Facts about the bus from Greenville, SC to Indianapolis

Compare all providers like Greyhound US and FlixBus that travel 7 times every day by bus from Greenville, SC to Indianapolis in one click! Book your bus ticket from Greenville, SC to Indianapolis starting from $73!

Cheapest Bus	$73
Fastest Bus	15h 35m
Earliest Bus	1:20 PM
Latest Bus	9:35 PM
Daily Bus Routes	7 Ø
Distance	397.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Greenville, SC to Indianapolis

Every day, 7 buses from 2 bus companies leave Greenville, SC for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/06/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

$95

Monday 09/07

$90

Tuesday 09/08

$78

Wednesday 09/09

$85

Thursday 09/10

$83

Friday 09/11

Saturday 09/12

Sunday 09/13

Monday 09/14

$77

Tuesday 09/15

$73

Wednesday 09/16

Thursday 09/17

Friday 09/18

$85

Saturday 09/19

$83

Sunday 09/20

Monday 09/21

$84

Tuesday 09/22

$85

Wednesday 09/23

Thursday 09/24

Friday 09/25

Saturday 09/26

$75

Sunday 09/27

$81

Monday 09/28

$81

Tuesday 09/29

$82

Wednesday 09/30

$87

Thursday 10/01

Friday 10/02

$75

Saturday 10/03

The cheapest time to travel from Greenville, SC to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Indianapolis, for the next 30 days.

With a price starting from $73, Tuesday is the cheapest day for a bus from Greenville, SC to Indianapolis. Thursday instead is the most expensive day with prices starting from $83.

Afternoon is the cheapest day time for bus tickets from Greenville, SC to Indianapolis, with $78. Evening is the most expensive time of the day with prices starting from $79.

How to save money travelling from Greenville, SC to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Indianapolis are also emptier.

All bus stations and stops in Greenville, SC and Indianapolis

In the map below, you can see where to find all bus stations in Greenville, SC and Indianapolis.

N Church St

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

McDonald's

Woodruff Rd 1111

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from Greenville, SC to Indianapolis

Want to know which seat classes are available on the buses from Greenville, SC to Indianapolis? Or which bus companies serve the route Greenville, SC to Indianapolis? Below you will find answers to your questions.

FAQs about the Greenville, SC to Indianapolis bus

How much does a Greenville, SC Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $73 and takes 18h 45m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $73 and $119. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from Greenville, SC to Indianapolis each day?

Every day, the Greenville, SC to Indianapolis bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Indianapolis take?

The fastest bus from Greenville, SC to Indianapolis is offered by FlixBus and takes 15h 35m. Bus tickets for this connection cost $95. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Indianapolis?

The earliest bus arriving in Indianapolis from Greenville, SC starts at 1:20 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Indianapolis?

The latest bus trip departing from Greenville, SC for Indianapolis starts at 9:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Indianapolis route?

When traveling by bus from Greenville, SC to Indianapolis, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Indianapolis?

You can check all the direct connections between Greenville, SC and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Greenville, SC to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Greenville, SC and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Indianapolis?

Prices and availability for 7 trips between Greenville, SC and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Indianapolis

Here’s an overview of the most popular bus routes to Greenville, SC and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!