Which bus from Milan to Palermo is the cheapest?

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Compare all timetables for the bus from Milan to Palermo

Here is a selection of the cheapest bus trips from the schedule from Milan to Palermo from various bus operators like FlixBus or Autoservizi Salemi for the next days.

today
$178
tomorrow
$92
Saturday
$76
Sunday
$110
Monday
$76
Tuesday
$64
Wednesday
$62

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 22h 30m 12:30 PM Milan San Donato Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $178
FlixBus 21h 55m 1:05 PM Milan Lampugnano Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $185
FlixBus 25h 35m 5:45 PM Milan Lampugnano Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $192
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $195
FlixBus 24h 50m 2:25 PM Milan San Donato Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $239
  • Did you know that if you travel from Milan to Palermo via Sesto San Giovanni, you can save more than $0? You will find the corresponding connections below.
    • FlixBus
      Save more than 1%
      27h 55m
      Milan
      5 mi
      7:05 AM
      Sesto San Giovanni
      Sesto 1° Maggio FS
      11:00 AM
      Palermo
      Via Tommaso Fazello Bus Stop
      0 mi
      FlixBus
      Economy
      $178
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $111? You can find the corresponding connections below.
    • FlixBus
      26h 15m
      0
      5:05 PM
      Milan
      San Donato Bus Station
      10:20 PM
      Siena
      Train Station
      0
      FlixBus
      Economy
      $13
      • Waiting Time 0h 5m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $54
    Travel time is 4h 20m longer, but you will save $111

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 25h 35m 5:45 PM Milan Lampugnano Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $92
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $93
Autoservizi Salemi 21h 45m 10:00 AM Milan Lampugnano Bus Station 7:45 AM Palermo Via Tommaso Fazello Bus Stop  Basic $94
Autoservizi Salemi 21h 0m 10:45 AM Milan San Donato Bus Station 7:45 AM Palermo Via Tommaso Fazello Bus Stop  Basic $94
FlixBus 22h 30m 12:30 PM Milan San Donato Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $100
  • Did you know that if you travel from Milan to Palermo via Sesto San Giovanni, you can save more than $-14? You will find the corresponding connections below.
    • FlixBus
      27h 55m
      Milan
      5 mi
      7:05 AM
      Sesto San Giovanni
      Sesto 1° Maggio FS
      11:00 AM
      Palermo
      Via Tommaso Fazello Bus Stop
      0 mi
      FlixBus
      Economy
      $106
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $37? You can find the corresponding connections below.
    • Itabus
      30h 45m
      0
      12:35 PM
      Milan
      San Donato Bus Station
      5:50 PM
      Siena
      Train Station
      0
      Itabus
      Premium Economy
      $12
      • Waiting Time 4h 35m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $44
    Travel time is 9h 45m longer, but you will save $37

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 22h 30m 12:30 PM Milan San Donato Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $76
FlixBus 24h 30m 2:45 PM Milan San Donato Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $87
FlixBus 24h 0m 3:15 PM Milan Lampugnano Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $93
FlixBus 21h 55m 1:05 PM Milan Lampugnano Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $108
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $120
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $21? You can find the corresponding connections below.
    • Itabus
      30h 45m
      0
      12:35 PM
      Milan
      San Donato Bus Station
      5:50 PM
      Siena
      Train Station
      0
      Itabus
      Premium Economy
      $12
      • Waiting Time 4h 35m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $44
    Travel time is 8h 50m longer, but you will save $21

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 22h 30m 12:30 PM Milan San Donato Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $110
FlixBus 24h 0m 3:15 PM Milan Lampugnano Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $112
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $119
FlixBus 25h 35m 5:45 PM Milan Lampugnano Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $121
FlixBus 24h 30m 2:45 PM Milan San Donato Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $126
  • Did you know that if you travel from Milan to Palermo via Sesto San Giovanni, you can save more than $3? You will find the corresponding connections below.
    • FlixBus
      Save more than 3%
      27h 55m
      Milan
      5 mi
      7:05 AM
      Sesto San Giovanni
      Sesto 1° Maggio FS
      11:00 AM
      Palermo
      Via Tommaso Fazello Bus Stop
      0 mi
      FlixBus
      Economy
      $107
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $55? You can find the corresponding connections below.
    • Itabus
      30h 45m
      0
      12:35 PM
      Milan
      San Donato Bus Station
      5:50 PM
      Siena
      Train Station
      0
      Itabus
      Premium Economy
      $12
      • Waiting Time 4h 35m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $44
    Travel time is 8h 15m longer, but you will save $55

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $76
FlixBus 25h 35m 5:45 PM Milan Lampugnano Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $76
FlixBus 24h 0m 3:15 PM Milan Lampugnano Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $78
Autoservizi Salemi 21h 45m 10:00 AM Milan Lampugnano Bus Station 7:45 AM Palermo Via Tommaso Fazello Bus Stop  Basic $93
Autoservizi Salemi 21h 0m 10:45 AM Milan San Donato Bus Station 7:45 AM Palermo Via Tommaso Fazello Bus Stop  Basic $93
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $21? You can find the corresponding connections below.
    • Itabus
      30h 45m
      0
      12:35 PM
      Milan
      San Donato Bus Station
      5:50 PM
      Siena
      Train Station
      0
      Itabus
      Premium Economy
      $12
      • Waiting Time 4h 35m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $44
    Travel time is 9h 45m longer, but you will save $21

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 24h 10m 3:05 PM Milan Lampugnano Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $64
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $67
FlixBus 25h 35m 5:45 PM Milan Lampugnano Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $67
FlixBus 21h 55m 1:05 PM Milan Lampugnano Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $83
FlixBus 26h 10m 8:50 AM Milan San Donato Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $93
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $9? You can find the corresponding connections below.
    • Itabus
      30h 45m
      0
      12:35 PM
      Milan
      San Donato Bus Station
      5:50 PM
      Siena
      Train Station
      0
      Itabus
      Premium Economy
      $12
      • Waiting Time 4h 35m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $44
    Travel time is 8h 50m longer, but you will save $9

Cheapest bus trips Wednesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 22h 30m 12:30 PM Milan San Donato Bus Station 11:00 AM Palermo Via Tommaso Fazello Bus Stop  Economy $62
FlixBus 24h 50m 6:30 PM Milan San Donato Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $65
FlixBus 25h 35m 5:45 PM Milan Lampugnano Bus Station 7:20 PM Palermo Via Tommaso Fazello Bus Stop  Economy $66
FlixBus 26h 30m 12:45 PM Milan San Donato Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $73
FlixBus 24h 0m 3:15 PM Milan Lampugnano Bus Station 3:15 PM Palermo Via Tommaso Fazello Bus Stop  Economy $73
  • Did you know that if you travel from Milan to Palermo via Siena, you can save more than $7? You can find the corresponding connections below.
    • Itabus
      30h 45m
      0
      12:35 PM
      Milan
      San Donato Bus Station
      5:50 PM
      Siena
      Train Station
      0
      Itabus
      Premium Economy
      $12
      • Waiting Time 4h 35m
    • FlixBus
      20h 55m
      0
      10:25 PM
      Siena
      Train Station
      7:20 PM
      Palermo
      Via Tommaso Fazello Bus Stop
      0
      FlixBus
      Economy
      $44
    Travel time is 8h 15m longer, but you will save $7

Best Price Offer: The price for the cheapest bus from Milan to Palermo is $54 on 5/12/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Milan and Palermo

See here how frequent the connections between Milan and Palermo are, during different times and days of the week.
Monday is the busiest day, with more than 8 daily buses from Milan to Palermo. Tuesday has instead the fewest connections, with only 5 daily coaches between Milan and Palermo.
The busiest time of the day is the Afternoon, with 31 buses from Milan to Palermo, while Morning sees the fewest connections between Milan and Palermo, with 6 offers.

Facts about the bus from Milan to Palermo

Compare all providers like FlixBus and Autoservizi Salemi that travel 6 times every day by bus from Milan to Palermo in one click! Book your bus ticket from Milan to Palermo starting from $54!

Cheapest Bus $54
Fastest Bus 21h 0m
Earliest Bus 12:30 PM
Latest Bus 6:30 PM
Daily Bus Routes 6 Ø
Distance 551.5 miles
Bus Companies FlixBus and Autoservizi Salemi

Cheapest bus connections from Milan to Palermo

Every day, 6 buses from 2 bus companies leave Milan for Palermo: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/30/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 04/26
Monday 04/27
Tuesday 04/28
Wednesday 04/29
Thursday 04/30
$178
Friday 05/01
$92
Saturday 05/02
$76
Sunday 05/03
$110
Monday 05/04
$76
Tuesday 05/05
$64
Wednesday 05/06
$62
Thursday 05/07
$74
Friday 05/08
$81
Saturday 05/09
$71
Sunday 05/10
$71
Monday 05/11
$55
Tuesday 05/12
$54
Wednesday 05/13
$60
Thursday 05/14
$69
Friday 05/15
$76
Saturday 05/16
$63
Sunday 05/17
$71
Monday 05/18
$61
Tuesday 05/19
$61
Wednesday 05/20
$69
Thursday 05/21
$68
Friday 05/22
$72
Saturday 05/23

The cheapest time to travel from Milan to Palermo

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Palermo, for the next 30 days.
With a price starting from $54, Tuesday is the cheapest day for a bus from Milan to Palermo. Friday instead is the most expensive day with prices starting from $72.
Afternoon is the cheapest day time for bus tickets from Milan to Palermo, with $62. Morning is the most expensive time of the day with prices starting from $93.

How to save money travelling from Milan to Palermo

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Palermo in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Palermo, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Palermo are also emptier.

All bus stations and stops in Milan and Palermo

In the map below, you can see where to find all bus stations in Milan and Palermo.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Milan to Palermo? Compare all modes of transports from Milan to Palermo.

Service and Comfort on the bus from Milan to Palermo

Want to know which seat classes are available on the buses from Milan to Palermo? Or which bus companies serve the route Milan to Palermo? Below you will find answers to your questions.

FAQs about the Milan to Palermo bus

How much does a Milan Palermo bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $54 and takes 22h 30m to reach Palermo. Compare offers to save money!

How much could I save by comparing buses from Milan to Palermo?

This route is offered by 2 companies with a range of ticket prices between $54 and $239. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Palermo.

On average, how many connections are available from Milan to Palermo each day?

Every day, the Milan to Palermo bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Palermo take?

The fastest bus from Milan to Palermo is offered by Autoservizi Salemi and takes 21h 0m. Bus tickets for this connection cost $94. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Palermo?

The earliest bus arriving in Palermo from Milan starts at 12:30 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Palermo?

The latest bus trip departing from Milan for Palermo starts at 6:30 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Palermo route?

When traveling by bus from Milan to Palermo, passengers can travel with FlixBus and Autoservizi Salemi. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Palermo?

You can check all the direct connections between Milan and Palermo by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Autoservizi Salemi.

What can I take with me on the Milan to Palermo bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Palermo bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Palermo bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Palermo on your planned travel date.

How does CheckMyBus find the best bus deals from Milan to Palermo?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between Milan and Palermo. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Milan to Palermo?

Prices and availability for 6 trips between Milan and Palermo change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Milan to Palermo

Basic
Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Milan and to Palermo

Here’s an overview of the most popular bus routes to Milan and to Palermo. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses Crotone - Milan Buses Crotone - Milan
Bus Lamezia Terme - Milan Bus Lamezia Terme - Milan
From Champigny-sur-Marne to Milan bus From Champigny-sur-Marne to Milan bus
Trento to Milan bus Trento to Milan bus
Bus from Castelvetrano to Palermo Bus from Castelvetrano to Palermo
Buses Enna to Palermo Buses Enna to Palermo
From Castellammare del Golfo to Palermo bus From Castellammare del Golfo to Palermo bus
Buses Lecce to Palermo Buses Lecce to Palermo
Popular Airport Shuttles to Milan and to Palermo
CheckMyBus › Buses in Italy › Bus to Milan › Bus to Palermo

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