Which bus from Mendoza to Santiago del Estero is the cheapest?

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Compare all timetables for the bus from Mendoza to Santiago del Estero

Here is a selection of the cheapest bus trips from the schedule from Mendoza to Santiago del Estero from various bus operators like 20 de Junio, Autotransportes San Juan or Andesmar for the next days.

today
$71
tomorrow
$71
Wednesday
$64
Thursday
$64
Friday
$64
Saturday
$64
Sunday
$64

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $23? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 5h 40m longer, but you will save $23

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $23? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 5h 40m longer, but you will save $23

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $64
Andesmar 16h 5m 9:30 PM Mendoza Bus Station 1:35 PM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $16? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 6h 45m longer, but you will save $16

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $64
Andesmar 16h 5m 9:30 PM Mendoza Bus Station 1:35 PM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $16? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 6h 45m longer, but you will save $16

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $64
Andesmar 16h 5m 9:30 PM Mendoza Bus Station 1:35 PM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $16? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 6h 45m longer, but you will save $16

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $64
Andesmar 16h 5m 9:30 PM Mendoza Bus Station 1:35 PM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $16? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 6h 45m longer, but you will save $16

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
Autotransportes San Juan 17h 10m 10:50 AM Mendoza Bus Station 4:00 AM Santiago del Estero Central Bus Station  Premium Economy $64
Andesmar 16h 5m 9:30 PM Mendoza Bus Station 1:35 PM Santiago del Estero Central Bus Station  Premium Economy $71
20 de Junio 18h 50m 9:00 PM Mendoza Bus Station 3:50 PM Santiago del Estero Central Bus Station  Premium Economy $74
  • Did you know that if you travel from Mendoza to Santiago del Estero via Córdoba, CD, you can save more than $16? You can find the corresponding connections below.
    • Del Sur y Media Agua
      22h 50m
      0
      8:30 PM
      Mendoza
      Bus Station
      6:45 AM
      Córdoba, CD
      Bus Station
      0
      Del Sur y Media Agua
      Premium Economy
      $27
      • Waiting Time 6h 30m
    • El Práctico
      6h 5m
      0
      1:15 PM
      Córdoba, CD
      Bus Station
      7:20 PM
      Santiago del Estero
      Central Bus Station
      0
      El Práctico
      Premium Economy
      $22
    Travel time is 6h 45m longer, but you will save $16

Best Price Offer: The price for the cheapest bus from Mendoza to Santiago del Estero is $63 on 8/2/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Mendoza and Santiago del Estero

See here how frequent the connections between Mendoza and Santiago del Estero are, during different times and days of the week.
Sunday is the busiest day, with more than 14 daily buses from Mendoza to Santiago del Estero. Wednesday has instead the fewest connections, with only 10 daily coaches between Mendoza and Santiago del Estero.
The busiest time of the day is the Evening, with 60 buses from Mendoza to Santiago del Estero, while Morning sees the fewest connections between Mendoza and Santiago del Estero, with 28 offers.

Facts about the bus from Mendoza to Santiago del Estero

Compare all providers like 20 de Junio, Autotransportes San Juan and Andesmar that travel 12 times every day by bus from Mendoza to Santiago del Estero in one click! Book your bus ticket from Mendoza to Santiago del Estero starting from $63!

Cheapest Bus $63
Fastest Bus 16h 5m
Earliest Bus 10:50 AM
Latest Bus 9:30 PM
Daily Bus Routes 12 Ø
Distance 445.5 miles
Bus Companies 20 de Junio, Autotransportes San Juan and Andesmar

Cheapest bus connections from Mendoza to Santiago del Estero

Every day, 12 buses from 3 bus companies leave Mendoza for Santiago del Estero: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/03/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 08/02
Monday 08/03
$71
Tuesday 08/04
$71
Wednesday 08/05
$64
Thursday 08/06
$64
Friday 08/07
$64
Saturday 08/08
$64
Sunday 08/09
$64
Monday 08/10
$64
Tuesday 08/11
$71
Wednesday 08/12
$71
Thursday 08/13
$71
Friday 08/14
$63
Saturday 08/15
$71
Sunday 08/16
$71
Monday 08/17
$71
Tuesday 08/18
$71
Wednesday 08/19
$71
Thursday 08/20
$71
Friday 08/21
$71
Saturday 08/22
$71
Sunday 08/23
Monday 08/24
$71
Tuesday 08/25
$71
Wednesday 08/26
$71
Thursday 08/27
$71
Friday 08/28
$71
Saturday 08/29

The cheapest time to travel from Mendoza to Santiago del Estero

See here on which day and which time of the day you can find the cheapest bus ticket from Mendoza to Santiago del Estero, for the next 30 days.
With a price starting from $63, Friday is the cheapest day for a bus from Mendoza to Santiago del Estero. Tuesday instead is the most expensive day with prices starting from $71.
Morning is the cheapest day time for bus tickets from Mendoza to Santiago del Estero, with $64. Evening is the most expensive time of the day with prices starting from $71.

How to save money travelling from Mendoza to Santiago del Estero

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mendoza to Santiago del Estero in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mendoza to Santiago del Estero, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mendoza to Santiago del Estero are also emptier.

All bus stations and stops in Mendoza and Santiago del Estero

In the map below, you can see where to find all bus stations in Mendoza and Santiago del Estero.

Service and Comfort on the bus from Mendoza to Santiago del Estero

Want to know which seat classes are available on the buses from Mendoza to Santiago del Estero? Or which bus companies serve the route Mendoza to Santiago del Estero? Below you will find answers to your questions.

FAQs about the Mendoza to Santiago del Estero bus

How much does a Mendoza Santiago del Estero bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $63 and takes 17h 10m to reach Santiago del Estero. Compare offers to save money!

How much could I save by comparing buses from Mendoza to Santiago del Estero?

This route is offered by 3 companies with a range of ticket prices between $63 and $111. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago del Estero.

On average, how many connections are available from Mendoza to Santiago del Estero each day?

Every day, the Mendoza to Santiago del Estero bus route is served by approximately 12 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mendoza to Santiago del Estero take?

The fastest bus from Mendoza to Santiago del Estero is offered by Andesmar and takes 16h 5m. Bus tickets for this connection cost $105. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mendoza to Santiago del Estero?

The earliest bus arriving in Santiago del Estero from Mendoza starts at 10:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mendoza to Santiago del Estero?

The latest bus trip departing from Mendoza for Santiago del Estero starts at 9:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mendoza Santiago del Estero route?

When traveling by bus from Mendoza to Santiago del Estero, passengers can travel with 20 de Junio, Autotransportes San Juan and Andesmar. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mendoza and Santiago del Estero?

You can check all the direct connections between Mendoza and Santiago del Estero by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: 20 de Junio, Autotransportes San Juan and Andesmar.

What can I take with me on the Mendoza to Santiago del Estero bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mendoza Santiago del Estero bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mendoza Santiago del Estero bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mendoza to Santiago del Estero on your planned travel date.

How does CheckMyBus find the best bus deals from Mendoza to Santiago del Estero?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 12 daily trips between Mendoza and Santiago del Estero. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mendoza to Santiago del Estero?

Prices and availability for 12 trips between Mendoza and Santiago del Estero change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mendoza to Santiago del Estero

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Mendoza and to Santiago del Estero

Here’s an overview of the most popular bus routes to Mendoza and to Santiago del Estero. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus to Mendoza from Lujan, BA Bus to Mendoza from Lujan, BA
Bus Resistencia - Mendoza Bus Resistencia - Mendoza
Buses Bahía Blanca to Mendoza Buses Bahía Blanca to Mendoza
Bus to Mendoza from Río Cuarto Bus to Mendoza from Río Cuarto
Buses Belén de Escobar - Santiago del Estero Buses Belén de Escobar - Santiago del Estero
Buses San Juan, SJ to Santiago del Estero Buses San Juan, SJ to Santiago del Estero
Buses from San Miguel de Tucumán to Santiago del Estero Buses from San Miguel de Tucumán to Santiago del Estero
Bus from San Salvador de Jujuy, JJ to Santiago del Estero Bus from San Salvador de Jujuy, JJ to Santiago del Estero
CheckMyBus › Buses in Argentina › Bus to Mendoza › Bus to Santiago del Estero

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