Bus San Diego to Indianapolis: Compare prices and save money

Compare all timetables for the bus from San Diego to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Diego to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today

$185

tomorrow

$184

Thursday

$179

Friday

$152

Saturday

$135

Sunday

$141

Monday

$175

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$185	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/3/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/5/2026 2:30:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 49h 40m
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$188	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/3/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/5/2026 7:30:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 51h 20m
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$188	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/3/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/5/2026 7:30:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 52h 45m
FlixBus	55h 5m	9:25 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$189	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/3/2026 9:25:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/5/2026 7:30:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 55h 5m
Greyhound US	56h 30m	11:45 AM	San Diego	Old Town Transit Center	11:15 PM	Indianapolis	Washington / Delaware	Economy	$189	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/3/2026 11:45:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 11/5/2026 11:15:00 PM. 50 Economy ticket for $189 per person are available. Travel duration is 56h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$184	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/4/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/6/2026 2:30:00 PM. 50 Economy ticket for $184 per person are available. Travel duration is 49h 40m
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$185	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/4/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/6/2026 7:30:00 PM. 50 Economy ticket for $185 per person are available. Travel duration is 52h 45m
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$187	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/4/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/6/2026 7:30:00 PM. 50 Economy ticket for $187 per person are available. Travel duration is 51h 20m
FlixBus	65h 55m	10:35 PM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$188	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/4/2026 10:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/7/2026 7:30:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 65h 55m
FlixBus	66h 15m	10:15 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$188	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/4/2026 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/7/2026 7:30:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 66h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$179	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/5/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/7/2026 2:30:00 PM. 50 Economy ticket for $179 per person are available. Travel duration is 49h 40m
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$180	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/5/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/7/2026 7:30:00 PM. 50 Economy ticket for $180 per person are available. Travel duration is 51h 20m
FlixBus	55h 5m	9:25 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$181	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/5/2026 9:25:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/7/2026 7:30:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 55h 5m
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$182	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/5/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/7/2026 7:30:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 52h 45m
FlixBus	66h 15m	10:15 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$188	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/5/2026 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/8/2026 7:30:00 PM. 50 Economy ticket for $188 per person are available. Travel duration is 66h 15m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$152	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/6/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/8/2026 7:30:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 51h 20m
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$153	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/6/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/8/2026 7:30:00 PM. 50 Economy ticket for $153 per person are available. Travel duration is 52h 45m
FlixBus	55h 5m	9:25 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$154	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/6/2026 9:25:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/8/2026 7:30:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 55h 5m
FlixBus	65h 55m	10:35 PM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$160	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/6/2026 10:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/9/2026 7:30:00 PM. 50 Economy ticket for $160 per person are available. Travel duration is 65h 55m
Greyhound US	54h 10m	7:45 PM	San Diego	Old Town Transit Center	4:55 AM	Indianapolis	Central Bus Station	Economy	$166	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/6/2026 7:45:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/9/2026 4:55:00 AM. 50 Economy ticket for $166 per person are available. Travel duration is 54h 10m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$135	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/7/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/9/2026 7:30:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 52h 45m
FlixBus	65h 55m	10:35 PM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$136	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/7/2026 10:35:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/10/2026 7:30:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 65h 55m
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$136	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/7/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/9/2026 7:30:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 51h 20m
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$136	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/7/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/9/2026 2:30:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 49h 40m
FlixBus	66h 15m	10:15 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$137	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/7/2026 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/10/2026 7:30:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 66h 15m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$141	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/8/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/10/2026 7:30:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 51h 20m
Greyhound US	49h 40m	9:50 AM	San Diego	Old Town Transit Center	2:30 PM	Indianapolis	Central Bus Station	Economy	$141	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/8/2026 9:50:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/10/2026 2:30:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 49h 40m
FlixBus	55h 5m	9:25 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$142	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 11/8/2026 9:25:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/10/2026 7:30:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 55h 5m
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$143	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/8/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/10/2026 7:30:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 52h 45m
FlixBus	66h 15m	10:15 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$144	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/8/2026 10:15:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/11/2026 7:30:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 66h 15m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	55h 30m	1:35 PM	San Diego	La Jolla Village	12:05 AM	Indianapolis	Washington / Delaware	Economy	$175	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 11/9/2026 1:35:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 11/12/2026 12:05:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 55h 30m
FlixBus	55h 55m	1:10 PM	San Diego	Seaport Village	12:05 AM	Indianapolis	Washington / Delaware	Economy	$176	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/9/2026 1:10:00 PM to Washington / Delaware, Indianapolis (USA) arriving at 11/12/2026 12:05:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 55h 55m
FlixBus	51h 20m	1:10 PM	San Diego	Seaport Village	7:30 PM	Indianapolis	Central Bus Station	Economy	$176	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 11/9/2026 1:10:00 PM to Central Bus Station, Indianapolis (USA) arriving at 11/11/2026 7:30:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 51h 20m
Greyhound US	52h 45m	11:45 AM	San Diego	Old Town Transit Center	7:30 PM	Indianapolis	Central Bus Station	Economy	$176	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/9/2026 11:45:00 AM to Central Bus Station, Indianapolis (USA) arriving at 11/11/2026 7:30:00 PM. 50 Economy ticket for $176 per person are available. Travel duration is 52h 45m
Greyhound US	57h 20m	11:45 AM	San Diego	Old Town Transit Center	12:05 AM	Indianapolis	Washington / Delaware	Economy	$177	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 11/9/2026 11:45:00 AM to Washington / Delaware, Indianapolis (USA) arriving at 11/12/2026 12:05:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 57h 20m

Best Price Offer: The price for the cheapest bus from San Diego to Indianapolis is $135 on 11/7/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Indianapolis

See here how frequent the connections between San Diego and Indianapolis are, during different times and days of the week.

Wednesday is the busiest day, with more than 25 daily buses from San Diego to Indianapolis. Thursday has instead the fewest connections, with only 7 daily coaches between San Diego and Indianapolis.

The busiest time of the day is the Evening, with 50 buses from San Diego to Indianapolis, while Afternoon sees the fewest connections between San Diego and Indianapolis, with 20 offers.

Facts about the bus from San Diego to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 15 times every day by bus from San Diego to Indianapolis in one click! Book your bus ticket from San Diego to Indianapolis starting from $135!

Cheapest Bus	$135
Fastest Bus	52h 40m
Earliest Bus	9:25 AM
Latest Bus	10:55 PM
Daily Bus Routes	15 Ø
Distance	1,785.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Indianapolis

Every day, 15 buses from 2 bus companies leave San Diego for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 11/03/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/01

Monday 11/02

Tuesday 11/03

$189

Wednesday 11/04

$184

Thursday 11/05

$179

Friday 11/06

$152

Saturday 11/07

$135

Sunday 11/08

$141

Monday 11/09

$175

Tuesday 11/10

Wednesday 11/11

$167

Thursday 11/12

$154

Friday 11/13

Saturday 11/14

$150

Sunday 11/15

Monday 11/16

$179

Tuesday 11/17

$167

Wednesday 11/18

$164

Thursday 11/19

$223

Friday 11/20

$257

Saturday 11/21

$272

Sunday 11/22

Monday 11/23

$313

Tuesday 11/24

$228

Wednesday 11/25

$206

Thursday 11/26

$239

Friday 11/27

Saturday 11/28

The cheapest time to travel from San Diego to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Indianapolis, for the next 30 days.

With a price starting from $135, Saturday is the cheapest day for a bus from San Diego to Indianapolis. Monday instead is the most expensive day with prices starting from $175.

Morning is the cheapest day time for bus tickets from San Diego to Indianapolis, with $135. Evening is the most expensive time of the day with prices starting from $136.

How to save money travelling from San Diego to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Indianapolis are also emptier.

All bus stations and stops in San Diego and Indianapolis

In the map below, you can see where to find all bus stations in San Diego and Indianapolis.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Seaport Village

W Harbor Dr 789

Santa Fe Depot

Kettner Blvd 1050

Downtown

Mile Square

Monument Circle 2250

Washington / Delaware

E Washington St between N Delaware St and N Alabama St

Greyhound Bus Station

S Illinois St 350

S Keystone Avenue

S Keystone Avenue 3649

BP Gas Station 70/91

N Post Rd 2102

Service and Comfort on the bus from San Diego to Indianapolis

Want to know which seat classes are available on the buses from San Diego to Indianapolis? Or which bus companies serve the route San Diego to Indianapolis? Below you will find answers to your questions.

FAQs about the San Diego to Indianapolis bus

How much does a San Diego Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $135 and takes 55h 45m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Diego to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $135 and $208. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Diego to Indianapolis each day?

Every day, the San Diego to Indianapolis bus route is served by approximately 15 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Indianapolis take?

The fastest bus from San Diego to Indianapolis is offered by Greyhound US and takes 52h 40m. Bus tickets for this connection cost $185. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Indianapolis?

The earliest bus arriving in Indianapolis from San Diego starts at 9:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Indianapolis?

The latest bus trip departing from San Diego for Indianapolis starts at 10:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Indianapolis route?

When traveling by bus from San Diego to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Indianapolis?

You can check all the direct connections between San Diego and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Indianapolis on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Indianapolis?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 15 daily trips between San Diego and Indianapolis. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Indianapolis?

Prices and availability for 15 trips between San Diego and Indianapolis change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Indianapolis

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Indianapolis

Here’s an overview of the most popular bus routes to San Diego and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!