Bus San Antonio, TX to Tupelo, MS - Compare all Companies

Compare all timetables for the bus from San Antonio, TX to Tupelo, MS

Here is a selection of the cheapest bus trips from the schedule from San Antonio, TX to Tupelo, MS from various bus operators like Greyhound Lines Mexico, FlixBus or Greyhound US for the next days.

today

tomorrow

Monday

$110

Tuesday

$130

Wednesday

Thursday

Friday

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	26h 35m	7:00 PM	San Antonio, TX	Bus Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$110	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/22/2026 7:00:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/23/2026 9:35:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 26h 35m
Greyhound US	22h 5m	12:35 PM	San Antonio, TX	Bus Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$110	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/22/2026 12:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/23/2026 10:40:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 22h 5m
FlixBus	25h 10m	9:55 PM	San Antonio, TX	Bus Station	11:05 PM	Tupelo, MS	Bus Stop	Economy	$110	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 6/22/2026 9:55:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/23/2026 11:05:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 25h 10m
FlixBus	26h 55m	7:45 AM	San Antonio, TX	Pearl District	10:40 AM	Tupelo, MS	Bus Stop	Economy	$110	A Bus from FlixBus goes from Pearl District, San Antonio, TX (USA) at 6/22/2026 7:45:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/23/2026 10:40:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 26h 55m
Greyhound Lines Mexico	21h 35m	1:30 AM	San Antonio, TX	Bus Station	11:05 PM	Tupelo, MS	Bus Stop	Economy	$152	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/22/2026 1:30:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/22/2026 11:05:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 21h 35m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound Lines Mexico	21h 35m	1:30 AM	San Antonio, TX	Bus Station	11:05 PM	Tupelo, MS	Bus Stop	Economy	$130	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/23/2026 1:30:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/23/2026 11:05:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 21h 35m
Greyhound US	22h 5m	12:35 PM	San Antonio, TX	Bus Station	10:40 AM	Tupelo, MS	Bus Stop	Economy	$130	A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/23/2026 12:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 10:40:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 22h 5m
FlixBus	25h 10m	9:55 PM	San Antonio, TX	Bus Station	11:05 PM	Tupelo, MS	Bus Stop	Economy	$130	A Bus from FlixBus goes from Bus Station, San Antonio, TX (USA) at 6/23/2026 9:55:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 11:05:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 25h 10m
Greyhound Lines Mexico	26h 35m	7:00 PM	San Antonio, TX	Bus Station	9:35 PM	Tupelo, MS	Bus Stop	Economy	$131	A Bus from Greyhound Lines Mexico goes from Bus Station, San Antonio, TX (USA) at 6/23/2026 7:00:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 6/24/2026 9:35:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 26h 35m

Did you know that if you travel from San Antonio, TX to Tupelo, MS via Memphis, you can save more than $26? You can find the corresponding connections below.
- Greyhound US
  
  22h 5m
  
  0
  
  12:35 PM
  
  San Antonio, TX
  Bus Station
  
  3:45 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $87
  
  A Bus from Greyhound US goes from Bus Station, San Antonio, TX (USA) at 6/22/2026 12:35:00 PM to Airways Transit Center, Memphis (USA) arriving at 6/23/2026 3:45:00 AM. 50 Economy ticket for $87 per person are available. Travel duration is 15h 10m
- Greyhound US
  
  1h 40m
  
  0
  
  9:00 AM
  
  Memphis
  Airways Transit Center
  
  10:40 AM
  
  Tupelo, MS
  Bus Stop
  
  0
  
  Economy
  
  $17
  
  A Bus from Greyhound US goes from Airways Transit Center, Memphis (USA) at 6/23/2026 9:00:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 6/23/2026 10:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 1h 40m
Travel time is 0h 30m longer, but you will save $26

Best Price Offer: The price for the cheapest bus from San Antonio, TX to Tupelo, MS is $100 on 6/19/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Antonio, TX and Tupelo, MS

See here how frequent the connections between San Antonio, TX and Tupelo, MS are, during different times and days of the week.

Monday is the busiest day, with more than 5 daily buses from San Antonio, TX to Tupelo, MS. Tuesday has instead the fewest connections, with only 4 daily coaches between San Antonio, TX and Tupelo, MS.

The busiest time of the day is the Evening, with 4 buses from San Antonio, TX to Tupelo, MS, while Morning sees the fewest connections between San Antonio, TX and Tupelo, MS, with 1 offers.

Facts about the bus from San Antonio, TX to Tupelo, MS

Compare all providers like Greyhound Lines Mexico, FlixBus and Greyhound US that travel 4 times every day by bus from San Antonio, TX to Tupelo, MS in one click! Book your bus ticket from San Antonio, TX to Tupelo, MS starting from $100!

Cheapest Bus	$100
Fastest Bus	21h 35m
Earliest Bus	1:30 AM
Latest Bus	9:55 PM
Daily Bus Routes	4 Ø
Distance	663.8 miles
Bus Companies	Greyhound Lines Mexico, FlixBus and Greyhound US

Cheapest bus connections from San Antonio, TX to Tupelo, MS

Every day, 4 buses from 3 bus companies leave San Antonio, TX for Tupelo, MS: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

Wednesday 06/17

Thursday 06/18

Friday 06/19

Saturday 06/20

Sunday 06/21

Monday 06/22

$110

Tuesday 06/23

$130

Wednesday 06/24

Thursday 06/25

Friday 06/26

Saturday 06/27

Sunday 06/28

$109

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

Saturday 07/11

The cheapest time to travel from San Antonio, TX to Tupelo, MS

See here on which day and which time of the day you can find the cheapest bus ticket from San Antonio, TX to Tupelo, MS, for the next 30 days.

With a price starting from $106, Monday is the cheapest day for a bus from San Antonio, TX to Tupelo, MS. Tuesday instead is the most expensive day with prices starting from $130.

Night is the cheapest day time for bus tickets from San Antonio, TX to Tupelo, MS, with $97. Afternoon is the most expensive time of the day with prices starting from $110.

How to save money travelling from San Antonio, TX to Tupelo, MS

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Antonio, TX to Tupelo, MS in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Antonio, TX to Tupelo, MS, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Antonio, TX to Tupelo, MS are also emptier.

All bus stations and stops in San Antonio, TX and Tupelo, MS

In the map below, you can see where to find all bus stations in San Antonio, TX and Tupelo, MS.

Bus Station

N St Mary's St 500

San Antonio

Pearl District

Avenue A 699-599

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

Bus Stop

S Eason Blvd 2831

Service and Comfort on the bus from San Antonio, TX to Tupelo, MS

Want to know which seat classes are available on the buses from San Antonio, TX to Tupelo, MS? Or which bus companies serve the route San Antonio, TX to Tupelo, MS? Below you will find answers to your questions.

FAQs about the San Antonio, TX to Tupelo, MS bus

How much does a San Antonio, TX Tupelo, MS bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $100 and takes 26h 55m to reach Tupelo, MS. Compare offers to save money!

How much could I save by comparing buses from San Antonio, TX to Tupelo, MS?

This route is offered by 3 companies with a range of ticket prices between $100 and $152. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Tupelo, MS.

On average, how many connections are available from San Antonio, TX to Tupelo, MS each day?

Every day, the San Antonio, TX to Tupelo, MS bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Antonio, TX to Tupelo, MS take?

The fastest bus from San Antonio, TX to Tupelo, MS is offered by Greyhound Lines Mexico and takes 21h 35m. Bus tickets for this connection cost $152. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Antonio, TX to Tupelo, MS?

The earliest bus arriving in Tupelo, MS from San Antonio, TX starts at 1:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Antonio, TX to Tupelo, MS?

The latest bus trip departing from San Antonio, TX for Tupelo, MS starts at 9:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Antonio, TX Tupelo, MS route?

When traveling by bus from San Antonio, TX to Tupelo, MS, passengers can travel with Greyhound Lines Mexico, FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Antonio, TX and Tupelo, MS?

You can check all the direct connections between San Antonio, TX and Tupelo, MS by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound Lines Mexico, FlixBus and Greyhound US.

What can I take with me on the San Antonio, TX to Tupelo, MS bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Antonio, TX Tupelo, MS bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Antonio, TX Tupelo, MS bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Antonio, TX to Tupelo, MS on your planned travel date.

How does CheckMyBus find the best bus deals from San Antonio, TX to Tupelo, MS?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between San Antonio, TX and Tupelo, MS. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Antonio, TX to Tupelo, MS?

Prices and availability for 4 trips between San Antonio, TX and Tupelo, MS change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Antonio, TX to Tupelo, MS

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Antonio, TX and to Tupelo, MS

Here’s an overview of the most popular bus routes to San Antonio, TX and to Tupelo, MS. Simply click on the connection of your choice, and you will find all the details about your bus route!