Bus Columbia, MO to Tupelo, MS - Compare all Companies

Compare all timetables for the bus from Columbia, MO to Tupelo, MS

Here is a selection of the cheapest bus trips from the schedule from Columbia, MO to Tupelo, MS from various bus operators like Greyhound US for the next days.

today

tomorrow

Thursday

Friday

$82

Saturday

Sunday

Monday

$76

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 35m	8:05 PM	Columbia, MO	Bus Stop	10:40 AM	Tupelo, MS	Bus Stop	Economy	$82	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 5/8/2026 8:05:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 5/9/2026 10:40:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 14h 35m
Greyhound US	14h 5m	8:35 PM	Columbia, MO	Red Thread	10:40 AM	Tupelo, MS	Bus Stop	Economy	$82	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 5/8/2026 8:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 5/9/2026 10:40:00 AM. 50 Economy ticket for $82 per person are available. Travel duration is 14h 5m
Greyhound US	12h 25m	10:40 AM	Columbia, MO	Red Thread	11:05 PM	Tupelo, MS	Bus Stop	Economy	$83	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 5/8/2026 10:40:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 5/8/2026 11:05:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 12h 25m
Greyhound US	14h 35m	8:30 AM	Columbia, MO	Bus Stop	11:05 PM	Tupelo, MS	Bus Stop	Economy	$84	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 5/8/2026 8:30:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 5/8/2026 11:05:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 14h 35m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	14h 35m	8:05 PM	Columbia, MO	Bus Stop	10:40 AM	Tupelo, MS	Bus Stop	Economy	$76	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 5/11/2026 8:05:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 5/12/2026 10:40:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 14h 35m
Greyhound US	12h 25m	10:40 AM	Columbia, MO	Red Thread	11:05 PM	Tupelo, MS	Bus Stop	Economy	$76	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 5/11/2026 10:40:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 5/11/2026 11:05:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 12h 25m
Greyhound US	14h 35m	8:30 AM	Columbia, MO	Bus Stop	11:05 PM	Tupelo, MS	Bus Stop	Economy	$77	A Bus from Greyhound US goes from Bus Stop, Columbia, MO (USA) at 5/11/2026 8:30:00 AM to Bus Stop, Tupelo, MS (USA) arriving at 5/11/2026 11:05:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 14h 35m
Greyhound US	14h 5m	8:35 PM	Columbia, MO	Red Thread	10:40 AM	Tupelo, MS	Bus Stop	Economy	$78	A Bus from Greyhound US goes from Red Thread, Columbia, MO (USA) at 5/11/2026 8:35:00 PM to Bus Stop, Tupelo, MS (USA) arriving at 5/12/2026 10:40:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 14h 5m

Best Price Offer: The price for the cheapest bus from Columbia, MO to Tupelo, MS is $70 on 5/13/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Columbia, MO and Tupelo, MS

See here how frequent the connections between Columbia, MO and Tupelo, MS are, during different times and days of the week.

Monday is the busiest day, with more than 4 daily buses from Columbia, MO to Tupelo, MS. Monday has instead the fewest connections, with only 4 daily coaches between Columbia, MO and Tupelo, MS.

The busiest time of the day is the Morning, with 4 buses from Columbia, MO to Tupelo, MS, while Morning sees the fewest connections between Columbia, MO and Tupelo, MS, with 4 offers.

Facts about the bus from Columbia, MO to Tupelo, MS

Compare all providers like Greyhound US that travel 4 times every day by bus from Columbia, MO to Tupelo, MS in one click! Book your bus ticket from Columbia, MO to Tupelo, MS starting from $70!

Cheapest Bus	$70
Fastest Bus	12h 25m
Earliest Bus	8:30 AM
Latest Bus	8:35 PM
Daily Bus Routes	4 Ø
Distance	381.7 miles
Bus Companies	Greyhound US

Cheapest bus connections from Columbia, MO to Tupelo, MS

Every day, 4 buses from 1 bus companies leave Columbia, MO for Tupelo, MS: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/05/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$82

Saturday 05/09

Sunday 05/10

Monday 05/11

$76

Tuesday 05/12

Wednesday 05/13

$70

Thursday 05/14

$71

Friday 05/15

$73

Saturday 05/16

Sunday 05/17

$70

Monday 05/18

Tuesday 05/19

Wednesday 05/20

$91

Thursday 05/21

$80

Friday 05/22

Saturday 05/23

Sunday 05/24

Monday 05/25

$75

Tuesday 05/26

Wednesday 05/27

$77

Thursday 05/28

Friday 05/29

Saturday 05/30

The cheapest time to travel from Columbia, MO to Tupelo, MS

See here on which day and which time of the day you can find the cheapest bus ticket from Columbia, MO to Tupelo, MS, for the next 30 days.

With a price starting from $73, Friday is the cheapest day for a bus from Columbia, MO to Tupelo, MS. Monday instead is the most expensive day with prices starting from $75.

Morning is the cheapest day time for bus tickets from Columbia, MO to Tupelo, MS, with $76. Morning is the most expensive time of the day with prices starting from $76.

How to save money travelling from Columbia, MO to Tupelo, MS

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Columbia, MO to Tupelo, MS in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Columbia, MO to Tupelo, MS, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Columbia, MO to Tupelo, MS are also emptier.

All bus stations and stops in Columbia, MO and Tupelo, MS

In the map below, you can see where to find all bus stations in Columbia, MO and Tupelo, MS.

Bus Stop

N 10th St 198

Red Thread

Highway 40 W 6401

University

Fellows Pl 1301-1349

Bus Stop

S Eason Blvd 2831

Service and Comfort on the bus from Columbia, MO to Tupelo, MS

Want to know which seat classes are available on the buses from Columbia, MO to Tupelo, MS? Or which bus companies serve the route Columbia, MO to Tupelo, MS? Below you will find answers to your questions.

FAQs about the Columbia, MO to Tupelo, MS bus

How much does a Columbia, MO Tupelo, MS bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $70 and takes 14h 35m to reach Tupelo, MS. Compare offers to save money!

How much could I save by comparing buses from Columbia, MO to Tupelo, MS?

This route is offered by 1 companies with a range of ticket prices between $70 and $84. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Tupelo, MS.

On average, how many connections are available from Columbia, MO to Tupelo, MS each day?

Every day, the Columbia, MO to Tupelo, MS bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Columbia, MO to Tupelo, MS take?

The fastest bus from Columbia, MO to Tupelo, MS is offered by Greyhound US and takes 12h 25m. Bus tickets for this connection cost $83. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Columbia, MO to Tupelo, MS?

The earliest bus arriving in Tupelo, MS from Columbia, MO starts at 8:30 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Columbia, MO to Tupelo, MS?

The latest bus trip departing from Columbia, MO for Tupelo, MS starts at 8:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Columbia, MO Tupelo, MS route?

When traveling by bus from Columbia, MO to Tupelo, MS, passengers can travel with Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Columbia, MO and Tupelo, MS?

You can check all the direct connections between Columbia, MO and Tupelo, MS by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Greyhound US.

What can I take with me on the Columbia, MO to Tupelo, MS bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Columbia, MO Tupelo, MS bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Columbia, MO Tupelo, MS bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Columbia, MO to Tupelo, MS on your planned travel date.

How does CheckMyBus find the best bus deals from Columbia, MO to Tupelo, MS?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Columbia, MO and Tupelo, MS. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Columbia, MO to Tupelo, MS?

Prices and availability for 4 trips between Columbia, MO and Tupelo, MS change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Columbia, MO to Tupelo, MS

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Columbia, MO and to Tupelo, MS

Here’s an overview of the most popular bus routes to Columbia, MO and to Tupelo, MS. Simply click on the connection of your choice, and you will find all the details about your bus route!