Bus Syracuse, NY to Greenville, SC: Compare prices and save money

Compare all timetables for the bus from Syracuse, NY to Greenville, SC

Here is a selection of the cheapest bus trips from the schedule from Syracuse, NY to Greenville, SC from various bus operators like Greyhound US or FlixBus for the next days.

today

tomorrow

Monday

$105

Tuesday

$117

Wednesday

Thursday

$125

Friday

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 15m	9:25 AM	Syracuse, NY	Regional Transit Center	8:40 AM	Greenville, SC	Woodruff Rd	Economy	$105	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 8/10/2026 9:25:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 8:40:00 AM. 50 Economy ticket for $105 per person are available. Travel duration is 23h 15m
Greyhound US	22h 25m	9:00 PM	Syracuse, NY	Regional Transit Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$113	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 8/10/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 7:25:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 22h 25m
FlixBus	23h 15m	2:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$126	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 8/10/2026 2:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/11/2026 1:15:00 PM. 50 Economy ticket for $126 per person are available. Travel duration is 23h 15m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 15m	9:25 AM	Syracuse, NY	Regional Transit Center	8:40 AM	Greenville, SC	Woodruff Rd	Economy	$117	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 8/11/2026 9:25:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 8:40:00 AM. 50 Economy ticket for $117 per person are available. Travel duration is 23h 15m
Greyhound US	35h 40m	9:00 PM	Syracuse, NY	Regional Transit Center	8:40 AM	Greenville, SC	Woodruff Rd	Economy	$120	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 8/11/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/13/2026 8:40:00 AM. 50 Economy ticket for $120 per person are available. Travel duration is 35h 40m
FlixBus	25h 55m	6:15 PM	Syracuse, NY	Regional Transit Center	8:10 PM	Greenville, SC	Woodruff Rd	Economy	$122	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 8/11/2026 6:15:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 8:10:00 PM. 50 Economy ticket for $122 per person are available. Travel duration is 25h 55m
FlixBus	23h 15m	2:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$130	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 8/11/2026 2:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/12/2026 1:15:00 PM. 50 Economy ticket for $130 per person are available. Travel duration is 23h 15m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	23h 15m	9:25 AM	Syracuse, NY	Regional Transit Center	8:40 AM	Greenville, SC	Woodruff Rd	Economy	$125	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 8/13/2026 9:25:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/14/2026 8:40:00 AM. 50 Economy ticket for $125 per person are available. Travel duration is 23h 15m
FlixBus	23h 15m	2:00 PM	Syracuse, NY	Regional Transit Center	1:15 PM	Greenville, SC	Woodruff Rd	Economy	$129	A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 8/13/2026 2:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/14/2026 1:15:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 23h 15m
Greyhound US	22h 25m	9:00 PM	Syracuse, NY	Regional Transit Center	7:25 PM	Greenville, SC	Woodruff Rd	Economy	$138	A Bus from Greyhound US goes from Regional Transit Center, Syracuse, NY (USA) at 8/13/2026 9:00:00 PM to Woodruff Rd, Greenville, SC (USA) arriving at 8/14/2026 7:25:00 PM. 50 Economy ticket for $138 per person are available. Travel duration is 22h 25m

Did you know that if you travel from Syracuse, NY to Greenville, SC via Charlotte, you can save more than $19? You can find the corresponding connections below.
- FlixBus
  
  29h 25m
  
  0
  
  3:15 AM
  
  Syracuse, NY
  Regional Transit Center
  
  12:45 AM
  
  Charlotte
  W Trade St
  
  0
  
  Economy
  
  $89
  
  A Bus from FlixBus goes from Regional Transit Center, Syracuse, NY (USA) at 8/9/2026 3:15:00 AM to W Trade St, Charlotte (USA) arriving at 8/10/2026 12:45:00 AM. 50 Economy ticket for $89 per person are available. Travel duration is 21h 30m
- FlixBus
  
  2h 0m
  
  0
  
  6:40 AM
  
  Charlotte
  W Trade St
  
  8:40 AM
  
  Greenville, SC
  Woodruff Rd
  
  0
  
  Economy
  
  $17
  
  A Bus from FlixBus goes from W Trade St, Charlotte (USA) at 8/10/2026 6:40:00 AM to Woodruff Rd, Greenville, SC (USA) arriving at 8/10/2026 8:40:00 AM. 50 Economy ticket for $17 per person are available. Travel duration is 2h 0m
Travel time is 7h 0m longer, but you will save $19

Best Price Offer: The price for the cheapest bus from Syracuse, NY to Greenville, SC is $93 on 8/26/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Syracuse, NY and Greenville, SC

See here how frequent the connections between Syracuse, NY and Greenville, SC are, during different times and days of the week.

Tuesday is the busiest day, with more than 4 daily buses from Syracuse, NY to Greenville, SC. Monday has instead the fewest connections, with only 3 daily coaches between Syracuse, NY and Greenville, SC.

The busiest time of the day is the Evening, with 4 buses from Syracuse, NY to Greenville, SC, while Morning sees the fewest connections between Syracuse, NY and Greenville, SC, with 3 offers.

Facts about the bus from Syracuse, NY to Greenville, SC

Compare all providers like Greyhound US and FlixBus that travel 3 times every day by bus from Syracuse, NY to Greenville, SC in one click! Book your bus ticket from Syracuse, NY to Greenville, SC starting from $93!

Cheapest Bus	$93
Fastest Bus	22h 25m
Earliest Bus	9:25 AM
Latest Bus	9:00 PM
Daily Bus Routes	3 Ø
Distance	658.2 miles
Bus Companies	Greyhound US and FlixBus

Cheapest bus connections from Syracuse, NY to Greenville, SC

Every day, 3 buses from 2 bus companies leave Syracuse, NY for Greenville, SC: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 08/08/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 08/02

Monday 08/03

Tuesday 08/04

Wednesday 08/05

Thursday 08/06

Friday 08/07

Saturday 08/08

Sunday 08/09

Monday 08/10

$105

Tuesday 08/11

$216

Wednesday 08/12

Thursday 08/13

$125

Friday 08/14

Saturday 08/15

$217

Sunday 08/16

$215

Monday 08/17

Tuesday 08/18

$215

Wednesday 08/19

$116

Thursday 08/20

$120

Friday 08/21

$215

Saturday 08/22

Sunday 08/23

$131

Monday 08/24

$101

Tuesday 08/25

Wednesday 08/26

$93

Thursday 08/27

$215

Friday 08/28

$100

Saturday 08/29

The cheapest time to travel from Syracuse, NY to Greenville, SC

See here on which day and which time of the day you can find the cheapest bus ticket from Syracuse, NY to Greenville, SC, for the next 30 days.

With a price starting from $95, Monday is the cheapest day for a bus from Syracuse, NY to Greenville, SC. Tuesday instead is the most expensive day with prices starting from $117.

Morning is the cheapest day time for bus tickets from Syracuse, NY to Greenville, SC, with $105. Afternoon is the most expensive time of the day with prices starting from $126.

How to save money travelling from Syracuse, NY to Greenville, SC

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Syracuse, NY to Greenville, SC in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Syracuse, NY to Greenville, SC, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Syracuse, NY to Greenville, SC are also emptier.

All bus stations and stops in Syracuse, NY and Greenville, SC

In the map below, you can see where to find all bus stations in Syracuse, NY and Greenville, SC.

University

University Pi 303

S State St & E Genesee St

Destiny USA

Destiny USA Dr 9090

New York State Fairgrounds

State Fair Blvd 581

Yang Di Chun BBQ

Erie Blvd E 2042

McDonald's

Woodruff Rd 1111

N Church St

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

Service and Comfort on the bus from Syracuse, NY to Greenville, SC

Want to know which seat classes are available on the buses from Syracuse, NY to Greenville, SC? Or which bus companies serve the route Syracuse, NY to Greenville, SC? Below you will find answers to your questions.

FAQs about the Syracuse, NY to Greenville, SC bus

How much does a Syracuse, NY Greenville, SC bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $93 and takes 23h 15m to reach Greenville, SC. Compare offers to save money!

How much could I save by comparing buses from Syracuse, NY to Greenville, SC?

This route is offered by 2 companies with a range of ticket prices between $93 and $138. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Greenville, SC.

On average, how many connections are available from Syracuse, NY to Greenville, SC each day?

Every day, the Syracuse, NY to Greenville, SC bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Syracuse, NY to Greenville, SC take?

The fastest bus from Syracuse, NY to Greenville, SC is offered by Greyhound US and takes 22h 25m. Bus tickets for this connection cost $113. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Syracuse, NY to Greenville, SC?

The earliest bus arriving in Greenville, SC from Syracuse, NY starts at 9:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Syracuse, NY to Greenville, SC?

The latest bus trip departing from Syracuse, NY for Greenville, SC starts at 9:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Syracuse, NY Greenville, SC route?

When traveling by bus from Syracuse, NY to Greenville, SC, passengers can travel with Greyhound US and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Syracuse, NY and Greenville, SC?

You can check all the direct connections between Syracuse, NY and Greenville, SC by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US and FlixBus.

What can I take with me on the Syracuse, NY to Greenville, SC bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Syracuse, NY Greenville, SC bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Syracuse, NY Greenville, SC bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Syracuse, NY to Greenville, SC on your planned travel date.

How does CheckMyBus find the best bus deals from Syracuse, NY to Greenville, SC?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Syracuse, NY and Greenville, SC. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Syracuse, NY to Greenville, SC?

Prices and availability for 3 trips between Syracuse, NY and Greenville, SC change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Syracuse, NY to Greenville, SC

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Syracuse, NY and to Greenville, SC

Here’s an overview of the most popular bus routes to Syracuse, NY and to Greenville, SC. Simply click on the connection of your choice, and you will find all the details about your bus route!