Bus from Milan to Palermo from $75

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Compare all timetables for the bus from Milan to Palermo

Here is a selection of the cheapest bus trips from the schedule from Milan to Palermo from various bus operators like FlixBus, Autoservizi Salemi or MarinoBus for the next days.
today
from $93
tomorrow
from $92
Friday
from $93
Saturday
from $104
Sunday
from $96
Monday
from $93
Tuesday
from $75

Cheapest bus trips today

Prices are for one way and one person
  • Autoservizi Salemi
    21h 45m
    0
    10:00 AM
    Milan
    Lampugnano Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • Autoservizi Salemi
    21h 0m
    0
    10:45 AM
    Milan
    San Donato Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • FlixBus
    22h 5m
    0
    12:55 PM
    Milan
    Lampugnano Bus Station
    11:00 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $108
  • FlixBus
    24h 55m
    0
    6:30 PM
    Milan
    San Donato Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $127
  • FlixBus
    25h 40m
    0
    5:45 PM
    Milan
    Lampugnano Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $127

Cheapest bus trips tomorrow

Prices are for one way and one person
  • Autoservizi Salemi
    21h 45m
    0
    10:00 AM
    Milan
    Lampugnano Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $92
  • Autoservizi Salemi
    21h 0m
    0
    10:45 AM
    Milan
    San Donato Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $92
  • MarinoBus
    24h 15m
    0
    8:40 AM
    Milan
    Lampugnano Bus Station
    8:55 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    MarinoBus
    Economy
    $96
  • FlixBus
    22h 5m
    0
    12:55 PM
    Milan
    Lampugnano Bus Station
    11:00 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $128
  • FlixBus
    24h 55m
    0
    6:30 PM
    Milan
    San Donato Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $143

Cheapest bus trips Friday

Prices are for one way and one person
  • Autoservizi Salemi
    21h 45m
    0
    10:00 AM
    Milan
    Lampugnano Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • FlixBus
    22h 5m
    0
    12:55 PM
    Milan
    Lampugnano Bus Station
    11:00 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $120
  • FlixBus
    24h 55m
    0
    6:30 PM
    Milan
    San Donato Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $148
  • FlixBus
    25h 40m
    0
    5:45 PM
    Milan
    Lampugnano Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $148

Cheapest bus trips Saturday

Prices are for one way and one person
  • FlixBus
    22h 5m
    0
    12:55 PM
    Milan
    Lampugnano Bus Station
    11:00 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $104
  • FlixBus
    24h 55m
    0
    6:30 PM
    Milan
    San Donato Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $114
  • FlixBus
    25h 40m
    0
    5:45 PM
    Milan
    Lampugnano Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $114
  • FlixBus
    21h 20m
    0
    5:05 PM
    Milan
    San Donato Bus Station
    2:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $148
  • FlixBus
    22h 5m
    0
    4:20 PM
    Milan
    Lampugnano Bus Station
    2:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $148
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $13? You can find the corresponding connections below.
    • FlixBus
      25h 20m
      0
      9:40 AM
      Milan
      San Donato Bus Station
      2:40 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $13
      • Waiting Time 4h 15m
    • FlixBus
      16h 5m
      0
      6:55 PM
      Siena
      Train Station
      11:00 AM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $79
    Travel time is 4h 0m longer, but you will save $13

Cheapest bus trips Sunday

Prices are for one way and one person
  • Autoservizi Salemi
    21h 45m
    0
    10:00 AM
    Milan
    Lampugnano Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $96
  • MarinoBus
    24h 15m
    0
    8:40 AM
    Milan
    Lampugnano Bus Station
    8:55 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    MarinoBus
    Economy
    $100
  • FlixBus
    24h 55m
    0
    6:30 PM
    Milan
    San Donato Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $110
  • FlixBus
    25h 40m
    0
    5:45 PM
    Milan
    Lampugnano Bus Station
    7:25 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $110
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $12? You can find the corresponding connections below.
    • FlixBus
      26h 10m
      0
      2:45 PM
      Milan
      San Donato Bus Station
      7:50 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $13
      • Waiting Time 1h 30m
    • FlixBus
      19h 35m
      0
      9:20 PM
      Siena
      Train Station
      4:55 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $72
    Travel time is 4h 25m longer, but you will save $12

Cheapest bus trips Monday

Prices are for one way and one person
  • Autoservizi Salemi
    21h 45m
    0
    10:00 AM
    Milan
    Lampugnano Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • Autoservizi Salemi
    21h 0m
    0
    10:45 AM
    Milan
    San Donato Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • FlixBus
    22h 5m
    0
    12:55 PM
    Milan
    Lampugnano Bus Station
    11:00 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $93
  • FlixBus
    25h 25m
    0
    3:30 PM
    Milan
    Lampugnano Bus Station
    4:55 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $104
  • MarinoBus
    24h 15m
    0
    8:40 AM
    Milan
    Lampugnano Bus Station
    8:55 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    MarinoBus
    Economy
    $109
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $9? You can find the corresponding connections below.
    • FlixBus
      26h 10m
      0
      2:45 PM
      Milan
      San Donato Bus Station
      7:50 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $13
      • Waiting Time 1h 30m
    • FlixBus
      19h 35m
      0
      9:20 PM
      Siena
      Train Station
      4:55 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $72
    Travel time is 5h 10m longer, but you will save $9

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    22h 5m
    0
    12:55 PM
    Milan
    Lampugnano Bus Station
    11:00 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $75
  • Autoservizi Salemi
    21h 45m
    0
    10:00 AM
    Milan
    Lampugnano Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • Autoservizi Salemi
    21h 0m
    0
    10:45 AM
    Milan
    San Donato Bus Station
    7:45 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    Autoservizi Salemi
    Economy
    $93
  • FlixBus
    25h 25m
    0
    3:30 PM
    Milan
    Lampugnano Bus Station
    4:55 PM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    FlixBus
    Economy
    $93
  • MarinoBus
    24h 15m
    0
    8:40 AM
    Milan
    Lampugnano Bus Station
    8:55 AM
    Palermo
    Via Tommaso Fazello Bus Stop
    0
    MarinoBus
    Economy
    $106

Frequency of bus connections between Milan and Palermo

See here how frequent the connections between Milan and Palermo are, during different times and days of the week.
Monday is the busiest day, with more than 12 daily buses from Milan to Palermo. Wednesday has instead the fewest connections, with only 8 daily coaches between Milan and Palermo.
The busiest time of the day is the Morning, with 35 buses from Milan to Palermo, while Evening sees the fewest connections between Milan and Palermo, with 5 offers.

Facts about the bus from Milan to Palermo

Compare all providers like FlixBus, Autoservizi Salemi and MarinoBus that travel 9 times every day by bus from Milan to Palermo in one click! Book your bus ticket from Milan to Palermo starting from $75!

Cheapest Bus $75
Fastest Bus 21h 0m
Earliest Bus 8:50 AM
Latest Bus 3:30 PM
Daily Bus Routes 9 Ø
Distance 551.5 miles
Bus Companies FlixBus, Autoservizi Salemi and MarinoBus

Cheapest bus connections from Milan to Palermo

Every day, 9 buses from 3 bus companies leave Milan for Palermo: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/18/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/15
Monday 06/16
Tuesday 06/17
Wednesday 06/18
$108
Thursday 06/19
$128
Friday 06/20
$120
Saturday 06/21
$104
Sunday 06/22
$110
Monday 06/23
$93
Tuesday 06/24
$75
Wednesday 06/25
$95
Thursday 06/26
$87
Friday 06/27
$110
Saturday 06/28
$87
Sunday 06/29
$101
Monday 06/30
$97
Tuesday 07/01
$80
Wednesday 07/02
$82
Thursday 07/03
$98
Friday 07/04
$89
Saturday 07/05
$115
Sunday 07/06
$87
Monday 07/07
$82
Tuesday 07/08
$75
Wednesday 07/09
$75
Thursday 07/10
$75
Friday 07/11
$77
Saturday 07/12

The cheapest time to travel from Milan to Palermo

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Palermo, for the next 30 days.
With a price starting from $75, Tuesday is the cheapest day for a bus from Milan to Palermo. Saturday instead is the most expensive day with prices starting from $104.
Afternoon is the cheapest day time for bus tickets from Milan to Palermo, with $75. Evening is the most expensive time of the day with prices starting from $110.

How to save money travelling from Milan to Palermo

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Palermo in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Palermo, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Palermo are also emptier.

All bus stations and stops in Milan and Palermo

In the map below, you can see where to find all bus stations in Milan and Palermo.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Milan to Palermo? Compare all modes of transports from Milan to Palermo.

Service and Comfort on the bus from Milan to Palermo

Want to know which seat classes are available on the buses from Milan to Palermo? Or which bus companies serve the route Milan to Palermo? Below you will find answers to your questions.

FAQs about the Milan to Palermo bus

How much does a Milan Palermo bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $75 and takes 22h 5m to reach Palermo. Compare offers to save money!

How much could I save by comparing buses from Milan to Palermo?

This route is offered by 3 companies with a range of ticket prices between $75 and $209. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Palermo.

On average, how many connections are available from Milan to Palermo each day?

Every day, the Milan to Palermo bus route is served by approximately 9 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Palermo take?

The fastest bus from Milan to Palermo is offered by Autoservizi Salemi and takes 21h 0m. Bus tickets for this connection cost $93. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Palermo?

The earliest bus arriving in Palermo from Milan starts at 8:50 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Palermo?

The latest bus trip departing from Milan for Palermo starts at 3:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Palermo route?

When traveling by bus from Milan to Palermo, passengers can travel with FlixBus, Autoservizi Salemi and MarinoBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Palermo?

You can check all the direct connections between Milan and Palermo by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Autoservizi Salemi and MarinoBus.

What can I take with me on the Milan to Palermo bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Palermo bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Palermo bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Palermo on your planned travel date.

Available seat classes which are offered on the bus route Milan to Palermo

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Milan and to Palermo

Here’s an overview of the most popular bus routes to Milan and to Palermo. Simply click on the connection of your choice, and you will find all the details about your bus route!
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Buses to Milan from Genoa Buses to Milan from Genoa
Buses to Milan from Naples Buses to Milan from Naples
Buses Florence - Milan Buses Florence - Milan
Trapani to Palermo bus Trapani to Palermo bus
Buses Taormina to Palermo Buses Taormina to Palermo
Bus to Palermo from Agrigento Bus to Palermo from Agrigento
From Siracusa to Palermo bus From Siracusa to Palermo bus
Popular Airport Shuttles to Milan and to Palermo
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