Bus Orlando, FL to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Orlando, FL to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Orlando, FL to Florence, SC from various bus operators like FlixBus for the next days.

today

tomorrow

$59

Wednesday

Thursday

$59

Friday

Saturday

Sunday

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 25m	4:00 AM	Orlando, FL	Bus Station	1:25 PM	Florence, SC	Bus Station	Economy	$59	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 4/21/2026 4:00:00 AM to Bus Station, Florence, SC (USA) arriving at 4/21/2026 1:25:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 9h 25m
FlixBus	16h 35m	10:55 PM	Orlando, FL	Bus Station	3:30 PM	Florence, SC	Bus Station	Economy	$98	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 4/21/2026 10:55:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 3:30:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 16h 35m
FlixBus	16h 25m	9:05 PM	Orlando, FL	Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$100	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 4/21/2026 9:05:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 1:30:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 16h 25m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	9h 25m	4:00 AM	Orlando, FL	Bus Station	1:25 PM	Florence, SC	Bus Station	Economy	$59	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 4/23/2026 4:00:00 AM to Bus Station, Florence, SC (USA) arriving at 4/23/2026 1:25:00 PM. 50 Economy ticket for $59 per person are available. Travel duration is 9h 25m
FlixBus	8h 25m	3:40 PM	Orlando, FL	Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$64	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 4/23/2026 3:40:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/24/2026 12:05:00 AM. 50 Economy ticket for $64 per person are available. Travel duration is 8h 25m
FlixBus	8h 40m	4:45 AM	Orlando, FL	Bus Station	1:25 PM	Florence, SC	Bus Station	Economy	$89	A Bus from FlixBus goes from Bus Station, Orlando, FL (USA) at 4/23/2026 4:45:00 AM to Bus Station, Florence, SC (USA) arriving at 4/23/2026 1:25:00 PM. 50 Economy ticket for $89 per person are available. Travel duration is 8h 40m
FlixBus	11h 20m	12:45 PM	Orlando, FL	Florida Mall	12:05 AM	Florence, SC	TA Travel Center	Economy	$90	A Bus from FlixBus goes from Florida Mall, Orlando, FL (USA) at 4/23/2026 12:45:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/24/2026 12:05:00 AM. 50 Economy ticket for $90 per person are available. Travel duration is 11h 20m

Best Price Offer: The price for the cheapest bus from Orlando, FL to Florence, SC is $55 on 4/28/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Orlando, FL and Florence, SC

See here how frequent the connections between Orlando, FL and Florence, SC are, during different times and days of the week.

Thursday is the busiest day, with more than 4 daily buses from Orlando, FL to Florence, SC. Tuesday has instead the fewest connections, with only 3 daily coaches between Orlando, FL and Florence, SC.

The busiest time of the day is the Night, with 3 buses from Orlando, FL to Florence, SC, while Afternoon sees the fewest connections between Orlando, FL and Florence, SC, with 2 offers.

Facts about the bus from Orlando, FL to Florence, SC

Compare all providers like FlixBus that travel 3 times every day by bus from Orlando, FL to Florence, SC in one click! Book your bus ticket from Orlando, FL to Florence, SC starting from $55!

Cheapest Bus	$55
Fastest Bus	8h 25m
Earliest Bus	4:00 AM
Latest Bus	3:40 PM
Daily Bus Routes	3 Ø
Distance	402.2 miles
Bus Companies	FlixBus

Cheapest bus connections from Orlando, FL to Florence, SC

Every day, 3 buses from 1 bus companies leave Orlando, FL for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

Tuesday 04/21

$59

Wednesday 04/22

Thursday 04/23

$59

Friday 04/24

Saturday 04/25

Sunday 04/26

Monday 04/27

Tuesday 04/28

$55

Wednesday 04/29

$59

Thursday 04/30

Friday 05/01

$62

Saturday 05/02

$62

Sunday 05/03

$68

Monday 05/04

Tuesday 05/05

$55

Wednesday 05/06

Thursday 05/07

Friday 05/08

$60

Saturday 05/09

$64

Sunday 05/10

$64

Monday 05/11

Tuesday 05/12

$85

Wednesday 05/13

$80

Thursday 05/14

$66

Friday 05/15

$66

Saturday 05/16

The cheapest time to travel from Orlando, FL to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Orlando, FL to Florence, SC, for the next 30 days.

With a price starting from $55, Tuesday is the cheapest day for a bus from Orlando, FL to Florence, SC. Thursday instead is the most expensive day with prices starting from $59.

Night is the cheapest day time for bus tickets from Orlando, FL to Florence, SC, with $55. Evening is the most expensive time of the day with prices starting from $98.

How to save money travelling from Orlando, FL to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Orlando, FL to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Orlando, FL to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Orlando, FL to Florence, SC are also emptier.

Beloved bus companies from Orlando, FL to Florence, SC

These are the most booked bus companies between Orlando, FL to Florence, SC from our users.

FlixBus from Orlando, FL to Florence, SC

Here you will find the key facts about the FlixBus bus route Orlando, FL to Florence, SC:

Cheapest Price	$59
Fastest Bus	8h 25m
Earliest Bus	4:00 AM
Last Bus	3:40 PM
Daily Connections	3 Ø
Found on	3/23/2026

All bus stations and stops in Orlando, FL and Florence, SC

In the map below, you can see where to find all bus stations in Orlando, FL and Florence, SC.

Bus Station

N John Young Pkwy 555

Florida Mall

Florida Mall Avenue 1602

RedCoach Station

Belle Isle

Universal Studio Orlando Resort

Universal Blvd 5800

Seaworld Hotels

International Dr 10100

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Orlando, FL to Florence, SC

Want to know which seat classes are available on the buses from Orlando, FL to Florence, SC? Or which bus companies serve the route Orlando, FL to Florence, SC? Below you will find answers to your questions.

FAQs about the Orlando, FL to Florence, SC bus

How much does a Orlando, FL Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $55 and takes 9h 25m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Orlando, FL to Florence, SC?

This route is offered by 1 companies with a range of ticket prices between $55 and $100. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Orlando, FL to Florence, SC each day?

Every day, the Orlando, FL to Florence, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Orlando, FL to Florence, SC take?

The fastest bus from Orlando, FL to Florence, SC is offered by FlixBus and takes 8h 25m. Bus tickets for this connection cost $64. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Orlando, FL to Florence, SC?

The earliest bus arriving in Florence, SC from Orlando, FL starts at 4:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Orlando, FL to Florence, SC?

The latest bus trip departing from Orlando, FL for Florence, SC starts at 3:40 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Orlando, FL Florence, SC route?

When traveling by bus from Orlando, FL to Florence, SC, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Orlando, FL and Florence, SC?

You can check all the direct connections between Orlando, FL and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Orlando, FL to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Orlando, FL Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Orlando, FL Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Orlando, FL to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Orlando, FL to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Orlando, FL and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Orlando, FL to Florence, SC?

Prices and availability for 3 trips between Orlando, FL and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Orlando, FL to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Orlando, FL and to Florence, SC

Here’s an overview of the most popular bus routes to Orlando, FL and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!