Which bus from Chicago to Florence, SC is the cheapest?

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Compare all timetables for the bus from Chicago to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Chicago to Florence, SC from various bus operators like Greyhound US or FlixBus for the next days.

today
$167
tomorrow
Monday
Tuesday
Wednesday
$161
Thursday
Friday

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 23h 45m 2:45 PM Chicago Downtown Bus Station 3:30 PM Florence, SC Bus Station  Economy $167
FlixBus 23h 30m 1:00 PM Chicago Downtown Bus Station 1:30 PM Florence, SC Bus Station  Economy $167
Greyhound US 37h 5m 10:00 AM Chicago Union Station 12:05 AM Florence, SC TA Travel Center  Economy $168
FlixBus 29h 5m 6:00 PM Chicago Downtown Bus Station 12:05 AM Florence, SC TA Travel Center  Economy $168
Greyhound US 29h 35m 11:10 PM Chicago Union Station 5:45 AM Florence, SC TA Travel Center  Economy $169
  • Did you know that if you travel from Chicago to Florence, SC via Charlotte, you can save more than $38? You can find the corresponding connections below.
    • Greyhound US
      32h 20m
      0
      6:10 AM
      Chicago
      Downtown Bus Station
      5:00 AM
      Charlotte
      W Trade St
      0
      Greyhound US
      Economy
      $106
      • Waiting Time 8h 15m
    • FlixBus
      2h 15m
      0
      1:15 PM
      Charlotte
      W Trade St
      3:30 PM
      Florence, SC
      Bus Station
      0
      FlixBus
      Economy
      $23
    Travel time is 7h 50m longer, but you will save $38

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Greyhound US 37h 5m 10:00 AM Chicago Union Station 12:05 AM Florence, SC TA Travel Center  Economy $161
Greyhound US 35h 35m 11:10 PM Chicago Union Station 11:45 AM Florence, SC Bus Station  Economy $162
Greyhound US 23h 45m 2:45 PM Chicago Downtown Bus Station 3:30 PM Florence, SC Bus Station  Economy $163
FlixBus 23h 30m 1:00 PM Chicago Downtown Bus Station 1:30 PM Florence, SC Bus Station  Economy $163
  • Did you know that if you travel from Chicago to Florence, SC via Charlotte, you can save more than $32? You can find the corresponding connections below.
    • Greyhound US
      32h 20m
      0
      6:10 AM
      Chicago
      Downtown Bus Station
      5:00 AM
      Charlotte
      W Trade St
      0
      Greyhound US
      Economy
      $106
      • Waiting Time 8h 15m
    • FlixBus
      2h 15m
      0
      1:15 PM
      Charlotte
      W Trade St
      3:30 PM
      Florence, SC
      Bus Station
      0
      FlixBus
      Economy
      $23
    Travel time is 7h 50m longer, but you will save $32

Best Price Offer: The price for the cheapest bus from Chicago to Florence, SC is $121 on 2/13/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Chicago and Florence, SC

See here how frequent the connections between Chicago and Florence, SC are, during different times and days of the week.
Wednesday is the busiest day, with more than 8 daily buses from Chicago to Florence, SC. Wednesday has instead the fewest connections, with only 8 daily coaches between Chicago and Florence, SC.
The busiest time of the day is the Evening, with 7 buses from Chicago to Florence, SC, while Morning sees the fewest connections between Chicago and Florence, SC, with 4 offers.

Facts about the bus from Chicago to Florence, SC

Compare all providers like Greyhound US and FlixBus that travel 8 times every day by bus from Chicago to Florence, SC in one click! Book your bus ticket from Chicago to Florence, SC starting from $121!

Cheapest Bus $121
Fastest Bus 24h 30m
Earliest Bus 10:00 AM
Latest Bus 11:10 PM
Daily Bus Routes 8 Ø
Distance 681.8 miles
Bus Companies Greyhound US and FlixBus

Cheapest bus connections from Chicago to Florence, SC

Every day, 8 buses from 2 bus companies leave Chicago for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/14/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 02/08
Monday 02/09
Tuesday 02/10
Wednesday 02/11
Thursday 02/12
Friday 02/13
Saturday 02/14
$167
Sunday 02/15
Monday 02/16
Tuesday 02/17
Wednesday 02/18
$161
Thursday 02/19
Friday 02/20
Saturday 02/21
Sunday 02/22
Monday 02/23
Tuesday 02/24
Wednesday 02/25
Thursday 02/26
Friday 02/27
Saturday 02/28
Sunday 03/01
Monday 03/02
Tuesday 03/03
Wednesday 03/04
Thursday 03/05
Friday 03/06
Saturday 03/07

The cheapest time to travel from Chicago to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Florence, SC, for the next 30 days.
With a price starting from $161, Wednesday is the cheapest day for a bus from Chicago to Florence, SC. Saturday instead is the most expensive day with prices starting from $167.
Morning is the cheapest day time for bus tickets from Chicago to Florence, SC, with $161. Afternoon is the most expensive time of the day with prices starting from $163.

How to save money travelling from Chicago to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Florence, SC are also emptier.

All bus stations and stops in Chicago and Florence, SC

In the map below, you can see where to find all bus stations in Chicago and Florence, SC.

Service and Comfort on the bus from Chicago to Florence, SC

Want to know which seat classes are available on the buses from Chicago to Florence, SC? Or which bus companies serve the route Chicago to Florence, SC? Below you will find answers to your questions.

FAQs about the Chicago to Florence, SC bus

How much does a Chicago Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $121 and takes 38h 5m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Chicago to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $121 and $179. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Chicago to Florence, SC each day?

Every day, the Chicago to Florence, SC bus route is served by approximately 8 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Florence, SC take?

The fastest bus from Chicago to Florence, SC is offered by FlixBus and takes 24h 30m. Bus tickets for this connection cost $167. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Florence, SC?

The earliest bus arriving in Florence, SC from Chicago starts at 10:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Florence, SC?

The latest bus trip departing from Chicago for Florence, SC starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Florence, SC route?

When traveling by bus from Chicago to Florence, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Florence, SC?

You can check all the direct connections between Chicago and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 8 daily trips between Chicago and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Florence, SC?

Prices and availability for 8 trips between Chicago and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Florence, SC

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Florence, SC

Here’s an overview of the most popular bus routes to Chicago and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!
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