Bus Florence, SC to Syracuse, NY - Compare all Companies

Compare all timetables for the bus from Florence, SC to Syracuse, NY

Here is a selection of the cheapest bus trips from the schedule from Florence, SC to Syracuse, NY from various bus operators like Greyhound US or FlixBus for the next days.

today

$101

tomorrow

Wednesday

$105

Thursday

$108

Friday

Saturday

Sunday

$104

Cheapest bus trips today
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 5m	4:30 PM	Florence, SC	Bus Station	1:35 PM	Syracuse, NY	Regional Transit Center		Economy	$101	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/20/2026 4:30:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/21/2026 1:35:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 21h 5m

Cheapest bus trips Wednesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 5m	4:30 PM	Florence, SC	Bus Station	1:35 PM	Syracuse, NY	Regional Transit Center		Economy	$105	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/22/2026 4:30:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/23/2026 1:35:00 PM. 50 Economy ticket for $105 per person are available. Travel duration is 21h 5m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 5m	4:30 PM	Florence, SC	Bus Station	1:35 PM	Syracuse, NY	Regional Transit Center		Economy	$108	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/23/2026 4:30:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/24/2026 1:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 21h 5m
	FlixBus	33h 30m	5:45 AM	Florence, SC	TA Travel Center	3:15 PM	Syracuse, NY	Regional Transit Center		Economy	$139	A Bus from FlixBus goes from TA Travel Center, Florence, SC (USA) at 4/23/2026 5:45:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/24/2026 3:15:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 33h 30m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 5m	4:30 PM	Florence, SC	Bus Station	1:35 PM	Syracuse, NY	Regional Transit Center		Economy	$104	A Bus from Greyhound US goes from Bus Station, Florence, SC (USA) at 4/26/2026 4:30:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/27/2026 1:35:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 21h 5m

Best Price Offer: The price for the cheapest bus from Florence, SC to Syracuse, NY is $101 on 4/20/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Florence, SC and Syracuse, NY

See here how frequent the connections between Florence, SC and Syracuse, NY are, during different times and days of the week.

Thursday is the busiest day, with more than 2 daily buses from Florence, SC to Syracuse, NY. Sunday has instead the fewest connections, with only 1 daily coaches between Florence, SC and Syracuse, NY.

The busiest time of the day is the Afternoon, with 4 buses from Florence, SC to Syracuse, NY, while Night sees the fewest connections between Florence, SC and Syracuse, NY, with 1 offers.

Facts about the bus from Florence, SC to Syracuse, NY

Compare all providers like Greyhound US and FlixBus that travel 1 times every day by bus from Florence, SC to Syracuse, NY in one click! Book your bus ticket from Florence, SC to Syracuse, NY starting from $101!

Cheapest Bus	$101
Fastest Bus	21h 5m
Earliest Bus	4:30 PM
Latest Bus	4:30 PM
Daily Bus Routes	1 Ø
Distance	642.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Florence, SC to Syracuse, NY

Every day, 1 buses from 2 bus companies leave Florence, SC for Syracuse, NY: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$101

Tuesday 04/21

Wednesday 04/22

$105

Thursday 04/23

$108

Friday 04/24

Saturday 04/25

Sunday 04/26

$104

Monday 04/27

Tuesday 04/28

$103

Wednesday 04/29

Thursday 04/30

Friday 05/01

$121

Saturday 05/02

Sunday 05/03

$108

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

Saturday 05/09

Sunday 05/10

$111

Monday 05/11

$113

Tuesday 05/12

$104

Wednesday 05/13

Thursday 05/14

$103

Friday 05/15

Saturday 05/16

The cheapest time to travel from Florence, SC to Syracuse, NY

See here on which day and which time of the day you can find the cheapest bus ticket from Florence, SC to Syracuse, NY, for the next 30 days.

With a price starting from $100, Monday is the cheapest day for a bus from Florence, SC to Syracuse, NY. Wednesday instead is the most expensive day with prices starting from $104.

Afternoon is the cheapest day time for bus tickets from Florence, SC to Syracuse, NY, with $101. Afternoon is the most expensive time of the day with prices starting from $101.

How to save money travelling from Florence, SC to Syracuse, NY

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Florence, SC to Syracuse, NY in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Florence, SC to Syracuse, NY, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Florence, SC to Syracuse, NY are also emptier.

All bus stations and stops in Florence, SC and Syracuse, NY

In the map below, you can see where to find all bus stations in Florence, SC and Syracuse, NY.

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

University

University Pi 303

Regional Transit Center

Walsh Cir 1

S State St & E Genesee St

Destiny USA

Destiny USA Dr 9090

New York State Fairgrounds

State Fair Blvd 581

Service and Comfort on the bus from Florence, SC to Syracuse, NY

Want to know which seat classes are available on the buses from Florence, SC to Syracuse, NY? Or which bus companies serve the route Florence, SC to Syracuse, NY? Below you will find answers to your questions.

FAQs about the Florence, SC to Syracuse, NY bus

How much does a Florence, SC Syracuse, NY bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $101 and takes 21h 5m to reach Syracuse, NY. Compare offers to save money!

How much could I save by comparing buses from Florence, SC to Syracuse, NY?

This route is offered by 2 companies with a range of ticket prices between $101 and $139. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Syracuse, NY.

On average, how many connections are available from Florence, SC to Syracuse, NY each day?

Every day, the Florence, SC to Syracuse, NY bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Florence, SC to Syracuse, NY take?

The fastest bus from Florence, SC to Syracuse, NY is offered by Greyhound US and takes 21h 5m. Bus tickets for this connection cost $101. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Florence, SC to Syracuse, NY?

The earliest bus arriving in Syracuse, NY from Florence, SC starts at 4:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Florence, SC to Syracuse, NY?

The latest bus trip departing from Florence, SC for Syracuse, NY starts at 4:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Florence, SC Syracuse, NY route?

When traveling by bus from Florence, SC to Syracuse, NY, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Florence, SC and Syracuse, NY?

You can check all the direct connections between Florence, SC and Syracuse, NY by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Florence, SC to Syracuse, NY bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Florence, SC Syracuse, NY bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Florence, SC Syracuse, NY bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Florence, SC to Syracuse, NY on your planned travel date.

How does CheckMyBus find the best bus deals from Florence, SC to Syracuse, NY?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Florence, SC and Syracuse, NY. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Florence, SC to Syracuse, NY?

Prices and availability for 1 trips between Florence, SC and Syracuse, NY change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Florence, SC to Syracuse, NY

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Florence, SC and to Syracuse, NY

Here’s an overview of the most popular bus routes to Florence, SC and to Syracuse, NY. Simply click on the connection of your choice, and you will find all the details about your bus route!