Compare all timetables for the bus from Chicago to Florence, SC
Here is a selection of the cheapest bus trips from the schedule from Chicago to Florence, SC from various bus operators like Greyhound US or FlixBus for the next days.
| Mode of Transport | BertCompanyCountOneCompanyName | Duration | Departure time | From | Departure | Arrival time | To | Destination | Logo | Seat classes | Price | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Greyhound US | 35h 35m | 11:10 PM | Chicago | Union Station | 11:45 AM | Florence, SC | Bus Station | Economy | $136 |
A Bus from Greyhound US goes from Union Station, Chicago (USA) at 1/19/2026 11:10:00 PM to Bus Station, Florence, SC (USA) arriving at 1/21/2026 11:45:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 35h 35m
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| Greyhound US | 23h 45m | 2:45 PM | Chicago | Downtown Bus Station | 3:30 PM | Florence, SC | Bus Station | Economy | $136 |
A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 1/19/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 1/20/2026 3:30:00 PM. 50 Economy ticket for $136 per person are available. Travel duration is 23h 45m
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| Greyhound US | 26h 30m | 10:00 AM | Chicago | Union Station | 1:30 PM | Florence, SC | Bus Station | Economy | $140 |
A Bus from Greyhound US goes from Union Station, Chicago (USA) at 1/19/2026 10:00:00 AM to Bus Station, Florence, SC (USA) arriving at 1/20/2026 1:30:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 26h 30m
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| FlixBus | 23h 30m | 1:00 PM | Chicago | Downtown Bus Station | 1:30 PM | Florence, SC | Bus Station | Economy | $221 |
A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 1/19/2026 1:00:00 PM to Bus Station, Florence, SC (USA) arriving at 1/20/2026 1:30:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 23h 30m
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Best Price Offer: The price for the cheapest bus from Chicago to Florence, SC is $111 on 1/30/2026. Flexible travelers save on ticket prices.
Facts about the bus from Chicago to Florence, SC
Compare all providers like Greyhound US and FlixBus that travel 4 times every day by bus from Chicago to Florence, SC in one click! Book your bus ticket from Chicago to Florence, SC starting from $111!
| Cheapest Bus | $111 |
| Fastest Bus | 24h 30m |
| Earliest Bus | 10:00 AM |
| Latest Bus | 11:10 PM |
| Daily Bus Routes | 4 Ø |
| Distance | 681.8 miles |
| Bus Companies | Greyhound US and FlixBus |
Cheapest bus connections from Chicago to Florence, SC
Every day, 4 buses from 2 bus companies leave Chicago for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 01/19/2026 and for the following days.
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday
01/18
Monday
01/19
$136
Tuesday
01/20
Wednesday
01/21
Thursday
01/22
Friday
01/23
Saturday
01/24
Sunday
01/25
Monday
01/26
$114
Tuesday
01/27
Wednesday
01/28
Thursday
01/29
Friday
01/30
$111
Saturday
01/31
Sunday
02/01
Monday
02/02
Tuesday
02/03
Wednesday
02/04
Thursday
02/05
Friday
02/06
Saturday
02/07
Sunday
02/08
Monday
02/09
Tuesday
02/10
Wednesday
02/11
Thursday
02/12
Friday
02/13
Saturday
02/14
How to save money travelling from Chicago to Florence, SC
Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:
Book the ticket from Chicago to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.
If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Florence, SC are also emptier.All bus stations and stops in Chicago and Florence, SC
In the map below, you can see where to find all bus stations in Chicago and Florence, SC.
Service and Comfort on the bus from Chicago to Florence, SC
Want to know which seat classes are available on the buses from Chicago to Florence, SC? Or which bus companies serve the route Chicago to Florence, SC? Below you will find answers to your questions.
FAQs about the Chicago to Florence, SC bus
How much does a Chicago Florence, SC bus trip cost?
This depends on, among other things, the day and time of travel. The cheapest trip is available from $111 and takes 36h 35m to reach Florence, SC. Compare offers to save money!
How much could I save by comparing buses from Chicago to Florence, SC?
This route is offered by 2 companies with a range of ticket prices between $111 and $221. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.
On average, how many connections are available from Chicago to Florence, SC each day?
Every day, the Chicago to Florence, SC bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.
How long does a bus journey from Chicago to Florence, SC take?
The fastest bus from Chicago to Florence, SC is offered by FlixBus and takes 24h 30m. Bus tickets for this connection cost $221. In this context, bear in mind that the journey can take longer due to traffic.
What time is the first bus from Chicago to Florence, SC?
The earliest bus arriving in Florence, SC from Chicago starts at 10:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.
What time is the last bus from Chicago to Florence, SC?
The latest bus trip departing from Chicago for Florence, SC starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.
Which bus companies operate the Chicago Florence, SC route?
When traveling by bus from Chicago to Florence, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.
Is there a direct bus between Chicago and Florence, SC?
You can check all the direct connections between Chicago and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.
What can I take with me on the Chicago to Florence, SC bus route?
Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.
What equipment is available for the Chicago Florence, SC bus route?
The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Florence, SC on your planned travel date.
How does CheckMyBus find the best bus deals from Chicago to Florence, SC?
CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Chicago and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.
How does CheckMyBus technology work for trips from Chicago to Florence, SC?
Prices and availability for 4 trips between Chicago and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.
Available seat classes which are offered on the bus route Chicago to Florence, SC
Economy
The cheapest option available for your ticket, it usually comes with reclinable seats and AC.
More bus routes to Chicago and to Florence, SC
Here’s an overview of the most popular bus routes to Chicago and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
- Bus Routes to Chicago
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- Bus Routes to Florence, SC
- Bus Allentown, PA to Florence, SC
- Bus Bridgeport, CT to Florence, SC
- Buses Columbia, SC - Florence, SC
- Buses Durham, NC to Florence, SC
- Bus Jacksonville, FL - Florence, SC
- Lakeland, FL to Florence, SC bus
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- Buses from New York to Florence, SC
- Bus from Orlando, FL to Florence, SC
- Bus Philadelphia to Florence, SC
- Bus to Florence, SC from Richmond, VA
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- Bus from Syracuse, NY to Florence, SC
- Bus from Tallahassee, FL to Florence, SC
- Buses Washington, DC to Florence, SC
Popular Airport Shuttles to Chicago and to Florence, SC
