Bus from San Diego to Chicago from $171

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Compare all timetables for the bus from San Diego to Chicago

Here is a selection of the cheapest bus trips from the schedule from San Diego to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today
tomorrow
$284
Saturday
$296
Sunday
Monday
$274
Tuesday
Wednesday

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 48h 35m 1:45 PM San Diego Seaport Village 4:20 PM Chicago Downtown Bus Station  Economy $284
Greyhound US 52h 30m 10:00 AM San Diego Old Town Transit Center 4:30 PM Chicago Downtown Bus Station  Economy $286
FlixBus 50h 5m 12:15 PM San Diego Old Town Transit Center 4:20 PM Chicago Downtown Bus Station  Economy $287
FlixBus 64h 15m 1:45 PM San Diego Seaport Village 8:00 AM Chicago Union Station  Economy $287
Greyhound US 51h 55m 10:00 AM San Diego Old Town Transit Center 3:55 PM Chicago 95th Red Line Station  Economy $296
  • Did you know that if you travel from San Diego to Chicago via El Cajon, CA, you can save more than $54? You can find the corresponding connections below.
    • FlixBus
      51h 55m
      0
      10:00 AM
      San Diego
      Old Town Transit Center
      10:20 AM
      El Cajon, CA
      Bus Stop
      0
      FlixBus
      Economy
      $8
      • Waiting Time 0h 5m
    • FlixBus
      51h 30m
      0
      10:25 AM
      El Cajon, CA
      Bus Stop
      3:55 PM
      Chicago
      95th Red Line Station
      0
      FlixBus
      Economy
      $222
    Travel time is 1h 20m longer, but you will save $54

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 64h 15m 1:45 PM San Diego Seaport Village 8:00 AM Chicago Union Station  Economy $296
FlixBus 50h 5m 12:15 PM San Diego Old Town Transit Center 4:20 PM Chicago Downtown Bus Station  Economy $298
FlixBus 48h 35m 1:45 PM San Diego Seaport Village 4:20 PM Chicago Downtown Bus Station  Economy $298
Greyhound US 55h 35m 6:45 AM San Diego Old Town Transit Center 4:20 PM Chicago Downtown Bus Station  Economy $299
Greyhound US 52h 30m 10:00 AM San Diego Old Town Transit Center 4:30 PM Chicago Downtown Bus Station  Economy $302
  • Did you know that if you travel from San Diego to Chicago via El Cajon, CA, you can save more than $66? You can find the corresponding connections below.
    • FlixBus
      51h 55m
      0
      10:00 AM
      San Diego
      Old Town Transit Center
      10:20 AM
      El Cajon, CA
      Bus Stop
      0
      FlixBus
      Economy
      $8
      • Waiting Time 0h 5m
    • FlixBus
      51h 30m
      0
      10:25 AM
      El Cajon, CA
      Bus Stop
      3:55 PM
      Chicago
      95th Red Line Station
      0
      FlixBus
      Economy
      $222
    Travel time is 1h 20m longer, but you will save $66

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
FlixBus 50h 5m 12:15 PM San Diego Old Town Transit Center 4:20 PM Chicago Downtown Bus Station  Economy $274
FlixBus 48h 10m 2:10 PM San Diego La Jolla Village 4:20 PM Chicago Downtown Bus Station  Economy $274
Greyhound US 55h 35m 6:45 AM San Diego Old Town Transit Center 4:20 PM Chicago Downtown Bus Station  Economy $276
FlixBus 48h 35m 1:45 PM San Diego Seaport Village 4:20 PM Chicago Downtown Bus Station  Economy $276
Greyhound US 58h 25m 7:35 PM San Diego Old Town Transit Center 8:00 AM Chicago Union Station  Economy $295
  • Did you know that if you travel from San Diego to Chicago via El Cajon, CA, you can save more than $44? You can find the corresponding connections below.
    • FlixBus
      51h 55m
      0
      10:00 AM
      San Diego
      Old Town Transit Center
      10:20 AM
      El Cajon, CA
      Bus Stop
      0
      FlixBus
      Economy
      $8
      • Waiting Time 0h 5m
    • FlixBus
      51h 30m
      0
      10:25 AM
      El Cajon, CA
      Bus Stop
      3:55 PM
      Chicago
      95th Red Line Station
      0
      FlixBus
      Economy
      $222
    Travel time is 1h 45m longer, but you will save $44

Best Price Offer: The price for the cheapest bus from San Diego to Chicago is $171 on 12/26/2025. Flexible travelers save on ticket prices.


Frequency of bus connections between San Diego and Chicago

See here how frequent the connections between San Diego and Chicago are, during different times and days of the week.
Saturday is the busiest day, with more than 18 daily buses from San Diego to Chicago. Monday has instead the fewest connections, with only 11 daily coaches between San Diego and Chicago.
The busiest time of the day is the Afternoon, with 30 buses from San Diego to Chicago, while Evening sees the fewest connections between San Diego and Chicago, with 6 offers.

Facts about the bus from San Diego to Chicago

Compare all providers like FlixBus and Greyhound US that travel 15 times every day by bus from San Diego to Chicago in one click! Book your bus ticket from San Diego to Chicago starting from $171!

Cheapest Bus $171
Fastest Bus 50h 10m
Earliest Bus 7:35 AM
Latest Bus 7:35 PM
Daily Bus Routes 15 Ø
Distance 1,730.9 miles
Bus Companies FlixBus and Greyhound US

Cheapest bus connections from San Diego to Chicago

Every day, 15 buses from 2 bus companies leave San Diego for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/04/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 11/30
Monday 12/01
Tuesday 12/02
Wednesday 12/03
Thursday 12/04
Friday 12/05
$293
Saturday 12/06
$309
Sunday 12/07
Monday 12/08
$274
Tuesday 12/09
Wednesday 12/10
Thursday 12/11
Friday 12/12
Saturday 12/13
Sunday 12/14
Monday 12/15
Tuesday 12/16
Wednesday 12/17
Thursday 12/18
Friday 12/19
Saturday 12/20
Sunday 12/21
Monday 12/22
Tuesday 12/23
Wednesday 12/24
Thursday 12/25
Friday 12/26
$171
Saturday 12/27

The cheapest time to travel from San Diego to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Chicago, for the next 30 days.
With a price starting from $171, Friday is the cheapest day for a bus from San Diego to Chicago. Saturday instead is the most expensive day with prices starting from $296.
Afternoon is the cheapest day time for bus tickets from San Diego to Chicago, with $274. Evening is the most expensive time of the day with prices starting from $295.

How to save money travelling from San Diego to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Chicago are also emptier.

Beloved bus companies from San Diego to Chicago

These are the most booked bus companies between San Diego to Chicago from our users.

FlixBus from San Diego to Chicago

FlixBus

Here you will find the key facts about the FlixBus bus route San Diego to Chicago:

Cheapest Price $274
Fastest Bus 50h 10m
Earliest Bus 7:35 AM
Last Bus 4:15 PM
Daily Connections 11 Ø
Found on 11/29/2025

All bus stations and stops in San Diego and Chicago

In the map below, you can see where to find all bus stations in San Diego and Chicago.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from San Diego to Chicago? Compare all modes of transports from San Diego to Chicago.

Service and Comfort on the bus from San Diego to Chicago

Want to know which seat classes are available on the buses from San Diego to Chicago? Or which bus companies serve the route San Diego to Chicago? Below you will find answers to your questions.

FAQs about the San Diego to Chicago bus

How much does a San Diego Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $171 and takes 52h 5m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from San Diego to Chicago?

This route is offered by 2 companies with a range of ticket prices between $171 and $329. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from San Diego to Chicago each day?

Every day, the San Diego to Chicago bus route is served by approximately 15 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Chicago take?

The fastest bus from San Diego to Chicago is offered by FlixBus and takes 50h 10m. Bus tickets for this connection cost $287. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Chicago?

The earliest bus arriving in Chicago from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Chicago?

The latest bus trip departing from San Diego for Chicago starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Chicago route?

When traveling by bus from San Diego to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Chicago?

You can check all the direct connections between San Diego and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Chicago on your planned travel date.

Available seat classes which are offered on the bus route San Diego to Chicago

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Chicago

Here’s an overview of the most popular bus routes to San Diego and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!
Buses from Sacramento to San Diego Buses from Sacramento to San Diego
Buses Ontario, CA - San Diego Buses Ontario, CA - San Diego
From Long Beach to San Diego bus From Long Beach to San Diego bus
Bus Houston - San Diego Bus Houston - San Diego
Bus Ann Arbor, MI to Chicago Bus Ann Arbor, MI to Chicago
Bus Nashville to Chicago Bus Nashville to Chicago
Buses Las Vegas to Chicago Buses Las Vegas to Chicago
Bus from Houston to Chicago Bus from Houston to Chicago
Popular Airport Shuttles to San Diego and to Chicago
CheckMyBus › Buses in USA › Bus to San Diego › Bus to Chicago

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