Bus Chicago to Florence, SC - Compare all Companies

Compare all timetables for the bus from Chicago to Florence, SC

Here is a selection of the cheapest bus trips from the schedule from Chicago to Florence, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

$113

tomorrow

$122

Monday

Tuesday

$107

Wednesday

Thursday

Friday

$109

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 45m	2:45 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$113	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/8/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 8/9/2026 1:30:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 21h 45m
FlixBus	23h 0m	1:30 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$115	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/8/2026 1:30:00 PM to Bus Station, Florence, SC (USA) arriving at 8/9/2026 1:30:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 23h 0m
FlixBus	36h 35m	11:55 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$115	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/8/2026 11:55:00 PM to Bus Station, Florence, SC (USA) arriving at 8/10/2026 1:30:00 PM. 50 Economy ticket for $115 per person are available. Travel duration is 36h 35m
Greyhound US	26h 15m	10:15 AM	Chicago	Canal & Van Buren	1:30 PM	Florence, SC	Bus Station	Economy	$122	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 8/8/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 8/9/2026 1:30:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 26h 15m
FlixBus	39h 15m	5:05 PM	Chicago	95th Red Line Station	9:20 AM	Florence, SC	Bus Station	Economy	$145	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/8/2026 5:05:00 PM to Bus Station, Florence, SC (USA) arriving at 8/10/2026 9:20:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 39h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	29h 5m	6:00 PM	Chicago	Downtown Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$122	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/9/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 8/11/2026 12:05:00 AM. 50 Economy ticket for $122 per person are available. Travel duration is 29h 5m
Greyhound US	36h 50m	10:15 AM	Chicago	Union Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$135	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 8/9/2026 10:15:00 AM to TA Travel Center, Florence, SC (USA) arriving at 8/11/2026 12:05:00 AM. 50 Economy ticket for $135 per person are available. Travel duration is 36h 50m
Greyhound US	53h 35m	11:10 PM	Chicago	Union Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$145	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 8/9/2026 11:10:00 PM to TA Travel Center, Florence, SC (USA) arriving at 8/12/2026 5:45:00 AM. 50 Economy ticket for $145 per person are available. Travel duration is 53h 35m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	29h 5m	6:00 PM	Chicago	Downtown Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$107	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/11/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 8/13/2026 12:05:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 29h 5m
Greyhound US	36h 50m	10:15 AM	Chicago	Union Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$111	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 8/11/2026 10:15:00 AM to TA Travel Center, Florence, SC (USA) arriving at 8/13/2026 12:05:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 36h 50m
Greyhound US	29h 35m	11:10 PM	Chicago	Union Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$144	A Bus from Greyhound US goes from Union Station, Chicago (USA) at 8/11/2026 11:10:00 PM to TA Travel Center, Florence, SC (USA) arriving at 8/13/2026 5:45:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 29h 35m
Greyhound US	29h 55m	10:50 PM	Chicago	Downtown Bus Station	5:45 AM	Florence, SC	TA Travel Center	Economy	$144	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/11/2026 10:50:00 PM to TA Travel Center, Florence, SC (USA) arriving at 8/13/2026 5:45:00 AM. 50 Economy ticket for $144 per person are available. Travel duration is 29h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	26h 15m	10:15 AM	Chicago	Canal & Van Buren	1:30 PM	Florence, SC	Bus Station	Economy	$109	A Bus from Greyhound US goes from Canal & Van Buren, Chicago (USA) at 8/14/2026 10:15:00 AM to Bus Station, Florence, SC (USA) arriving at 8/15/2026 1:30:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 26h 15m
Greyhound US	25h 50m	6:30 AM	Chicago	Downtown Bus Station	9:20 AM	Florence, SC	Bus Station	Economy	$110	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/14/2026 6:30:00 AM to Bus Station, Florence, SC (USA) arriving at 8/15/2026 9:20:00 AM. 50 Economy ticket for $110 per person are available. Travel duration is 25h 50m
Greyhound US	21h 45m	2:45 PM	Chicago	Downtown Bus Station	1:30 PM	Florence, SC	Bus Station	Economy	$110	A Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 8/14/2026 2:45:00 PM to Bus Station, Florence, SC (USA) arriving at 8/15/2026 1:30:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 21h 45m
FlixBus	29h 5m	6:00 PM	Chicago	Downtown Bus Station	12:05 AM	Florence, SC	TA Travel Center	Economy	$117	A Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 8/14/2026 6:00:00 PM to TA Travel Center, Florence, SC (USA) arriving at 8/16/2026 12:05:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 29h 5m
FlixBus	23h 0m	1:30 PM	Chicago	95th Red Line Station	1:30 PM	Florence, SC	Bus Station	Economy	$120	A Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 8/14/2026 1:30:00 PM to Bus Station, Florence, SC (USA) arriving at 8/15/2026 1:30:00 PM. 50 Economy ticket for $120 per person are available. Travel duration is 23h 0m

Best Price Offer: The price for the cheapest bus from Chicago to Florence, SC is $77 on 8/26/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Chicago and Florence, SC

See here how frequent the connections between Chicago and Florence, SC are, during different times and days of the week.

Friday is the busiest day, with more than 11 daily buses from Chicago to Florence, SC. Sunday has instead the fewest connections, with only 3 daily coaches between Chicago and Florence, SC.

The busiest time of the day is the Evening, with 11 buses from Chicago to Florence, SC, while Night sees the fewest connections between Chicago and Florence, SC, with 1 offers.

Facts about the bus from Chicago to Florence, SC

Compare all providers like Greyhound US and FlixBus that travel 6 times every day by bus from Chicago to Florence, SC in one click! Book your bus ticket from Chicago to Florence, SC starting from $77!

Cheapest Bus	$77
Fastest Bus	22h 45m
Earliest Bus	10:15 AM
Latest Bus	11:10 PM
Daily Bus Routes	6 Ø
Distance	681.8 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Chicago to Florence, SC

Every day, 6 buses from 2 bus companies leave Chicago for Florence, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/08/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

Saturday 08/08

$94

Sunday 08/09

$122

Monday 08/10

Tuesday 08/11

$107

Wednesday 08/12

Thursday 08/13

Friday 08/14

$117

Saturday 08/15

Sunday 08/16

Monday 08/17

$136

Tuesday 08/18

$128

Wednesday 08/19

$129

Thursday 08/20

$132

Friday 08/21

$132

Saturday 08/22

Sunday 08/23

Monday 08/24

Tuesday 08/25

$84

Wednesday 08/26

$77

Thursday 08/27

$104

Friday 08/28

$83

Saturday 08/29

The cheapest time to travel from Chicago to Florence, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Chicago to Florence, SC, for the next 30 days.

With a price starting from $81, Saturday is the cheapest day for a bus from Chicago to Florence, SC. Sunday instead is the most expensive day with prices starting from $122.

Night is the cheapest day time for bus tickets from Chicago to Florence, SC, with $77. Afternoon is the most expensive time of the day with prices starting from $110.

How to save money travelling from Chicago to Florence, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Chicago to Florence, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Chicago to Florence, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Chicago to Florence, SC are also emptier.

Beloved bus companies from Chicago to Florence, SC

These are the most booked bus companies between Chicago to Florence, SC from our users.

FlixBus from Chicago to Florence, SC

Here you will find the key facts about the FlixBus bus route Chicago to Florence, SC:

Cheapest Price	$107
Fastest Bus	24h 0m
Earliest Bus	1:30 PM
Last Bus	6:00 PM
Daily Connections	2 Ø
Found on	7/15/2026

All bus stations and stops in Chicago and Florence, SC

In the map below, you can see where to find all bus stations in Chicago and Florence, SC.

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Bus Station

S Irby St 611

TA Travel Center

W Lucas St 2301

Exxon Gas Station

W Lucas Street 1901

McDonalds

W. Lucas St. 1908

Shell Gas Station

W Lucas Street 1832

Service and Comfort on the bus from Chicago to Florence, SC

Want to know which seat classes are available on the buses from Chicago to Florence, SC? Or which bus companies serve the route Chicago to Florence, SC? Below you will find answers to your questions.

FAQs about the Chicago to Florence, SC bus

How much does a Chicago Florence, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $77 and takes 30h 5m to reach Florence, SC. Compare offers to save money!

How much could I save by comparing buses from Chicago to Florence, SC?

This route is offered by 2 companies with a range of ticket prices between $77 and $205. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Florence, SC.

On average, how many connections are available from Chicago to Florence, SC each day?

Every day, the Chicago to Florence, SC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Chicago to Florence, SC take?

The fastest bus from Chicago to Florence, SC is offered by Greyhound US and takes 22h 45m. Bus tickets for this connection cost $113. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Chicago to Florence, SC?

The earliest bus arriving in Florence, SC from Chicago starts at 10:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Chicago to Florence, SC?

The latest bus trip departing from Chicago for Florence, SC starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Chicago Florence, SC route?

When traveling by bus from Chicago to Florence, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Chicago and Florence, SC?

You can check all the direct connections between Chicago and Florence, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Chicago to Florence, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Chicago Florence, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Chicago Florence, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Chicago to Florence, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Chicago to Florence, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Chicago and Florence, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Chicago to Florence, SC?

Prices and availability for 6 trips between Chicago and Florence, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Chicago to Florence, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Chicago and to Florence, SC

Here’s an overview of the most popular bus routes to Chicago and to Florence, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!