Bus Mendoza to Santiago del Estero - Compare all Companies

Compare all timetables for the bus from Mendoza to Santiago del Estero

Here is a selection of the cheapest bus trips from the schedule from Mendoza to Santiago del Estero from various bus operators like Andesmar, 20 de Junio or Autotransportes San Juan for the next days.

today

$99

tomorrow

$69

Monday

$48

Tuesday

$69

Wednesday

$76

Thursday

Friday

$43

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Autotransportes San Juan	17h 10m	10:50 AM	Mendoza	Bus Station	4:00 AM	Santiago del Estero	Central Bus Station	Premium Economy	$99	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/19/2026 10:50:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/20/2026 4:00:00 AM. 50 Premium Economy ticket for $99 per person are available. Travel duration is 17h 10m
Autotransportes San Juan	17h 10m	4:00 PM	Mendoza	Bus Station	9:10 AM	Santiago del Estero	Central Bus Station	Premium Economy	$99	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/19/2026 4:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/20/2026 9:10:00 AM. 50 Premium Economy ticket for $99 per person are available. Travel duration is 17h 10m
Andesmar	17h 5m	8:30 PM	Mendoza	Bus Station	1:35 PM	Santiago del Estero	Central Bus Station	Premium Economy	$99	A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/19/2026 8:30:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/20/2026 1:35:00 PM. 50 Premium Economy ticket for $99 per person are available. Travel duration is 17h 5m
20 de Junio	18h 50m	9:00 PM	Mendoza	Bus Station	3:50 PM	Santiago del Estero	Central Bus Station	Premium Economy	$137	A Bus from 20 de Junio goes from Bus Station, Mendoza (Argentina) at 9/19/2026 9:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/20/2026 3:50:00 PM. 50 Premium Economy ticket for $137 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Mendoza to Santiago del Estero via Concepción, TC, you can save more than $35? You can find the corresponding connections below.
- Flecha Bus
  
  19h 50m
  
  0
  
  8:00 PM
  
  Mendoza
  Bus Station
  
  8:45 AM
  
  Concepción, TC
  Bus Stop
  
  0
  
  Premium Economy
  
  $48
  
  A Bus from Flecha Bus goes from Bus Station, Mendoza (Argentina) at 9/20/2026 8:00:00 PM to Bus Stop, Concepción, TC (Argentina) arriving at 9/21/2026 8:45:00 AM. 50 Premium Economy ticket for $48 per person are available. Travel duration is 12h 45m
- 20 de Junio
  
  4h 20m
  
  0
  
  11:30 AM
  
  Concepción, TC
  Bus Stop
  
  3:50 PM
  
  Santiago del Estero
  Central Bus Station
  
  0
  
  Premium Economy
  
  $16
  
  A Bus from 20 de Junio goes from Bus Stop, Concepción, TC (Argentina) at 9/21/2026 11:30:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/21/2026 3:50:00 PM. 50 Premium Economy ticket for $16 per person are available. Travel duration is 4h 20m
Travel time is 2h 45m longer, but you will save $35

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Autotransportes San Juan	17h 10m	10:50 AM	Mendoza	Bus Station	4:00 AM	Santiago del Estero	Central Bus Station	Premium Economy	$69	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/20/2026 10:50:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/21/2026 4:00:00 AM. 50 Premium Economy ticket for $69 per person are available. Travel duration is 17h 10m
20 de Junio	18h 50m	9:00 PM	Mendoza	Bus Station	3:50 PM	Santiago del Estero	Central Bus Station	Premium Economy	$76	A Bus from 20 de Junio goes from Bus Station, Mendoza (Argentina) at 9/20/2026 9:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/21/2026 3:50:00 PM. 50 Premium Economy ticket for $76 per person are available. Travel duration is 18h 50m
Andesmar	17h 5m	8:30 PM	Mendoza	Bus Station	1:35 PM	Santiago del Estero	Central Bus Station	Premium Economy	$86	A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/20/2026 8:30:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/21/2026 1:35:00 PM. 50 Premium Economy ticket for $86 per person are available. Travel duration is 17h 5m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Andesmar	17h 5m	8:30 PM	Mendoza	Bus Station	1:35 PM	Santiago del Estero	Central Bus Station	Premium Economy	$48	A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/21/2026 8:30:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/22/2026 1:35:00 PM. 50 Premium Economy ticket for $48 per person are available. Travel duration is 17h 5m
Autotransportes San Juan	17h 10m	4:00 PM	Mendoza	Bus Station	9:10 AM	Santiago del Estero	Central Bus Station	Premium Economy	$49	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/21/2026 4:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/22/2026 9:10:00 AM. 50 Premium Economy ticket for $49 per person are available. Travel duration is 17h 10m
Autotransportes San Juan	17h 10m	10:50 AM	Mendoza	Bus Station	4:00 AM	Santiago del Estero	Central Bus Station	Premium Economy	$69	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/21/2026 10:50:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/22/2026 4:00:00 AM. 50 Premium Economy ticket for $69 per person are available. Travel duration is 17h 10m
20 de Junio	18h 50m	9:00 PM	Mendoza	Bus Station	3:50 PM	Santiago del Estero	Central Bus Station	Premium Economy	$69	A Bus from 20 de Junio goes from Bus Station, Mendoza (Argentina) at 9/21/2026 9:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/22/2026 3:50:00 PM. 50 Premium Economy ticket for $69 per person are available. Travel duration is 18h 50m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Autotransportes San Juan	17h 10m	10:50 AM	Mendoza	Bus Station	4:00 AM	Santiago del Estero	Central Bus Station	Premium Economy	$69	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/22/2026 10:50:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/23/2026 4:00:00 AM. 50 Premium Economy ticket for $69 per person are available. Travel duration is 17h 10m
20 de Junio	18h 50m	9:00 PM	Mendoza	Bus Station	3:50 PM	Santiago del Estero	Central Bus Station	Premium Economy	$76	A Bus from 20 de Junio goes from Bus Station, Mendoza (Argentina) at 9/22/2026 9:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/23/2026 3:50:00 PM. 50 Premium Economy ticket for $76 per person are available. Travel duration is 18h 50m
Andesmar	17h 5m	8:30 PM	Mendoza	Bus Station	1:35 PM	Santiago del Estero	Central Bus Station	Premium Economy	$86	A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/22/2026 8:30:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/23/2026 1:35:00 PM. 50 Premium Economy ticket for $86 per person are available. Travel duration is 17h 5m

Did you know that if you travel from Mendoza to Santiago del Estero via La Rioja, LR, you can save more than $18? You can find the corresponding connections below.
- Vía Tac
  
  25h 15m
  
  0
  
  12:20 PM
  
  Mendoza
  Bus Station
  
  9:15 PM
  
  La Rioja, LR
  Central bus station
  
  0
  
  Premium Economy
  
  $34
  
  A Bus from Vía Tac goes from Bus Station, Mendoza (Argentina) at 9/22/2026 12:20:00 PM to Central bus station, La Rioja, LR (Argentina) arriving at 9/22/2026 9:15:00 PM. 50 Premium Economy ticket for $34 per person are available. Travel duration is 8h 55m
- Andesmar
  
  8h 55m
  
  0
  
  4:40 AM
  
  La Rioja, LR
  Central bus station
  
  1:35 PM
  
  Santiago del Estero
  Central Bus Station
  
  0
  
  Premium Economy
  
  $17
  
  A Bus from Andesmar goes from Central bus station, La Rioja, LR (Argentina) at 9/23/2026 4:40:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/23/2026 1:35:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 8h 55m
Travel time is 8h 10m longer, but you will save $18

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
20 de Junio	18h 50m	9:00 PM	Mendoza	Bus Station	3:50 PM	Santiago del Estero	Central Bus Station	Premium Economy	$76	A Bus from 20 de Junio goes from Bus Station, Mendoza (Argentina) at 9/23/2026 9:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/24/2026 3:50:00 PM. 50 Premium Economy ticket for $76 per person are available. Travel duration is 18h 50m
Andesmar	17h 5m	8:30 PM	Mendoza	Bus Station	1:35 PM	Santiago del Estero	Central Bus Station	Premium Economy	$86	A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/23/2026 8:30:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/24/2026 1:35:00 PM. 50 Premium Economy ticket for $86 per person are available. Travel duration is 17h 5m
Autotransportes San Juan	17h 10m	10:50 AM	Mendoza	Bus Station	4:00 AM	Santiago del Estero	Central Bus Station	Premium Economy	$99	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/23/2026 10:50:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/24/2026 4:00:00 AM. 50 Premium Economy ticket for $99 per person are available. Travel duration is 17h 10m
Autotransportes San Juan	17h 10m	4:00 PM	Mendoza	Bus Station	9:10 AM	Santiago del Estero	Central Bus Station	Premium Economy	$99	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/23/2026 4:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/24/2026 9:10:00 AM. 50 Premium Economy ticket for $99 per person are available. Travel duration is 17h 10m

Did you know that if you travel from Mendoza to Santiago del Estero via La Rioja, LR, you can save more than $25? You can find the corresponding connections below.
- Vía Tac
  
  25h 15m
  
  0
  
  12:20 PM
  
  Mendoza
  Bus Station
  
  9:15 PM
  
  La Rioja, LR
  Central bus station
  
  0
  
  Premium Economy
  
  $34
  
  A Bus from Vía Tac goes from Bus Station, Mendoza (Argentina) at 9/22/2026 12:20:00 PM to Central bus station, La Rioja, LR (Argentina) arriving at 9/22/2026 9:15:00 PM. 50 Premium Economy ticket for $34 per person are available. Travel duration is 8h 55m
- Andesmar
  
  8h 55m
  
  0
  
  4:40 AM
  
  La Rioja, LR
  Central bus station
  
  1:35 PM
  
  Santiago del Estero
  Central Bus Station
  
  0
  
  Premium Economy
  
  $17
  
  A Bus from Andesmar goes from Central bus station, La Rioja, LR (Argentina) at 9/23/2026 4:40:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/23/2026 1:35:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 8h 55m
Travel time is 8h 10m longer, but you will save $25

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Andesmar	17h 5m	8:30 PM	Mendoza	Bus Station	1:35 PM	Santiago del Estero	Central Bus Station	Premium Economy	$43	A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/25/2026 8:30:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/26/2026 1:35:00 PM. 50 Premium Economy ticket for $43 per person are available. Travel duration is 17h 5m
Autotransportes San Juan	17h 10m	10:50 AM	Mendoza	Bus Station	4:00 AM	Santiago del Estero	Central Bus Station	Premium Economy	$69	A Bus from Autotransportes San Juan goes from Bus Station, Mendoza (Argentina) at 9/25/2026 10:50:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/26/2026 4:00:00 AM. 50 Premium Economy ticket for $69 per person are available. Travel duration is 17h 10m
20 de Junio	18h 50m	9:00 PM	Mendoza	Bus Station	3:50 PM	Santiago del Estero	Central Bus Station	Premium Economy	$76	A Bus from 20 de Junio goes from Bus Station, Mendoza (Argentina) at 9/25/2026 9:00:00 PM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/26/2026 3:50:00 PM. 50 Premium Economy ticket for $76 per person are available. Travel duration is 18h 50m

Did you know that if you travel from Mendoza to Santiago del Estero via La Rioja, LR, you can save more than $5? You can find the corresponding connections below.
- Andesmar
  
  25h 35m
  
  0
  
  12:00 PM
  
  Mendoza
  Bus Station
  
  8:10 PM
  
  La Rioja, LR
  Central bus station
  
  0
  
  Premium Economy
  
  $21
  
  A Bus from Andesmar goes from Bus Station, Mendoza (Argentina) at 9/26/2026 12:00:00 PM to Central bus station, La Rioja, LR (Argentina) arriving at 9/26/2026 8:10:00 PM. 50 Premium Economy ticket for $21 per person are available. Travel duration is 8h 10m
- Andesmar
  
  8h 55m
  
  0
  
  4:40 AM
  
  La Rioja, LR
  Central bus station
  
  1:35 PM
  
  Santiago del Estero
  Central Bus Station
  
  0
  
  Premium Economy
  
  $17
  
  A Bus from Andesmar goes from Central bus station, La Rioja, LR (Argentina) at 9/27/2026 4:40:00 AM to Central Bus Station, Santiago del Estero (Argentina) arriving at 9/27/2026 1:35:00 PM. 50 Premium Economy ticket for $17 per person are available. Travel duration is 8h 55m
Travel time is 8h 30m longer, but you will save $5

Best Price Offer: The price for the cheapest bus from Mendoza to Santiago del Estero is $43 on 9/25/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Mendoza and Santiago del Estero

See here how frequent the connections between Mendoza and Santiago del Estero are, during different times and days of the week.

Monday is the busiest day, with more than 16 daily buses from Mendoza to Santiago del Estero. Saturday has instead the fewest connections, with only 12 daily coaches between Mendoza and Santiago del Estero.

The busiest time of the day is the Evening, with 68 buses from Mendoza to Santiago del Estero, while Afternoon sees the fewest connections between Mendoza and Santiago del Estero, with 6 offers.

Facts about the bus from Mendoza to Santiago del Estero

Compare all providers like Andesmar, 20 de Junio and Autotransportes San Juan that travel 14 times every day by bus from Mendoza to Santiago del Estero in one click! Book your bus ticket from Mendoza to Santiago del Estero starting from $43!

Cheapest Bus	$43
Fastest Bus	17h 5m
Earliest Bus	10:50 AM
Latest Bus	9:00 PM
Daily Bus Routes	14 Ø
Distance	445.5 miles
Bus Companies	Andesmar, 20 de Junio and Autotransportes San Juan

Cheapest bus connections from Mendoza to Santiago del Estero

Every day, 14 buses from 3 bus companies leave Mendoza for Santiago del Estero: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/19/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/13

Monday 09/14

Tuesday 09/15

Wednesday 09/16

Thursday 09/17

Friday 09/18

Saturday 09/19

$99

Sunday 09/20

$76

Monday 09/21

$48

Tuesday 09/22

$76

Wednesday 09/23

$99

Thursday 09/24

Friday 09/25

$43

Saturday 09/26

$43

Sunday 09/27

$99

Monday 09/28

$43

Tuesday 09/29

$43

Wednesday 09/30

$43

Thursday 10/01

Friday 10/02

$69

Saturday 10/03

$48

Sunday 10/04

$48

Monday 10/05

$48

Tuesday 10/06

$48

Wednesday 10/07

$48

Thursday 10/08

$48

Friday 10/09

$48

Saturday 10/10

The cheapest time to travel from Mendoza to Santiago del Estero

See here on which day and which time of the day you can find the cheapest bus ticket from Mendoza to Santiago del Estero, for the next 30 days.

With a price starting from $43, Friday is the cheapest day for a bus from Mendoza to Santiago del Estero. Sunday instead is the most expensive day with prices starting from $48.

Evening is the cheapest day time for bus tickets from Mendoza to Santiago del Estero, with $43. Morning is the most expensive time of the day with prices starting from $69.

How to save money travelling from Mendoza to Santiago del Estero

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Mendoza to Santiago del Estero in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Mendoza to Santiago del Estero, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Mendoza to Santiago del Estero are also emptier.

All bus stations and stops in Mendoza and Santiago del Estero

In the map below, you can see where to find all bus stations in Mendoza and Santiago del Estero.

Bus Station

Juan B. Alberdi s/n

Hotel Internacional

Av. Sarmiento 720

Hotel Hyatt

Chile 1124

Puente del Inca

Hotel Aconcagua

San Lorenzo 545

Central Bus Station

Av. Roca Norte 100

Av. Libertad & Av. Aguirre

Ambargasta

El Saladillo

Regional Hospital "Dr. Ramón Carrillo"

Service and Comfort on the bus from Mendoza to Santiago del Estero

Want to know which seat classes are available on the buses from Mendoza to Santiago del Estero? Or which bus companies serve the route Mendoza to Santiago del Estero? Below you will find answers to your questions.

FAQs about the Mendoza to Santiago del Estero bus

How much does a Mendoza Santiago del Estero bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $43 and takes 17h 5m to reach Santiago del Estero. Compare offers to save money!

How much could I save by comparing buses from Mendoza to Santiago del Estero?

This route is offered by 3 companies with a range of ticket prices between $43 and $179. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Santiago del Estero.

On average, how many connections are available from Mendoza to Santiago del Estero each day?

Every day, the Mendoza to Santiago del Estero bus route is served by approximately 14 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Mendoza to Santiago del Estero take?

The fastest bus from Mendoza to Santiago del Estero is offered by Andesmar and takes 17h 5m. Bus tickets for this connection cost $99. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Mendoza to Santiago del Estero?

The earliest bus arriving in Santiago del Estero from Mendoza starts at 10:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Mendoza to Santiago del Estero?

The latest bus trip departing from Mendoza for Santiago del Estero starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Mendoza Santiago del Estero route?

When traveling by bus from Mendoza to Santiago del Estero, passengers can travel with Andesmar, 20 de Junio and Autotransportes San Juan. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Mendoza and Santiago del Estero?

You can check all the direct connections between Mendoza and Santiago del Estero by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Andesmar, 20 de Junio and Autotransportes San Juan.

What can I take with me on the Mendoza to Santiago del Estero bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Mendoza Santiago del Estero bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Mendoza Santiago del Estero bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Mendoza to Santiago del Estero on your planned travel date.

How does CheckMyBus find the best bus deals from Mendoza to Santiago del Estero?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 14 daily trips between Mendoza and Santiago del Estero. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Mendoza to Santiago del Estero?

Prices and availability for 14 trips between Mendoza and Santiago del Estero change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Mendoza to Santiago del Estero

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Mendoza and to Santiago del Estero

Here’s an overview of the most popular bus routes to Mendoza and to Santiago del Estero. Simply click on the connection of your choice, and you will find all the details about your bus route!