Bus San Diego to Durham, NC: Compare prices and save money

Compare all timetables for the bus from San Diego to Durham, NC

Here is a selection of the cheapest bus trips from the schedule from San Diego to Durham, NC from various bus operators like FlixBus or Greyhound US for the next days.

today

$247

tomorrow

Sunday

$266

Monday

Tuesday

$224

Wednesday

$233

Thursday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	62h 5m	3:55 PM	San Diego	Old Town Transit Center	9:00 AM	Durham, NC	Exxon	Economy	$247	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/19/2025 3:55:00 PM to Exxon, Durham, NC (USA) arriving at 12/22/2025 9:00:00 AM. 50 Economy ticket for $247 per person are available. Travel duration is 62h 5m
FlixBus	61h 45m	4:15 PM	San Diego	La Jolla Village	9:00 AM	Durham, NC	Exxon	Economy	$247	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/19/2025 4:15:00 PM to Exxon, Durham, NC (USA) arriving at 12/22/2025 9:00:00 AM. 50 Economy ticket for $247 per person are available. Travel duration is 61h 45m
FlixBus	64h 15m	1:45 PM	San Diego	Seaport Village	9:00 AM	Durham, NC	Exxon	Economy	$248	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/19/2025 1:45:00 PM to Exxon, Durham, NC (USA) arriving at 12/22/2025 9:00:00 AM. 50 Economy ticket for $248 per person are available. Travel duration is 64h 15m
Greyhound US	63h 35m	7:35 PM	San Diego	Old Town Transit Center	2:10 PM	Durham, NC	Exxon	Economy	$308	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/19/2025 7:35:00 PM to Exxon, Durham, NC (USA) arriving at 12/22/2025 2:10:00 PM. 50 Economy ticket for $308 per person are available. Travel duration is 63h 35m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	62h 5m	3:55 PM	San Diego	Old Town Transit Center	9:00 AM	Durham, NC	Exxon	Economy	$266	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 3:55:00 PM to Exxon, Durham, NC (USA) arriving at 12/24/2025 9:00:00 AM. 50 Economy ticket for $266 per person are available. Travel duration is 62h 5m
FlixBus	61h 45m	4:15 PM	San Diego	La Jolla Village	9:00 AM	Durham, NC	Exxon	Economy	$266	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/21/2025 4:15:00 PM to Exxon, Durham, NC (USA) arriving at 12/24/2025 9:00:00 AM. 50 Economy ticket for $266 per person are available. Travel duration is 61h 45m
FlixBus	64h 15m	1:45 PM	San Diego	Seaport Village	9:00 AM	Durham, NC	Exxon	Economy	$266	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/21/2025 1:45:00 PM to Exxon, Durham, NC (USA) arriving at 12/24/2025 9:00:00 AM. 50 Economy ticket for $266 per person are available. Travel duration is 64h 15m
Greyhound US	63h 35m	7:35 PM	San Diego	Old Town Transit Center	2:10 PM	Durham, NC	Exxon	Economy	$307	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 7:35:00 PM to Exxon, Durham, NC (USA) arriving at 12/24/2025 2:10:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 63h 35m
Greyhound US	60h 5m	10:00 AM	San Diego	Old Town Transit Center	1:05 AM	Durham, NC	Exxon	Economy	$315	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/21/2025 10:00:00 AM to Exxon, Durham, NC (USA) arriving at 12/24/2025 1:05:00 AM. 50 Economy ticket for $315 per person are available. Travel duration is 60h 5m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	64h 15m	1:45 PM	San Diego	Seaport Village	9:00 AM	Durham, NC	Exxon	Economy	$224	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/23/2025 1:45:00 PM to Exxon, Durham, NC (USA) arriving at 12/26/2025 9:00:00 AM. 50 Economy ticket for $224 per person are available. Travel duration is 64h 15m
Greyhound US	64h 50m	6:45 AM	San Diego	Old Town Transit Center	2:35 AM	Durham, NC	Exxon	Economy	$225	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/23/2025 6:45:00 AM to Exxon, Durham, NC (USA) arriving at 12/26/2025 2:35:00 AM. 50 Economy ticket for $225 per person are available. Travel duration is 64h 50m
FlixBus	65h 45m	12:15 PM	San Diego	Old Town Transit Center	9:00 AM	Durham, NC	Exxon	Economy	$225	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/23/2025 12:15:00 PM to Exxon, Durham, NC (USA) arriving at 12/26/2025 9:00:00 AM. 50 Economy ticket for $225 per person are available. Travel duration is 65h 45m
FlixBus	63h 50m	2:10 PM	San Diego	La Jolla Village	9:00 AM	Durham, NC	Exxon	Economy	$225	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/23/2025 2:10:00 PM to Exxon, Durham, NC (USA) arriving at 12/26/2025 9:00:00 AM. 50 Economy ticket for $225 per person are available. Travel duration is 63h 50m
Greyhound US	63h 35m	7:35 PM	San Diego	Old Town Transit Center	2:10 PM	Durham, NC	Exxon	Economy	$247	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/23/2025 7:35:00 PM to Exxon, Durham, NC (USA) arriving at 12/26/2025 2:10:00 PM. 50 Economy ticket for $247 per person are available. Travel duration is 63h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	63h 35m	7:35 PM	San Diego	Old Town Transit Center	2:10 PM	Durham, NC	Exxon	Economy	$233	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 7:35:00 PM to Exxon, Durham, NC (USA) arriving at 12/27/2025 2:10:00 PM. 50 Economy ticket for $233 per person are available. Travel duration is 63h 35m
Greyhound US	64h 50m	6:45 AM	San Diego	Old Town Transit Center	2:35 AM	Durham, NC	Exxon	Economy	$236	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 6:45:00 AM to Exxon, Durham, NC (USA) arriving at 12/27/2025 2:35:00 AM. 50 Economy ticket for $236 per person are available. Travel duration is 64h 50m
FlixBus	62h 10m	7:55 AM	San Diego	La Jolla Village	1:05 AM	Durham, NC	Exxon	Economy	$251	A Bus from FlixBus goes from La Jolla Village, San Diego (USA) at 12/24/2025 7:55:00 AM to Exxon, Durham, NC (USA) arriving at 12/27/2025 1:05:00 AM. 50 Economy ticket for $251 per person are available. Travel duration is 62h 10m
FlixBus	62h 30m	7:35 AM	San Diego	Old Town Transit Center	1:05 AM	Durham, NC	Exxon	Economy	$252	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 12/24/2025 7:35:00 AM to Exxon, Durham, NC (USA) arriving at 12/27/2025 1:05:00 AM. 50 Economy ticket for $252 per person are available. Travel duration is 62h 30m
FlixBus	64h 15m	1:45 PM	San Diego	Seaport Village	9:00 AM	Durham, NC	Exxon	Economy	$275	A Bus from FlixBus goes from Seaport Village, San Diego (USA) at 12/24/2025 1:45:00 PM to Exxon, Durham, NC (USA) arriving at 12/27/2025 9:00:00 AM. 50 Economy ticket for $275 per person are available. Travel duration is 64h 15m

Best Price Offer: The price for the cheapest bus from San Diego to Durham, NC is $224 on 12/23/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Durham, NC

See here how frequent the connections between San Diego and Durham, NC are, during different times and days of the week.

Sunday is the busiest day, with more than 7 daily buses from San Diego to Durham, NC. Friday has instead the fewest connections, with only 4 daily coaches between San Diego and Durham, NC.

The busiest time of the day is the Afternoon, with 12 buses from San Diego to Durham, NC, while Evening sees the fewest connections between San Diego and Durham, NC, with 4 offers.

Facts about the bus from San Diego to Durham, NC

Compare all providers like FlixBus and Greyhound US that travel 6 times every day by bus from San Diego to Durham, NC in one click! Book your bus ticket from San Diego to Durham, NC starting from $224!

Cheapest Bus	$224
Fastest Bus	63h 5m
Earliest Bus	1:45 PM
Latest Bus	7:35 PM
Daily Bus Routes	6 Ø
Distance	2,179.8 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Durham, NC

Every day, 6 buses from 2 bus companies leave San Diego for Durham, NC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/19/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

Friday 12/19

$247

Saturday 12/20

Sunday 12/21

$266

Monday 12/22

Tuesday 12/23

$224

Wednesday 12/24

$233

Thursday 12/25

Friday 12/26

$239

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

Sunday 01/04

Monday 01/05

Tuesday 01/06

Wednesday 01/07

Thursday 01/08

Friday 01/09

Saturday 01/10

The cheapest time to travel from San Diego to Durham, NC

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Durham, NC, for the next 30 days.

With a price starting from $224, Tuesday is the cheapest day for a bus from San Diego to Durham, NC. Sunday instead is the most expensive day with prices starting from $266.

Afternoon is the cheapest day time for bus tickets from San Diego to Durham, NC, with $224. Evening is the most expensive time of the day with prices starting from $233.

How to save money travelling from San Diego to Durham, NC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Durham, NC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Durham, NC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Durham, NC are also emptier.

All bus stations and stops in San Diego and Durham, NC

In the map below, you can see where to find all bus stations in San Diego and Durham, NC.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Transportation Center

W Pettigrew St 515

Exxon

Hillsborough Rd 3454

BP Guess Road

Guess Road 2918

BP Hillandale Rd

Hillandale Rd 1815

Chapel Hill and Willard St

W Chapel Hill

Service and Comfort on the bus from San Diego to Durham, NC

Want to know which seat classes are available on the buses from San Diego to Durham, NC? Or which bus companies serve the route San Diego to Durham, NC? Below you will find answers to your questions.

FAQs about the San Diego to Durham, NC bus

How much does a San Diego Durham, NC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $224 and takes 67h 15m to reach Durham, NC. Compare offers to save money!

How much could I save by comparing buses from San Diego to Durham, NC?

This route is offered by 2 companies with a range of ticket prices between $224 and $331. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Durham, NC.

On average, how many connections are available from San Diego to Durham, NC each day?

Every day, the San Diego to Durham, NC bus route is served by approximately 6 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Durham, NC take?

The fastest bus from San Diego to Durham, NC is offered by Greyhound US and takes 63h 5m. Bus tickets for this connection cost $315. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Durham, NC?

The earliest bus arriving in Durham, NC from San Diego starts at 1:45 PM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Durham, NC?

The latest bus trip departing from San Diego for Durham, NC starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Durham, NC route?

When traveling by bus from San Diego to Durham, NC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Durham, NC?

You can check all the direct connections between San Diego and Durham, NC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Durham, NC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Durham, NC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Durham, NC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Durham, NC on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Durham, NC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 6 daily trips between San Diego and Durham, NC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Durham, NC?

Prices and availability for 6 trips between San Diego and Durham, NC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Durham, NC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Durham, NC

Here’s an overview of the most popular bus routes to San Diego and to Durham, NC. Simply click on the connection of your choice, and you will find all the details about your bus route!