Bus from La Serena to Antofagasta from $22

Compare all the bus companies and find the best price with CheckMyBus
The Best Deals Save up to 70%
The Most Choices Millions of routes worldwide
Easy and Transparent Compare offers with 1 click

Compare all timetables for the bus from La Serena to Antofagasta

Here is a selection of the cheapest bus trips from the schedule from La Serena to Antofagasta from various bus operators like Pluss Chile, Pullman Bus or Cikbus Elité for the next days.

today
$33
tomorrow
$33
Friday
$28
Saturday
$28
Sunday
$29
Monday
$33
Tuesday
$29

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Nueva Andimar Vip 11h 35m 2:00 PM La Serena Central Bus Station 1:35 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $33
Pullman San Andres 12h 10m 8:30 PM La Serena Central Bus Station 8:40 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35
Cormar Bus 11h 10m 3:30 PM La Serena Central Bus Station 2:40 AM Antofagasta Camus Bus Station  First Class $36
Cikbus Elité 11h 45m 5:15 AM La Serena Central Bus Station 5:00 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $38
FlixBus 11h 35m 8:15 PM La Serena Central Bus Station 7:50 AM Antofagasta Carlos Oviedo Cavada Bus Station  Business $39

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Nueva Andimar Vip 11h 35m 2:00 PM La Serena Central Bus Station 1:35 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $33
Pullman San Andres 12h 10m 10:00 PM La Serena Central Bus Station 10:10 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35
Cormar Bus 10h 30m 7:45 PM La Serena Central Bus Station 6:15 AM Antofagasta Carlos Oviedo Cavada Bus Station  First Class $38
FlixBus 11h 35m 8:15 PM La Serena Central Bus Station 7:50 AM Antofagasta Carlos Oviedo Cavada Bus Station  Business $39
Pluss Chile 10h 45m 1:50 AM La Serena Central Bus Station 12:35 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $40

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Cormar Bus 11h 30m 6:40 PM La Serena Central Bus Station 6:10 AM Antofagasta Camus Bus Station  Premium Economy $28
Pluss Chile 10h 45m 1:50 AM La Serena Central Bus Station 12:35 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $28
Nueva Andimar Vip 11h 35m 2:00 PM La Serena Central Bus Station 1:35 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $30
Cikbus Elité 11h 30m 2:15 AM La Serena Central Bus Station 1:45 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $31
Pullman San Andres 12h 10m 1:30 PM La Serena Central Bus Station 1:40 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Nueva Andimar Vip 11h 35m 7:15 PM La Serena Central Bus Station 6:50 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $28
Pluss Chile 10h 45m 1:50 AM La Serena Central Bus Station 12:35 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $28
Cikbus Elité 11h 0m 11:00 PM La Serena Central Bus Station 10:00 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $31
Pullman San Andres 12h 10m 10:00 PM La Serena Central Bus Station 10:10 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35
Cormar Bus 11h 0m 1:35 AM La Serena Central Bus Station 12:35 PM Antofagasta Camus Bus Station  First Class $38

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Cormar Bus 11h 30m 6:40 PM La Serena Central Bus Station 6:10 AM Antofagasta Camus Bus Station  Premium Economy $29
Nueva Andimar Vip 11h 35m 2:00 PM La Serena Central Bus Station 1:35 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $33
Pullman San Andres 12h 10m 10:00 PM La Serena Central Bus Station 10:10 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35
FlixBus 11h 35m 8:15 PM La Serena Central Bus Station 7:50 AM Antofagasta Carlos Oviedo Cavada Bus Station  Business $39
Pluss Chile 10h 45m 1:50 AM La Serena Central Bus Station 12:35 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $40

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Nueva Andimar Vip 11h 35m 2:00 PM La Serena Central Bus Station 1:35 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $33
FlixBus 11h 35m 4:00 PM La Serena Central Bus Station 3:35 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $33
Pullman San Andres 12h 10m 10:00 PM La Serena Central Bus Station 10:10 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35
Cikbus Elité 11h 45m 5:15 AM La Serena Central Bus Station 5:00 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $38
Cormar Bus 11h 10m 3:10 PM La Serena Central Bus Station 2:20 AM Antofagasta Camus Bus Station  First Class $39
  • Did you know that if you travel from La Serena to Antofagasta via Ovalle, you can save more than $5? You can find the corresponding connections below.
    • kupos.cl
      15h 45m
      0
      3:05 PM
      La Serena
      Avda. Fco de Aguirre Station
      4:25 PM
      Ovalle
      Bus Station
      0
      kupos.cl
      Premium Economy
      $4
    • Waiting Time 1h 20m
    • FlixBus
      13h 5m
      0
      5:45 PM
      Ovalle
      Bus Station
      6:50 AM
      Antofagasta
      Carlos Oviedo Cavada Bus Station
      0
      FlixBus
      Economy
      $24
    Travel time is 4h 35m longer, but you will save $5

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Cormar Bus 11h 30m 6:40 PM La Serena Central Bus Station 6:10 AM Antofagasta Camus Bus Station  Premium Economy $29
Nueva Andimar Vip 11h 35m 7:15 PM La Serena Central Bus Station 6:50 AM Antofagasta Carlos Oviedo Cavada Bus Station  Economy $31
Pullman San Andres 12h 10m 10:00 PM La Serena Central Bus Station 10:10 AM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $35
Cikbus Elité 11h 45m 5:15 AM La Serena Central Bus Station 5:00 PM Antofagasta Carlos Oviedo Cavada Bus Station  Premium Economy $38
FlixBus 11h 35m 8:15 PM La Serena Central Bus Station 7:50 AM Antofagasta Carlos Oviedo Cavada Bus Station  Business $39

Best Price Offer: The price for the cheapest bus from La Serena to Antofagasta is $22 on 1/7/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between La Serena and Antofagasta

See here how frequent the connections between La Serena and Antofagasta are, during different times and days of the week.
Monday is the busiest day, with more than 89 daily buses from La Serena to Antofagasta. Thursday has instead the fewest connections, with only 51 daily coaches between La Serena and Antofagasta.
The busiest time of the day is the Evening, with 237 buses from La Serena to Antofagasta, while Morning sees the fewest connections between La Serena and Antofagasta, with 35 offers.

Facts about the bus from La Serena to Antofagasta

Compare all providers like Pluss Chile, Pullman Bus and Cikbus Elité that travel 76 times every day by bus from La Serena to Antofagasta in one click! Book your bus ticket from La Serena to Antofagasta starting from $22!

Cheapest Bus $22
Fastest Bus 10h 30m
Earliest Bus 12:25 AM
Latest Bus 11:45 PM
Daily Bus Routes 76 Ø
Distance 435.4 miles
Bus Companies Pluss Chile, Pullman Bus, Cikbus Elité, Pullman San Andres, Cormar Bus, FlixBus and Nueva Andimar Vip

Cheapest bus connections from La Serena to Antofagasta

Every day, 76 buses from 7 bus companies leave La Serena for Antofagasta: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/24/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 12/21
Monday 12/22
Tuesday 12/23
Wednesday 12/24
$33
Thursday 12/25
$33
Friday 12/26
$28
Saturday 12/27
$33
Sunday 12/28
$40
Monday 12/29
$33
Tuesday 12/30
$35
Wednesday 12/31
$31
Thursday 01/01
$33
Friday 01/02
$28
Saturday 01/03
$32
Sunday 01/04
$33
Monday 01/05
$26
Tuesday 01/06
$22
Wednesday 01/07
$22
Thursday 01/08
$23
Friday 01/09
$25
Saturday 01/10
$24
Sunday 01/11
$25
Monday 01/12
$24
Tuesday 01/13
$22
Wednesday 01/14
$22
Thursday 01/15
$26
Friday 01/16
$28
Saturday 01/17

The cheapest time to travel from La Serena to Antofagasta

See here on which day and which time of the day you can find the cheapest bus ticket from La Serena to Antofagasta, for the next 30 days.
With a price starting from $22, Tuesday is the cheapest day for a bus from La Serena to Antofagasta. Friday instead is the most expensive day with prices starting from $25.
Night is the cheapest day time for bus tickets from La Serena to Antofagasta, with $22. Morning is the most expensive time of the day with prices starting from $28.

How to save money travelling from La Serena to Antofagasta

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from La Serena to Antofagasta in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from La Serena to Antofagasta, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from La Serena to Antofagasta are also emptier.

Latest reviews for bus companies on the route La Serena - Antofagasta

Cormar Bus
Scarleth, 6/15/2025
Aún voy a bordo, pero no podía dejar pasar la oportunidad de felicitar la amabilidad del personal del bus, si bien cumplen con todo los estándares de calidad que ofrecen, mi asiento tuvo un defecto y ... Aún voy a bordo, pero no podía dejar pasar la oportunidad de felicitar la amabilidad del personal del bus, si bien cumplen con todo los estándares de calidad que ofrecen, mi asiento tuvo un defecto y no se podia tirar para atrás, el auxiliar fué informado y de inmediato me resolvió usar otro asiento aunque esté fuera mas caro, incluso nos movió junto a mi pareja para que no estuvieramos separados aunque el asiento de él estaba bien. Muy agradecida por la atención desde que me subí hasta ahora que estoy rumbo a mi hogar. Muchas gracias, no todas las lineas se toman en serio el servicio al cliente, lo digo por experiencia. Un abrazo

All bus stations and stops in La Serena and Antofagasta

In the map below, you can see where to find all bus stations in La Serena and Antofagasta.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from La Serena to Antofagasta? Compare all modes of transports from La Serena to Antofagasta.

Service and Comfort on the bus from La Serena to Antofagasta

Want to know which seat classes are available on the buses from La Serena to Antofagasta? Or which bus companies serve the route La Serena to Antofagasta? Below you will find answers to your questions.

FAQs about the La Serena to Antofagasta bus

How much does a La Serena Antofagasta bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $22 and takes 11h 35m to reach Antofagasta. Compare offers to save money!

How much could I save by comparing buses from La Serena to Antofagasta?

This route is offered by 7 companies with a range of ticket prices between $22 and $66. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Antofagasta.

On average, how many connections are available from La Serena to Antofagasta each day?

Every day, the La Serena to Antofagasta bus route is served by approximately 76 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from La Serena to Antofagasta take?

The fastest bus from La Serena to Antofagasta is offered by Cormar Bus and takes 10h 30m. Bus tickets for this connection cost $41. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from La Serena to Antofagasta?

The earliest bus arriving in Antofagasta from La Serena starts at 12:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from La Serena to Antofagasta?

The latest bus trip departing from La Serena for Antofagasta starts at 11:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the La Serena Antofagasta route?

When traveling by bus from La Serena to Antofagasta, passengers can travel with Pluss Chile, Pullman Bus and Cikbus Elité. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between La Serena and Antofagasta?

You can check all the direct connections between La Serena and Antofagasta by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Pluss Chile, Pullman Bus and Cikbus Elité.

What can I take with me on the La Serena to Antofagasta bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the La Serena Antofagasta bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the La Serena Antofagasta bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from La Serena to Antofagasta on your planned travel date.

How does CheckMyBus find the best bus deals from La Serena to Antofagasta?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 76 daily trips between La Serena and Antofagasta. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from La Serena to Antofagasta?

Prices and availability for 76 trips between La Serena and Antofagasta change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route La Serena to Antofagasta

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

Business
Business

Comfortable seating, food and drink service, accompanied generally by ticket flexibility.

First Class
First

Best of the best: you will find the most comfortable accommodation to work or relax during your travel.

More bus routes to La Serena and to Antofagasta

Here’s an overview of the most popular bus routes to La Serena and to Antofagasta. Simply click on the connection of your choice, and you will find all the details about your bus route!

The CheckMyBus App

Free Download

App Store
CheckMyBus App
Close
GPDR CheckMyBus shield

We value your privacy!

To

show

you

the

best

bus

offers,

we

and

our

partners

use

technical,

analytical,

and

marketing

cookies

to

personalize

the

ads.

We

remember

your

anonymized

details

to

provide

a

personalized

experience.