Bus Houston to Lake City, FL - Compare all Companies

Compare all timetables for the bus from Houston to Lake City, FL

Here is a selection of the cheapest bus trips from the schedule from Houston to Lake City, FL from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

$102

Monday

Tuesday

$134

Wednesday

$138

Thursday

Friday

$103

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 25m	10:00 PM	Houston	Harrisburg Blvd Station	7:25 PM	Lake City, FL	Bus Stop	Economy	$102	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/8/2026 10:00:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/9/2026 7:25:00 PM. 50 Economy ticket for $102 per person are available. Travel duration is 20h 25m
Greyhound US	27h 10m	5:00 AM	Houston	Harrisburg Blvd Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/8/2026 5:00:00 AM to Bus Stop, Lake City, FL (USA) arriving at 2/9/2026 9:10:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 27h 10m
Greyhound US	17h 55m	6:35 PM	Houston	Harrisburg Blvd Station	1:30 PM	Lake City, FL	Bus Stop	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/8/2026 6:35:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/9/2026 1:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 17h 55m
FlixBus	22h 40m	1:50 PM	Houston	Uptown/Upper Kirby	1:30 PM	Lake City, FL	Bus Stop	Economy	$103	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 2/8/2026 1:50:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/9/2026 1:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 40m
FlixBus	19h 25m	5:05 PM	Houston	Downtown Houston	1:30 PM	Lake City, FL	Bus Stop	Economy	$103	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 2/8/2026 5:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/9/2026 1:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 19h 25m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 25m	10:00 PM	Houston	Harrisburg Blvd Station	7:25 PM	Lake City, FL	Bus Stop	Economy	$134	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/10/2026 10:00:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/11/2026 7:25:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 20h 25m
Greyhound US	27h 10m	5:00 AM	Houston	Harrisburg Blvd Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$149	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/10/2026 5:00:00 AM to Bus Stop, Lake City, FL (USA) arriving at 2/11/2026 9:10:00 AM. 50 Economy ticket for $149 per person are available. Travel duration is 27h 10m
Greyhound US	17h 55m	6:35 PM	Houston	Harrisburg Blvd Station	1:30 PM	Lake City, FL	Bus Stop	Economy	$150	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/10/2026 6:35:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/11/2026 1:30:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 17h 55m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 25m	10:00 PM	Houston	Harrisburg Blvd Station	7:25 PM	Lake City, FL	Bus Stop	Economy	$138	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/11/2026 10:00:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/12/2026 7:25:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 20h 25m
Greyhound US	27h 10m	5:00 AM	Houston	Harrisburg Blvd Station	9:10 AM	Lake City, FL	Bus Stop	Economy	$139	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/11/2026 5:00:00 AM to Bus Stop, Lake City, FL (USA) arriving at 2/12/2026 9:10:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 27h 10m
FlixBus	22h 40m	1:50 PM	Houston	Uptown/Upper Kirby	1:30 PM	Lake City, FL	Bus Stop	Economy	$139	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 2/11/2026 1:50:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/12/2026 1:30:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 22h 40m
FlixBus	22h 20m	2:10 PM	Houston	Downtown Houston	1:30 PM	Lake City, FL	Bus Stop	Economy	$139	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 2/11/2026 2:10:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/12/2026 1:30:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 22h 20m
Greyhound US	17h 55m	6:35 PM	Houston	Harrisburg Blvd Station	1:30 PM	Lake City, FL	Bus Stop	Economy	$140	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/11/2026 6:35:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/12/2026 1:30:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 17h 55m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 55m	6:35 PM	Houston	Harrisburg Blvd Station	1:30 PM	Lake City, FL	Bus Stop	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/13/2026 6:35:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/14/2026 1:30:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 17h 55m
Greyhound US	20h 25m	10:00 PM	Houston	Harrisburg Blvd Station	7:25 PM	Lake City, FL	Bus Stop	Economy	$103	A Bus from Greyhound US goes from Harrisburg Blvd Station, Houston (USA) at 2/13/2026 10:00:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/14/2026 7:25:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 20h 25m
FlixBus	19h 25m	5:05 PM	Houston	Downtown Houston	1:30 PM	Lake City, FL	Bus Stop	Economy	$104	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 2/13/2026 5:05:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/14/2026 1:30:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 19h 25m
FlixBus	22h 40m	1:50 PM	Houston	Uptown/Upper Kirby	1:30 PM	Lake City, FL	Bus Stop	Economy	$109	A Bus from FlixBus goes from Uptown/Upper Kirby, Houston (USA) at 2/13/2026 1:50:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/14/2026 1:30:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 22h 40m
FlixBus	19h 35m	10:50 PM	Houston	Downtown Houston	7:25 PM	Lake City, FL	Bus Stop	Economy	$109	A Bus from FlixBus goes from Downtown Houston, Houston (USA) at 2/13/2026 10:50:00 PM to Bus Stop, Lake City, FL (USA) arriving at 2/14/2026 7:25:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 19h 35m

Best Price Offer: The price for the cheapest bus from Houston to Lake City, FL is $90 on 2/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Houston and Lake City, FL

See here how frequent the connections between Houston and Lake City, FL are, during different times and days of the week.

Sunday is the busiest day, with more than 6 daily buses from Houston to Lake City, FL. Tuesday has instead the fewest connections, with only 3 daily coaches between Houston and Lake City, FL.

The busiest time of the day is the Evening, with 11 buses from Houston to Lake City, FL, while Night sees the fewest connections between Houston and Lake City, FL, with 4 offers.

Facts about the bus from Houston to Lake City, FL

Compare all providers like Greyhound US and FlixBus that travel 5 times every day by bus from Houston to Lake City, FL in one click! Book your bus ticket from Houston to Lake City, FL starting from $90!

Cheapest Bus	$90
Fastest Bus	18h 55m
Earliest Bus	5:00 AM
Latest Bus	10:50 PM
Daily Bus Routes	5 Ø
Distance	762.5 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Houston to Lake City, FL

Every day, 5 buses from 2 bus companies leave Houston for Lake City, FL: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 02/07/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 02/01

Monday 02/02

Tuesday 02/03

Wednesday 02/04

Thursday 02/05

Friday 02/06

Saturday 02/07

Sunday 02/08

$102

Monday 02/09

Tuesday 02/10

$134

Wednesday 02/11

$138

Thursday 02/12

Friday 02/13

$103

Saturday 02/14

Sunday 02/15

Monday 02/16

Tuesday 02/17

Wednesday 02/18

Thursday 02/19

Friday 02/20

Saturday 02/21

Sunday 02/22

Monday 02/23

Tuesday 02/24

Wednesday 02/25

Thursday 02/26

Friday 02/27

Saturday 02/28

The cheapest time to travel from Houston to Lake City, FL

See here on which day and which time of the day you can find the cheapest bus ticket from Houston to Lake City, FL, for the next 30 days.

With a price starting from $102, Sunday is the cheapest day for a bus from Houston to Lake City, FL. Wednesday instead is the most expensive day with prices starting from $138.

Evening is the cheapest day time for bus tickets from Houston to Lake City, FL, with $102. Afternoon is the most expensive time of the day with prices starting from $103.

How to save money travelling from Houston to Lake City, FL

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Houston to Lake City, FL in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Houston to Lake City, FL, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Houston to Lake City, FL are also emptier.

All bus stations and stops in Houston and Lake City, FL

In the map below, you can see where to find all bus stations in Houston and Lake City, FL.

Downtown Houston

Gray St 605

Harrisburg Blvd Station

Harrisburg Blvd 7000

Main Street

Main St 2121

Uptown/Upper Kirby

Southwest Fwy 2525

Chase Bank

Milam Street 212

Lake City Bus Stop

Bus Stop

S Marion Ave 251

Service and Comfort on the bus from Houston to Lake City, FL

Want to know which seat classes are available on the buses from Houston to Lake City, FL? Or which bus companies serve the route Houston to Lake City, FL? Below you will find answers to your questions.

FAQs about the Houston to Lake City, FL bus

How much does a Houston Lake City, FL bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $90 and takes 21h 25m to reach Lake City, FL. Compare offers to save money!

How much could I save by comparing buses from Houston to Lake City, FL?

This route is offered by 2 companies with a range of ticket prices between $90 and $150. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Lake City, FL.

On average, how many connections are available from Houston to Lake City, FL each day?

Every day, the Houston to Lake City, FL bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Houston to Lake City, FL take?

The fastest bus from Houston to Lake City, FL is offered by Greyhound US and takes 18h 55m. Bus tickets for this connection cost $103. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Houston to Lake City, FL?

The earliest bus arriving in Lake City, FL from Houston starts at 5:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Houston to Lake City, FL?

The latest bus trip departing from Houston for Lake City, FL starts at 10:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Houston Lake City, FL route?

When traveling by bus from Houston to Lake City, FL, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Houston and Lake City, FL?

You can check all the direct connections between Houston and Lake City, FL by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Houston to Lake City, FL bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Houston Lake City, FL bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Houston Lake City, FL bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Houston to Lake City, FL on your planned travel date.

How does CheckMyBus find the best bus deals from Houston to Lake City, FL?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Houston and Lake City, FL. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Houston to Lake City, FL?

Prices and availability for 5 trips between Houston and Lake City, FL change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Houston to Lake City, FL

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Houston and to Lake City, FL

Here’s an overview of the most popular bus routes to Houston and to Lake City, FL. Simply click on the connection of your choice, and you will find all the details about your bus route!