Bus Greenville, SC to Philadelphia - Compare all Companies

Compare all timetables for the bus from Greenville, SC to Philadelphia

Here is a selection of the cheapest bus trips from the schedule from Greenville, SC to Philadelphia from various bus operators like FlixBus or Greyhound US for the next days.

today

tomorrow

$75

Saturday

$84

Sunday

$76

Monday

$77

Tuesday

$75

Wednesday

$83

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 35m	7:10 AM	Greenville, SC	Woodruff Rd	3:45 AM	Philadelphia	Convention Center	Economy	$75	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/8/2026 7:10:00 AM to Convention Center, Philadelphia (USA) arriving at 5/9/2026 3:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 20h 35m
Greyhound US	17h 10m	7:10 AM	Greenville, SC	Woodruff Rd	12:20 AM	Philadelphia	Spring Garden St Station	Economy	$76	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/8/2026 7:10:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/9/2026 12:20:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 17h 10m
Greyhound US	15h 0m	7:10 AM	Greenville, SC	Woodruff Rd	10:10 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$76	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/8/2026 7:10:00 AM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/8/2026 10:10:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 0m
FlixBus	14h 0m	12:15 PM	Greenville, SC	Woodruff Rd	2:15 AM	Philadelphia	Spring Garden St Station	Economy	$76	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/8/2026 12:15:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/9/2026 2:15:00 AM. 50 Economy ticket for $76 per person are available. Travel duration is 14h 0m
FlixBus	16h 30m	4:15 PM	Greenville, SC	Woodruff Rd	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$77	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/8/2026 4:15:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/9/2026 8:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 30m

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 0m	7:10 AM	Greenville, SC	Woodruff Rd	10:10 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$84	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/9/2026 7:10:00 AM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/9/2026 10:10:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 15h 0m
Greyhound US	17h 10m	7:10 AM	Greenville, SC	Woodruff Rd	12:20 AM	Philadelphia	Spring Garden St Station	Economy	$84	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/9/2026 7:10:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/10/2026 12:20:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 17h 10m
FlixBus	22h 15m	4:15 PM	Greenville, SC	Woodruff Rd	2:30 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$84	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/9/2026 4:15:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/10/2026 2:30:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 22h 15m
FlixBus	14h 30m	4:15 PM	Greenville, SC	Woodruff Rd	6:45 AM	Philadelphia	Convention Center	Economy	$84	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/9/2026 4:15:00 PM to Convention Center, Philadelphia (USA) arriving at 5/10/2026 6:45:00 AM. 50 Economy ticket for $84 per person are available. Travel duration is 14h 30m
FlixBus	17h 5m	10:00 PM	Greenville, SC	Woodruff Rd	3:05 PM	Philadelphia	Convention Center	Economy	$84	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/9/2026 10:00:00 PM to Convention Center, Philadelphia (USA) arriving at 5/10/2026 3:05:00 PM. 50 Economy ticket for $84 per person are available. Travel duration is 17h 5m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	15h 0m	7:10 AM	Greenville, SC	Woodruff Rd	10:10 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$76	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/10/2026 7:10:00 AM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/10/2026 10:10:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 0m
Greyhound US	20h 35m	7:10 AM	Greenville, SC	Woodruff Rd	3:45 AM	Philadelphia	Convention Center	Economy	$77	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/10/2026 7:10:00 AM to Convention Center, Philadelphia (USA) arriving at 5/11/2026 3:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 20h 35m
FlixBus	14h 5m	12:15 PM	Greenville, SC	Woodruff Rd	2:20 AM	Philadelphia	Spring Garden St Station	Economy	$78	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/10/2026 12:15:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/11/2026 2:20:00 AM. 50 Economy ticket for $78 per person are available. Travel duration is 14h 5m
FlixBus	17h 5m	10:00 PM	Greenville, SC	Woodruff Rd	3:05 PM	Philadelphia	Convention Center	Economy	$79	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/10/2026 10:00:00 PM to Convention Center, Philadelphia (USA) arriving at 5/11/2026 3:05:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 17h 5m
FlixBus	13h 45m	10:00 PM	Greenville, SC	Woodruff Rd	11:45 AM	Philadelphia	Spring Garden St Station	Economy	$79	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/10/2026 10:00:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/11/2026 11:45:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 13h 45m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 35m	7:10 AM	Greenville, SC	Woodruff Rd	3:45 AM	Philadelphia	Convention Center	Economy	$77	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/11/2026 7:10:00 AM to Convention Center, Philadelphia (USA) arriving at 5/12/2026 3:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 20h 35m
FlixBus	14h 30m	4:15 PM	Greenville, SC	Woodruff Rd	6:45 AM	Philadelphia	Convention Center	Economy	$77	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/11/2026 4:15:00 PM to Convention Center, Philadelphia (USA) arriving at 5/12/2026 6:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 14h 30m
FlixBus	17h 5m	10:00 PM	Greenville, SC	Woodruff Rd	3:05 PM	Philadelphia	Convention Center	Economy	$77	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/11/2026 10:00:00 PM to Convention Center, Philadelphia (USA) arriving at 5/12/2026 3:05:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 17h 5m
FlixBus	16h 30m	4:15 PM	Greenville, SC	Woodruff Rd	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$77	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/11/2026 4:15:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/12/2026 8:45:00 AM. 50 Economy ticket for $77 per person are available. Travel duration is 16h 30m
Greyhound US	17h 10m	7:10 AM	Greenville, SC	Woodruff Rd	12:20 AM	Philadelphia	Spring Garden St Station	Economy	$79	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/11/2026 7:10:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/12/2026 12:20:00 AM. 50 Economy ticket for $79 per person are available. Travel duration is 17h 10m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	20h 35m	7:10 AM	Greenville, SC	Woodruff Rd	3:45 AM	Philadelphia	Convention Center	Economy	$75	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/12/2026 7:10:00 AM to Convention Center, Philadelphia (USA) arriving at 5/13/2026 3:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 20h 35m
FlixBus	14h 30m	4:15 PM	Greenville, SC	Woodruff Rd	6:45 AM	Philadelphia	Convention Center	Economy	$75	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/12/2026 4:15:00 PM to Convention Center, Philadelphia (USA) arriving at 5/13/2026 6:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 14h 30m
FlixBus	22h 15m	4:15 PM	Greenville, SC	Woodruff Rd	2:30 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$75	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/12/2026 4:15:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/13/2026 2:30:00 PM. 50 Economy ticket for $75 per person are available. Travel duration is 22h 15m
FlixBus	16h 30m	4:15 PM	Greenville, SC	Woodruff Rd	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$75	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/12/2026 4:15:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/13/2026 8:45:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 16h 30m
Greyhound US	15h 0m	7:10 AM	Greenville, SC	Woodruff Rd	10:10 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$76	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/12/2026 7:10:00 AM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/12/2026 10:10:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 15h 0m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	17h 15m	7:10 AM	Greenville, SC	Woodruff Rd	12:25 AM	Philadelphia	Spring Garden St Station	Economy	$83	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/13/2026 7:10:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/14/2026 12:25:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 17h 15m
Greyhound US	15h 30m	10:50 AM	Greenville, SC	Woodruff Rd	2:20 AM	Philadelphia	Spring Garden St Station	Economy	$83	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/13/2026 10:50:00 AM to Spring Garden St Station, Philadelphia (USA) arriving at 5/14/2026 2:20:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 30m
Greyhound US	15h 0m	7:10 AM	Greenville, SC	Woodruff Rd	10:10 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$83	A Bus from Greyhound US goes from Woodruff Rd, Greenville, SC (USA) at 5/13/2026 7:10:00 AM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/13/2026 10:10:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 15h 0m
FlixBus	16h 30m	4:15 PM	Greenville, SC	Woodruff Rd	8:45 AM	Philadelphia	Spring Garden St Station	Economy	$83	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/13/2026 4:15:00 PM to Spring Garden St Station, Philadelphia (USA) arriving at 5/14/2026 8:45:00 AM. 50 Economy ticket for $83 per person are available. Travel duration is 16h 30m
FlixBus	18h 25m	10:00 PM	Greenville, SC	Woodruff Rd	4:25 PM	Philadelphia	Schuylkill Ave and Walnut Street	Economy	$83	A Bus from FlixBus goes from Woodruff Rd, Greenville, SC (USA) at 5/13/2026 10:00:00 PM to Schuylkill Ave and Walnut Street, Philadelphia (USA) arriving at 5/14/2026 4:25:00 PM. 50 Economy ticket for $83 per person are available. Travel duration is 18h 25m

Best Price Offer: The price for the cheapest bus from Greenville, SC to Philadelphia is $73 on 5/4/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Greenville, SC and Philadelphia

See here how frequent the connections between Greenville, SC and Philadelphia are, during different times and days of the week.

Sunday is the busiest day, with more than 22 daily buses from Greenville, SC to Philadelphia. Monday has instead the fewest connections, with only 11 daily coaches between Greenville, SC and Philadelphia.

The busiest time of the day is the Afternoon, with 39 buses from Greenville, SC to Philadelphia, while Evening sees the fewest connections between Greenville, SC and Philadelphia, with 27 offers.

Facts about the bus from Greenville, SC to Philadelphia

Compare all providers like FlixBus and Greyhound US that travel 16 times every day by bus from Greenville, SC to Philadelphia in one click! Book your bus ticket from Greenville, SC to Philadelphia starting from $73!

Cheapest Bus	$73
Fastest Bus	13h 45m
Earliest Bus	7:10 AM
Latest Bus	10:00 PM
Daily Bus Routes	16 Ø
Distance	530.0 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from Greenville, SC to Philadelphia

Every day, 16 buses from 2 bus companies leave Greenville, SC for Philadelphia: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 05/07/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 05/03

Monday 05/04

Tuesday 05/05

Wednesday 05/06

Thursday 05/07

Friday 05/08

$75

Saturday 05/09

$84

Sunday 05/10

$76

Monday 05/11

$77

Tuesday 05/12

$75

Wednesday 05/13

$83

Thursday 05/14

Friday 05/15

$81

Saturday 05/16

$80

Sunday 05/17

$75

Monday 05/18

$78

Tuesday 05/19

Wednesday 05/20

$76

Thursday 05/21

$77

Friday 05/22

$87

Saturday 05/23

$84

Sunday 05/24

$84

Monday 05/25

$90

Tuesday 05/26

$84

Wednesday 05/27

Thursday 05/28

Friday 05/29

Saturday 05/30

The cheapest time to travel from Greenville, SC to Philadelphia

See here on which day and which time of the day you can find the cheapest bus ticket from Greenville, SC to Philadelphia, for the next 30 days.

With a price starting from $65, Sunday is the cheapest day for a bus from Greenville, SC to Philadelphia. Wednesday instead is the most expensive day with prices starting from $76.

Afternoon is the cheapest day time for bus tickets from Greenville, SC to Philadelphia, with $75. Evening is the most expensive time of the day with prices starting from $77.

How to save money travelling from Greenville, SC to Philadelphia

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Greenville, SC to Philadelphia in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Greenville, SC to Philadelphia, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Greenville, SC to Philadelphia are also emptier.

All bus stations and stops in Greenville, SC and Philadelphia

In the map below, you can see where to find all bus stations in Greenville, SC and Philadelphia.

McDonald's

Woodruff Rd 1111

Woodruff Rd

Woodruff Rd 1116

Greyhound Bus Station

Hendrix Dr 9

Guadalajara Supermarket

White Horse Rd 2803

N Church St

Central Bus Station

Filbert St 1001

Market St

Spring Garden St Station

Spring Garden St & 2nd St

JFK & Broad

John F Kennedy Blvd 1401

Philadelphia, PA

Service and Comfort on the bus from Greenville, SC to Philadelphia

Want to know which seat classes are available on the buses from Greenville, SC to Philadelphia? Or which bus companies serve the route Greenville, SC to Philadelphia? Below you will find answers to your questions.

FAQs about the Greenville, SC to Philadelphia bus

How much does a Greenville, SC Philadelphia bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $73 and takes 22h 15m to reach Philadelphia. Compare offers to save money!

How much could I save by comparing buses from Greenville, SC to Philadelphia?

This route is offered by 2 companies with a range of ticket prices between $73 and $101. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Philadelphia.

On average, how many connections are available from Greenville, SC to Philadelphia each day?

Every day, the Greenville, SC to Philadelphia bus route is served by approximately 16 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Greenville, SC to Philadelphia take?

The fastest bus from Greenville, SC to Philadelphia is offered by FlixBus and takes 13h 45m. Bus tickets for this connection cost $81. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Greenville, SC to Philadelphia?

The earliest bus arriving in Philadelphia from Greenville, SC starts at 7:10 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Greenville, SC to Philadelphia?

The latest bus trip departing from Greenville, SC for Philadelphia starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Greenville, SC Philadelphia route?

When traveling by bus from Greenville, SC to Philadelphia, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Greenville, SC and Philadelphia?

You can check all the direct connections between Greenville, SC and Philadelphia by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the Greenville, SC to Philadelphia bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Greenville, SC Philadelphia bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Greenville, SC Philadelphia bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Greenville, SC to Philadelphia on your planned travel date.

How does CheckMyBus find the best bus deals from Greenville, SC to Philadelphia?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 16 daily trips between Greenville, SC and Philadelphia. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Greenville, SC to Philadelphia?

Prices and availability for 16 trips between Greenville, SC and Philadelphia change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Greenville, SC to Philadelphia

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Greenville, SC and to Philadelphia

Here’s an overview of the most popular bus routes to Greenville, SC and to Philadelphia. Simply click on the connection of your choice, and you will find all the details about your bus route!