Bus Milan to Palermo - Compare all Companies

Compare all timetables for the bus from Milan to Palermo

Here is a selection of the cheapest bus trips from the schedule from Milan to Palermo from various bus operators like FlixBus or Autoservizi Salemi for the next days.

today

$129

tomorrow

$95

Thursday

$105

Friday

$95

Saturday

$109

Sunday

$114

Monday

$93

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$129	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/16/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/17/2026 11:00:00 AM. 50 Economy ticket for $129 per person are available. Travel duration is 21h 55m
FlixBus	24h 50m	6:30 PM	Milan	San Donato Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$134	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/16/2026 6:30:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/17/2026 7:20:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 24h 50m
FlixBus	25h 35m	5:45 PM	Milan	Lampugnano Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$135	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/16/2026 5:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/17/2026 7:20:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 25h 35m
FlixBus	22h 15m	12:45 PM	Milan	San Donato Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$138	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/16/2026 12:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/17/2026 11:00:00 AM. 50 Economy ticket for $138 per person are available. Travel duration is 22h 15m
FlixBus	21h 50m	5:25 PM	Milan	San Donato Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$150	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/16/2026 5:25:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/17/2026 3:15:00 PM. 50 Economy ticket for $150 per person are available. Travel duration is 21h 50m

Did you know that if you travel from Milan to Palermo via Assago, you can save more than $-7? You will find the corresponding connections below.
- FlixBus
  
  25h 55m
  
  Milan
  
  5 mi
  
  9:05 AM
  
  Assago
  Milanofiori Forum
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0 mi
  
  Economy
  
  $136
  
  A Bus from FlixBus goes from Milanofiori Forum, Assago (Italy) at 6/16/2026 9:05:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/17/2026 11:00:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 25h 55m
Did you know that if you travel from Milan to Palermo via Siena, you can save more than $36? You can find the corresponding connections below.
- Itabus
  
  24h 20m
  
  0
  
  10:40 AM
  
  Milan
  Lampugnano Bus Station
  
  4:20 PM
  
  Siena
  Train Station
  
  0
  
  Premium Economy
  
  $9
  
  A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 6/18/2026 10:40:00 AM to Train Station, Siena (Italy) arriving at 6/18/2026 4:20:00 PM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 5h 40m
- FlixBus
  
  16h 0m
  
  0
  
  7:00 PM
  
  Siena
  Train Station
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $84
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/18/2026 7:00:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 11:00:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 16h 0m
Travel time is 2h 30m longer, but you will save $36

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Autoservizi Salemi	21h 45m	10:00 AM	Milan	Lampugnano Bus Station	7:45 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$95	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 6/17/2026 10:00:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/18/2026 7:45:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 21h 45m
Autoservizi Salemi	21h 0m	10:45 AM	Milan	San Donato Bus Station	7:45 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$95	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 6/17/2026 10:45:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/18/2026 7:45:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 21h 0m
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$108	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/17/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/18/2026 11:00:00 AM. 50 Economy ticket for $108 per person are available. Travel duration is 21h 55m
FlixBus	22h 15m	12:45 PM	Milan	San Donato Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$123	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/17/2026 12:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/18/2026 11:00:00 AM. 50 Economy ticket for $123 per person are available. Travel duration is 22h 15m
FlixBus	25h 35m	5:45 PM	Milan	Lampugnano Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$126	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/17/2026 5:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/18/2026 7:20:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 25h 35m

Did you know that if you travel from Milan to Palermo via Siena, you can save more than $12? You can find the corresponding connections below.
- FlixBus
  
  26h 15m
  
  0
  
  5:05 PM
  
  Milan
  San Donato Bus Station
  
  10:20 PM
  
  Siena
  Train Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/18/2026 5:05:00 PM to Train Station, Siena (Italy) arriving at 6/18/2026 10:20:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 15m
- FlixBus
  
  20h 55m
  
  0
  
  10:25 PM
  
  Siena
  Train Station
  
  7:20 PM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $75
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/18/2026 10:25:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 7:20:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 20h 55m
Travel time is 5h 15m longer, but you will save $12

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$105	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/18/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 11:00:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 21h 55m
FlixBus	21h 50m	5:25 PM	Milan	San Donato Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$121	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/18/2026 5:25:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 3:15:00 PM. 50 Economy ticket for $121 per person are available. Travel duration is 21h 50m
FlixBus	22h 35m	4:40 PM	Milan	Lampugnano Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$124	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/18/2026 4:40:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 3:15:00 PM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 35m
FlixBus	24h 50m	6:30 PM	Milan	San Donato Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$134	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/18/2026 6:30:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 7:20:00 PM. 50 Economy ticket for $134 per person are available. Travel duration is 24h 50m
FlixBus	25h 35m	5:45 PM	Milan	Lampugnano Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$135	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/18/2026 5:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/19/2026 7:20:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 25h 35m

Did you know that if you travel from Milan to Palermo via Siena, you can save more than $29? You can find the corresponding connections below.
- FlixBus
  
  22h 35m
  
  0
  
  12:25 PM
  
  Milan
  Lampugnano Bus Station
  
  6:15 PM
  
  Siena
  Train Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/19/2026 12:25:00 PM to Train Station, Siena (Italy) arriving at 6/19/2026 6:15:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 50m
- FlixBus
  
  16h 0m
  
  0
  
  7:00 PM
  
  Siena
  Train Station
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $68
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/19/2026 7:00:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 11:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 16h 0m
Travel time is 0h 45m longer, but you will save $29

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Autoservizi Salemi	21h 45m	10:00 AM	Milan	Lampugnano Bus Station	7:45 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$95	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 6/19/2026 10:00:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 7:45:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 21h 45m
Autoservizi Salemi	21h 0m	10:45 AM	Milan	San Donato Bus Station	7:45 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$95	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 6/19/2026 10:45:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 7:45:00 AM. 50 Economy ticket for $95 per person are available. Travel duration is 21h 0m
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$111	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/19/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 11:00:00 AM. 50 Economy ticket for $111 per person are available. Travel duration is 21h 55m
FlixBus	22h 15m	12:45 PM	Milan	San Donato Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$136	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/19/2026 12:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 11:00:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 22h 15m
FlixBus	22h 35m	4:40 PM	Milan	Lampugnano Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$137	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/19/2026 4:40:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 3:15:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 22h 35m

Did you know that if you travel from Milan to Palermo via Siena, you can save more than $19? You can find the corresponding connections below.
- FlixBus
  
  22h 35m
  
  0
  
  12:25 PM
  
  Milan
  Lampugnano Bus Station
  
  6:15 PM
  
  Siena
  Train Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/19/2026 12:25:00 PM to Train Station, Siena (Italy) arriving at 6/19/2026 6:15:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 50m
- FlixBus
  
  16h 0m
  
  0
  
  7:00 PM
  
  Siena
  Train Station
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $68
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/19/2026 7:00:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 11:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 16h 0m
Travel time is 1h 35m longer, but you will save $19

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	22h 35m	4:40 PM	Milan	Lampugnano Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$109	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/20/2026 4:40:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/21/2026 3:15:00 PM. 50 Economy ticket for $109 per person are available. Travel duration is 22h 35m
FlixBus	21h 50m	5:25 PM	Milan	San Donato Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$111	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/20/2026 5:25:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/21/2026 3:15:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 21h 50m
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$114	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/20/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/21/2026 11:00:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 21h 55m
FlixBus	22h 15m	12:45 PM	Milan	San Donato Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$124	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/20/2026 12:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/21/2026 11:00:00 AM. 50 Economy ticket for $124 per person are available. Travel duration is 22h 15m
FlixBus	25h 35m	5:45 PM	Milan	Lampugnano Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$141	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/20/2026 5:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/21/2026 7:20:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 25h 35m

Did you know that if you travel from Milan to Palermo via Siena, you can save more than $33? You can find the corresponding connections below.
- FlixBus
  
  22h 35m
  
  0
  
  12:25 PM
  
  Milan
  Lampugnano Bus Station
  
  6:15 PM
  
  Siena
  Train Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/19/2026 12:25:00 PM to Train Station, Siena (Italy) arriving at 6/19/2026 6:15:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 50m
- FlixBus
  
  16h 0m
  
  0
  
  7:00 PM
  
  Siena
  Train Station
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $68
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/19/2026 7:00:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/20/2026 11:00:00 AM. 50 Economy ticket for $68 per person are available. Travel duration is 16h 0m
Travel time is 0h 45m longer, but you will save $33

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$114	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/21/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/22/2026 11:00:00 AM. 50 Economy ticket for $114 per person are available. Travel duration is 21h 55m
FlixBus	22h 15m	12:45 PM	Milan	San Donato Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$147	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/21/2026 12:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/22/2026 11:00:00 AM. 50 Economy ticket for $147 per person are available. Travel duration is 22h 15m
FlixBus	21h 50m	5:25 PM	Milan	San Donato Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$149	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/21/2026 5:25:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/22/2026 3:15:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 21h 50m
FlixBus	22h 35m	4:40 PM	Milan	Lampugnano Bus Station	3:15 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$151	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/21/2026 4:40:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/22/2026 3:15:00 PM. 50 Economy ticket for $151 per person are available. Travel duration is 22h 35m
FlixBus	25h 35m	5:45 PM	Milan	Lampugnano Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$155	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/21/2026 5:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/22/2026 7:20:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 25h 35m

Did you know that if you travel from Milan to Palermo via Siena, you can save more than $44? You can find the corresponding connections below.
- FlixBus
  
  22h 35m
  
  0
  
  12:25 PM
  
  Milan
  Lampugnano Bus Station
  
  6:15 PM
  
  Siena
  Train Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/23/2026 12:25:00 PM to Train Station, Siena (Italy) arriving at 6/23/2026 6:15:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 50m
- FlixBus
  
  16h 0m
  
  0
  
  7:00 PM
  
  Siena
  Train Station
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $62
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/23/2026 7:00:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/24/2026 11:00:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 0m
Travel time is 0h 45m longer, but you will save $44

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Autoservizi Salemi	21h 45m	10:00 AM	Milan	Lampugnano Bus Station	7:45 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$93	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 6/22/2026 10:00:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/23/2026 7:45:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 21h 45m
Autoservizi Salemi	21h 0m	10:45 AM	Milan	San Donato Bus Station	7:45 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$93	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 6/22/2026 10:45:00 AM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/23/2026 7:45:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 21h 0m
FlixBus	21h 55m	1:05 PM	Milan	Lampugnano Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$101	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/22/2026 1:05:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/23/2026 11:00:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 21h 55m
FlixBus	22h 15m	12:45 PM	Milan	San Donato Bus Station	11:00 AM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$105	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/22/2026 12:45:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/23/2026 11:00:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 22h 15m
FlixBus	24h 50m	6:30 PM	Milan	San Donato Bus Station	7:20 PM	Palermo	Via Tommaso Fazello Bus Stop	Economy	$113	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 6/22/2026 6:30:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/23/2026 7:20:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 24h 50m

Did you know that if you travel from Milan to Palermo via Siena, you can save more than $23? You can find the corresponding connections below.
- FlixBus
  
  22h 35m
  
  0
  
  12:25 PM
  
  Milan
  Lampugnano Bus Station
  
  6:15 PM
  
  Siena
  Train Station
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 6/23/2026 12:25:00 PM to Train Station, Siena (Italy) arriving at 6/23/2026 6:15:00 PM. 50 Economy ticket for $9 per person are available. Travel duration is 5h 50m
- FlixBus
  
  16h 0m
  
  0
  
  7:00 PM
  
  Siena
  Train Station
  
  11:00 AM
  
  Palermo
  Via Tommaso Fazello Bus Stop
  
  0
  
  Economy
  
  $62
  
  A Bus from FlixBus goes from Train Station, Siena (Italy) at 6/23/2026 7:00:00 PM to Via Tommaso Fazello Bus Stop, Palermo (Italy) arriving at 6/24/2026 11:00:00 AM. 50 Economy ticket for $62 per person are available. Travel duration is 16h 0m
Travel time is 1h 35m longer, but you will save $23

Best Price Offer: The price for the cheapest bus from Milan to Palermo is $84 on 6/29/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Milan and Palermo

See here how frequent the connections between Milan and Palermo are, during different times and days of the week.

Monday is the busiest day, with more than 8 daily buses from Milan to Palermo. Sunday has instead the fewest connections, with only 6 daily coaches between Milan and Palermo.

The busiest time of the day is the Afternoon, with 34 buses from Milan to Palermo, while Morning sees the fewest connections between Milan and Palermo, with 7 offers.

Facts about the bus from Milan to Palermo

Compare all providers like FlixBus and Autoservizi Salemi that travel 6 times every day by bus from Milan to Palermo in one click! Book your bus ticket from Milan to Palermo starting from $84!

Cheapest Bus	$84
Fastest Bus	21h 0m
Earliest Bus	12:45 PM
Latest Bus	6:30 PM
Daily Bus Routes	6 Ø
Distance	551.5 miles
Bus Companies	FlixBus and Autoservizi Salemi

Cheapest bus connections from Milan to Palermo

Every day, 6 buses from 2 bus companies leave Milan for Palermo: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/16/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/14

Monday 06/15

Tuesday 06/16

$129

Wednesday 06/17

$108

Thursday 06/18

$105

Friday 06/19

$111

Saturday 06/20

$109

Sunday 06/21

$114

Monday 06/22

$101

Tuesday 06/23

$86

Wednesday 06/24

$90

Thursday 06/25

$94

Friday 06/26

$108

Saturday 06/27

$102

Sunday 06/28

$111

Monday 06/29

$84

Tuesday 06/30

$97

Wednesday 07/01

$111

Thursday 07/02

$97

Friday 07/03

$94

Saturday 07/04

$116

Sunday 07/05

$105

Monday 07/06

$101

Tuesday 07/07

$94

Wednesday 07/08

$94

Thursday 07/09

$95

Friday 07/10

$116

Saturday 07/11

The cheapest time to travel from Milan to Palermo

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Palermo, for the next 30 days.

With a price starting from $84, Monday is the cheapest day for a bus from Milan to Palermo. Saturday instead is the most expensive day with prices starting from $102.

Morning is the cheapest day time for bus tickets from Milan to Palermo, with $93. Evening is the most expensive time of the day with prices starting from $113.

How to save money travelling from Milan to Palermo

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Palermo in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Palermo, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Palermo are also emptier.

All bus stations and stops in Milan and Palermo

In the map below, you can see where to find all bus stations in Milan and Palermo.

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Central Station - Piazza Luigi di Savoia

Piazza Duca D'Aosta 16

Duomo Bus Stop

Piazza del Duomo

Oreto Orsi Bus Stop

Via Oreto 389

Piazza Cairoli Bus Station

Piazza Cairoli Piazza Cairoli

Piazza Indipendenza Station

Piazza Indipendenza Palazzo Reale

Via Tommaso Fazello Bus Stop

Via Tommaso Fazello

Via della Libertà

Via della Libertà 163

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Milan to Palermo? Compare all modes of transports from Milan to Palermo.

Service and Comfort on the bus from Milan to Palermo

Want to know which seat classes are available on the buses from Milan to Palermo? Or which bus companies serve the route Milan to Palermo? Below you will find answers to your questions.

FAQs about the Milan to Palermo bus

How much does a Milan Palermo bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $84 and takes 21h 45m to reach Palermo. Compare offers to save money!

How much could I save by comparing buses from Milan to Palermo?

This route is offered by 2 companies with a range of ticket prices between $84 and $156. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Palermo.

On average, how many connections are available from Milan to Palermo each day?

Every day, the Milan to Palermo bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Palermo take?

The fastest bus from Milan to Palermo is offered by Autoservizi Salemi and takes 21h 0m. Bus tickets for this connection cost $95. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Palermo?

The earliest bus arriving in Palermo from Milan starts at 12:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Palermo?

The latest bus trip departing from Milan for Palermo starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Palermo route?

When traveling by bus from Milan to Palermo, passengers can travel with FlixBus and Autoservizi Salemi. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Palermo?

You can check all the direct connections between Milan and Palermo by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Autoservizi Salemi.

What can I take with me on the Milan to Palermo bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Palermo bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Palermo bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Palermo on your planned travel date.

How does CheckMyBus find the best bus deals from Milan to Palermo?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Milan and Palermo. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Milan to Palermo?

Prices and availability for 6 trips between Milan and Palermo change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Milan to Palermo

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Milan and to Palermo

Here’s an overview of the most popular bus routes to Milan and to Palermo. Simply click on the connection of your choice, and you will find all the details about your bus route!