Bus Syracuse, NY to Florence, SC: Compare prices and save money

Compare all timetables for the bus from Syracuse, NY to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Syracuse, NY to Florence, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

$254

tomorrow

Monday

Tuesday

Wednesday

$203

Thursday

$117

Friday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 20m	9:25 AM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$254	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/14/2026 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 2/15/2026 5:45:00 AM. 50 Economy ticket for $254 per person are available. Travel duration is 20h 20m
Greyhound US	32h 45m	9:00 PM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$255	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/14/2026 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 2/16/2026 5:45:00 AM. 50 Economy ticket for $255 per person are available. Travel duration is 32h 45m
FlixBus	20h 45m	3:00 PM	Syracuse, NY	Regional Transit Center	11:45 AM	Florence, SC	Bus Station	Economy	$260	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 2/14/2026 3:00:00 PM to Bus Station, Florence, SC (USA) arriving at 2/15/2026 11:45:00 AM. 50 Economy ticket for $260 per person are available. Travel duration is 20h 45m

Did you know that if you travel from Syracuse, NY to Florence, SC via Washington, DC, you can save more than $83? You can find the corresponding connections below.
- Greyhound US
  
  28h 5m
  
  0
  
  3:55 AM
  
  Syracuse, NY
  Regional Transit Center
  
  4:45 PM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $71
  
  A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/15/2026 3:55:00 AM to Union Station, Washington, DC (USA) arriving at 2/15/2026 4:45:00 PM. 50 Economy ticket for $71 per person are available. Travel duration is 12h 50m
- Wanda Coach
  
  7h 59m
  
  0
  
  12:01 AM
  
  Washington, DC
  Benning Rd NE
  
  8:00 AM
  
  Florence, SC
  Shell Gas Station
  
  0
  
  Economy
  
  $100
  
  A Bus from Wanda Coach goes from Benning Rd NE, Washington, DC (USA) at 2/16/2026 12:01:00 AM to Shell Gas Station, Florence, SC (USA) arriving at 2/16/2026 8:00:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 7h 59m
Travel time is 7h 45m longer, but you will save $83

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	32h 45m	9:00 PM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$203	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/18/2026 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 2/20/2026 5:45:00 AM. 50 Economy ticket for $203 per person are available. Travel duration is 32h 45m
Greyhound US	20h 20m	9:25 AM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$205	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/18/2026 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 2/19/2026 5:45:00 AM. 50 Economy ticket for $205 per person are available. Travel duration is 20h 20m
FlixBus	23h 45m	12:00 PM	Syracuse, NY	Regional Transit Center	11:45 AM	Florence, SC	Bus Station	Economy	$205	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 2/18/2026 12:00:00 PM to Bus Station, Florence, SC (USA) arriving at 2/19/2026 11:45:00 AM. 50 Economy ticket for $205 per person are available. Travel duration is 23h 45m

Did you know that if you travel from Syracuse, NY to Florence, SC via Washington, DC, you can save more than $76? You can find the corresponding connections below.
- Greyhound US
  
  28h 15m
  
  0
  
  7:30 AM
  
  Syracuse, NY
  Regional Transit Center
  
  6:55 PM
  
  Washington, DC
  Union Station
  
  0
  
  Economy
  
  $72
  
  A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/19/2026 7:30:00 AM to Union Station, Washington, DC (USA) arriving at 2/19/2026 6:55:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 11h 25m
- Greyhound US
  
  13h 35m
  
  0
  
  10:10 PM
  
  Washington, DC
  Union Station
  
  11:45 AM
  
  Florence, SC
  Bus Station
  
  0
  
  Economy
  
  $55
  
  A Bus from Greyhound US goes from Union Station, Washington, DC (USA) at 2/19/2026 10:10:00 PM to Bus Station, Florence, SC (USA) arriving at 2/20/2026 11:45:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 13h 35m
Travel time is 7h 55m longer, but you will save $76

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 45m	2:00 PM	Syracuse, NY	Regional Transit Center	11:45 AM	Florence, SC	Bus Station	Economy	$117	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 2/19/2026 2:00:00 PM to Bus Station, Florence, SC (USA) arriving at 2/20/2026 11:45:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 21h 45m
Greyhound US	32h 45m	9:00 PM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$118	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/19/2026 9:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 2/21/2026 5:45:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 32h 45m
Greyhound US	20h 20m	9:25 AM	Syracuse, NY	Regional Transit Center	5:45 AM	Florence, SC	TA Travel Center	Economy	$123	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 2/19/2026 9:25:00 AM to TA Travel Center, Florence, SC (USA) arriving at 2/20/2026 5:45:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 20h 20m

Best Price Offer: The price for the cheapest bus from Syracuse, NY to Florence, SC is $117 on 2/19/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Syracuse, NY and Florence, SC

See here how frequent the connections between Syracuse, NY and Florence, SC are, during different times and days of the week.

Wednesday is the busiest day, with more than 3 daily buses from Syracuse, NY to Florence, SC. Wednesday has instead the fewest connections, with only 3 daily coaches between Syracuse, NY and Florence, SC.

The busiest time of the day is the Morning, with 3 buses from Syracuse, NY to Florence, SC, while Morning sees the fewest connections between Syracuse, NY and Florence, SC, with 3 offers.

Facts about the bus from Syracuse, NY to Florence, SC

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from Syracuse, NY to Florence, SC in one click! Book your bus ticket from Syracuse, NY to Florence, SC starting from $117!

Cheapest Bus	$117
Fastest Bus	20h 20m
Earliest Bus	9:25 AM
Latest Bus	9:00 PM
Daily Bus Routes	3 Ø
Distance	642.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Syracuse, NY to Florence, SC

Every day, 3 buses from 2 bus companies leave Syracuse, NY for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/14/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/08

Monday 02/09

Tuesday 02/10

Wednesday 02/11

Thursday 02/12

Friday 02/13

Saturday 02/14

$254

Sunday 02/15

Monday 02/16

Tuesday 02/17

Wednesday 02/18

$203

Thursday 02/19

$117

Friday 02/20

Saturday 02/21

Sunday 02/22

Monday 02/23

Tuesday 02/24

Wednesday 02/25

Thursday 02/26

Friday 02/27

Saturday 02/28

Sunday 03/01

Monday 03/02

Tuesday 03/03

Wednesday 03/04

Thursday 03/05

Friday 03/06

Saturday 03/07

The cheapest time to travel from Syracuse, NY to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Syracuse, NY to Florence, SC, for the next 30 days.

With a price starting from $117, Thursday is the cheapest day for a bus from Syracuse, NY to Florence, SC. Saturday instead is the most expensive day with prices starting from $254.

Afternoon is the cheapest day time for bus tickets from Syracuse, NY to Florence, SC, with $117. Morning is the most expensive time of the day with prices starting from $123.

How to save money travelling from Syracuse, NY to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Syracuse, NY to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Syracuse, NY to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Syracuse, NY to Florence, SC are also emptier.

All bus stations and stops in Syracuse, NY and Florence, SC

In the map below, you can see where to find all bus stations in Syracuse, NY and Florence, SC.

University

University Pi 303

Regional Transit Center

Walsh Cir 1

Destiny USA

Destiny USA Dr 9090

S State St & E Genesee St

New York State Fairgrounds

State Fair Blvd 581

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Syracuse, NY to Florence, SC

Want to know which seat classes are available on the buses from Syracuse, NY to Florence, SC? Or which bus companies serve the route Syracuse, NY to Florence, SC? Below you will find answers to your questions.

FAQs about the Syracuse, NY to Florence, SC bus

How much does a Syracuse, NY Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $117 and takes 21h 45m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Syracuse, NY to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $117 and $260. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Syracuse, NY to Florence, SC each day?

Every day, the Syracuse, NY to Florence, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Syracuse, NY to Florence, SC take?

The fastest bus from Syracuse, NY to Florence, SC is offered by Greyhound US and takes 20h 20m. Bus tickets for this connection cost $254. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Syracuse, NY to Florence, SC?

The earliest bus arriving in Florence, SC from Syracuse, NY starts at 9:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Syracuse, NY to Florence, SC?

The latest bus trip departing from Syracuse, NY for Florence, SC starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Syracuse, NY Florence, SC route?

When traveling by bus from Syracuse, NY to Florence, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Syracuse, NY and Florence, SC?

You can check all the direct connections between Syracuse, NY and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Syracuse, NY to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Syracuse, NY Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Syracuse, NY Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Syracuse, NY to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Syracuse, NY to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Syracuse, NY and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Syracuse, NY to Florence, SC?

Prices and availability for 3 trips between Syracuse, NY and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Syracuse, NY to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Syracuse, NY and to Florence, SC

Here’s an overview of the most popular bus routes to Syracuse, NY and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!