Bus Syracuse, NY to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Syracuse, NY to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Syracuse, NY to Florence, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Saturday

$142

Sunday

Monday

$113

Tuesday

Wednesday

$118

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 20m	9:25 AM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$142	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 12/6/2025 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 12/7/2025 5:45:00 AM. 50 Economy ticket for $142 per person are available. Travel duration is 20h 20m
FlixBus	20h 45m	3:00 PM	Syracuse, NY	Regional Transit Center	11:45 AM	Florence, SC	Bus Station	Economy	$158	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 12/6/2025 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/7/2025 11:45:00 AM. 50 Economy ticket for $158 per person are available. Travel duration is 20h 45m
Greyhound US	32h 45m	9:00 PM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$181	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 12/6/2025 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/8/2025 5:45:00 AM. 50 Economy ticket for $181 per person are available. Travel duration is 32h 45m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	20h 45m	3:00 PM	Syracuse, NY	Regional Transit Center	11:45 AM	Florence, SC	Bus Station		Economy	$113	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 12/8/2025 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 12/9/2025 11:45:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 20h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	32h 45m	9:00 PM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$118	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 12/10/2025 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 12/12/2025 5:45:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 32h 45m
FlixBus	23h 40m	12:05 PM	Syracuse, NY	Regional Transit Center	11:45 AM	Florence, SC	Bus Station	Economy	$123	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 12/10/2025 12:05:00 PM to Bus Station, Florence, SC (USA) arriving at 12/11/2025 11:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 23h 40m
Greyhound US	20h 20m	9:25 AM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$133	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 12/10/2025 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 12/11/2025 5:45:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 20h 20m

Best Price Offer: The price for the cheapest bus from Syracuse, NY to Florence, SC is $113 on 12/8/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Syracuse, NY and Florence, SC

See here how frequent the connections between Syracuse, NY and Florence, SC are, during different times and days of the week.

Wednesday is the busiest day, with more than 3 daily buses from Syracuse, NY to Florence, SC. Monday has instead the fewest connections, with only 1 daily coaches between Syracuse, NY and Florence, SC.

The busiest time of the day is the Afternoon, with 3 buses from Syracuse, NY to Florence, SC, while Morning sees the fewest connections between Syracuse, NY and Florence, SC, with 2 offers.

Facts about the bus from Syracuse, NY to Florence, SC

Compare all providers like Greyhound US and FlixBus that travel 2 times every day by bus from Syracuse, NY to Florence, SC in one click! Book your bus ticket from Syracuse, NY to Florence, SC starting from $113!

Cheapest Bus	$113
Fastest Bus	20h 20m
Earliest Bus	9:25 AM
Latest Bus	9:00 PM
Daily Bus Routes	2 Ø
Distance	642.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Syracuse, NY to Florence, SC

Every day, 2 buses from 2 bus companies leave Syracuse, NY for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

Saturday 12/06

$142

Sunday 12/07

Monday 12/08

$113

Tuesday 12/09

Wednesday 12/10

$118

Thursday 12/11

$117

Friday 12/12

Saturday 12/13

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

The cheapest time to travel from Syracuse, NY to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Syracuse, NY to Florence, SC, for the next 30 days.

With a price starting from $112, Monday is the cheapest day for a bus from Syracuse, NY to Florence, SC. Saturday instead is the most expensive day with prices starting from $142.

Afternoon is the cheapest day time for bus tickets from Syracuse, NY to Florence, SC, with $113. Morning is the most expensive time of the day with prices starting from $133.

How to save money travelling from Syracuse, NY to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Syracuse, NY to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Syracuse, NY to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Syracuse, NY to Florence, SC are also emptier.

All bus stations and stops in Syracuse, NY and Florence, SC

In the map below, you can see where to find all bus stations in Syracuse, NY and Florence, SC.

University

University Pi 303

Regional Transit Center

Walsh Cir 1

Destiny USA

Destiny USA Dr 9090

New York State Fairgrounds

State Fair Blvd 581

S State St & E Genesee St

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Syracuse, NY to Florence, SC

Want to know which seat classes are available on the buses from Syracuse, NY to Florence, SC? Or which bus companies serve the route Syracuse, NY to Florence, SC? Below you will find answers to your questions.

FAQs about the Syracuse, NY to Florence, SC bus

How much does a Syracuse, NY Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $113 and takes 20h 45m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Syracuse, NY to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $113 and $181. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Syracuse, NY to Florence, SC each day?

Every day, the Syracuse, NY to Florence, SC bus route is served by approximately 2 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Syracuse, NY to Florence, SC take?

The fastest bus from Syracuse, NY to Florence, SC is offered by Greyhound US and takes 20h 20m. Bus tickets for this connection cost $142. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Syracuse, NY to Florence, SC?

The earliest bus arriving in Florence, SC from Syracuse, NY starts at 9:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Syracuse, NY to Florence, SC?

The latest bus trip departing from Syracuse, NY for Florence, SC starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Syracuse, NY Florence, SC route?

When traveling by bus from Syracuse, NY to Florence, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Syracuse, NY and Florence, SC?

You can check all the direct connections between Syracuse, NY and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Syracuse, NY to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Syracuse, NY Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Syracuse, NY Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Syracuse, NY to Florence, SC on your planned travel date.

Available seat classes which are offered on the bus route Syracuse, NY to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Syracuse, NY and to Florence, SC

Here’s an overview of the most popular bus routes to Syracuse, NY and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!