Bus Greenville, SC to Syracuse, NY - Compare all Companies

Compare all timetables for the bus from Greenville, SC to Syracuse, NY

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Syracuse, NY from various bus operators like FlixBus or Greyhound US for the next days.

today

$90

tomorrow

$107

Wednesday

$106

Thursday

Friday

Saturday

$113

Sunday

$100

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 0m	4:15 PM	Greenville, SC	Woodruff Rd	3:15 PM	Syracuse, NY	Regional Transit Center	Economy	$90	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/20/2026 4:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/21/2026 3:15:00 PM. 50 Economy ticket for $90 per person are available. Travel duration is 23h 0m
Greyhound US	21h 40m	7:25 AM	Greenville, SC	Woodruff Rd	5:05 AM	Syracuse, NY	Regional Transit Center	Economy	$91	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/20/2026 7:25:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/21/2026 5:05:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 21h 40m
FlixBus	23h 5m	12:15 PM	Greenville, SC	Woodruff Rd	11:20 AM	Syracuse, NY	Regional Transit Center	Economy	$91	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/20/2026 12:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/21/2026 11:20:00 AM. 50 Economy ticket for $91 per person are available. Travel duration is 23h 5m
FlixBus	21h 30m	10:00 PM	Greenville, SC	Woodruff Rd	7:30 PM	Syracuse, NY	Regional Transit Center	Economy	$91	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/20/2026 10:00:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/21/2026 7:30:00 PM. 50 Economy ticket for $91 per person are available. Travel duration is 21h 30m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	23h 0m	4:15 PM	Greenville, SC	Woodruff Rd	3:15 PM	Syracuse, NY	Regional Transit Center	Economy	$107	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 4:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/22/2026 3:15:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 23h 0m
Greyhound US	21h 55m	7:10 AM	Greenville, SC	Woodruff Rd	5:05 AM	Syracuse, NY	Regional Transit Center	Economy	$108	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 7:10:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/22/2026 5:05:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 21h 55m
Greyhound US	26h 45m	10:50 AM	Greenville, SC	Woodruff Rd	1:35 PM	Syracuse, NY	Regional Transit Center	Economy	$108	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 10:50:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/22/2026 1:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 45m
FlixBus	21h 30m	10:00 PM	Greenville, SC	Woodruff Rd	7:30 PM	Syracuse, NY	Regional Transit Center	Economy	$108	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/21/2026 10:00:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/22/2026 7:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 21h 30m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 55m	7:10 AM	Greenville, SC	Woodruff Rd	5:05 AM	Syracuse, NY	Regional Transit Center	Economy	$106	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 7:10:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/23/2026 5:05:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 21h 55m
FlixBus	23h 0m	4:15 PM	Greenville, SC	Woodruff Rd	3:15 PM	Syracuse, NY	Regional Transit Center	Economy	$107	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 4:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/23/2026 3:15:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 23h 0m
Greyhound US	26h 45m	10:50 AM	Greenville, SC	Woodruff Rd	1:35 PM	Syracuse, NY	Regional Transit Center	Economy	$108	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 10:50:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/23/2026 1:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 26h 45m
FlixBus	21h 30m	10:00 PM	Greenville, SC	Woodruff Rd	7:30 PM	Syracuse, NY	Regional Transit Center	Economy	$108	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/22/2026 10:00:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/23/2026 7:30:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 21h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 55m	7:10 AM	Greenville, SC	Woodruff Rd	5:05 AM	Syracuse, NY	Regional Transit Center	Economy	$113	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/25/2026 7:10:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/26/2026 5:05:00 AM. 50 Economy ticket for $113 per person are available. Travel duration is 21h 55m
FlixBus	23h 0m	4:15 PM	Greenville, SC	Woodruff Rd	3:15 PM	Syracuse, NY	Regional Transit Center	Economy	$114	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/25/2026 4:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/26/2026 3:15:00 PM. 50 Economy ticket for $114 per person are available. Travel duration is 23h 0m
FlixBus	23h 5m	12:15 PM	Greenville, SC	Woodruff Rd	11:20 AM	Syracuse, NY	Regional Transit Center	Economy	$115	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/25/2026 12:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/26/2026 11:20:00 AM. 50 Economy ticket for $115 per person are available. Travel duration is 23h 5m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	21h 55m	7:10 AM	Greenville, SC	Woodruff Rd	5:05 AM	Syracuse, NY	Regional Transit Center	Economy	$100	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 4/26/2026 7:10:00 AM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/27/2026 5:05:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 21h 55m
FlixBus	23h 5m	12:15 PM	Greenville, SC	Woodruff Rd	11:20 AM	Syracuse, NY	Regional Transit Center	Economy	$100	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/26/2026 12:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/27/2026 11:20:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 23h 5m
FlixBus	23h 0m	4:15 PM	Greenville, SC	Woodruff Rd	3:15 PM	Syracuse, NY	Regional Transit Center	Economy	$100	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 4/26/2026 4:15:00 PM to Regional Transit Center, Syracuse, NY (USA) arriving at 4/27/2026 3:15:00 PM. 50 Economy ticket for $100 per person are available. Travel duration is 23h 0m

Best Price Offer: The price for the cheapest bus from Greenville, SC to Syracuse, NY is $86 on 4/27/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Syracuse, NY

See here how frequent the connections between Greenville, SC and Syracuse, NY are, during different times and days of the week.

Tuesday is the busiest day, with more than 8 daily buses from Greenville, SC to Syracuse, NY. Sunday has instead the fewest connections, with only 3 daily coaches between Greenville, SC and Syracuse, NY.

The busiest time of the day is the Morning, with 11 buses from Greenville, SC to Syracuse, NY, while Evening sees the fewest connections between Greenville, SC and Syracuse, NY, with 5 offers.

Facts about the bus from Greenville, SC to Syracuse, NY

Compare all providers like FlixBus and Greyhound US that travel 5 times every day by bus from Greenville, SC to Syracuse, NY in one click! Book your bus ticket from Greenville, SC to Syracuse, NY starting from $86!

Cheapest Bus	$86
Fastest Bus	21h 30m
Earliest Bus	7:25 AM
Latest Bus	4:15 PM
Daily Bus Routes	5 Ø
Distance	658.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Syracuse, NY

Every day, 5 buses from 2 bus companies leave Greenville, SC for Syracuse, NY: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$90

Tuesday 04/21

$111

Wednesday 04/22

$110

Thursday 04/23

Friday 04/24

Saturday 04/25

$113

Sunday 04/26

$100

Monday 04/27

$86

Tuesday 04/28

Wednesday 04/29

$115

Thursday 04/30

$101

Friday 05/01

$107

Saturday 05/02

$113

Sunday 05/03

$100

Monday 05/04

$99

Tuesday 05/05

$103

Wednesday 05/06

Thursday 05/07

Friday 05/08

$107

Saturday 05/09

$115

Sunday 05/10

$110

Monday 05/11

$105

Tuesday 05/12

Wednesday 05/13

$114

Thursday 05/14

Friday 05/15

$105

Saturday 05/16

The cheapest time to travel from Greenville, SC to Syracuse, NY

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Syracuse, NY, for the next 30 days.

With a price starting from $86, Monday is the cheapest day for a bus from Greenville, SC to Syracuse, NY. Saturday instead is the most expensive day with prices starting from $108.

Afternoon is the cheapest day time for bus tickets from Greenville, SC to Syracuse, NY, with $90. Morning is the most expensive time of the day with prices starting from $91.

How to save money travelling from Greenville, SC to Syracuse, NY

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Syracuse, NY in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Syracuse, NY, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Syracuse, NY are also emptier.

All bus stations and stops in Greenville, SC and Syracuse, NY

In the map below, you can see where to find all bus stations in Greenville, SC and Syracuse, NY.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

University

University Pi 303

Regional Transit Center

Walsh Cir 1

S State St & E Genesee St

Destiny USA

Destiny USA Dr 9090

New York State Fairgrounds

State Fair Blvd 581

Service and Comfort on the bus from Greenville, SC to Syracuse, NY

Want to know which seat classes are available on the buses from Greenville, SC to Syracuse, NY? Or which bus companies serve the route Greenville, SC to Syracuse, NY? Below you will find answers to your questions.

FAQs about the Greenville, SC to Syracuse, NY bus

How much does a Greenville, SC Syracuse, NY bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $86 and takes 23h 0m to reach Syracuse, NY. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Syracuse, NY?

This route is offered by 2 companies with a range of ticket prices between $86 and $115. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Syracuse, NY.

On average, how many connections are available from Greenville, SC to Syracuse, NY each day?

Every day, the Greenville, SC to Syracuse, NY bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Syracuse, NY take?

The fastest bus from Greenville, SC to Syracuse, NY is offered by FlixBus and takes 21h 30m. Bus tickets for this connection cost $91. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Syracuse, NY?

The earliest bus arriving in Syracuse, NY from Greenville, SC starts at 7:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Syracuse, NY?

The latest bus trip departing from Greenville, SC for Syracuse, NY starts at 4:15 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Syracuse, NY route?

When traveling by bus from Greenville, SC to Syracuse, NY, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Syracuse, NY?

You can check all the direct connections between Greenville, SC and Syracuse, NY by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Syracuse, NY bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Syracuse, NY bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Syracuse, NY bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Syracuse, NY on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Syracuse, NY?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Greenville, SC and Syracuse, NY. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Syracuse, NY?

Prices and availability for 5 trips between Greenville, SC and Syracuse, NY change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Syracuse, NY

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Syracuse, NY

Here’s an overview of the most popular bus routes to Greenville, SC and to Syracuse, NY. Simply click on the connection of your choice, and you will find all the details about your bus route!