Bus from San Diego to Indianapolis from $275

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Compare all timetables for the bus from San Diego to Indianapolis

Here is a selection of the cheapest bus trips from the schedule from San Diego to Indianapolis from various bus operators like FlixBus or Greyhound US for the next days.

today
$305
tomorrow
Monday
$313
Tuesday
Wednesday
Thursday
$361
Friday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 56h 5m 12:15 PM San Diego Old Town Transit Center 11:20 PM Indianapolis Washington / Delaware  Economy $305
FlixBus 50h 10m 2:10 PM San Diego La Jolla Village 7:20 PM Indianapolis Central Bus Station  Economy $307
FlixBus 50h 35m 1:45 PM San Diego Seaport Village 7:20 PM Indianapolis Central Bus Station  Economy $307
Greyhound US 56h 25m 10:00 AM San Diego Old Town Transit Center 9:25 PM Indianapolis Washington / Delaware  Economy $308
Greyhound US 49h 30m 10:00 AM San Diego Old Town Transit Center 2:30 PM Indianapolis Central Bus Station  Economy $318

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 51h 55m 7:35 AM San Diego Old Town Transit Center 2:30 PM Indianapolis Central Bus Station  Economy $313
FlixBus 51h 35m 7:55 AM San Diego La Jolla Village 2:30 PM Indianapolis Central Bus Station  Economy $313
FlixBus 56h 5m 12:15 PM San Diego Old Town Transit Center 11:20 PM Indianapolis Washington / Delaware  Economy $316
Greyhound US 49h 30m 10:00 AM San Diego Old Town Transit Center 2:30 PM Indianapolis Central Bus Station  Economy $319
Greyhound US 54h 10m 7:35 PM San Diego Old Town Transit Center 4:45 AM Indianapolis Central Bus Station  Economy $327
  • Did you know that if you travel from San Diego to Indianapolis via St. Louis, MO, you can save more than $73? You can find the corresponding connections below.
    • FlixBus
      62h 40m
      0
      1:45 PM
      San Diego
      Seaport Village
      12:55 PM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $199
      • Waiting Time 13h 5m
    • FlixBus
      4h 25m
      0
      2:00 AM
      St. Louis, MO
      Gateway Station
      7:25 AM
      Indianapolis
      Central Bus Station
      0
      FlixBus
      Economy
      $41
    Travel time is 10h 10m longer, but you will save $73

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 58h 55m 9:25 AM San Diego Old Town Transit Center 11:20 PM Indianapolis Washington / Delaware  Economy $361
FlixBus 54h 35m 1:45 PM San Diego Seaport Village 11:20 PM Indianapolis Washington / Delaware  Economy $361
FlixBus 54h 10m 2:10 PM San Diego La Jolla Village 11:20 PM Indianapolis Washington / Delaware  Economy $363
Greyhound US 54h 10m 7:35 PM San Diego Old Town Transit Center 4:45 AM Indianapolis Central Bus Station  Economy $419
Greyhound US 57h 50m 7:35 PM San Diego Old Town Transit Center 8:25 AM Indianapolis Washington / Delaware  Economy $424
  • Did you know that if you travel from San Diego to Indianapolis via St. Louis, MO, you can save more than $121? You can find the corresponding connections below.
    • FlixBus
      62h 40m
      0
      1:45 PM
      San Diego
      Seaport Village
      12:55 PM
      St. Louis, MO
      Gateway Station
      0
      FlixBus
      Economy
      $199
      • Waiting Time 13h 5m
    • FlixBus
      4h 25m
      0
      2:00 AM
      St. Louis, MO
      Gateway Station
      7:25 AM
      Indianapolis
      Central Bus Station
      0
      FlixBus
      Economy
      $41
    Travel time is 5h 30m longer, but you will save $121

Best Price Offer: The price for the cheapest bus from San Diego to Indianapolis is $275 on 12/8/2025. Flexible travelers save on ticket prices.


Frequency of bus connections between San Diego and Indianapolis

See here how frequent the connections between San Diego and Indianapolis are, during different times and days of the week.
Monday is the busiest day, with more than 18 daily buses from San Diego to Indianapolis. Monday has instead the fewest connections, with only 18 daily coaches between San Diego and Indianapolis.
The busiest time of the day is the Afternoon, with 28 buses from San Diego to Indianapolis, while Evening sees the fewest connections between San Diego and Indianapolis, with 6 offers.

Facts about the bus from San Diego to Indianapolis

Compare all providers like FlixBus and Greyhound US that travel 18 times every day by bus from San Diego to Indianapolis in one click! Book your bus ticket from San Diego to Indianapolis starting from $275!

Cheapest Bus $275
Fastest Bus 52h 30m
Earliest Bus 7:35 AM
Latest Bus 7:35 PM
Daily Bus Routes 18 Ø
Distance 1,785.2 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from San Diego to Indianapolis

Every day, 18 buses from 2 bus companies leave San Diego for Indianapolis: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/13/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 12/07
Monday 12/08
Tuesday 12/09
Wednesday 12/10
Thursday 12/11
Friday 12/12
Saturday 12/13
$305
Sunday 12/14
Monday 12/15
$313
Tuesday 12/16
Wednesday 12/17
Thursday 12/18
$361
Friday 12/19
Saturday 12/20
Sunday 12/21
Monday 12/22
Tuesday 12/23
Wednesday 12/24
Thursday 12/25
Friday 12/26
Saturday 12/27
Sunday 12/28
Monday 12/29
Tuesday 12/30
Wednesday 12/31
Thursday 01/01
Friday 01/02
Saturday 01/03

The cheapest time to travel from San Diego to Indianapolis

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Indianapolis, for the next 30 days.
With a price starting from $305, Saturday is the cheapest day for a bus from San Diego to Indianapolis. Thursday instead is the most expensive day with prices starting from $361.
Afternoon is the cheapest day time for bus tickets from San Diego to Indianapolis, with $305. Evening is the most expensive time of the day with prices starting from $327.

How to save money travelling from San Diego to Indianapolis

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Indianapolis in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Indianapolis, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Indianapolis are also emptier.

All bus stations and stops in San Diego and Indianapolis

In the map below, you can see where to find all bus stations in San Diego and Indianapolis.

Service and Comfort on the bus from San Diego to Indianapolis

Want to know which seat classes are available on the buses from San Diego to Indianapolis? Or which bus companies serve the route San Diego to Indianapolis? Below you will find answers to your questions.

FAQs about the San Diego to Indianapolis bus

How much does a San Diego Indianapolis bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $275 and takes 59h 5m to reach Indianapolis. Compare offers to save money!

How much could I save by comparing buses from San Diego to Indianapolis?

This route is offered by 2 companies with a range of ticket prices between $275 and $463. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Indianapolis.

On average, how many connections are available from San Diego to Indianapolis each day?

Every day, the San Diego to Indianapolis bus route is served by approximately 18 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Indianapolis take?

The fastest bus from San Diego to Indianapolis is offered by Greyhound US and takes 52h 30m. Bus tickets for this connection cost $318. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Indianapolis?

The earliest bus arriving in Indianapolis from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Indianapolis?

The latest bus trip departing from San Diego for Indianapolis starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Indianapolis route?

When traveling by bus from San Diego to Indianapolis, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Indianapolis?

You can check all the direct connections between San Diego and Indianapolis by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Indianapolis bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Indianapolis bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Indianapolis bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Indianapolis on your planned travel date.

Available seat classes which are offered on the bus route San Diego to Indianapolis

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Indianapolis

Here’s an overview of the most popular bus routes to San Diego and to Indianapolis. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses to San Diego from New York Buses to San Diego from New York
From Dallas to San Diego bus From Dallas to San Diego bus
From Fresno, CA to San Diego bus From Fresno, CA to San Diego bus
Buses Los Angeles to San Diego Buses Los Angeles to San Diego
Bus Dallas to Indianapolis Bus Dallas to Indianapolis
Buses from Boston, MA to Indianapolis Buses from Boston, MA to Indianapolis
Buses from Philadelphia to Indianapolis Buses from Philadelphia to Indianapolis
Bus Knoxville, TN to Indianapolis Bus Knoxville, TN to Indianapolis
Popular Airport Shuttles to San Diego and to Indianapolis
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