Bus Philadelphia to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Philadelphia to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Philadelphia to Florence, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$141

Wednesday

$122

Thursday

Friday

Saturday

Sunday

$128

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	13h 45m	10:00 PM	Philadelphia	Spring Garden St Station	11:45 AM	Florence, SC	Bus Station	Economy	$141	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/23/2025 10:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/24/2025 11:45:00 AM. 50 Economy ticket for $141 per person are available. Travel duration is 13h 45m
Greyhound US	15h 15m	8:30 PM	Philadelphia	Spring Garden St Station	11:45 AM	Florence, SC	Bus Station	Economy	$176	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/23/2025 8:30:00 PM to Bus Station, Florence, SC (USA) arriving at 12/24/2025 11:45:00 AM. 50 Economy ticket for $176 per person are available. Travel duration is 15h 15m
FlixBus	17h 30m	12:15 PM	Philadelphia	IRS Building	5:45 AM	Florence, SC	TA Travel Center	Economy	$199	A Bus from FlixBus goes from IRS Building, Philadelphia (USA) at 12/23/2025 12:15:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/24/2025 5:45:00 AM. 50 Economy ticket for $199 per person are available. Travel duration is 17h 30m
FlixBus	11h 15m	6:30 PM	Philadelphia	Spring Garden St Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$203	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/23/2025 6:30:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/24/2025 5:45:00 AM. 50 Economy ticket for $203 per person are available. Travel duration is 11h 15m
Greyhound US	15h 45m	8:00 PM	Philadelphia	IRS Building	11:45 AM	Florence, SC	Bus Station	Economy	$204	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/23/2025 8:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/24/2025 11:45:00 AM. 50 Economy ticket for $204 per person are available. Travel duration is 15h 45m

Did you know that if you travel from Philadelphia to Florence, SC via Washington, DC, you can save more than $28? You can find the corresponding connections below.
- Distribusion
  
  15h 50m
  
  0
  
  4:10 PM
  
  Philadelphia
  520 N Christopher Columbus Blvd. Bus Stop
  
  8:15 PM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $13
  
  A Bus from Distribusion goes from 520 N Christopher Columbus Blvd. Bus Stop, Philadelphia (USA) at 12/24/2025 4:10:00 PM to Union Station, Washington, DC (USA) arriving at 12/24/2025 8:15:00 PM. 50 Economy ticket for $13 per person are available. Travel duration is 4h 5m
- iLIKEBUS
  
  7h 59m
  
  0
  
  12:01 AM
  
  Washington, DC
  Benning Rd NE
  
  8:00 AM
  
  Florence, SC
  Shell Gas Station
  
  0
  
  Economy
  
  $100
  
  A Bus from iLIKEBUS goes from Benning Rd NE, Washington, DC (USA) at 12/25/2025 12:01:00 AM to Shell Gas Station, Florence, SC (USA) arriving at 12/25/2025 8:00:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 7h 59m
Travel time is 4h 35m longer, but you will save $28

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	13h 45m	10:00 PM	Philadelphia	Spring Garden St Station	11:45 AM	Florence, SC	Bus Station	Economy	$122	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/24/2025 10:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/25/2025 11:45:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 13h 45m
Greyhound US	15h 45m	8:00 PM	Philadelphia	IRS Building	11:45 AM	Florence, SC	Bus Station	Economy	$123	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/24/2025 8:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/25/2025 11:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 15h 45m
Greyhound US	15h 15m	8:30 PM	Philadelphia	Spring Garden St Station	11:45 AM	Florence, SC	Bus Station	Economy	$124	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/24/2025 8:30:00 PM to Bus Station, Florence, SC (USA) arriving at 12/25/2025 11:45:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 15h 15m
FlixBus	17h 30m	12:15 PM	Philadelphia	IRS Building	5:45 AM	Florence, SC	TA Travel Center	Economy	$151	A Bus from FlixBus goes from IRS Building, Philadelphia (USA) at 12/24/2025 12:15:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/25/2025 5:45:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 17h 30m
Greyhound US	11h 55m	5:50 PM	Philadelphia	Spring Garden St Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$151	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/24/2025 5:50:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/25/2025 5:45:00 AM. 50 Economy ticket for $151 per person are available. Travel duration is 11h 55m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 45m	2:00 PM	Philadelphia	JFK & Broad	11:45 AM	Florence, SC	Bus Station	Economy	$128	A Bus from FlixBus goes from JFK & Broad, Philadelphia (USA) at 12/28/2025 2:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/29/2025 11:45:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 21h 45m
FlixBus	13h 45m	10:00 PM	Philadelphia	Spring Garden St Station	11:45 AM	Florence, SC	Bus Station	Economy	$128	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/28/2025 10:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/29/2025 11:45:00 AM. 50 Economy ticket for $128 per person are available. Travel duration is 13h 45m
Greyhound US	15h 15m	8:30 PM	Philadelphia	Spring Garden St Station	11:45 AM	Florence, SC	Bus Station	Economy	$129	A Bus from Greyhound US goes from Spring Garden St Station, Philadelphia (USA) at 12/28/2025 8:30:00 PM to Bus Station, Florence, SC (USA) arriving at 12/29/2025 11:45:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 15h 15m
Greyhound US	15h 45m	8:00 PM	Philadelphia	IRS Building	11:45 AM	Florence, SC	Bus Station	Economy	$132	A Bus from Greyhound US goes from IRS Building, Philadelphia (USA) at 12/28/2025 8:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/29/2025 11:45:00 AM. 50 Economy ticket for $132 per person are available. Travel duration is 15h 45m
FlixBus	11h 15m	6:30 PM	Philadelphia	Spring Garden St Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$143	A Bus from FlixBus goes from Spring Garden St Station, Philadelphia (USA) at 12/28/2025 6:30:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/29/2025 5:45:00 AM. 50 Economy ticket for $143 per person are available. Travel duration is 11h 15m

Did you know that if you travel from Philadelphia to Florence, SC via Baltimore, MD, you can save more than $24? You can find the corresponding connections below.
- Busbud
  
  12h 30m
  
  0
  
  11:15 PM
  
  Philadelphia
  Convention Center
  
  1:20 AM
  
  Baltimore, MD
  Downtown Bus Station
  
  0
  
  Economy
  
  $25
  
  A Bus from Busbud goes from Convention Center, Philadelphia (USA) at 12/27/2025 11:15:00 PM to Downtown Bus Station, Baltimore, MD (USA) arriving at 12/28/2025 1:20:00 AM. 50 Economy ticket for $25 per person are available. Travel duration is 2h 5m
- Busbud
  
  10h 10m
  
  0
  
  1:35 AM
  
  Baltimore, MD
  Downtown Bus Station
  
  11:45 AM
  
  Florence, SC
  Bus Station
  
  0
  
  Economy
  
  $79
  
  A Bus from Busbud goes from Downtown Bus Station, Baltimore, MD (USA) at 12/28/2025 1:35:00 AM to Bus Station, Florence, SC (USA) arriving at 12/28/2025 11:45:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 10h 10m
Travel time is 1h 15m longer, but you will save $24

Best Price Offer: The price for the cheapest bus from Philadelphia to Florence, SC is $122 on 12/24/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Philadelphia and Florence, SC

See here how frequent the connections between Philadelphia and Florence, SC are, during different times and days of the week.

Sunday is the busiest day, with more than 7 daily buses from Philadelphia to Florence, SC. Sunday has instead the fewest connections, with only 7 daily coaches between Philadelphia and Florence, SC.

The busiest time of the day is the Evening, with 12 buses from Philadelphia to Florence, SC, while Morning sees the fewest connections between Philadelphia and Florence, SC, with 2 offers.

Facts about the bus from Philadelphia to Florence, SC

Compare all providers like FlixBus and Greyhound US that travel 7 times every day by bus from Philadelphia to Florence, SC in one click! Book your bus ticket from Philadelphia to Florence, SC starting from $122!

Cheapest Bus	$122
Fastest Bus	11h 15m
Earliest Bus	10:40 AM
Latest Bus	10:00 PM
Daily Bus Routes	7 Ø
Distance	471.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Philadelphia to Florence, SC

Every day, 7 buses from 2 bus companies leave Philadelphia for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/22/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/21

Monday 12/22

Tuesday 12/23

$141

Wednesday 12/24

$122

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

$128

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

Sunday 01/11

Monday 01/12

Tuesday 01/13

Wednesday 01/14

Thursday 01/15

Friday 01/16

Saturday 01/17

The cheapest time to travel from Philadelphia to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Philadelphia to Florence, SC, for the next 30 days.

With a price starting from $122, Wednesday is the cheapest day for a bus from Philadelphia to Florence, SC. Tuesday instead is the most expensive day with prices starting from $141.

Evening is the cheapest day time for bus tickets from Philadelphia to Florence, SC, with $122. Morning is the most expensive time of the day with prices starting from $152.

How to save money travelling from Philadelphia to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Philadelphia to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Philadelphia to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Philadelphia to Florence, SC are also emptier.

All bus stations and stops in Philadelphia and Florence, SC

In the map below, you can see where to find all bus stations in Philadelphia and Florence, SC.

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

JFK & Broad

John F Kennedy Blvd 1401

Philadelphia, PA

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Philadelphia to Florence, SC

Want to know which seat classes are available on the buses from Philadelphia to Florence, SC? Or which bus companies serve the route Philadelphia to Florence, SC? Below you will find answers to your questions.

FAQs about the Philadelphia to Florence, SC bus

How much does a Philadelphia Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $122 and takes 13h 45m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Philadelphia to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $122 and $224. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Philadelphia to Florence, SC each day?

Every day, the Philadelphia to Florence, SC bus route is served by approximately 7 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Philadelphia to Florence, SC take?

The fastest bus from Philadelphia to Florence, SC is offered by FlixBus and takes 11h 15m. Bus tickets for this connection cost $203. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Philadelphia to Florence, SC?

The earliest bus arriving in Florence, SC from Philadelphia starts at 10:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Philadelphia to Florence, SC?

The latest bus trip departing from Philadelphia for Florence, SC starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Philadelphia Florence, SC route?

When traveling by bus from Philadelphia to Florence, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Philadelphia and Florence, SC?

You can check all the direct connections between Philadelphia and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Philadelphia to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Philadelphia Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Philadelphia Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Philadelphia to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Philadelphia to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 7 daily trips between Philadelphia and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Philadelphia to Florence, SC?

Prices and availability for 7 trips between Philadelphia and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Philadelphia to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Philadelphia and to Florence, SC

Here’s an overview of the most popular bus routes to Philadelphia and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!