Bus San Diego to Chicago: Compare prices and save money

Compare all timetables for the bus from San Diego to Chicago

Here is a selection of the cheapest bus trips from the schedule from San Diego to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

$326

tomorrow

Sunday

$326

Monday

Tuesday

$207

Wednesday

$183

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	64h 15m	1:45 PM	San Diego	Seaport Village	8:00 AM	Chicago	Union Station	Economy	$326	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/19/2025 1:45:00 PM to Union Station, Chicago (USA) arriving at 12/22/2025 8:00:00 AM. 50 Economy ticket for $326 per person are available. Travel duration is 64h 15m
FlixBus	48h 35m	1:45 PM	San Diego	Seaport Village	4:20 PM	Chicago	Downtown Bus Station	Economy	$334	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/19/2025 1:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/21/2025 4:20:00 PM. 50 Economy ticket for $334 per person are available. Travel duration is 48h 35m
FlixBus	50h 5m	12:15 PM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$336	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/19/2025 12:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/21/2025 4:20:00 PM. 50 Economy ticket for $336 per person are available. Travel duration is 50h 5m
Greyhound US	54h 35m	7:35 PM	San Diego	Old Town Transit Center	4:10 AM	Chicago	Downtown Bus Station	Economy	$400	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/19/2025 7:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/22/2025 4:10:00 AM. 50 Economy ticket for $400 per person are available. Travel duration is 54h 35m
Greyhound US	58h 25m	7:35 PM	San Diego	Old Town Transit Center	8:00 AM	Chicago	Union Station	Economy	$403	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/19/2025 7:35:00 PM to Union Station, Chicago (USA) arriving at 12/22/2025 8:00:00 AM. 50 Economy ticket for $403 per person are available. Travel duration is 58h 25m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	48h 35m	1:45 PM	San Diego	Seaport Village	4:20 PM	Chicago	Downtown Bus Station	Economy	$326	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/21/2025 1:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 4:20:00 PM. 50 Economy ticket for $326 per person are available. Travel duration is 48h 35m
FlixBus	50h 5m	12:15 PM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$329	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 12:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 4:20:00 PM. 50 Economy ticket for $329 per person are available. Travel duration is 50h 5m
FlixBus	48h 10m	2:10 PM	San Diego	La Jolla Village	4:20 PM	Chicago	Downtown Bus Station	Economy	$330	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/21/2025 2:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 4:20:00 PM. 50 Economy ticket for $330 per person are available. Travel duration is 48h 10m
Greyhound US	55h 35m	6:45 AM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$339	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 6:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 4:20:00 PM. 50 Economy ticket for $339 per person are available. Travel duration is 55h 35m
Greyhound US	52h 30m	10:00 AM	San Diego	Old Town Transit Center	4:30 PM	Chicago	Downtown Bus Station	Economy	$353	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 10:00:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 4:30:00 PM. 50 Economy ticket for $353 per person are available. Travel duration is 52h 30m

Did you know that if you travel from San Diego to Chicago via El Cajon, CA, you can save more than $73? You can find the corresponding connections below.
- FlixBus
  
  52h 30m
  
  0
  
  10:00 AM
  
  San Diego
  Old Town Transit Center
  
  10:20 AM
  
  El Cajon, CA
  Bus Stop
  
  0
  
  Economy
  
  $9
  
  A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 10:00:00 AM to Bus Stop, El Cajon, CA (USA) arriving at 12/21/2025 10:20:00 AM. 50 Economy ticket for $9 per person are available. Travel duration is 0h 20m
- FlixBus
  
  52h 5m
  
  0
  
  10:25 AM
  
  El Cajon, CA
  Bus Stop
  
  4:30 PM
  
  Chicago
  Downtown Bus Station
  
  0
  
  Economy
  
  $244
  
  A Bus from FlixBus goes from Bus Stop, El Cajon, CA (USA) at 12/21/2025 10:25:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/23/2025 4:30:00 PM. 50 Economy ticket for $244 per person are available. Travel duration is 52h 5m
Travel time is 2h 20m longer, but you will save $73

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	48h 35m	1:45 PM	San Diego	Seaport Village	4:20 PM	Chicago	Downtown Bus Station	Economy	$207	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/23/2025 1:45:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 4:20:00 PM. 50 Economy ticket for $207 per person are available. Travel duration is 48h 35m
FlixBus	50h 5m	12:15 PM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$209	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/23/2025 12:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 4:20:00 PM. 50 Economy ticket for $209 per person are available. Travel duration is 50h 5m
FlixBus	48h 10m	2:10 PM	San Diego	La Jolla Village	4:20 PM	Chicago	Downtown Bus Station	Economy	$210	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/23/2025 2:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 4:20:00 PM. 50 Economy ticket for $210 per person are available. Travel duration is 48h 10m
Greyhound US	55h 35m	6:45 AM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$215	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/23/2025 6:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/25/2025 4:20:00 PM. 50 Economy ticket for $215 per person are available. Travel duration is 55h 35m
Greyhound US	54h 35m	7:35 PM	San Diego	Old Town Transit Center	4:10 AM	Chicago	Downtown Bus Station	Economy	$225	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/23/2025 7:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/26/2025 4:10:00 AM. 50 Economy ticket for $225 per person are available. Travel duration is 54h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	54h 35m	7:35 PM	San Diego	Old Town Transit Center	4:10 AM	Chicago	Downtown Bus Station	Economy	$183	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 7:35:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/27/2025 4:10:00 AM. 50 Economy ticket for $183 per person are available. Travel duration is 54h 35m
Greyhound US	55h 35m	6:45 AM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$217	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 6:45:00 AM to Downtown Bus Station, Chicago (USA) arriving at 12/26/2025 4:20:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 55h 35m
Greyhound US	58h 25m	7:35 PM	San Diego	Old Town Transit Center	8:00 AM	Chicago	Union Station	Economy	$217	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 7:35:00 PM to Union Station, Chicago (USA) arriving at 12/27/2025 8:00:00 AM. 50 Economy ticket for $217 per person are available. Travel duration is 58h 25m
FlixBus	50h 5m	12:15 PM	San Diego	Old Town Transit Center	4:20 PM	Chicago	Downtown Bus Station	Economy	$217	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 12:15:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/26/2025 4:20:00 PM. 50 Economy ticket for $217 per person are available. Travel duration is 50h 5m
FlixBus	48h 10m	2:10 PM	San Diego	La Jolla Village	4:20 PM	Chicago	Downtown Bus Station	Economy	$218	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/24/2025 2:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 12/26/2025 4:20:00 PM. 50 Economy ticket for $218 per person are available. Travel duration is 48h 10m

Best Price Offer: The price for the cheapest bus from San Diego to Chicago is $183 on 12/24/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Chicago

See here how frequent the connections between San Diego and Chicago are, during different times and days of the week.

Sunday is the busiest day, with more than 18 daily buses from San Diego to Chicago. Friday has instead the fewest connections, with only 10 daily coaches between San Diego and Chicago.

The busiest time of the day is the Afternoon, with 37 buses from San Diego to Chicago, while Evening sees the fewest connections between San Diego and Chicago, with 8 offers.

Facts about the bus from San Diego to Chicago

Compare all providers like FlixBus and Greyhound US that travel 14 times every day by bus from San Diego to Chicago in one click! Book your bus ticket from San Diego to Chicago starting from $183!

Cheapest Bus	$183
Fastest Bus	50h 10m
Earliest Bus	12:15 PM
Latest Bus	7:35 PM
Daily Bus Routes	14 Ø
Distance	1,730.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Chicago

Every day, 14 buses from 2 bus companies leave San Diego for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$326

Saturday 12/20

Sunday 12/21

$344

Monday 12/22

Tuesday 12/23

$207

Wednesday 12/24

$183

Thursday 12/25

Friday 12/26

$278

Saturday 12/27

Sunday 12/28

$318

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from San Diego to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Chicago, for the next 30 days.

With a price starting from $183, Wednesday is the cheapest day for a bus from San Diego to Chicago. Sunday instead is the most expensive day with prices starting from $318.

Evening is the cheapest day time for bus tickets from San Diego to Chicago, with $183. Morning is the most expensive time of the day with prices starting from $215.

How to save money travelling from San Diego to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Chicago are also emptier.

Beloved bus companies from San Diego to Chicago

These are the most booked bus companies between San Diego to Chicago from our users.

FlixBus from San Diego to Chicago

Here you will find the key facts about the FlixBus bus route San Diego to Chicago:

Cheapest Price	$207
Fastest Bus	50h 10m
Earliest Bus	12:15 PM
Last Bus	2:10 PM
Daily Connections	10 Ø
Found on	12/15/2025

All bus stations and stops in San Diego and Chicago

In the map below, you can see where to find all bus stations in San Diego and Chicago.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from San Diego to Chicago? Compare all modes of transports from San Diego to Chicago.

Service and Comfort on the bus from San Diego to Chicago

Want to know which seat classes are available on the buses from San Diego to Chicago? Or which bus companies serve the route San Diego to Chicago? Below you will find answers to your questions.

FAQs about the San Diego to Chicago bus

How much does a San Diego Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $183 and takes 56h 35m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from San Diego to Chicago?

This route is offered by 2 companies with a range of ticket prices between $183 and $403. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from San Diego to Chicago each day?

Every day, the San Diego to Chicago bus route is served by approximately 14 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Chicago take?

The fastest bus from San Diego to Chicago is offered by FlixBus and takes 50h 10m. Bus tickets for this connection cost $336. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Chicago?

The earliest bus arriving in Chicago from San Diego starts at 12:15 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Chicago?

The latest bus trip departing from San Diego for Chicago starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Chicago route?

When traveling by bus from San Diego to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Chicago?

You can check all the direct connections between San Diego and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 14 daily trips between San Diego and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Chicago?

Prices and availability for 14 trips between San Diego and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Chicago

Here’s an overview of the most popular bus routes to San Diego and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!