What is the best way to travel from Chicago to St. Louis, MO?
Looking for a trip? Compare all the available Buses and Flights for the journey to St. Louis, MO from Chicago. Check between different modes of transportation, look for the cheapest tickets, fastest rides and most popular stations, and see all 2 available companies to find your perfect trip!
What is the cheapest way to reach St. Louis, MO from Chicago?
You can get to St. Louis, MO with just $40 by taking a Bus from Greyhound US, but you can find many more cheap offers: we have selected the best ones for next few days here for you.
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 11:10:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 6h 40m
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Greyhound US9h 5m010:50 PMChicagoDowntown Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 10:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/14/2025 7:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 9h 5m
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Greyhound US8h 45m011:10 PMChicagoUnion Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/13/2025 11:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/14/2025 7:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 8h 45m
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FlixBus5h 50m09:45 AMChicagoDowntown Bus Station3:35 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 3:35:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 5h 50m
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Greyhound US9h 10m06:10 AMChicagoDowntown Bus Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 3:20:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 9h 10m
Cheapest Buses Saturday
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Skyscanner1h 31m09:30 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:01 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 9:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 11:01:00 AM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 31m
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Skyscanner1h 25m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 10:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 12:15:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 25m
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Skyscanner1h 25m01:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:25 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 1:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 2:25:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 25m
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United Airlines1h 26m02:14 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:40 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 2:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 3:40:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 26m
Cheapest Flights Sunday
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FlixBus5h 45m012:40 AMChicago95th Red Line Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 6:25:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 45m
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 11:10:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 6h 40m
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Greyhound US8h 15m011:40 PMChicago95th Red Line Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 11:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 7:55:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 15m
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Skyscanner1h 25m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 10:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 12:15:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 25m
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Skyscanner1h 28m03:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:03 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 3:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 5:03:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 28m
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Skyscanner1h 27m05:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:17 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 5:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 7:17:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 27m
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United Airlines1h 23m01:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 1:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 2:23:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 23m
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United Airlines1h 26m02:14 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:40 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 2:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 3:40:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 26m
Cheapest Buses Monday
Cheapest Flights Monday
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Greyhound US9h 15m02:10 PMChicago95th Red Line Station11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 11:25:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 9h 15m
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Greyhound US8h 15m011:40 PMChicago95th Red Line Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 11:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 7:55:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 8h 15m
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FlixBus9h 55m05:25 AMChicago95th Red Line Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 5:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 3:20:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 9h 55m
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FlixBus15h 30m011:50 PMChicago95th Red Line Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 11:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 3:20:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 15h 30m
Cheapest Buses Tuesday
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Greyhound US9h 15m02:10 PMChicago95th Red Line Station11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/17/2025 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 11:25:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 9h 15m
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Greyhound US7h 55m010:30 PMChicago95th Red Line Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/17/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 6:25:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 7h 55m
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Greyhound US9h 10m06:10 AMChicagoDowntown Bus Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/17/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 3:20:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 9h 10m
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Greyhound US8h 40m02:45 PMChicagoDowntown Bus Station11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/17/2025 2:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 11:25:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 8h 40m
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Greyhound US8h 45m09:40 PMChicagoDowntown Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/17/2025 9:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 6:25:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 8h 45m
Cheapest Buses Wednesday
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 11:10:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 40m
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FlixBus6h 10m012:15 AMChicagoDowntown Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 6:25:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 6h 10m
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FlixBus5h 50m09:45 AMChicagoDowntown Bus Station3:35 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 3:35:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 5h 50m
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Greyhound US9h 5m010:50 PMChicagoDowntown Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 10:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 7:55:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 9h 5m
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Greyhound US8h 45m011:10 PMChicagoUnion Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/18/2025 11:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 7:55:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 8h 45m
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Skyscanner1h 37m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 10:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 12:27:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 37m
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Skyscanner1h 30m012:56 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 12:56:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 2:26:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 30m
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Skyscanner1h 27m03:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 3:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 4:27:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 27m
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Skyscanner1h 30m04:24 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:54 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 4:24:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 5:54:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 30m
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Skyscanner1h 28m05:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:18 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 5:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 7:18:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 28m
Cheapest Buses Thursday
Cheapest Flights Thursday
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FlixBus6h 10m012:15 AMChicagoDowntown Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/19/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 6:25:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 10m
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/19/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 11:10:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 40m
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FlixBus5h 45m012:40 AMChicago95th Red Line Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/19/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 6:25:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 5h 45m
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Greyhound US8h 15m011:40 PMChicago95th Red Line Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/19/2025 11:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 7:55:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 15m
Cheapest Buses Friday
What are the fastest trips from Chicago to St. Louis, MO?
You can get to St. Louis, MO from Chicago in just 1h 23m with a Flight from United Airlines. This is not the only option, and you can click on any of the offers below to compare it with the other modes of transportations.
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FlixBus5h 50m09:45 AMChicagoDowntown Bus Station3:35 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 3:35:00 PM. 50 Economy ticket for $52 per person are available. Travel duration is 5h 50m
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 11:10:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 6h 40m
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Greyhound US8h 45m011:10 PMChicagoUnion Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/13/2025 11:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/14/2025 7:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 8h 45m
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Greyhound US9h 5m010:50 PMChicagoDowntown Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 10:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/14/2025 7:55:00 AM. 50 Economy ticket for $52 per person are available. Travel duration is 9h 5m
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Greyhound US9h 10m06:10 AMChicagoDowntown Bus Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/13/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/13/2025 3:20:00 PM. 50 Economy ticket for $53 per person are available. Travel duration is 9h 10m
Fastest Buses Saturday
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Skyscanner1h 25m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 10:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 12:15:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 25m
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Skyscanner1h 25m01:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:25 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 1:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 2:25:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 25m
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United Airlines1h 26m02:14 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:40 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 2:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 3:40:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 26m
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Skyscanner1h 31m09:30 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center11:01 AMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/14/2025 9:30:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/14/2025 11:01:00 AM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 31m
Fastest Flights Sunday
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United Airlines1h 23m01:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:23 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 1:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 2:23:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 23m
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Skyscanner1h 25m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:15 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 10:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 12:15:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 25m
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United Airlines1h 26m02:14 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center3:40 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from United Airlines goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 2:14:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 3:40:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 26m
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Skyscanner1h 27m05:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:17 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 5:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 7:17:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 27m
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Skyscanner1h 28m03:35 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:03 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/15/2025 3:35:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/15/2025 5:03:00 PM. 50 Economy ticket for $306 per person are available. Travel duration is 1h 28m
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FlixBus5h 45m012:40 AMChicago95th Red Line Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 6:25:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 5h 45m
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/15/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/15/2025 11:10:00 PM. 50 Economy ticket for $49 per person are available. Travel duration is 6h 40m
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Greyhound US8h 15m011:40 PMChicago95th Red Line Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/15/2025 11:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 7:55:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 15m
Fastest Flights Monday
Fastest Buses Monday
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Greyhound US8h 15m011:40 PMChicago95th Red Line Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 11:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 7:55:00 AM. 50 Economy ticket for $44 per person are available. Travel duration is 8h 15m
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Greyhound US9h 15m02:10 PMChicago95th Red Line Station11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 11:25:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 9h 15m
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FlixBus9h 55m05:25 AMChicago95th Red Line Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 5:25:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/16/2025 3:20:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 9h 55m
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FlixBus15h 30m011:50 PMChicago95th Red Line Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/16/2025 11:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 3:20:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 15h 30m
Fastest Buses Tuesday
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Greyhound US7h 55m010:30 PMChicago95th Red Line Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/17/2025 10:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 6:25:00 AM. 50 Economy ticket for $40 per person are available. Travel duration is 7h 55m
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Greyhound US8h 40m02:45 PMChicagoDowntown Bus Station11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/17/2025 2:45:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 11:25:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 8h 40m
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Greyhound US8h 45m09:40 PMChicagoDowntown Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/17/2025 9:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 6:25:00 AM. 50 Economy ticket for $43 per person are available. Travel duration is 8h 45m
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Greyhound US9h 10m06:10 AMChicagoDowntown Bus Station3:20 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/17/2025 6:10:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 3:20:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 9h 10m
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Greyhound US9h 15m02:10 PMChicago95th Red Line Station11:25 PMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/17/2025 2:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/17/2025 11:25:00 PM. 50 Economy ticket for $40 per person are available. Travel duration is 9h 15m
Fastest Buses Wednesday
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Skyscanner1h 27m03:00 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center4:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 3:00:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 4:27:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 27m
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Skyscanner1h 28m05:50 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center7:18 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 5:50:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 7:18:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 28m
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Skyscanner1h 30m012:56 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center2:26 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 12:56:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 2:26:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 30m
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Skyscanner1h 30m04:24 PMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center5:54 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 4:24:00 PM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 5:54:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 30m
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Skyscanner1h 37m010:50 AMChicago O'Hare AirportChicago O'Hare Airport - Bus/Shuttle Center12:27 PMSt. Louis Lambert AirportSt. Louis Lambert Airport0EconomyA Flight from Skyscanner goes from Chicago O'Hare Airport - Bus/Shuttle Center, Chicago O'Hare Airport (USA) at 12/18/2025 10:50:00 AM to St. Louis Lambert Airport, St. Louis Lambert Airport (USA) arriving at 12/18/2025 12:27:00 PM. 50 Economy ticket for $307 per person are available. Travel duration is 1h 37m
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FlixBus5h 50m09:45 AMChicagoDowntown Bus Station3:35 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 9:45:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 3:35:00 PM. 50 Economy ticket for $50 per person are available. Travel duration is 5h 50m
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FlixBus6h 10m012:15 AMChicagoDowntown Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 6:25:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 6h 10m
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/18/2025 11:10:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 40m
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Greyhound US8h 45m011:10 PMChicagoUnion Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Union Station, Chicago (USA) at 12/18/2025 11:10:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 7:55:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 8h 45m
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Greyhound US9h 5m010:50 PMChicagoDowntown Bus Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from Downtown Bus Station, Chicago (USA) at 12/18/2025 10:50:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 7:55:00 AM. 50 Economy ticket for $54 per person are available. Travel duration is 9h 5m
Fastest Flights Thursday
Fastest Buses Thursday
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FlixBus5h 45m012:40 AMChicago95th Red Line Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from 95th Red Line Station, Chicago (USA) at 12/19/2025 12:40:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 6:25:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 5h 45m
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FlixBus6h 10m012:15 AMChicagoDowntown Bus Station6:25 AMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/19/2025 12:15:00 AM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 6:25:00 AM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 10m
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FlixBus6h 40m04:30 PMChicagoDowntown Bus Station11:10 PMSt. Louis, MOGateway Station0EconomyA Bus from FlixBus goes from Downtown Bus Station, Chicago (USA) at 12/19/2025 4:30:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/19/2025 11:10:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 6h 40m
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Greyhound US8h 15m011:40 PMChicago95th Red Line Station7:55 AMSt. Louis, MOGateway Station0EconomyA Bus from Greyhound US goes from 95th Red Line Station, Chicago (USA) at 12/19/2025 11:40:00 PM to Gateway Station, St. Louis, MO (USA) arriving at 12/20/2025 7:55:00 AM. 50 Economy ticket for $55 per person are available. Travel duration is 8h 15m
Fastest Buses Friday
Here you will find all operators and timetables for a
Bus from Chicago to St. Louis, MO
What are the most popular stations in Chicago and St. Louis, MO?
In Chicago, you will usually depart from California & 35th Street Bus Stop, Downtown Bus Station or 95th Red Line Station, while in St. Louis, MO you will be arriving at Gateway Station, Lindbergh @ Hackberry NB Bus Stop or Skinker Boulevard, but there are many more stops to explore in both locations.
How do I decide? Some tips and tricks from our experience
Are you having trouble deciding on how to get to St. Louis, MO from Chicago? With 6 connections between 2 Bus and Flight operators, it can be difficult to find the one ride that will make you happy. But we have some tips that can help you make the best informed decision. First of all, the best trip is always the one that meets all your needs, so make a list of all the things that you want from this journey and look for something that will satisfy all of them. Here we will go through some of the factors mostly commonly taken into consideration.
Look for the lowest price
Ticket price is usually the main concern: even if you can afford to pay more, why do it if there are cheaper options? Saving on the trip means that you can spend more on the vacation itself! Between Chicago and St. Louis, MO, you can pay as low as $40 with a Bus from Greyhound US.Travel duration
Time is also an important factor. An earlier departure may allow you to see a beautiful sunset or relax before an important event. And remember, time is money, so paying more for a shorter trip may be well worth it. For longer distances, flights are without doubt the best options, but be mindful of airport times and possible delays: a high-speed train may end up cheaper and faster! Here the quicker option is definitely the Flight from United Airlines: you will get to St. Louis, MO in just 1h 23m.Comfort makes all the difference
You should always take into account what your personal travelling preferences are. Is one hand luggage enough, or are you trasporting more? Would you like to have a snack during the journey? Can you relax in a busy compartment, or do you need space for yourself? Even among the same mode of transportation, different companies will offer you varying levels of comfort and amenities. The main operators connecting Chicago and St. Louis, MO are Greyhound US, FlixBus and Skyscanner, but be sure to check what they have to offer!Save money with deals, and always compare
One last tip? Even if you live in Chicago and St. Louis, MO is your only destination, it may be wise to check the offers from and to nearby cities or, if you are flyng, nearby airports. Check the trips from Cicero, IL or to Sauget, IL, and look at flights from Chicago Midway Airport, and landing at St. Louis Lambert Airport. Comparing different routes may allow you to find deals or promotions you were not aware of. Consider also signing up to CheckMyBus to see even more exclusive promotions!Which companies offer a trip from Chicago to St. Louis, MO?
The most popular companies between Chicago and St. Louis, MO, are Greyhound US, FlixBus and Skyscanner. Be sure to check their seat class offers and the amenities that they provide.
Bus companies: Greyhound US and FlixBus
Airlines: Skyscanner and United Airlines
All you need to know when you travel from Chicago to St. Louis, MO
Check all information on comfort and services on all modes of transports from Chicago to St. Louis, MO. See which seat classes are available, and what amenities are other advantages offered by the operators on your journey.
FAQs about the trip from Chicago to St. Louis, MO
How can I reach St. Louis, MO from Chicago?
Every day, there are on average 6 connections between Bus and Flight, with which you can get to St. Louis, MO from Chicago.
How far is St. Louis, MO from Chicago?
The distance between Chicago and St. Louis, MO is 262.3 miles.
What is the most ecofriendly mode of transport between Chicago and St. Louis, MO?
Trains and buses are by far the greenest options, with trains surpassing buses on longer routes. Planes will always be the worst polluters, especially in shorter flights, were the emissions from the takeoff and landing are less offset by the distance.
On this particular route, a bus will emit, per person, a total of 11 kgs of CO2, a train 15 kgs, a car 72 kgs, and a flight 104 kgs.
What is the cheapest mode of transport from Chicago to St. Louis, MO?
You can get to St. Louis, MO with just $40 by taking a Bus from Greyhound US.
What is the fastest way to get from Chicago to St. Louis, MO?
While a plane is travelling fastest boarding and transfer to airport consumes a lot of time. Usually, high speed trains are better than flights if pure train travel time is below 4 hours. For this particular route, you can get to St. Louis, MO in just 1h 23m with a Flight from United Airlines.
More routes to Chicago and to St. Louis, MO
Looking for more options? Here you can see the most popular routes to Chicago and to St. Louis, MO. Simply click on a connection, and you’ll find all the details about the route!
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