Bus Madison, WI to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Madison, WI to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Madison, WI to Florence, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$131

Tuesday

$127

Wednesday

Thursday

$134

Friday

$135

Saturday

$127

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	29h 30m	7:00 AM	Madison, WI	W Transfer Point	1:30 PM	Florence, SC	Bus Station	Economy	$131	A Bus from FlixBus goes from W Transfer Point, Madison, WI (USA) at 7/20/2026 7:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/21/2026 1:30:00 PM. 50 Economy ticket for $131 per person are available. Travel duration is 29h 30m
FlixBus	29h 45m	6:45 AM	Madison, WI	University Wisconsin-Madison	1:30 PM	Florence, SC	Bus Station	Economy	$132	A Bus from FlixBus goes from University Wisconsin-Madison, Madison, WI (USA) at 7/20/2026 6:45:00 AM to Bus Station, Florence, SC (USA) arriving at 7/21/2026 1:30:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 29h 45m
FlixBus	39h 0m	1:45 PM	Madison, WI	W Transfer Point	5:45 AM	Florence, SC	TA Travel Center	Economy	$169	A Bus from FlixBus goes from W Transfer Point, Madison, WI (USA) at 7/20/2026 1:45:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/22/2026 5:45:00 AM. 50 Economy ticket for $169 per person are available. Travel duration is 39h 0m
Greyhound US	38h 10m	6:00 PM	Madison, WI	University Wisconsin-Madison	9:10 AM	Florence, SC	Bus Station	Economy	$223	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/20/2026 6:00:00 PM to Bus Station, Florence, SC (USA) arriving at 7/22/2026 9:10:00 AM. 50 Economy ticket for $223 per person are available. Travel duration is 38h 10m
Greyhound US	34h 45m	6:00 PM	Madison, WI	University Wisconsin-Madison	5:45 AM	Florence, SC	TA Travel Center	Economy	$248	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/20/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/22/2026 5:45:00 AM. 50 Economy ticket for $248 per person are available. Travel duration is 34h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	29h 30m	7:00 AM	Madison, WI	Dutch Mill Park & Ride	1:30 PM	Florence, SC	Bus Station	Economy	$127	A Bus from FlixBus goes from Dutch Mill Park & Ride, Madison, WI (USA) at 7/21/2026 7:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/22/2026 1:30:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 29h 30m
FlixBus	29h 45m	6:45 AM	Madison, WI	Chazen Museum	1:30 PM	Florence, SC	Bus Station	Economy	$128	A Bus from FlixBus goes from Chazen Museum, Madison, WI (USA) at 7/21/2026 6:45:00 AM to Bus Station, Florence, SC (USA) arriving at 7/22/2026 1:30:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 29h 45m
FlixBus	33h 40m	1:25 PM	Madison, WI	University Wisconsin-Madison	12:05 AM	Florence, SC	TA Travel Center	Economy	$130	A Bus from FlixBus goes from University Wisconsin-Madison, Madison, WI (USA) at 7/21/2026 1:25:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/23/2026 12:05:00 AM. 50 Economy ticket for $130 per person are available. Travel duration is 33h 40m
Greyhound US	38h 10m	6:00 PM	Madison, WI	Chazen Museum	9:10 AM	Florence, SC	Bus Station	Economy	$223	A Bus from Greyhound US goes from Chazen Museum, Madison, WI (USA) at 7/21/2026 6:00:00 PM to Bus Station, Florence, SC (USA) arriving at 7/23/2026 9:10:00 AM. 50 Economy ticket for $223 per person are available. Travel duration is 38h 10m
Greyhound US	34h 45m	6:00 PM	Madison, WI	University Wisconsin-Madison	5:45 AM	Florence, SC	TA Travel Center	Economy	$234	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/21/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/23/2026 5:45:00 AM. 50 Economy ticket for $234 per person are available. Travel duration is 34h 45m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	40h 20m	6:45 AM	Madison, WI	University Wisconsin-Madison	12:05 AM	Florence, SC	TA Travel Center	Economy	$134	A Bus from FlixBus goes from University Wisconsin-Madison, Madison, WI (USA) at 7/23/2026 6:45:00 AM to TA Travel Center, Florence, SC (USA) arriving at 7/25/2026 12:05:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 40h 20m
FlixBus	40h 5m	7:00 AM	Madison, WI	W Transfer Point	12:05 AM	Florence, SC	TA Travel Center	Economy	$134	A Bus from FlixBus goes from W Transfer Point, Madison, WI (USA) at 7/23/2026 7:00:00 AM to TA Travel Center, Florence, SC (USA) arriving at 7/25/2026 12:05:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 40h 5m
FlixBus	29h 30m	7:00 AM	Madison, WI	W Transfer Point	1:30 PM	Florence, SC	Bus Station	Economy	$134	A Bus from FlixBus goes from W Transfer Point, Madison, WI (USA) at 7/23/2026 7:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/24/2026 1:30:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 29h 30m
Greyhound US	38h 10m	6:00 PM	Madison, WI	University Wisconsin-Madison	9:10 AM	Florence, SC	Bus Station	Economy	$230	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/23/2026 6:00:00 PM to Bus Station, Florence, SC (USA) arriving at 7/25/2026 9:10:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 38h 10m
Greyhound US	34h 45m	6:00 PM	Madison, WI	University Wisconsin-Madison	5:45 AM	Florence, SC	TA Travel Center	Economy	$245	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/23/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/25/2026 5:45:00 AM. 50 Economy ticket for $245 per person are available. Travel duration is 34h 45m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	33h 40m	1:25 PM	Madison, WI	University Wisconsin-Madison	12:05 AM	Florence, SC	TA Travel Center	Economy	$135	A Bus from FlixBus goes from University Wisconsin-Madison, Madison, WI (USA) at 7/24/2026 1:25:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/26/2026 12:05:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 33h 40m
FlixBus	33h 20m	1:45 PM	Madison, WI	W Transfer Point	12:05 AM	Florence, SC	TA Travel Center	Economy	$135	A Bus from FlixBus goes from W Transfer Point, Madison, WI (USA) at 7/24/2026 1:45:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/26/2026 12:05:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 33h 20m
FlixBus	29h 45m	6:45 AM	Madison, WI	University Wisconsin-Madison	1:30 PM	Florence, SC	Bus Station	Economy	$139	A Bus from FlixBus goes from University Wisconsin-Madison, Madison, WI (USA) at 7/24/2026 6:45:00 AM to Bus Station, Florence, SC (USA) arriving at 7/25/2026 1:30:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 29h 45m
Greyhound US	38h 10m	6:00 PM	Madison, WI	University Wisconsin-Madison	9:10 AM	Florence, SC	Bus Station	Economy	$242	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/24/2026 6:00:00 PM to Bus Station, Florence, SC (USA) arriving at 7/26/2026 9:10:00 AM. 50 Economy ticket for $242 per person are available. Travel duration is 38h 10m
Greyhound US	34h 45m	6:00 PM	Madison, WI	University Wisconsin-Madison	5:45 AM	Florence, SC	TA Travel Center	Economy	$255	A Bus from Greyhound US goes from University Wisconsin-Madison, Madison, WI (USA) at 7/24/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 7/26/2026 5:45:00 AM. 50 Economy ticket for $255 per person are available. Travel duration is 34h 45m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	29h 45m	6:45 AM	Madison, WI	Chazen Museum	1:30 PM	Florence, SC	Bus Station	Economy	$127	A Bus from FlixBus goes from Chazen Museum, Madison, WI (USA) at 7/25/2026 6:45:00 AM to Bus Station, Florence, SC (USA) arriving at 7/26/2026 1:30:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 29h 45m
FlixBus	29h 30m	7:00 AM	Madison, WI	Dutch Mill Park & Ride	1:30 PM	Florence, SC	Bus Station	Economy	$127	A Bus from FlixBus goes from Dutch Mill Park & Ride, Madison, WI (USA) at 7/25/2026 7:00:00 AM to Bus Station, Florence, SC (USA) arriving at 7/26/2026 1:30:00 PM. 50 Economy ticket for $127 per person are available. Travel duration is 29h 30m
Greyhound US	38h 10m	6:00 PM	Madison, WI	Chazen Museum	9:10 AM	Florence, SC	Bus Station	Economy	$218	A Bus from Greyhound US goes from Chazen Museum, Madison, WI (USA) at 7/25/2026 6:00:00 PM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 9:10:00 AM. 50 Economy ticket for $218 per person are available. Travel duration is 38h 10m
FlixBus	42h 25m	1:45 PM	Madison, WI	Dutch Mill Park & Ride	9:10 AM	Florence, SC	Bus Station	Economy	$220	A Bus from FlixBus goes from Dutch Mill Park & Ride, Madison, WI (USA) at 7/25/2026 1:45:00 PM to Bus Station, Florence, SC (USA) arriving at 7/27/2026 9:10:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 42h 25m

Best Price Offer: The price for the cheapest bus from Madison, WI to Florence, SC is $126 on 7/29/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Madison, WI and Florence, SC

See here how frequent the connections between Madison, WI and Florence, SC are, during different times and days of the week.

Tuesday is the busiest day, with more than 11 daily buses from Madison, WI to Florence, SC. Saturday has instead the fewest connections, with only 4 daily coaches between Madison, WI and Florence, SC.

The busiest time of the day is the Morning, with 14 buses from Madison, WI to Florence, SC, while Evening sees the fewest connections between Madison, WI and Florence, SC, with 10 offers.

Facts about the bus from Madison, WI to Florence, SC

Compare all providers like FlixBus and Greyhound US that travel 7 times every day by bus from Madison, WI to Florence, SC in one click! Book your bus ticket from Madison, WI to Florence, SC starting from $126!

Cheapest Bus	$126
Fastest Bus	30h 30m
Earliest Bus	6:45 AM
Latest Bus	6:00 PM
Daily Bus Routes	7 Ø
Distance	803.5 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Madison, WI to Florence, SC

Every day, 7 buses from 2 bus companies leave Madison, WI for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 07/19/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 07/19

Monday 07/20

$131

Tuesday 07/21

$126

Wednesday 07/22

Thursday 07/23

$134

Friday 07/24

$135

Saturday 07/25

$126

Sunday 07/26

$132

Monday 07/27

$131

Tuesday 07/28

$130

Wednesday 07/29

$126

Thursday 07/30

$131

Friday 07/31

$131

Saturday 08/01

$130

Sunday 08/02

$175

Monday 08/03

Tuesday 08/04

Wednesday 08/05

$130

Thursday 08/06

$127

Friday 08/07

$127

Saturday 08/08

$126

Sunday 08/09

Monday 08/10

Tuesday 08/11

Wednesday 08/12

$130

Thursday 08/13

Friday 08/14

Saturday 08/15

The cheapest time to travel from Madison, WI to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Madison, WI to Florence, SC, for the next 30 days.

With a price starting from $126, Tuesday is the cheapest day for a bus from Madison, WI to Florence, SC. Monday instead is the most expensive day with prices starting from $131.

Morning is the cheapest day time for bus tickets from Madison, WI to Florence, SC, with $127. Evening is the most expensive time of the day with prices starting from $218.

How to save money travelling from Madison, WI to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Madison, WI to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Madison, WI to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Madison, WI to Florence, SC are also emptier.

All bus stations and stops in Madison, WI and Florence, SC

In the map below, you can see where to find all bus stations in Madison, WI and Florence, SC.

Dutch Mill Park & Ride

E Broadway

Bus Stop

Memorial Union Building

Langdon Street 800

E Washington at E Johnson

UW Hospital

Highland Ave 600

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Madison, WI to Florence, SC

Want to know which seat classes are available on the buses from Madison, WI to Florence, SC? Or which bus companies serve the route Madison, WI to Florence, SC? Below you will find answers to your questions.

FAQs about the Madison, WI to Florence, SC bus

How much does a Madison, WI Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $126 and takes 30h 30m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Madison, WI to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $126 and $255. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Madison, WI to Florence, SC each day?

Every day, the Madison, WI to Florence, SC bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Madison, WI to Florence, SC take?

The fastest bus from Madison, WI to Florence, SC is offered by FlixBus and takes 30h 30m. Bus tickets for this connection cost $131. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Madison, WI to Florence, SC?

The earliest bus arriving in Florence, SC from Madison, WI starts at 6:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Madison, WI to Florence, SC?

The latest bus trip departing from Madison, WI for Florence, SC starts at 6:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Madison, WI Florence, SC route?

When traveling by bus from Madison, WI to Florence, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Madison, WI and Florence, SC?

You can check all the direct connections between Madison, WI and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Madison, WI to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Madison, WI Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Madison, WI Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Madison, WI to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Madison, WI to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Madison, WI and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Madison, WI to Florence, SC?

Prices and availability for 7 trips between Madison, WI and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Madison, WI to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Madison, WI and to Florence, SC

Here’s an overview of the most popular bus routes to Madison, WI and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!