Compare all timetables for the bus from Syracuse, NY to Florence, SC
Here is a selection of the cheapest bus trips from the schedule from Syracuse, NY to Florence, SC from various bus operators like FlixBus or Greyhound US for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 20h 45m | 3:00 PM | Syracuse, NY | Regional Transit Center | 11:45 AM | Florence, SC | Bus Station | Economy | $99 |
A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/20/2026 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/21/2026 11:45:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 20h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 20h 45m | 3:00 PM | Syracuse, NY | Regional Transit Center | 11:45 AM | Florence, SC | Bus Station | Economy | $104 |
A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/21/2026 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 11:45:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 45m
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| Greyhound US | 32h 45m | 9:00 PM | Syracuse, NY | Regional Transit Center | 5:45 AM | Florence, SC | TA Travel Center | Economy | $107 |
A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/21/2026 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/23/2026 5:45:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 32h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FlixBus | 20h 45m | 3:00 PM | Syracuse, NY | Regional Transit Center | 11:45 AM | Florence, SC | Bus Station | Economy | $100 |
A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/22/2026 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/23/2026 11:45:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 20h 45m
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| Greyhound US | 20h 20m | 9:25 AM | Syracuse, NY | Regional Transit Center | 5:45 AM | Florence, SC | TA Travel Center | Economy | $104 |
A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/22/2026 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 4/23/2026 5:45:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 20h 20m
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| Greyhound US | 32h 45m | 9:00 PM | Syracuse, NY | Regional Transit Center | 5:45 AM | Florence, SC | TA Travel Center | Economy | $107 |
A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/22/2026 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/24/2026 5:45:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 32h 45m
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| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 20h 20m | 9:25 AM | Syracuse, NY | Regional Transit Center | 5:45 AM | Florence, SC | TA Travel Center | Economy | $108 |
A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/26/2026 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 4/27/2026 5:45:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 20h 20m
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| FlixBus | 20h 45m | 3:00 PM | Syracuse, NY | Regional Transit Center | 11:45 AM | Florence, SC | Bus Station | Economy | $108 |
A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/26/2026 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/27/2026 11:45:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 20h 45m
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Best Price Offer: The price for the cheapest bus from Syracuse, NY to Florence, SC is $92 on 5/5/2026. Flexible travelers save on ticket prices.
Frequency of bus connections between Syracuse, NY and Florence, SC
Wednesday
is the busiest day, with more than 4 daily buses from Syracuse, NY to Florence, SC. Sunday has instead the fewest connections, with only 2 daily coaches between Syracuse, NY and Florence, SC.
The busiest time of the day is the Afternoon, with 6 buses from Syracuse, NY to Florence, SC, while Morning sees the fewest connections between Syracuse, NY and Florence, SC, with 2 offers.
Facts about the bus from Syracuse, NY to Florence, SC
Compare all providers like FlixBus and Greyhound US that travel 2 times every day by bus from Syracuse, NY to Florence, SC in one click! Book your bus ticket from Syracuse, NY to Florence, SC starting from $92!
| Cheapest Bus | $92 |
| Fastest Bus | 20h 20m |
| Earliest Bus | 3:00 PM |
| Latest Bus | 3:00 PM |
| Daily Bus Routes | 2 Ø |
| Distance | 642.2 miles |
| Bus Companies | FlixBus and Greyhound US |
Cheapest bus connections from Syracuse, NY to Florence, SC
Every day, 2 buses from 2 bus companies leave Syracuse, NY for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
04/19
Monday
04/20
$99
Tuesday
04/21
$104
Wednesday
04/22
$100
Thursday
04/23
Friday
04/24
Saturday
04/25
Sunday
04/26
$108
Monday
04/27
$113
Tuesday
04/28
$101
Wednesday
04/29
$98
Thursday
04/30
$98
Friday
05/01
$112
Saturday
05/02
$106
Sunday
05/03
$107
Monday
05/04
$94
Tuesday
05/05
$92
Wednesday
05/06
Thursday
05/07
Friday
05/08
Saturday
05/09
$97
Sunday
05/10
Monday
05/11
$101
Tuesday
05/12
$107
Wednesday
05/13
Thursday
05/14
$103
Friday
05/15
Saturday
05/16
The cheapest time to travel from Syracuse, NY to Florence, SC
With a price starting from $92, Tuesday is the cheapest day for a bus from Syracuse, NY to Florence, SC. Sunday instead is the most expensive day with prices starting from $107.
Afternoon
is the cheapest day time for bus tickets from Syracuse, NY to Florence, SC, with $99. Evening is the most expensive time of the day with prices starting from $106.
How to save money travelling from Syracuse, NY to Florence, SC
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from Syracuse, NY to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Syracuse, NY to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Syracuse, NY to Florence, SC are also emptier.Beloved bus companies from Syracuse, NY to Florence, SC
These are the most booked bus companies between Syracuse, NY to Florence, SC from our users.
FlixBus from Syracuse, NY to Florence, SC
Here you will find the key facts about the FlixBus bus route Syracuse, NY to Florence, SC:
| Cheapest Price | $99 |
| Fastest Bus | 20h 45m |
| Earliest Bus | 3:00 PM |
| Last Bus | 3:00 PM |
| Daily Connections | 1 Ø |
| Found on | 3/26/2026 |
All bus stations and stops in Syracuse, NY and Florence, SC
In the map below, you can see where to find all bus stations in Syracuse, NY and Florence, SC.
Service and Comfort on the bus from Syracuse, NY to Florence, SC
Want to know which seat classes are available on the buses from Syracuse, NY to Florence, SC? Or which bus companies serve the route Syracuse, NY to Florence, SC? Below you will find answers to your questions.
FAQs about the Syracuse, NY to Florence, SC bus
How much does a Syracuse, NY Florence, SC bus trip cost?
This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 20h 45m to reach Florence, SC. Compare offers to save money!
How much could I save by comparing buses from Syracuse, NY to Florence, SC?
This route is offered by 2 companies with a range of ticket prices between $92 and $108. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.
On average, how many connections are available from Syracuse, NY to Florence, SC each day?
Every day, the Syracuse, NY to Florence, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.
How long does a bus journey from Syracuse, NY to Florence, SC take?
The fastest bus from Syracuse, NY to Florence, SC is offered by Greyhound US and takes 20h 20m. Bus tickets for this connection cost $104. In this context, bear in mind that the journey can take longer due to traffic.
What time is the first bus from Syracuse, NY to Florence, SC?
The earliest bus arriving in Florence, SC from Syracuse, NY starts at 3:00 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.
What time is the last bus from Syracuse, NY to Florence, SC?
The latest bus trip departing from Syracuse, NY for Florence, SC starts at 3:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.
Which bus companies operate the Syracuse, NY Florence, SC route?
When traveling by bus from Syracuse, NY to Florence, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.
Is there a direct bus between Syracuse, NY and Florence, SC?
You can check all the direct connections between Syracuse, NY and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.
What can I take with me on the Syracuse, NY to Florence, SC bus route?
Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Syracuse, NY Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.
What equipment is available for the Syracuse, NY Florence, SC bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Syracuse, NY to Florence, SC on your planned travel date.
How does CheckMyBus find the best bus deals from Syracuse, NY to Florence, SC?
CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 2 daily trips between Syracuse, NY and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.
How does CheckMyBus technology work for trips from Syracuse, NY to Florence, SC?
Prices and availability for 2 trips between Syracuse, NY and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.
Available seat classes which are offered on the bus route Syracuse, NY to Florence, SC
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Syracuse, NY and to Florence, SC
Here’s an overview of the most popular bus routes to Syracuse, NY and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
- Bus Routes to Syracuse, NY
- Bus Atlanta, GA to Syracuse, NY
- Buses Baltimore, MD - Syracuse, NY
- Buses Binghamton, NY - Syracuse, NY
- From Boston, MA to Syracuse, NY bus
- Bus Buffalo, NY to Syracuse, NY
- Charlotte to Syracuse, NY bus
- Bus Cornwall, ON - Syracuse, NY
- From Denton, TX to Syracuse, NY bus
- From Ithaca, NY to Syracuse, NY bus
- Bus from Jacksonville, NC to Syracuse, NY
- Bus Newark to Syracuse, NY
- Buses Orlando, FL - Syracuse, NY
- Bus from Philadelphia to Syracuse, NY
- Bus to Syracuse, NY from Rochester, NY
- Bus Silver Spring, MD to Syracuse, NY
- Buses The Woodlands, TX to Syracuse, NY
- Buses to Syracuse, NY from Toronto, ON
- Buses to Syracuse, NY from Utica, NY
- Bus Washington, DC to Syracuse, NY
- Buses Wichita Falls, TX - Syracuse, NY
- Bus Routes to Florence, SC
- Bus Allentown, PA - Florence, SC
- Buses to Florence, SC from Baltimore, MD
- Bus Charleston, SC - Florence, SC
- Chicago to Florence, SC bus
- Buses College Park, MD - Florence, SC
- Buses to Florence, SC from Columbia, SC
- Buses Dallas - Florence, SC
- Bus Jacksonville, FL - Florence, SC
- Bus from Lewiston, ME to Florence, SC
- From Miami to Florence, SC bus
- Buses Newark to Florence, SC
- Buses to Florence, SC from Oklahoma City, OK
- Orlando, FL to Florence, SC bus
- Buses Philadelphia to Florence, SC
- Bus to Florence, SC from Raleigh, NC
- Buses to Florence, SC from Richmond, VA
- Bus from Shreveport, LA to Florence, SC
- Buses from Washington, DC to Florence, SC
Popular Airport Shuttles to Syracuse, NY and to Florence, SC
