Bus from Philadelphia to Florence, SC from $69

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Compare all timetables for the bus from Philadelphia to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Philadelphia to Florence, SC from various bus operators like FlixBus or Greyhound US for the next days.

today
tomorrow
$124
Sunday
Monday
Tuesday
Wednesday
$110
Thursday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 17h 30m 12:15 PM Philadelphia IRS Building 5:45 AM Florence, SC TA Travel Center  Economy $124
FlixBus 11h 15m 6:30 PM Philadelphia Spring Garden St Station 5:45 AM Florence, SC TA Travel Center  Economy $124
Greyhound US 15h 45m 8:00 PM Philadelphia IRS Building 11:45 AM Florence, SC Bus Station  Economy $124
Greyhound US 15h 15m 8:30 PM Philadelphia Spring Garden St Station 11:45 AM Florence, SC Bus Station  Economy $124
FlixBus 13h 45m 10:00 PM Philadelphia Spring Garden St Station 11:45 AM Florence, SC Bus Station  Economy $125
  • Did you know that if you travel from Philadelphia to Florence, SC via Washington, DC, you can save more than $41? You can find the corresponding connections below.
    • Busbud
      15h 15m
      0
      8:30 PM
      Philadelphia
      Convention Center
      11:50 PM
      Washington, DC
      Union Station
      0
      Busbud
      Economy
      $20
      • Waiting Time 3h 50m
    • FlixBus
      8h 5m
      0
      3:40 AM
      Washington, DC
      Union Station
      11:45 AM
      Florence, SC
      Bus Station
      0
      FlixBus
      Economy
      $63
    Travel time is 4h 0m longer, but you will save $41

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 11h 15m 6:30 PM Philadelphia Spring Garden St Station 5:45 AM Florence, SC TA Travel Center  Economy $110
Greyhound US 15h 45m 8:00 PM Philadelphia IRS Building 11:45 AM Florence, SC Bus Station  Economy $110
FlixBus 17h 15m 6:30 PM Philadelphia Spring Garden St Station 11:45 AM Florence, SC Bus Station  Economy $111
Greyhound US 11h 55m 5:50 PM Philadelphia Spring Garden St Station 5:45 AM Florence, SC TA Travel Center  Economy $111
FlixBus 19h 15m 10:30 AM Philadelphia IRS Building 5:45 AM Florence, SC TA Travel Center  Economy $112
  • Did you know that if you travel from Philadelphia to Florence, SC via Baltimore, MD, you can save more than $36? You can find the corresponding connections below.
    • FlixBus
      15h 15m
      0
      8:30 PM
      Philadelphia
      Spring Garden St Station
      10:40 PM
      Baltimore, MD
      Downtown Bus Station
      0
      FlixBus
      Economy
      $23
      • Waiting Time 2h 55m
    • Busbud
      10h 10m
      0
      1:35 AM
      Baltimore, MD
      Downtown Bus Station
      11:45 AM
      Florence, SC
      Bus Station
      0
      Busbud
      Economy
      $50
    Travel time is 4h 0m longer, but you will save $36

Best Price Offer: The price for the cheapest bus from Philadelphia to Florence, SC is $69 on 2/5/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Philadelphia and Florence, SC

See here how frequent the connections between Philadelphia and Florence, SC are, during different times and days of the week.
Wednesday is the busiest day, with more than 6 daily buses from Philadelphia to Florence, SC. Wednesday has instead the fewest connections, with only 6 daily coaches between Philadelphia and Florence, SC.
The busiest time of the day is the Evening, with 8 buses from Philadelphia to Florence, SC, while Morning sees the fewest connections between Philadelphia and Florence, SC, with 1 offers.

Facts about the bus from Philadelphia to Florence, SC

Compare all providers like FlixBus and Greyhound US that travel 6 times every day by bus from Philadelphia to Florence, SC in one click! Book your bus ticket from Philadelphia to Florence, SC starting from $69!

Cheapest Bus $69
Fastest Bus 11h 15m
Earliest Bus 12:15 PM
Latest Bus 8:30 PM
Daily Bus Routes 6 Ø
Distance 471.3 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from Philadelphia to Florence, SC

Every day, 6 buses from 2 bus companies leave Philadelphia for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/06/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/01
Monday 02/02
Tuesday 02/03
Wednesday 02/04
Thursday 02/05
Friday 02/06
Saturday 02/07
$124
Sunday 02/08
Monday 02/09
Tuesday 02/10
Wednesday 02/11
$110
Thursday 02/12
Friday 02/13
Saturday 02/14
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28

The cheapest time to travel from Philadelphia to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Philadelphia to Florence, SC, for the next 30 days.
With a price starting from $110, Wednesday is the cheapest day for a bus from Philadelphia to Florence, SC. Saturday instead is the most expensive day with prices starting from $124.
Evening is the cheapest day time for bus tickets from Philadelphia to Florence, SC, with $110. Afternoon is the most expensive time of the day with prices starting from $111.

How to save money travelling from Philadelphia to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Philadelphia to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Philadelphia to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Philadelphia to Florence, SC are also emptier.

All bus stations and stops in Philadelphia and Florence, SC

In the map below, you can see where to find all bus stations in Philadelphia and Florence, SC.

Service and Comfort on the bus from Philadelphia to Florence, SC

Want to know which seat classes are available on the buses from Philadelphia to Florence, SC? Or which bus companies serve the route Philadelphia to Florence, SC? Below you will find answers to your questions.

FAQs about the Philadelphia to Florence, SC bus

How much does a Philadelphia Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $69 and takes 15h 45m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Philadelphia to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $69 and $125. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Philadelphia to Florence, SC each day?

Every day, the Philadelphia to Florence, SC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Philadelphia to Florence, SC take?

The fastest bus from Philadelphia to Florence, SC is offered by FlixBus and takes 11h 15m. Bus tickets for this connection cost $124. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Philadelphia to Florence, SC?

The earliest bus arriving in Florence, SC from Philadelphia starts at 12:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Philadelphia to Florence, SC?

The latest bus trip departing from Philadelphia for Florence, SC starts at 8:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Philadelphia Florence, SC route?

When traveling by bus from Philadelphia to Florence, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Philadelphia and Florence, SC?

You can check all the direct connections between Philadelphia and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Philadelphia to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Philadelphia Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Philadelphia Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Philadelphia to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Philadelphia to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Philadelphia and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Philadelphia to Florence, SC?

Prices and availability for 6 trips between Philadelphia and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Philadelphia to Florence, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Philadelphia and to Florence, SC

Here’s an overview of the most popular bus routes to Philadelphia and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Popular Airport Shuttles to Philadelphia and to Florence, SC
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