Bus San Diego to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Diego to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Diego to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today

$287

tomorrow

$290

Sunday

Monday

$275

Tuesday

Wednesday

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 55m	7:35 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$287	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/5/2025 7:35:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/7/2025 2:30:00 PM. 50 Economy ticket for $287 per person are available. Travel duration is 51h 55m
FlixBus	51h 35m	7:55 AM	San Diego	La Jolla Village	2:30 PM	Indianapolis	Central Bus Station	Economy	$287	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/5/2025 7:55:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/7/2025 2:30:00 PM. 50 Economy ticket for $287 per person are available. Travel duration is 51h 35m
FlixBus	54h 10m	2:10 PM	San Diego	La Jolla Village	11:20 PM	Indianapolis	Washington / Delaware	Economy	$289	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/5/2025 2:10:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/7/2025 11:20:00 PM. 50 Economy ticket for $289 per person are available. Travel duration is 54h 10m
Greyhound US	56h 25m	10:00 AM	San Diego	Old Town Transit Center	9:25 PM	Indianapolis	Washington / Delaware	Economy	$290	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/5/2025 10:00:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/7/2025 9:25:00 PM. 50 Economy ticket for $290 per person are available. Travel duration is 56h 25m
Greyhound US	49h 30m	10:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$293	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/5/2025 10:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/7/2025 2:30:00 PM. 50 Economy ticket for $293 per person are available. Travel duration is 49h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	58h 30m	7:55 AM	San Diego	La Jolla Village	9:25 PM	Indianapolis	Washington / Delaware	Economy	$290	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/6/2025 7:55:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/8/2025 9:25:00 PM. 50 Economy ticket for $290 per person are available. Travel duration is 58h 30m
FlixBus	54h 10m	2:10 PM	San Diego	La Jolla Village	11:20 PM	Indianapolis	Washington / Delaware	Economy	$290	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/6/2025 2:10:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/8/2025 11:20:00 PM. 50 Economy ticket for $290 per person are available. Travel duration is 54h 10m
FlixBus	56h 5m	12:15 PM	San Diego	Old Town Transit Center	11:20 PM	Indianapolis	Washington / Delaware	Economy	$291	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/6/2025 12:15:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/8/2025 11:20:00 PM. 50 Economy ticket for $291 per person are available. Travel duration is 56h 5m
Greyhound US	56h 25m	10:00 AM	San Diego	Old Town Transit Center	9:25 PM	Indianapolis	Washington / Delaware	Economy	$293	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/6/2025 10:00:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 12/8/2025 9:25:00 PM. 50 Economy ticket for $293 per person are available. Travel duration is 56h 25m
Greyhound US	49h 30m	10:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$299	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/6/2025 10:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/8/2025 2:30:00 PM. 50 Economy ticket for $299 per person are available. Travel duration is 49h 30m

Did you know that if you travel from San Diego to Indianapolis via St. Louis, MO, you can save more than $40? You can find the corresponding connections below.
- Busbud
  
  51h 55m
  
  0
  
  7:35 AM
  
  San Diego
  Old Town Transit Center
  
  7:10 AM
  
  St. Louis, MO
  Gateway Station
  
  0
  
  Economy
  
  $214
  
  A Bus from Busbud goes from Old Town Transit Center, San Diego (USA) at 12/8/2025 7:35:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/10/2025 7:10:00 AM. 50 Economy ticket for $214 per person are available. Travel duration is 45h 35m
- Busbud
  
  4h 45m
  
  0
  
  8:45 AM
  
  St. Louis, MO
  Gateway Station
  
  2:30 PM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $36
  
  A Bus from Busbud goes from Gateway Station, St. Louis, MO (USA) at 12/10/2025 8:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/10/2025 2:30:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 4h 45m
Travel Time is 0h 35m shorter, and you will save $40

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	52h 5m	12:15 PM	San Diego	Old Town Transit Center	7:20 PM	Indianapolis	Central Bus Station	Economy	$275	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/8/2025 12:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/10/2025 7:20:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 52h 5m
FlixBus	50h 10m	2:10 PM	San Diego	La Jolla Village	7:20 PM	Indianapolis	Central Bus Station	Economy	$275	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/8/2025 2:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/10/2025 7:20:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 50h 10m
FlixBus	54h 35m	1:45 PM	San Diego	Seaport Village	11:20 PM	Indianapolis	Washington / Delaware	Economy	$275	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/8/2025 1:45:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/10/2025 11:20:00 PM. 50 Economy ticket for $275 per person are available. Travel duration is 54h 35m
Greyhound US	49h 30m	10:00 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$277	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/8/2025 10:00:00 AM to Central Bus Station, Indianapolis (USA) arriving at 12/10/2025 2:30:00 PM. 50 Economy ticket for $277 per person are available. Travel duration is 49h 30m
Greyhound US	57h 50m	7:35 PM	San Diego	Old Town Transit Center	8:25 AM	Indianapolis	Washington / Delaware	Economy	$296	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/8/2025 7:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 12/11/2025 8:25:00 AM. 50 Economy ticket for $296 per person are available. Travel duration is 57h 50m

Did you know that if you travel from San Diego to Indianapolis via Phoenix, AZ, you can save more than $67? You can find the corresponding connections below.
- Busbud
  
  69h 45m
  
  0
  
  1:45 PM
  
  San Diego
  Seaport Village
  
  2:05 AM
  
  Phoenix, AZ
  Bus Station
  
  0
  
  Economy
  
  $52
  
  A Bus from Busbud goes from Seaport Village, San Diego (USA) at 12/9/2025 1:45:00 PM to Bus Station, Phoenix, AZ (USA) arriving at 12/10/2025 2:05:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 11h 20m
- FlixBus
  
  36h 45m
  
  0
  
  11:45 PM
  
  Phoenix, AZ
  Bus Station
  
  2:30 PM
  
  Indianapolis
  Central Bus Station
  
  0
  
  Economy
  
  $156
  
  A Bus from FlixBus goes from Bus Station, Phoenix, AZ (USA) at 12/10/2025 11:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 12/12/2025 2:30:00 PM. 50 Economy ticket for $156 per person are available. Travel duration is 36h 45m
Travel time is 17h 15m longer, but you will save $67

Best Price Offer: The price for the cheapest bus from San Diego to Indianapolis is $266 on 12/2/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Indianapolis

See here how frequent the connections between San Diego and Indianapolis are, during different times and days of the week.

Monday is the busiest day, with more than 18 daily buses from San Diego to Indianapolis. Monday has instead the fewest connections, with only 18 daily coaches between San Diego and Indianapolis.

The busiest time of the day is the Afternoon, with 30 buses from San Diego to Indianapolis, while Evening sees the fewest connections between San Diego and Indianapolis, with 6 offers.

Facts about the bus from San Diego to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 18 times every day by bus from San Diego to Indianapolis in one click! Book your bus ticket from San Diego to Indianapolis starting from $266!

Cheapest Bus	$266
Fastest Bus	52h 30m
Earliest Bus	7:35 AM
Latest Bus	7:35 PM
Daily Bus Routes	18 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Indianapolis

Every day, 18 buses from 2 bus companies leave San Diego for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$287

Saturday 12/06

$290

Sunday 12/07

Monday 12/08

$275

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from San Diego to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Indianapolis, for the next 30 days.

With a price starting from $275, Monday is the cheapest day for a bus from San Diego to Indianapolis. Saturday instead is the most expensive day with prices starting from $290.

Afternoon is the cheapest day time for bus tickets from San Diego to Indianapolis, with $275. Evening is the most expensive time of the day with prices starting from $296.

How to save money travelling from San Diego to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Indianapolis are also emptier.

All bus stations and stops in San Diego and Indianapolis

In the map below, you can see where to find all bus stations in San Diego and Indianapolis.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Central Bus Station

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

Service and Comfort on the bus from San Diego to Indianapolis

Want to know which seat classes are available on the buses from San Diego to Indianapolis? Or which bus companies serve the route San Diego to Indianapolis? Below you will find answers to your questions.

FAQs about the San Diego to Indianapolis bus

How much does a San Diego Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $266 and takes 57h 35m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Diego to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $266 and $324. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Diego to Indianapolis each day?

Every day, the San Diego to Indianapolis bus route is served by approximately 18 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Indianapolis take?

The fastest bus from San Diego to Indianapolis is offered by Greyhound US and takes 52h 30m. Bus tickets for this connection cost $293. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Indianapolis?

The earliest bus arriving in Indianapolis from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Indianapolis?

The latest bus trip departing from San Diego for Indianapolis starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Indianapolis route?

When traveling by bus from San Diego to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Indianapolis?

You can check all the direct connections between San Diego and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route San Diego to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Indianapolis

Here’s an overview of the most popular bus routes to San Diego and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!