Bus Santa Ana, CA to San Antonio, TX: Compare prices and save money

Compare all timetables for the bus from Santa Ana, CA to San Antonio, TX

Here is a selection of the cheapest bus trips from the schedule from Santa Ana, CA to San Antonio, TX from various bus operators like Greyhound US for the next days.

today

$109

tomorrow

$127

Wednesday

$134

Thursday

Friday

$103

Saturday

$139

Sunday

$177

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 50m	11:35 AM	Santa Ana, CA	Bus Stop	12:25 AM	San Antonio, TX	Bus Station	Economy	$109	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/27/2026 11:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 4/29/2026 12:25:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 34h 50m
Greyhound US	37h 50m	8:05 AM	Santa Ana, CA	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$110	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/27/2026 8:05:00 AM to Bus Station, San Antonio, TX (USA) arriving at 4/28/2026 11:55:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 37h 50m
Greyhound US	37h 35m	9:20 PM	Santa Ana, CA	Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$110	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/27/2026 9:20:00 PM to Bus Station, San Antonio, TX (USA) arriving at 4/29/2026 12:55:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 37h 35m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 50m	11:35 AM	Santa Ana, CA	Bus Stop	12:25 AM	San Antonio, TX	Bus Station	Economy	$127	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/28/2026 11:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 4/30/2026 12:25:00 AM. 50 Economy ticket for $127 per person are available. Travel duration is 34h 50m
Greyhound US	37h 50m	8:05 AM	Santa Ana, CA	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$130	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/28/2026 8:05:00 AM to Bus Station, San Antonio, TX (USA) arriving at 4/29/2026 11:55:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 37h 50m
Greyhound US	37h 35m	9:20 PM	Santa Ana, CA	Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$144	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/28/2026 9:20:00 PM to Bus Station, San Antonio, TX (USA) arriving at 4/30/2026 12:55:00 PM. 50 Economy ticket for $144 per person are available. Travel duration is 37h 35m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 50m	11:35 AM	Santa Ana, CA	Bus Stop	12:25 AM	San Antonio, TX	Bus Station	Economy	$134	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/29/2026 11:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/1/2026 12:25:00 AM. 50 Economy ticket for $134 per person are available. Travel duration is 34h 50m
Greyhound US	37h 50m	8:05 AM	Santa Ana, CA	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$138	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/29/2026 8:05:00 AM to Bus Station, San Antonio, TX (USA) arriving at 4/30/2026 11:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 37h 50m
Greyhound US	37h 35m	9:20 PM	Santa Ana, CA	Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$138	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/29/2026 9:20:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/1/2026 12:55:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 37h 35m

Did you know that if you travel from Santa Ana, CA to San Antonio, TX via Anaheim, CA, you can save more than $1? You will find the corresponding connections below.
- Save more than 1%
  
  34h 30m
  
  Santa Ana, CA
  
  7 mi
  
  11:55 AM
  
  Anaheim, CA
  Anaheim Regional Transportation Intermodal Center
  
  12:25 AM
  
  San Antonio, TX
  Bus Station
  
  0 mi
  
  Economy
  
  $133
  
  A Bus from goes from Anaheim Regional Transportation Intermodal Center, Anaheim, CA (USA) at 4/29/2026 11:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/1/2026 12:25:00 AM. 50 Economy ticket for $133 per person are available. Travel duration is 34h 30m
Did you know that if you travel from Santa Ana, CA to San Antonio, TX via Glendale, AZ, you can save more than $13? You can find the corresponding connections below.
- Greyhound US
  
  50h 10m
  
  0
  
  8:45 AM
  
  Santa Ana, CA
  Bus Stop
  
  10:59 PM
  
  Glendale, AZ
  Central Bus Station
  
  0
  
  Economy
  
  $48
  
  A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/29/2026 8:45:00 AM to Central Bus Station, Glendale, AZ (USA) arriving at 4/29/2026 10:59:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 14h 14m
- Greyhound US
  
  35h 50m
  
  0
  
  11:05 PM
  
  Glendale, AZ
  Central Bus Station
  
  12:55 PM
  
  San Antonio, TX
  Bus Station
  
  0
  
  Economy
  
  $73
  
  A Bus from Greyhound US goes from Central Bus Station, Glendale, AZ (USA) at 4/29/2026 11:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/1/2026 12:55:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 35h 50m
Travel time is 13h 20m longer, but you will save $13

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 50m	11:35 AM	Santa Ana, CA	Bus Stop	12:25 AM	San Antonio, TX	Bus Station	Economy	$103	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/1/2026 11:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/3/2026 12:25:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 34h 50m
Greyhound US	37h 50m	8:05 AM	Santa Ana, CA	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$110	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/1/2026 8:05:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/2/2026 11:55:00 PM. 50 Economy ticket for $110 per person are available. Travel duration is 37h 50m
Greyhound US	37h 35m	9:20 PM	Santa Ana, CA	Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$118	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/1/2026 9:20:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/3/2026 12:55:00 PM. 50 Economy ticket for $118 per person are available. Travel duration is 37h 35m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	37h 35m	9:20 PM	Santa Ana, CA	Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$139	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/2/2026 9:20:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/4/2026 12:55:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 37h 35m
Greyhound US	37h 50m	8:05 AM	Santa Ana, CA	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$174	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/2/2026 8:05:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/3/2026 11:55:00 PM. 50 Economy ticket for $174 per person are available. Travel duration is 37h 50m
Greyhound US	34h 50m	11:35 AM	Santa Ana, CA	Bus Stop	12:25 AM	San Antonio, TX	Bus Station	Economy	$209	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/2/2026 11:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/4/2026 12:25:00 AM. 50 Economy ticket for $209 per person are available. Travel duration is 34h 50m

Did you know that if you travel from Santa Ana, CA to San Antonio, TX via Anaheim, CA, you can save more than $0? You will find the corresponding connections below.
- Save more than 1%
  
  37h 15m
  
  Santa Ana, CA
  
  7 mi
  
  9:40 PM
  
  Anaheim, CA
  Anaheim Regional Transportation Intermodal Center
  
  12:55 PM
  
  San Antonio, TX
  Bus Station
  
  0 mi
  
  Economy
  
  $139
  
  A Bus from goes from Anaheim Regional Transportation Intermodal Center, Anaheim, CA (USA) at 5/2/2026 9:40:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/4/2026 12:55:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 37h 15m
Did you know that if you travel from Santa Ana, CA to San Antonio, TX via Glendale, AZ, you can save more than $18? You can find the corresponding connections below.
- Greyhound US
  
  50h 10m
  
  0
  
  8:45 AM
  
  Santa Ana, CA
  Bus Stop
  
  10:59 PM
  
  Glendale, AZ
  Central Bus Station
  
  0
  
  Economy
  
  $48
  
  A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/29/2026 8:45:00 AM to Central Bus Station, Glendale, AZ (USA) arriving at 4/29/2026 10:59:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 14h 14m
- Greyhound US
  
  35h 50m
  
  0
  
  11:05 PM
  
  Glendale, AZ
  Central Bus Station
  
  12:55 PM
  
  San Antonio, TX
  Bus Station
  
  0
  
  Economy
  
  $73
  
  A Bus from Greyhound US goes from Central Bus Station, Glendale, AZ (USA) at 4/29/2026 11:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/1/2026 12:55:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 35h 50m
Travel time is 13h 20m longer, but you will save $18

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	34h 50m	11:35 AM	Santa Ana, CA	Bus Stop	12:25 AM	San Antonio, TX	Bus Station	Economy	$177	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/3/2026 11:35:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/5/2026 12:25:00 AM. 50 Economy ticket for $177 per person are available. Travel duration is 34h 50m
Greyhound US	37h 50m	8:05 AM	Santa Ana, CA	Bus Stop	11:55 PM	San Antonio, TX	Bus Station	Economy	$180	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/3/2026 8:05:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/4/2026 11:55:00 PM. 50 Economy ticket for $180 per person are available. Travel duration is 37h 50m
Greyhound US	37h 35m	9:20 PM	Santa Ana, CA	Bus Stop	12:55 PM	San Antonio, TX	Bus Station	Economy	$182	A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 5/3/2026 9:20:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/5/2026 12:55:00 PM. 50 Economy ticket for $182 per person are available. Travel duration is 37h 35m

Did you know that if you travel from Santa Ana, CA to San Antonio, TX via Anaheim, CA, you can save more than $-1? You will find the corresponding connections below.
- 34h 30m
  
  Santa Ana, CA
  
  7 mi
  
  11:55 AM
  
  Anaheim, CA
  Anaheim Regional Transportation Intermodal Center
  
  12:25 AM
  
  San Antonio, TX
  Bus Station
  
  0 mi
  
  Economy
  
  $178
  
  A Bus from goes from Anaheim Regional Transportation Intermodal Center, Anaheim, CA (USA) at 5/3/2026 11:55:00 AM to Bus Station, San Antonio, TX (USA) arriving at 5/5/2026 12:25:00 AM. 50 Economy ticket for $178 per person are available. Travel duration is 34h 30m
Did you know that if you travel from Santa Ana, CA to San Antonio, TX via Glendale, AZ, you can save more than $56? You can find the corresponding connections below.
- Greyhound US
  
  50h 10m
  
  0
  
  8:45 AM
  
  Santa Ana, CA
  Bus Stop
  
  10:59 PM
  
  Glendale, AZ
  Central Bus Station
  
  0
  
  Economy
  
  $48
  
  A Bus from Greyhound US goes from Bus Stop, Santa Ana, CA (USA) at 4/29/2026 8:45:00 AM to Central Bus Station, Glendale, AZ (USA) arriving at 4/29/2026 10:59:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 14h 14m
- Greyhound US
  
  35h 50m
  
  0
  
  11:05 PM
  
  Glendale, AZ
  Central Bus Station
  
  12:55 PM
  
  San Antonio, TX
  Bus Station
  
  0
  
  Economy
  
  $73
  
  A Bus from Greyhound US goes from Central Bus Station, Glendale, AZ (USA) at 4/29/2026 11:05:00 PM to Bus Station, San Antonio, TX (USA) arriving at 5/1/2026 12:55:00 PM. 50 Economy ticket for $73 per person are available. Travel duration is 35h 50m
Travel time is 13h 20m longer, but you will save $56

Best Price Offer: The price for the cheapest bus from Santa Ana, CA to San Antonio, TX is $91 on 5/4/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Santa Ana, CA and San Antonio, TX

See here how frequent the connections between Santa Ana, CA and San Antonio, TX are, during different times and days of the week.

Monday is the busiest day, with more than 6 daily buses from Santa Ana, CA to San Antonio, TX. Sunday has instead the fewest connections, with only 3 daily coaches between Santa Ana, CA and San Antonio, TX.

The busiest time of the day is the Morning, with 18 buses from Santa Ana, CA to San Antonio, TX, while Evening sees the fewest connections between Santa Ana, CA and San Antonio, TX, with 9 offers.

Facts about the bus from Santa Ana, CA to San Antonio, TX

Compare all providers like Greyhound US that travel 4 times every day by bus from Santa Ana, CA to San Antonio, TX in one click! Book your bus ticket from Santa Ana, CA to San Antonio, TX starting from $91!

Cheapest Bus	$91
Fastest Bus	36h 50m
Earliest Bus	8:05 AM
Latest Bus	9:20 PM
Daily Bus Routes	4 Ø
Distance	1,177.4 miles
Bus Companies	Greyhound US

Cheapest bus connections from Santa Ana, CA to San Antonio, TX

Every day, 4 buses from 1 bus companies leave Santa Ana, CA for San Antonio, TX: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/27/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/26

Monday 04/27

$113

Tuesday 04/28

$127

Wednesday 04/29

$134

Thursday 04/30

Friday 05/01

$103

Saturday 05/02

$154

Sunday 05/03

$177

Monday 05/04

$91

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$99

Saturday 05/09

$105

Sunday 05/10

$99

Monday 05/11

$99

Tuesday 05/12

$109

Wednesday 05/13

$107

Thursday 05/14

Friday 05/15

$116

Saturday 05/16

$119

Sunday 05/17

$103

Monday 05/18

$103

Tuesday 05/19

$138

Wednesday 05/20

$127

Thursday 05/21

$143

Friday 05/22

$126

Saturday 05/23

The cheapest time to travel from Santa Ana, CA to San Antonio, TX

See here on which day and which time of the day you can find the cheapest bus ticket from Santa Ana, CA to San Antonio, TX, for the next 30 days.

With a price starting from $91, Monday is the cheapest day for a bus from Santa Ana, CA to San Antonio, TX. Tuesday instead is the most expensive day with prices starting from $109.

Morning is the cheapest day time for bus tickets from Santa Ana, CA to San Antonio, TX, with $103. Evening is the most expensive time of the day with prices starting from $110.

How to save money travelling from Santa Ana, CA to San Antonio, TX

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santa Ana, CA to San Antonio, TX in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santa Ana, CA to San Antonio, TX, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santa Ana, CA to San Antonio, TX are also emptier.

All bus stations and stops in Santa Ana, CA and San Antonio, TX

In the map below, you can see where to find all bus stations in Santa Ana, CA and San Antonio, TX.

Bus Stop

1000 E Santa Ana Blvd 105

Train Station

W 1st St 101-155

Bus Station

N St Mary's St 500

San Antonio

Commerce & Bowie Bus Stop

W. Southcross & Buffalo Bus Stop

La Cantera

La Cantera Pkwy 15900

Service and Comfort on the bus from Santa Ana, CA to San Antonio, TX

Want to know which seat classes are available on the buses from Santa Ana, CA to San Antonio, TX? Or which bus companies serve the route Santa Ana, CA to San Antonio, TX? Below you will find answers to your questions.

FAQs about the Santa Ana, CA to San Antonio, TX bus

How much does a Santa Ana, CA San Antonio, TX bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $91 and takes 36h 50m to reach San Antonio, TX. Compare offers to save money!

How much could I save by comparing buses from Santa Ana, CA to San Antonio, TX?

This route is offered by 1 companies with a range of ticket prices between $91 and $213. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to San Antonio, TX.

On average, how many connections are available from Santa Ana, CA to San Antonio, TX each day?

Every day, the Santa Ana, CA to San Antonio, TX bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santa Ana, CA to San Antonio, TX take?

The fastest bus from Santa Ana, CA to San Antonio, TX is offered by Greyhound US and takes 36h 50m. Bus tickets for this connection cost $109. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santa Ana, CA to San Antonio, TX?

The earliest bus arriving in San Antonio, TX from Santa Ana, CA starts at 8:05 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santa Ana, CA to San Antonio, TX?

The latest bus trip departing from Santa Ana, CA for San Antonio, TX starts at 9:20 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santa Ana, CA San Antonio, TX route?

When traveling by bus from Santa Ana, CA to San Antonio, TX, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santa Ana, CA and San Antonio, TX?

You can check all the direct connections between Santa Ana, CA and San Antonio, TX by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Santa Ana, CA to San Antonio, TX bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santa Ana, CA San Antonio, TX bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santa Ana, CA San Antonio, TX bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santa Ana, CA to San Antonio, TX on your planned travel date.

How does CheckMyBus find the best bus deals from Santa Ana, CA to San Antonio, TX?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Santa Ana, CA and San Antonio, TX. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santa Ana, CA to San Antonio, TX?

Prices and availability for 4 trips between Santa Ana, CA and San Antonio, TX change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santa Ana, CA to San Antonio, TX

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santa Ana, CA and to San Antonio, TX

Here’s an overview of the most popular bus routes to Santa Ana, CA and to San Antonio, TX. Simply click on the connection of your choice, and you will find all the details about your bus route!