Bus Tupelo, MS to Columbia, MO: Compare prices and save money

Compare all timetables for the bus from Tupelo, MS to Columbia, MO

Here is a selection of the cheapest bus trips from the schedule from Tupelo, MS to Columbia, MO from various bus operators like Greyhound US for the next days.

today

tomorrow

$68

Saturday

$63

Sunday

$64

Monday

$68

Tuesday

$79

Wednesday

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	13h 20m	5:35 AM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$68	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/15/2026 5:35:00 AM to Red Thread, Columbia, MO (USA) arriving at 5/15/2026 6:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 13h 20m
	Greyhound US	21h 10m	9:45 PM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$69	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/15/2026 9:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 5/16/2026 6:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 21h 10m

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	13h 20m	5:35 AM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$63	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/16/2026 5:35:00 AM to Red Thread, Columbia, MO (USA) arriving at 5/16/2026 6:55:00 PM. 50 Economy ticket for $63 per person are available. Travel duration is 13h 20m
	Greyhound US	21h 10m	9:45 PM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$64	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/16/2026 9:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 5/17/2026 6:55:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 21h 10m

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	13h 20m	5:35 AM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$64	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/17/2026 5:35:00 AM to Red Thread, Columbia, MO (USA) arriving at 5/17/2026 6:55:00 PM. 50 Economy ticket for $64 per person are available. Travel duration is 13h 20m
	Greyhound US	21h 10m	9:45 PM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$65	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/17/2026 9:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 5/18/2026 6:55:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 21h 10m

Cheapest bus trips Monday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	21h 10m	9:45 PM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$68	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/18/2026 9:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 5/19/2026 6:55:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 21h 10m
	Greyhound US	13h 20m	5:35 AM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$69	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/18/2026 5:35:00 AM to Red Thread, Columbia, MO (USA) arriving at 5/18/2026 6:55:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 13h 20m

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	Greyhound US	13h 20m	5:35 AM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$79	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/19/2026 5:35:00 AM to Red Thread, Columbia, MO (USA) arriving at 5/19/2026 6:55:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 20m
	Greyhound US	21h 10m	9:45 PM	Tupelo, MS	Bus Stop	6:55 PM	Columbia, MO	Red Thread		Economy	$79	A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/19/2026 9:45:00 PM to Red Thread, Columbia, MO (USA) arriving at 5/20/2026 6:55:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 21h 10m

Did you know that if you travel from Tupelo, MS to Columbia, MO via Memphis, you can save more than $12? You can find the corresponding connections below.
- Greyhound US
  
  13h 20m
  
  0
  
  5:35 AM
  
  Tupelo, MS
  Bus Stop
  
  7:25 AM
  
  Memphis
  Airways Transit Center
  
  0
  
  Economy
  
  $16
  
  A Bus from Greyhound US goes from Bus Stop, Tupelo, MS (USA) at 5/18/2026 5:35:00 AM to Airways Transit Center, Memphis (USA) arriving at 5/18/2026 7:25:00 AM. 50 Economy ticket for $16 per person are available. Travel duration is 1h 50m
- FlixBus
  
  7h 55m
  
  0
  
  11:00 AM
  
  Memphis
  Airways Transit Center
  
  6:55 PM
  
  Columbia, MO
  Red Thread
  
  0
  
  Economy
  
  $51
  
  A Bus from FlixBus goes from Airways Transit Center, Memphis (USA) at 5/18/2026 11:00:00 AM to Red Thread, Columbia, MO (USA) arriving at 5/18/2026 6:55:00 PM. 50 Economy ticket for $51 per person are available. Travel duration is 7h 55m
Travel time is the same as the direct connection, but you will save $12

Best Price Offer: The price for the cheapest bus from Tupelo, MS to Columbia, MO is $63 on 5/16/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Tupelo, MS and Columbia, MO

See here how frequent the connections between Tupelo, MS and Columbia, MO are, during different times and days of the week.

Monday is the busiest day, with more than 4 daily buses from Tupelo, MS to Columbia, MO. Sunday has instead the fewest connections, with only 2 daily coaches between Tupelo, MS and Columbia, MO.

The busiest time of the day is the Evening, with 8 buses from Tupelo, MS to Columbia, MO, while Evening sees the fewest connections between Tupelo, MS and Columbia, MO, with 8 offers.

Facts about the bus from Tupelo, MS to Columbia, MO

Compare all providers like Greyhound US that travel 3 times every day by bus from Tupelo, MS to Columbia, MO in one click! Book your bus ticket from Tupelo, MS to Columbia, MO starting from $63!

Cheapest Bus	$63
Fastest Bus	13h 20m
Earliest Bus	5:35 AM
Latest Bus	9:45 PM
Daily Bus Routes	3 Ø
Distance	381.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Tupelo, MS to Columbia, MO

Every day, 3 buses from 1 bus companies leave Tupelo, MS for Columbia, MO: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/14/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/10

Monday 05/11

Tuesday 05/12

Wednesday 05/13

Thursday 05/14

Friday 05/15

$68

Saturday 05/16

$63

Sunday 05/17

$64

Monday 05/18

$72

Tuesday 05/19

$79

Wednesday 05/20

Thursday 05/21

Friday 05/22

$74

Saturday 05/23

$77

Sunday 05/24

Monday 05/25

$79

Tuesday 05/26

$70

Wednesday 05/27

Thursday 05/28

$73

Friday 05/29

$74

Saturday 05/30

$69

Sunday 05/31

Monday 06/01

$69

Tuesday 06/02

$72

Wednesday 06/03

Thursday 06/04

Friday 06/05

Saturday 06/06

The cheapest time to travel from Tupelo, MS to Columbia, MO

See here on which day and which time of the day you can find the cheapest bus ticket from Tupelo, MS to Columbia, MO, for the next 30 days.

With a price starting from $63, Saturday is the cheapest day for a bus from Tupelo, MS to Columbia, MO. Friday instead is the most expensive day with prices starting from $68.

Night is the cheapest day time for bus tickets from Tupelo, MS to Columbia, MO, with $63. Evening is the most expensive time of the day with prices starting from $64.

How to save money travelling from Tupelo, MS to Columbia, MO

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Tupelo, MS to Columbia, MO in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Tupelo, MS to Columbia, MO, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Tupelo, MS to Columbia, MO are also emptier.

All bus stations and stops in Tupelo, MS and Columbia, MO

In the map below, you can see where to find all bus stations in Tupelo, MS and Columbia, MO.

Bus Stop

S Eason Blvd 2831

Bus Stop

N 10th St 198

Red Thread

Highway 40 W 6401

University

Fellows Pl 1301-1349

Service and Comfort on the bus from Tupelo, MS to Columbia, MO

Want to know which seat classes are available on the buses from Tupelo, MS to Columbia, MO? Or which bus companies serve the route Tupelo, MS to Columbia, MO? Below you will find answers to your questions.

FAQs about the Tupelo, MS to Columbia, MO bus

How much does a Tupelo, MS Columbia, MO bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $63 and takes 13h 20m to reach Columbia, MO. Compare offers to save money!

How much could I save by comparing buses from Tupelo, MS to Columbia, MO?

This route is offered by 1 companies with a range of ticket prices between $63 and $83. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Columbia, MO.

On average, how many connections are available from Tupelo, MS to Columbia, MO each day?

Every day, the Tupelo, MS to Columbia, MO bus route is served by approximately 3 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Tupelo, MS to Columbia, MO take?

The fastest bus from Tupelo, MS to Columbia, MO is offered by Greyhound US and takes 13h 20m. Bus tickets for this connection cost $68. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Tupelo, MS to Columbia, MO?

The earliest bus arriving in Columbia, MO from Tupelo, MS starts at 5:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Tupelo, MS to Columbia, MO?

The latest bus trip departing from Tupelo, MS for Columbia, MO starts at 9:45 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Tupelo, MS Columbia, MO route?

When traveling by bus from Tupelo, MS to Columbia, MO, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Tupelo, MS and Columbia, MO?

You can check all the direct connections between Tupelo, MS and Columbia, MO by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Tupelo, MS to Columbia, MO bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Tupelo, MS Columbia, MO bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Tupelo, MS Columbia, MO bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Tupelo, MS to Columbia, MO on your planned travel date.

How does CheckMyBus find the best bus deals from Tupelo, MS to Columbia, MO?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 3 daily trips between Tupelo, MS and Columbia, MO. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Tupelo, MS to Columbia, MO?

Prices and availability for 3 trips between Tupelo, MS and Columbia, MO change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Tupelo, MS to Columbia, MO

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Tupelo, MS and to Columbia, MO

Here’s an overview of the most popular bus routes to Tupelo, MS and to Columbia, MO. Simply click on the connection of your choice, and you will find all the details about your bus route!