Bus Chicago to Florence, SC - Compare all Companies

Compare all timetables for the bus from Chicago to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Chicago to Florence, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

$109

tomorrow

$107

Wednesday

Thursday

$107

Friday

$110

Saturday

$114

Sunday

$107

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	26h 15m	10:15 AM	Chicago	Canal & Van Buren	1:30 PM	Florence, SC	Bus Station	Economy	$109	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/20/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 4/21/2026 1:30:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 26h 15m
FlixBus	23h 30m	1:00 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$110	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/20/2026 1:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/21/2026 1:30:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 23h 30m
Greyhound US	23h 45m	2:45 PM	Chicago	Downtown Bus Station	3:30 PM	Florence, SC	Bus Station	Economy	$110	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 4/20/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 4/21/2026 3:30:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 23h 45m
Greyhound US	35h 35m	11:10 PM	Chicago	Canal & Van Buren	11:45 AM	Florence, SC	Bus Station	Economy	$114	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/20/2026 11:10:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 11:45:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 35h 35m
FlixBus	23h 0m	1:30 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$116	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 4/20/2026 1:30:00 PM to Bus Station, Florence, SC (USA) arriving at 4/21/2026 1:30:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 23h 0m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 30m	1:00 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$107	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/21/2026 1:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 1:30:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 23h 30m
Greyhound US	26h 15m	10:15 AM	Chicago	Canal & Van Buren	1:30 PM	Florence, SC	Bus Station	Economy	$108	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/21/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 1:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 15m
Greyhound US	35h 35m	11:10 PM	Chicago	Canal & Van Buren	11:45 AM	Florence, SC	Bus Station	Economy	$108	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/21/2026 11:10:00 PM to Bus Station, Florence, SC (USA) arriving at 4/23/2026 11:45:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 35h 35m
Greyhound US	23h 45m	2:45 PM	Chicago	Downtown Bus Station	3:30 PM	Florence, SC	Bus Station	Economy	$110	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 4/21/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 3:30:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 23h 45m
FlixBus	23h 0m	1:30 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$116	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 4/21/2026 1:30:00 PM to Bus Station, Florence, SC (USA) arriving at 4/22/2026 1:30:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 23h 0m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 30m	1:00 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$107	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/23/2026 1:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/24/2026 1:30:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 23h 30m
Greyhound US	26h 15m	10:15 AM	Chicago	Canal & Van Buren	1:30 PM	Florence, SC	Bus Station	Economy	$108	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/23/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 4/24/2026 1:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 15m
Greyhound US	23h 45m	2:45 PM	Chicago	Downtown Bus Station	3:30 PM	Florence, SC	Bus Station	Economy	$110	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 4/23/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 4/24/2026 3:30:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 23h 45m
Greyhound US	35h 35m	11:10 PM	Chicago	Canal & Van Buren	11:45 AM	Florence, SC	Bus Station	Economy	$112	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/23/2026 11:10:00 PM to Bus Station, Florence, SC (USA) arriving at 4/25/2026 11:45:00 AM. 50 Economy ticket for $112 per person are available. Travel duration is 35h 35m
FlixBus	23h 0m	1:30 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$116	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 4/23/2026 1:30:00 PM to Bus Station, Florence, SC (USA) arriving at 4/24/2026 1:30:00 PM. 50 Economy ticket for $116 per person are available. Travel duration is 23h 0m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	29h 35m	11:10 PM	Chicago	Union Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$110	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 4/24/2026 11:10:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/26/2026 5:45:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 29h 35m
Greyhound US	29h 55m	10:50 PM	Chicago	Downtown Bus Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$110	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 4/24/2026 10:50:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/26/2026 5:45:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 29h 55m
FlixBus	23h 30m	1:00 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$111	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/24/2026 1:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/25/2026 1:30:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 23h 30m
FlixBus	29h 5m	6:00 PM	Chicago	Downtown Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$111	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/24/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/26/2026 12:05:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 29h 5m
Greyhound US	35h 35m	11:10 PM	Chicago	Union Station	11:45 AM	Florence, SC	Bus Station	Economy	$111	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 4/24/2026 11:10:00 PM to Bus Station, Florence, SC (USA) arriving at 4/26/2026 11:45:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 35h 35m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	26h 15m	10:15 AM	Chicago	Canal & Van Buren	1:30 PM	Florence, SC	Bus Station	Economy	$114	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 4/25/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 4/26/2026 1:30:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 26h 15m
Greyhound US	23h 45m	2:45 PM	Chicago	Downtown Bus Station	3:30 PM	Florence, SC	Bus Station	Economy	$114	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 4/25/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 4/26/2026 3:30:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 45m
FlixBus	29h 5m	6:00 PM	Chicago	Downtown Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$117	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/25/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/27/2026 12:05:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 29h 5m
FlixBus	36h 40m	11:50 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$118	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 4/25/2026 11:50:00 PM to Bus Station, Florence, SC (USA) arriving at 4/27/2026 1:30:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 36h 40m
Greyhound US	36h 50m	10:15 AM	Chicago	Union Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$119	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 4/25/2026 10:15:00 AM to TA Travel Center, Florence, SC (USA) arriving at 4/27/2026 12:05:00 AM. 50 Economy ticket for $119 per person are available. Travel duration is 36h 50m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	35h 35m	11:10 PM	Chicago	Union Station	11:45 AM	Florence, SC	Bus Station	Economy	$107	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 4/26/2026 11:10:00 PM to Bus Station, Florence, SC (USA) arriving at 4/28/2026 11:45:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 35h 35m
FlixBus	29h 5m	6:00 PM	Chicago	Downtown Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$107	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/26/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 4/28/2026 12:05:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 29h 5m
Greyhound US	26h 15m	10:15 AM	Chicago	Union Station	1:30 PM	Florence, SC	Bus Station	Economy	$108	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 4/26/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 4/27/2026 1:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 15m
Greyhound US	23h 45m	2:45 PM	Chicago	Downtown Bus Station	3:30 PM	Florence, SC	Bus Station	Economy	$108	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 4/26/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 4/27/2026 3:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 23h 45m
FlixBus	23h 30m	1:00 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$110	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 4/26/2026 1:00:00 PM to Bus Station, Florence, SC (USA) arriving at 4/27/2026 1:30:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 23h 30m

Best Price Offer: The price for the cheapest bus from Chicago to Florence, SC is $92 on 5/10/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Florence, SC

See here how frequent the connections between Chicago and Florence, SC are, during different times and days of the week.

Friday is the busiest day, with more than 20 daily buses from Chicago to Florence, SC. Sunday has instead the fewest connections, with only 6 daily coaches between Chicago and Florence, SC.

The busiest time of the day is the Afternoon, with 24 buses from Chicago to Florence, SC, while Night sees the fewest connections between Chicago and Florence, SC, with 5 offers.

Facts about the bus from Chicago to Florence, SC

Compare all providers like Greyhound US and FlixBus that travel 10 times every day by bus from Chicago to Florence, SC in one click! Book your bus ticket from Chicago to Florence, SC starting from $92!

Cheapest Bus	$92
Fastest Bus	24h 0m
Earliest Bus	5:45 AM
Latest Bus	11:10 PM
Daily Bus Routes	10 Ø
Distance	681.8 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Florence, SC

Every day, 10 buses from 2 bus companies leave Chicago for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$113

Tuesday 04/21

$107

Wednesday 04/22

Thursday 04/23

$107

Friday 04/24

$112

Saturday 04/25

$113

Sunday 04/26

$107

Monday 04/27

$104

Tuesday 04/28

$106

Wednesday 04/29

Thursday 04/30

$111

Friday 05/01

$114

Saturday 05/02

$115

Sunday 05/03

$113

Monday 05/04

$108

Tuesday 05/05

$123

Wednesday 05/06

Thursday 05/07

Friday 05/08

Saturday 05/09

$96

Sunday 05/10

$92

Monday 05/11

$93

Tuesday 05/12

$93

Wednesday 05/13

$116

Thursday 05/14

$110

Friday 05/15

$122

Saturday 05/16

The cheapest time to travel from Chicago to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Florence, SC, for the next 30 days.

With a price starting from $92, Sunday is the cheapest day for a bus from Chicago to Florence, SC. Friday instead is the most expensive day with prices starting from $110.

Night is the cheapest day time for bus tickets from Chicago to Florence, SC, with $92. Morning is the most expensive time of the day with prices starting from $108.

How to save money travelling from Chicago to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Florence, SC are also emptier.

All bus stations and stops in Chicago and Florence, SC

In the map below, you can see where to find all bus stations in Chicago and Florence, SC.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Chicago to Florence, SC

Want to know which seat classes are available on the buses from Chicago to Florence, SC? Or which bus companies serve the route Chicago to Florence, SC? Below you will find answers to your questions.

FAQs about the Chicago to Florence, SC bus

How much does a Chicago Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 24h 30m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Chicago to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $92 and $135. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Chicago to Florence, SC each day?

Every day, the Chicago to Florence, SC bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Florence, SC take?

The fastest bus from Chicago to Florence, SC is offered by FlixBus and takes 24h 0m. Bus tickets for this connection cost $116. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Florence, SC?

The earliest bus arriving in Florence, SC from Chicago starts at 5:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Florence, SC?

The latest bus trip departing from Chicago for Florence, SC starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Florence, SC route?

When traveling by bus from Chicago to Florence, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Florence, SC?

You can check all the direct connections between Chicago and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between Chicago and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Florence, SC?

Prices and availability for 10 trips between Chicago and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Florence, SC

Here’s an overview of the most popular bus routes to Chicago and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!