Bus from Pisa to Palermo from $42

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Compare all timetables for the bus from Pisa to Palermo

Here is a selection of the cheapest bus trips from the schedule from Pisa to Palermo from various bus operators like FlixBus for the next days.

today
$45
tomorrow
$61
Monday
$44
Tuesday
$43
Wednesday
$51
Thursday
$47
Friday
$51

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 28h 55m 6:05 AM Pisa Parking Aurelia 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $45
FlixBus 21h 35m 1:25 PM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $55
FlixBus 21h 50m 5:25 PM Pisa Pietrasantina Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $67

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 28h 55m 6:05 AM Pisa Parking Aurelia 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $61
FlixBus 21h 35m 1:25 PM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $79
FlixBus 21h 50m 5:25 PM Pisa Pietrasantina Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $107

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 28h 55m 6:05 AM Pisa Parking Aurelia 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $44
FlixBus 21h 35m 1:25 PM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $45
FlixBus 21h 50m 5:25 PM Pisa Pietrasantina Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $52

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 28h 55m 6:05 AM Pisa Parking Aurelia 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $43
FlixBus 21h 35m 1:25 PM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $43
FlixBus 22h 5m 5:10 PM Pisa Pietrasantina Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $58

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 27h 45m 7:15 AM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $51
FlixBus 22h 5m 5:10 PM Pisa Parking Aurelia 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $58

Cheapest bus trips Thursday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 28h 55m 6:05 AM Pisa Parking Aurelia 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $47
FlixBus 23h 0m 12:00 PM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $48
FlixBus 21h 50m 5:25 PM Pisa Pietrasantina Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $51
  • Did you know that if you travel from Pisa to Palermo via Siena, you can save more than $6? You can find the corresponding connections below.
    • FlixBus
      25h 55m
      0
      5:25 PM
      Pisa
      Pietrasantina Bus Station
      7:40 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $12
      • Waiting Time 2h 45m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $29
    Travel time is 4h 5m longer, but you will save $6

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 21h 35m 1:25 PM Pisa Pietrasantina Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $51
FlixBus 28h 55m 6:05 AM Pisa Parking Aurelia 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $52
FlixBus 21h 50m 5:25 PM Pisa Pietrasantina Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $56
  • Did you know that if you travel from Pisa to Palermo via Siena, you can save more than $10? You can find the corresponding connections below.
    • FlixBus
      25h 55m
      0
      5:25 PM
      Pisa
      Pietrasantina Bus Station
      7:40 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $12
      • Waiting Time 2h 45m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $29
    Travel time is 4h 20m longer, but you will save $10

Best Price Offer: The price for the cheapest bus from Pisa to Palermo is $42 on 10/24/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Pisa and Palermo

See here how frequent the connections between Pisa and Palermo are, during different times and days of the week.
Sunday is the busiest day, with more than 3 daily buses from Pisa to Palermo. Sunday has instead the fewest connections, with only 3 daily coaches between Pisa and Palermo.
The busiest time of the day is the Afternoon, with 14 buses from Pisa to Palermo, while Morning sees the fewest connections between Pisa and Palermo, with 7 offers.

Facts about the bus from Pisa to Palermo

Compare all providers like FlixBus that travel 3 times every day by bus from Pisa to Palermo in one click! Book your bus ticket from Pisa to Palermo starting from $42!

Cheapest Bus $42
Fastest Bus 21h 35m
Earliest Bus 6:05 AM
Latest Bus 5:25 PM
Daily Bus Routes 3 Ø
Distance 417.1 miles
Bus Companies FlixBus

Cheapest bus connections from Pisa to Palermo

Every day, 3 buses from 1 bus companies leave Pisa for Palermo: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 10/17/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 10/11
Monday 10/12
Tuesday 10/13
Wednesday 10/14
Thursday 10/15
Friday 10/16
Saturday 10/17
$55
Sunday 10/18
$79
Monday 10/19
$45
Tuesday 10/20
$43
Wednesday 10/21
$51
Thursday 10/22
$48
Friday 10/23
$51
Saturday 10/24
$42
Sunday 10/25
$57
Monday 10/26
$55
Tuesday 10/27
$55
Wednesday 10/28
$69
Thursday 10/29
$88
Friday 10/30
$101
Saturday 10/31
$64
Sunday 11/01
$73
Monday 11/02
$70
Tuesday 11/03
$57
Wednesday 11/04
$54
Thursday 11/05
$64
Friday 11/06
$57
Saturday 11/07

The cheapest time to travel from Pisa to Palermo

See here on which day and which time of the day you can find the cheapest bus ticket from Pisa to Palermo, for the next 30 days.
With a price starting from $42, Saturday is the cheapest day for a bus from Pisa to Palermo. Sunday instead is the most expensive day with prices starting from $57.
Morning is the cheapest day time for bus tickets from Pisa to Palermo, with $43. Afternoon is the most expensive time of the day with prices starting from $43.

How to save money travelling from Pisa to Palermo

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Pisa to Palermo in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Pisa to Palermo, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Pisa to Palermo are also emptier.

All bus stations and stops in Pisa and Palermo

In the map below, you can see where to find all bus stations in Pisa and Palermo.

Service and Comfort on the bus from Pisa to Palermo

Want to know which seat classes are available on the buses from Pisa to Palermo? Or which bus companies serve the route Pisa to Palermo? Below you will find answers to your questions.

FAQs about the Pisa to Palermo bus

How much does a Pisa Palermo bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $42 and takes 28h 55m to reach Palermo. Compare offers to save money!

How much could I save by comparing buses from Pisa to Palermo?

This route is offered by 1 companies with a range of ticket prices between $42 and $107. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Palermo.

On average, how many connections are available from Pisa to Palermo each day?

Every day, the Pisa to Palermo bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Pisa to Palermo take?

The fastest bus from Pisa to Palermo is offered by FlixBus and takes 21h 35m. Bus tickets for this connection cost $55. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Pisa to Palermo?

The earliest bus arriving in Palermo from Pisa starts at 6:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Pisa to Palermo?

The latest bus trip departing from Pisa for Palermo starts at 5:25 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Pisa Palermo route?

When traveling by bus from Pisa to Palermo, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Pisa and Palermo?

You can check all the direct connections between Pisa and Palermo by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Pisa to Palermo bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Pisa Palermo bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Pisa Palermo bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Pisa to Palermo on your planned travel date.

How does CheckMyBus find the best bus deals from Pisa to Palermo?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Pisa and Palermo. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Pisa to Palermo?

Prices and availability for 3 trips between Pisa and Palermo change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Pisa to Palermo

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Pisa and to Palermo

Here’s an overview of the most popular bus routes to Pisa and to Palermo. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses from Verona to Pisa Buses from Verona to Pisa
Buses Pescara to Pisa Buses Pescara to Pisa
Buses Bari to Pisa Buses Bari to Pisa
Bus to Pisa from Spezzano Albanese Bus to Pisa from Spezzano Albanese
Buses Gole Alcantara - Palermo Buses Gole Alcantara - Palermo
Buses to Palermo from Agira Buses to Palermo from Agira
Bus from Licata to Palermo Bus from Licata to Palermo
Buses Lamezia Terme - Palermo Buses Lamezia Terme - Palermo
Popular Airport Shuttles to Pisa and to Palermo
CheckMyBus › Buses in Italy › Bus to Pisa › Bus to Palermo

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