Bus San Diego to Chicago: Compare prices and save money

Compare all timetables for the bus from San Diego to Chicago

Here is a selection of the cheapest bus trips from the schedule from San Diego to Chicago from various bus operators like FlixBus or Greyhound US for the next days.

today

$108

tomorrow

$135

Wednesday

$142

Thursday

$160

Friday

$141

Saturday

$155

Sunday

$139

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$108	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/22/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 6:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 51h 25m
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$108	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/22/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 6:35:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 54h 45m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$111	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/22/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/24/2026 6:35:00 PM. 50 Economy ticket for $111 per person are available. Travel duration is 55h 10m
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$127	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/22/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 5:20:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 55h 25m
FlixBus	49h 15m	1:10 PM	San Diego	Seaport Village	4:25 PM	Chicago	Downtown Bus Station	Economy	$132	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/22/2026 1:10:00 PM to Downtown Bus Station, Chicago (USA) arriving at 6/24/2026 4:25:00 PM. 50 Economy ticket for $132 per person are available. Travel duration is 49h 15m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$135	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/23/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 51h 25m
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$135	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/23/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $135 per person are available. Travel duration is 54h 45m
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$136	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/23/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 5:20:00 AM. 50 Economy ticket for $136 per person are available. Travel duration is 55h 25m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$137	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/23/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $137 per person are available. Travel duration is 55h 10m
FlixBus	51h 0m	1:35 PM	San Diego	La Jolla Village	6:35 PM	Chicago	95th Red Line Station	Economy	$140	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/23/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/25/2026 6:35:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 51h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$142	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/24/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 6:35:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 51h 25m
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$143	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/24/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 6:35:00 PM. 50 Economy ticket for $143 per person are available. Travel duration is 54h 45m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$144	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/24/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 6:35:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 55h 10m
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$146	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/24/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 5:20:00 AM. 50 Economy ticket for $146 per person are available. Travel duration is 55h 25m
FlixBus	51h 0m	1:35 PM	San Diego	La Jolla Village	6:35 PM	Chicago	95th Red Line Station	Economy	$147	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/24/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/26/2026 6:35:00 PM. 50 Economy ticket for $147 per person are available. Travel duration is 51h 0m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$160	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/25/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 5:20:00 AM. 50 Economy ticket for $160 per person are available. Travel duration is 55h 25m
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$161	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/25/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 6:35:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 51h 25m
FlixBus	51h 0m	1:35 PM	San Diego	La Jolla Village	6:35 PM	Chicago	95th Red Line Station	Economy	$161	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/25/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 6:35:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 51h 0m
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$161	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/25/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 6:35:00 PM. 50 Economy ticket for $161 per person are available. Travel duration is 54h 45m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$163	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/25/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/27/2026 6:35:00 PM. 50 Economy ticket for $163 per person are available. Travel duration is 55h 10m

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$141	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/26/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 6:35:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 51h 25m
FlixBus	51h 0m	1:35 PM	San Diego	La Jolla Village	6:35 PM	Chicago	95th Red Line Station	Economy	$141	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/26/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 6:35:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 51h 0m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$142	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/26/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 6:35:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 55h 10m
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$142	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/26/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/28/2026 6:35:00 PM. 50 Economy ticket for $142 per person are available. Travel duration is 54h 45m
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$224	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/26/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 5:20:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 55h 25m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$155	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/27/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 6:35:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 54h 45m
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$156	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/27/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/30/2026 5:20:00 AM. 50 Economy ticket for $156 per person are available. Travel duration is 55h 25m
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$157	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/27/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 6:35:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 51h 25m
FlixBus	51h 0m	1:35 PM	San Diego	La Jolla Village	6:35 PM	Chicago	95th Red Line Station	Economy	$157	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 6/27/2026 1:35:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 6:35:00 PM. 50 Economy ticket for $157 per person are available. Travel duration is 51h 0m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$158	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/27/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/29/2026 6:35:00 PM. 50 Economy ticket for $158 per person are available. Travel duration is 55h 10m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	55h 25m	7:55 PM	San Diego	Old Town Transit Center	5:20 AM	Chicago	95th Red Line Station	Economy	$139	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/28/2026 7:55:00 PM to 95th Red Line Station, Chicago (USA) arriving at 7/1/2026 5:20:00 AM. 50 Economy ticket for $139 per person are available. Travel duration is 55h 25m
FlixBus	51h 25m	1:10 PM	San Diego	Seaport Village	6:35 PM	Chicago	95th Red Line Station	Economy	$140	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 6/28/2026 1:10:00 PM to 95th Red Line Station, Chicago (USA) arriving at 6/30/2026 6:35:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 51h 25m
Greyhound US	54h 45m	9:50 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$140	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 6/28/2026 9:50:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/30/2026 6:35:00 PM. 50 Economy ticket for $140 per person are available. Travel duration is 54h 45m
FlixBus	55h 10m	9:25 AM	San Diego	Old Town Transit Center	6:35 PM	Chicago	95th Red Line Station	Economy	$141	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/28/2026 9:25:00 AM to 95th Red Line Station, Chicago (USA) arriving at 6/30/2026 6:35:00 PM. 50 Economy ticket for $141 per person are available. Travel duration is 55h 10m
FlixBus	54h 30m	7:35 AM	San Diego	Old Town Transit Center	4:05 PM	Chicago	Downtown Bus Station	Economy	$149	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 6/28/2026 7:35:00 AM to Downtown Bus Station, Chicago (USA) arriving at 6/30/2026 4:05:00 PM. 50 Economy ticket for $149 per person are available. Travel duration is 54h 30m

Best Price Offer: The price for the cheapest bus from San Diego to Chicago is $101 on 6/21/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Chicago

See here how frequent the connections between San Diego and Chicago are, during different times and days of the week.

Wednesday is the busiest day, with more than 28 daily buses from San Diego to Chicago. Thursday has instead the fewest connections, with only 5 daily coaches between San Diego and Chicago.

The busiest time of the day is the Morning, with 49 buses from San Diego to Chicago, while Evening sees the fewest connections between San Diego and Chicago, with 23 offers.

Facts about the bus from San Diego to Chicago

Compare all providers like FlixBus and Greyhound US that travel 15 times every day by bus from San Diego to Chicago in one click! Book your bus ticket from San Diego to Chicago starting from $101!

Cheapest Bus	$101
Fastest Bus	50h 50m
Earliest Bus	7:35 AM
Latest Bus	7:55 PM
Daily Bus Routes	15 Ø
Distance	1,730.9 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Chicago

Every day, 15 buses from 2 bus companies leave San Diego for Chicago: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 06/21

Monday 06/22

$136

Tuesday 06/23

$135

Wednesday 06/24

$142

Thursday 06/25

$160

Friday 06/26

$141

Saturday 06/27

$155

Sunday 06/28

$139

Monday 06/29

Tuesday 06/30

Wednesday 07/01

Thursday 07/02

Friday 07/03

Saturday 07/04

$126

Sunday 07/05

Monday 07/06

Tuesday 07/07

Wednesday 07/08

Thursday 07/09

Friday 07/10

$142

Saturday 07/11

$133

Sunday 07/12

$146

Monday 07/13

$127

Tuesday 07/14

$134

Wednesday 07/15

$152

Thursday 07/16

$184

Friday 07/17

$156

Saturday 07/18

The cheapest time to travel from San Diego to Chicago

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Chicago, for the next 30 days.

With a price starting from $108, Monday is the cheapest day for a bus from San Diego to Chicago. Thursday instead is the most expensive day with prices starting from $160.

Afternoon is the cheapest day time for bus tickets from San Diego to Chicago, with $108. Evening is the most expensive time of the day with prices starting from $127.

How to save money travelling from San Diego to Chicago

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Chicago in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Chicago, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Chicago are also emptier.

All bus stations and stops in San Diego and Chicago

In the map below, you can see where to find all bus stations in San Diego and Chicago.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

Downtown

95th Red Line Station

W. 95th St 14

Downtown Bus Station

West Harrison Street 630-670

Union Station

S Canal St 225

Cumberland CTA

N Cumberland Ave 5800

Canal & Van Buren

S Canal St 310-320

Service and Comfort on the bus from San Diego to Chicago

Want to know which seat classes are available on the buses from San Diego to Chicago? Or which bus companies serve the route San Diego to Chicago? Below you will find answers to your questions.

FAQs about the San Diego to Chicago bus

How much does a San Diego Chicago bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $101 and takes 53h 25m to reach Chicago. Compare offers to save money!

How much could I save by comparing buses from San Diego to Chicago?

This route is offered by 2 companies with a range of ticket prices between $101 and $224. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Chicago.

On average, how many connections are available from San Diego to Chicago each day?

Every day, the San Diego to Chicago bus route is served by approximately 15 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Chicago take?

The fastest bus from San Diego to Chicago is offered by FlixBus and takes 50h 50m. Bus tickets for this connection cost $136. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Chicago?

The earliest bus arriving in Chicago from San Diego starts at 7:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Chicago?

The latest bus trip departing from San Diego for Chicago starts at 7:55 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Chicago route?

When traveling by bus from San Diego to Chicago, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Chicago?

You can check all the direct connections between San Diego and Chicago by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Chicago bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Chicago bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Chicago bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Chicago on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Chicago?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 15 daily trips between San Diego and Chicago. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Chicago?

Prices and availability for 15 trips between San Diego and Chicago change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Chicago

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Chicago

Here’s an overview of the most popular bus routes to San Diego and to Chicago. Simply click on the connection of your choice, and you will find all the details about your bus route!