Bus Syracuse, NY to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Syracuse, NY to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Syracuse, NY to Greenville, SC from various bus operators like FlixBus or Greyhound US for the next days.

today

$98

tomorrow

Wednesday

Thursday

$103

Friday

Saturday

$107

Sunday

$104

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 50m	10:45 AM	Syracuse, NY	Regional Transit Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$98	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/20/2026 10:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/21/2026 8:35:00 AM. 50 Economy ticket for $98 per person are available. Travel duration is 21h 50m
Greyhound US	22h 25m	9:00 PM	Syracuse, NY	Regional Transit Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$98	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/20/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/21/2026 7:25:00 PM. 50 Economy ticket for $98 per person are available. Travel duration is 22h 25m
FlixBus	22h 15m	3:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$101	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/20/2026 3:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/21/2026 1:15:00 PM. 50 Economy ticket for $101 per person are available. Travel duration is 22h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 50m	10:45 AM	Syracuse, NY	Regional Transit Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/23/2026 10:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 8:35:00 AM. 50 Economy ticket for $103 per person are available. Travel duration is 21h 50m
FlixBus	22h 15m	3:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$103	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/23/2026 3:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 1:15:00 PM. 50 Economy ticket for $103 per person are available. Travel duration is 22h 15m
Greyhound US	22h 25m	9:00 PM	Syracuse, NY	Regional Transit Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$104	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/23/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/24/2026 7:25:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 22h 25m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 50m	10:45 AM	Syracuse, NY	Regional Transit Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$107	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/25/2026 10:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/26/2026 8:35:00 AM. 50 Economy ticket for $107 per person are available. Travel duration is 21h 50m
FlixBus	22h 15m	3:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$107	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/25/2026 3:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/26/2026 1:15:00 PM. 50 Economy ticket for $107 per person are available. Travel duration is 22h 15m
Greyhound US	22h 25m	9:00 PM	Syracuse, NY	Regional Transit Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$108	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/25/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/26/2026 7:25:00 PM. 50 Economy ticket for $108 per person are available. Travel duration is 22h 25m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	21h 50m	10:45 AM	Syracuse, NY	Regional Transit Center	8:35 AM	Greenville, SC	Woodruff Rd	Economy	$104	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/26/2026 10:45:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 4/27/2026 8:35:00 AM. 50 Economy ticket for $104 per person are available. Travel duration is 21h 50m
FlixBus	22h 15m	3:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$104	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 4/26/2026 3:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/27/2026 1:15:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 22h 15m
Greyhound US	22h 25m	9:00 PM	Syracuse, NY	Regional Transit Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$104	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 4/26/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 4/27/2026 7:25:00 PM. 50 Economy ticket for $104 per person are available. Travel duration is 22h 25m

Best Price Offer: The price for the cheapest bus from Syracuse, NY to Greenville, SC is $92 on 5/4/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Syracuse, NY and Greenville, SC

See here how frequent the connections between Syracuse, NY and Greenville, SC are, during different times and days of the week.

Sunday is the busiest day, with more than 6 daily buses from Syracuse, NY to Greenville, SC. Saturday has instead the fewest connections, with only 3 daily coaches between Syracuse, NY and Greenville, SC.

The busiest time of the day is the Morning, with 7 buses from Syracuse, NY to Greenville, SC, while Morning sees the fewest connections between Syracuse, NY and Greenville, SC, with 7 offers.

Facts about the bus from Syracuse, NY to Greenville, SC

Compare all providers like FlixBus and Greyhound US that travel 5 times every day by bus from Syracuse, NY to Greenville, SC in one click! Book your bus ticket from Syracuse, NY to Greenville, SC starting from $92!

Cheapest Bus	$92
Fastest Bus	21h 50m
Earliest Bus	10:45 AM
Latest Bus	9:00 PM
Daily Bus Routes	5 Ø
Distance	658.2 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Syracuse, NY to Greenville, SC

Every day, 5 buses from 2 bus companies leave Syracuse, NY for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/20/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/19

Monday 04/20

$98

Tuesday 04/21

$215

Wednesday 04/22

$222

Thursday 04/23

$107

Friday 04/24

Saturday 04/25

$107

Sunday 04/26

$108

Monday 04/27

$215

Tuesday 04/28

$107

Wednesday 04/29

$100

Thursday 04/30

$102

Friday 05/01

$102

Saturday 05/02

$100

Sunday 05/03

$228

Monday 05/04

$92

Tuesday 05/05

$100

Wednesday 05/06

Thursday 05/07

Friday 05/08

Saturday 05/09

$219

Sunday 05/10

$110

Monday 05/11

$107

Tuesday 05/12

$219

Wednesday 05/13

$101

Thursday 05/14

$98

Friday 05/15

Saturday 05/16

The cheapest time to travel from Syracuse, NY to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Syracuse, NY to Greenville, SC, for the next 30 days.

With a price starting from $92, Monday is the cheapest day for a bus from Syracuse, NY to Greenville, SC. Sunday instead is the most expensive day with prices starting from $104.

Morning is the cheapest day time for bus tickets from Syracuse, NY to Greenville, SC, with $98. Afternoon is the most expensive time of the day with prices starting from $101.

How to save money travelling from Syracuse, NY to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Syracuse, NY to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Syracuse, NY to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Syracuse, NY to Greenville, SC are also emptier.

All bus stations and stops in Syracuse, NY and Greenville, SC

In the map below, you can see where to find all bus stations in Syracuse, NY and Greenville, SC.

University

University Pi 303

Regional Transit Center

Walsh Cir 1

S State St & E Genesee St

Destiny USA

Destiny USA Dr 9090

New York State Fairgrounds

State Fair Blvd 581

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

N Church St

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Syracuse, NY to Greenville, SC

Want to know which seat classes are available on the buses from Syracuse, NY to Greenville, SC? Or which bus companies serve the route Syracuse, NY to Greenville, SC? Below you will find answers to your questions.

FAQs about the Syracuse, NY to Greenville, SC bus

How much does a Syracuse, NY Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $92 and takes 21h 50m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Syracuse, NY to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $92 and $108. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Syracuse, NY to Greenville, SC each day?

Every day, the Syracuse, NY to Greenville, SC bus route is served by approximately 5 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Syracuse, NY to Greenville, SC take?

The fastest bus from Syracuse, NY to Greenville, SC is offered by FlixBus and takes 21h 50m. Bus tickets for this connection cost $102. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Syracuse, NY to Greenville, SC?

The earliest bus arriving in Greenville, SC from Syracuse, NY starts at 10:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Syracuse, NY to Greenville, SC?

The latest bus trip departing from Syracuse, NY for Greenville, SC starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Syracuse, NY Greenville, SC route?

When traveling by bus from Syracuse, NY to Greenville, SC, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Syracuse, NY and Greenville, SC?

You can check all the direct connections between Syracuse, NY and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Syracuse, NY to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Syracuse, NY Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Syracuse, NY Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Syracuse, NY to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Syracuse, NY to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 5 daily trips between Syracuse, NY and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Syracuse, NY to Greenville, SC?

Prices and availability for 5 trips between Syracuse, NY and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Syracuse, NY to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Syracuse, NY and to Greenville, SC

Here’s an overview of the most popular bus routes to Syracuse, NY and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!