Bus Jacksonville, FL to San Diego - Compare all Companies

Compare all timetables for the bus from Jacksonville, FL to San Diego

Here is a selection of the cheapest bus trips from the schedule from Jacksonville, FL to San Diego from various bus operators like FlixBus or Greyhound US for the next days.

today

$233

tomorrow

$230

Saturday

Sunday

$215

Monday

$227

Tuesday

$181

Wednesday

$224

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	65h 55m	9:25 PM	Jacksonville, FL	Amtrak Train Station	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$233	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/3/2026 9:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/6/2026 12:20:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 65h 55m
FlixBus	65h 20m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$290	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/3/2026 9:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/6/2026 11:45:00 AM. 50 Economy ticket for $290 per person are available. Travel duration is 65h 20m
FlixBus	64h 0m	9:25 PM	Jacksonville, FL	Amtrak Train Station	10:25 AM	San Diego	Seaport Village	Economy	$291	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/3/2026 9:25:00 PM to Seaport Village, San Diego (USA) arriving at 9/6/2026 10:25:00 AM. 50 Economy ticket for $291 per person are available. Travel duration is 64h 0m
FlixBus	63h 40m	9:25 PM	Jacksonville, FL	Amtrak Train Station	10:05 AM	San Diego	Old Town Transit Center	Economy	$291	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/3/2026 9:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/6/2026 10:05:00 AM. 50 Economy ticket for $291 per person are available. Travel duration is 63h 40m
FlixBus	63h 15m	9:25 PM	Jacksonville, FL	Amtrak Train Station	9:40 AM	San Diego	La Jolla Village	Economy	$293	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/3/2026 9:25:00 PM to La Jolla Village, San Diego (USA) arriving at 9/6/2026 9:40:00 AM. 50 Economy ticket for $293 per person are available. Travel duration is 63h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	65h 30m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:55 AM	San Diego	Seaport Village	Economy	$230	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/4/2026 9:25:00 PM to Seaport Village, San Diego (USA) arriving at 9/7/2026 11:55:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 65h 30m
FlixBus	65h 10m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:35 AM	San Diego	Old Town Transit Center	Economy	$230	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/4/2026 9:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/7/2026 11:35:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 65h 10m
FlixBus	64h 50m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:15 AM	San Diego	La Jolla Village	Economy	$230	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/4/2026 9:25:00 PM to La Jolla Village, San Diego (USA) arriving at 9/7/2026 11:15:00 AM. 50 Economy ticket for $230 per person are available. Travel duration is 64h 50m
Greyhound US	59h 50m	9:30 AM	Jacksonville, FL	Amtrak Train Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$312	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/4/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 9/6/2026 6:20:00 PM. 50 Economy ticket for $312 per person are available. Travel duration is 59h 50m
Greyhound US	63h 45m	9:30 AM	Jacksonville, FL	Amtrak Train Station	10:15 PM	San Diego	Seaport Village	Economy	$358	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/4/2026 9:30:00 AM to Seaport Village, San Diego (USA) arriving at 9/6/2026 10:15:00 PM. 50 Economy ticket for $358 per person are available. Travel duration is 63h 45m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	63h 45m	9:30 AM	Jacksonville, FL	Amtrak Train Station	10:15 PM	San Diego	Seaport Village	Economy	$215	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/6/2026 9:30:00 AM to Seaport Village, San Diego (USA) arriving at 9/8/2026 10:15:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 63h 45m
Greyhound US	59h 15m	9:30 AM	Jacksonville, FL	Amtrak Train Station	5:45 PM	San Diego	Old Town Transit Center	Economy	$216	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/6/2026 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/8/2026 5:45:00 PM. 50 Economy ticket for $216 per person are available. Travel duration is 59h 15m
Greyhound US	63h 15m	9:30 AM	Jacksonville, FL	Amtrak Train Station	9:45 PM	San Diego	La Jolla Village	Economy	$216	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/6/2026 9:30:00 AM to La Jolla Village, San Diego (USA) arriving at 9/8/2026 9:45:00 PM. 50 Economy ticket for $216 per person are available. Travel duration is 63h 15m
FlixBus	65h 20m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$220	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/6/2026 9:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/9/2026 11:45:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 65h 20m
FlixBus	70h 0m	9:25 PM	Jacksonville, FL	Amtrak Train Station	4:25 PM	San Diego	Old Town Transit Center	Economy	$220	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/6/2026 9:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/9/2026 4:25:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 70h 0m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	59h 50m	9:30 AM	Jacksonville, FL	Amtrak Train Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$227	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/7/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 9/9/2026 6:20:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 59h 50m
FlixBus	71h 55m	9:25 PM	Jacksonville, FL	Amtrak Train Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$230	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/7/2026 9:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/10/2026 6:20:00 PM. 50 Economy ticket for $230 per person are available. Travel duration is 71h 55m
FlixBus	65h 55m	9:25 PM	Jacksonville, FL	Amtrak Train Station	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$268	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/7/2026 9:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/10/2026 12:20:00 PM. 50 Economy ticket for $268 per person are available. Travel duration is 65h 55m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	63h 45m	9:30 AM	Jacksonville, FL	Amtrak Train Station	10:15 PM	San Diego	Seaport Village	Economy	$181	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/8/2026 9:30:00 AM to Seaport Village, San Diego (USA) arriving at 9/10/2026 10:15:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 63h 45m
Greyhound US	59h 15m	9:30 AM	Jacksonville, FL	Amtrak Train Station	5:45 PM	San Diego	Old Town Transit Center	Economy	$181	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/8/2026 9:30:00 AM to Old Town Transit Center, San Diego (USA) arriving at 9/10/2026 5:45:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 59h 15m
Greyhound US	63h 15m	9:30 AM	Jacksonville, FL	Amtrak Train Station	9:45 PM	San Diego	La Jolla Village	Economy	$181	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/8/2026 9:30:00 AM to La Jolla Village, San Diego (USA) arriving at 9/10/2026 9:45:00 PM. 50 Economy ticket for $181 per person are available. Travel duration is 63h 15m
FlixBus	65h 20m	9:25 PM	Jacksonville, FL	Amtrak Train Station	11:45 AM	San Diego	Old Town Transit Center	Economy	$183	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/8/2026 9:25:00 PM to Old Town Transit Center, San Diego (USA) arriving at 9/11/2026 11:45:00 AM. 50 Economy ticket for $183 per person are available. Travel duration is 65h 20m
FlixBus	69h 30m	9:25 PM	Jacksonville, FL	Amtrak Train Station	3:55 PM	San Diego	La Jolla Village	Economy	$183	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/8/2026 9:25:00 PM to La Jolla Village, San Diego (USA) arriving at 9/11/2026 3:55:00 PM. 50 Economy ticket for $183 per person are available. Travel duration is 69h 30m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	59h 50m	9:30 AM	Jacksonville, FL	Amtrak Train Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$224	A Bus from Greyhound US goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/9/2026 9:30:00 AM to San Ysidro Transit Center, San Diego (USA) arriving at 9/11/2026 6:20:00 PM. 50 Economy ticket for $224 per person are available. Travel duration is 59h 50m
FlixBus	65h 55m	9:25 PM	Jacksonville, FL	Amtrak Train Station	12:20 PM	San Diego	San Ysidro Transit Center	Economy	$235	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/9/2026 9:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/12/2026 12:20:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 65h 55m
FlixBus	71h 55m	9:25 PM	Jacksonville, FL	Amtrak Train Station	6:20 PM	San Diego	San Ysidro Transit Center	Economy	$235	A Bus from FlixBus goes from Amtrak Train Station, Jacksonville, FL (USA) at 9/9/2026 9:25:00 PM to San Ysidro Transit Center, San Diego (USA) arriving at 9/12/2026 6:20:00 PM. 50 Economy ticket for $235 per person are available. Travel duration is 71h 55m

Best Price Offer: The price for the cheapest bus from Jacksonville, FL to San Diego is $137 on 9/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Jacksonville, FL and San Diego

See here how frequent the connections between Jacksonville, FL and San Diego are, during different times and days of the week.

Friday is the busiest day, with more than 9 daily buses from Jacksonville, FL to San Diego. Monday has instead the fewest connections, with only 3 daily coaches between Jacksonville, FL and San Diego.

The busiest time of the day is the Evening, with 21 buses from Jacksonville, FL to San Diego, while Morning sees the fewest connections between Jacksonville, FL and San Diego, with 13 offers.

Facts about the bus from Jacksonville, FL to San Diego

Compare all providers like FlixBus and Greyhound US that travel 5 times every day by bus from Jacksonville, FL to San Diego in one click! Book your bus ticket from Jacksonville, FL to San Diego starting from $137!

Cheapest Bus	$137
Fastest Bus	56h 15m
Earliest Bus	9:25 PM
Latest Bus	9:25 PM
Daily Bus Routes	5 Ø
Distance	2,087.1 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Jacksonville, FL to San Diego

Every day, 5 buses from 2 bus companies leave Jacksonville, FL for San Diego: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/03/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/30

Monday 08/31

Tuesday 09/01

Wednesday 09/02

Thursday 09/03

$233

Friday 09/04

$230

Saturday 09/05

Sunday 09/06

$232

Monday 09/07

$227

Tuesday 09/08

$181

Wednesday 09/09

$224

Thursday 09/10

Friday 09/11

Saturday 09/12

$162

Sunday 09/13

Monday 09/14

Tuesday 09/15

Wednesday 09/16

$143

Thursday 09/17

$170

Friday 09/18

$162

Saturday 09/19

$169

Sunday 09/20

Monday 09/21

Tuesday 09/22

Wednesday 09/23

$164

Thursday 09/24

Friday 09/25

$137

Saturday 09/26

The cheapest time to travel from Jacksonville, FL to San Diego

See here on which day and which time of the day you can find the cheapest bus ticket from Jacksonville, FL to San Diego, for the next 30 days.

With a price starting from $137, Friday is the cheapest day for a bus from Jacksonville, FL to San Diego. Monday instead is the most expensive day with prices starting from $227.

Morning is the cheapest day time for bus tickets from Jacksonville, FL to San Diego, with $181. Evening is the most expensive time of the day with prices starting from $183.

How to save money travelling from Jacksonville, FL to San Diego

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Jacksonville, FL to San Diego in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Jacksonville, FL to San Diego, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Jacksonville, FL to San Diego are also emptier.

All bus stations and stops in Jacksonville, FL and San Diego

In the map below, you can see where to find all bus stations in Jacksonville, FL and San Diego.

Downtown Bus Stop

West Forsyth Street 1111

Beaver St. & Ocean St. Bus Stop

Central Bus Station

Old St. Augustine Rd

Old St. Augustine Rd 10584-13

Southpoint Bus Stop

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

Downtown

Service and Comfort on the bus from Jacksonville, FL to San Diego

Want to know which seat classes are available on the buses from Jacksonville, FL to San Diego? Or which bus companies serve the route Jacksonville, FL to San Diego? Below you will find answers to your questions.

FAQs about the Jacksonville, FL to San Diego bus

How much does a Jacksonville, FL San Diego bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $137 and takes 60h 45m to reach San Diego. Compare offers to save money!

How much could I save by comparing buses from Jacksonville, FL to San Diego?

This route is offered by 2 companies with a range of ticket prices between $137 and $369. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Diego.

On average, how many connections are available from Jacksonville, FL to San Diego each day?

Every day, the Jacksonville, FL to San Diego bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Jacksonville, FL to San Diego take?

The fastest bus from Jacksonville, FL to San Diego is offered by Greyhound US and takes 56h 15m. Bus tickets for this connection cost $369. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Jacksonville, FL to San Diego?

The earliest bus arriving in San Diego from Jacksonville, FL starts at 9:25 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Jacksonville, FL to San Diego?

The latest bus trip departing from Jacksonville, FL for San Diego starts at 9:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Jacksonville, FL San Diego route?

When traveling by bus from Jacksonville, FL to San Diego, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Jacksonville, FL and San Diego?

You can check all the direct connections between Jacksonville, FL and San Diego by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Jacksonville, FL to San Diego bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Jacksonville, FL San Diego bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Jacksonville, FL San Diego bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Jacksonville, FL to San Diego on your planned travel date.

How does CheckMyBus find the best bus deals from Jacksonville, FL to San Diego?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Jacksonville, FL and San Diego. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Jacksonville, FL to San Diego?

Prices and availability for 5 trips between Jacksonville, FL and San Diego change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Jacksonville, FL to San Diego

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Jacksonville, FL and to San Diego

Here’s an overview of the most popular bus routes to Jacksonville, FL and to San Diego. Simply click on the connection of your choice, and you will find all the details about your bus route!