Bus Isernia to Rome - Compare all Companies

Compare all timetables for the bus from Isernia to Rome

Here is a selection of the cheapest bus trips from the schedule from Isernia to Rome from various bus operators like FlixBus for the next days.

today

tomorrow

$27

Sunday

$38

Monday

Tuesday

$19

Wednesday

Thursday

$20

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	6h 55m	3:50 PM	Isernia	Central Bus Station	10:45 PM	Rome	Tiburtina Bus Station		Economy	$27	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/13/2025 3:50:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 12/13/2025 10:45:00 PM. 50 Economy ticket for $27 per person are available. Travel duration is 6h 55m
	FlixBus	9h 5m	11:25 AM	Isernia	Central Bus Station	8:30 PM	Rome	Tiburtina Bus Station		Economy	$39	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/13/2025 11:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/13/2025 8:30:00 PM. 50 Economy ticket for $39 per person are available. Travel duration is 9h 5m

Did you know that if you travel from Isernia to Rome via Vairano Patenora, you can save more than $6? You can find the corresponding connections below.
- Autoservizi Cerella
  
  5h 49m
  
  0
  
  5:05 PM
  
  Isernia
  Train Station
  
  5:50 PM
  
  Vairano Patenora
  Scalo
  
  0
  
  Economy
  
  $5
  
  A Bus from Autoservizi Cerella goes from Train Station, Isernia (Italy) at 12/14/2025 5:05:00 PM to Scalo, Vairano Patenora (Italy) arriving at 12/14/2025 5:50:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 0h 45m
- Omio
  
  4h 19m
  
  0
  
  6:35 PM
  
  Vairano Patenora
  Scalo
  
  10:54 PM
  
  Rome
  Termini Central Station
  
  0
  
  Economy
  
  $16
  
  A Bus from Omio goes from Scalo, Vairano Patenora (Italy) at 12/14/2025 6:35:00 PM to Termini Central Station, Rome (Italy) arriving at 12/14/2025 10:54:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 19m
Travel Time is 1h 6m shorter, and you will save $6

Cheapest bus trips Sunday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	6h 55m	3:50 PM	Isernia	Central Bus Station	10:45 PM	Rome	Tiburtina Bus Station		Economy	$38	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/14/2025 3:50:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 12/14/2025 10:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 55m
	FlixBus	9h 5m	11:25 AM	Isernia	Central Bus Station	8:30 PM	Rome	Tiburtina Bus Station		Economy	$43	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/14/2025 11:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/14/2025 8:30:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 9h 5m

Did you know that if you travel from Isernia to Rome via Vairano Patenora, you can save more than $17? You can find the corresponding connections below.
- Autoservizi Cerella
  
  5h 49m
  
  0
  
  5:05 PM
  
  Isernia
  Train Station
  
  5:50 PM
  
  Vairano Patenora
  Scalo
  
  0
  
  Economy
  
  $5
  
  A Bus from Autoservizi Cerella goes from Train Station, Isernia (Italy) at 12/14/2025 5:05:00 PM to Scalo, Vairano Patenora (Italy) arriving at 12/14/2025 5:50:00 PM. 50 Economy ticket for $5 per person are available. Travel duration is 0h 45m
- Omio
  
  4h 19m
  
  0
  
  6:35 PM
  
  Vairano Patenora
  Scalo
  
  10:54 PM
  
  Rome
  Termini Central Station
  
  0
  
  Economy
  
  $16
  
  A Bus from Omio goes from Scalo, Vairano Patenora (Italy) at 12/14/2025 6:35:00 PM to Termini Central Station, Rome (Italy) arriving at 12/14/2025 10:54:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 4h 19m
Travel Time is 1h 6m shorter, and you will save $17

Cheapest bus trips Tuesday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	7h 5m	3:50 PM	Isernia	Central Bus Station	10:55 PM	Rome	Tiburtina Bus Station		Economy	$19	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/16/2025 3:50:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 12/16/2025 10:55:00 PM. 50 Economy ticket for $19 per person are available. Travel duration is 7h 5m

Cheapest bus trips Thursday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	FlixBus	6h 55m	3:50 PM	Isernia	Central Bus Station	10:45 PM	Rome	Tiburtina Bus Station		Economy	$20	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/18/2025 3:50:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 12/18/2025 10:45:00 PM. 50 Economy ticket for $20 per person are available. Travel duration is 6h 55m
	FlixBus	9h 5m	11:25 AM	Isernia	Central Bus Station	8:30 PM	Rome	Tiburtina Bus Station		Economy	$36	A Bus from FlixBus goes from Central Bus Station, Isernia (Italy) at 12/18/2025 11:25:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/18/2025 8:30:00 PM. 50 Economy ticket for $36 per person are available. Travel duration is 9h 5m

Best Price Offer: The price for the cheapest bus from Isernia to Rome is $19 on 12/16/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Isernia and Rome

See here how frequent the connections between Isernia and Rome are, during different times and days of the week.

Sunday is the busiest day, with more than 2 daily buses from Isernia to Rome. Tuesday has instead the fewest connections, with only 1 daily coaches between Isernia and Rome.

The busiest time of the day is the Afternoon, with 4 buses from Isernia to Rome, while Morning sees the fewest connections between Isernia and Rome, with 3 offers.

Facts about the bus from Isernia to Rome

Compare all providers like FlixBus that travel 1 times every day by bus from Isernia to Rome in one click! Book your bus ticket from Isernia to Rome starting from $19!

Cheapest Bus	$19
Fastest Bus	6h 55m
Earliest Bus	11:25 AM
Latest Bus	3:50 PM
Daily Bus Routes	1 Ø
Distance	91.9 miles
Bus Companies	FlixBus

Cheapest bus connections from Isernia to Rome

Every day, 1 buses from 1 bus companies leave Isernia for Rome: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/12/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/07

Monday 12/08

Tuesday 12/09

Wednesday 12/10

Thursday 12/11

Friday 12/12

Saturday 12/13

$27

Sunday 12/14

$38

Monday 12/15

Tuesday 12/16

$19

Wednesday 12/17

Thursday 12/18

$20

Friday 12/19

$31

Saturday 12/20

Sunday 12/21

Monday 12/22

Tuesday 12/23

Wednesday 12/24

Thursday 12/25

Friday 12/26

Saturday 12/27

Sunday 12/28

Monday 12/29

Tuesday 12/30

Wednesday 12/31

Thursday 01/01

Friday 01/02

Saturday 01/03

The cheapest time to travel from Isernia to Rome

See here on which day and which time of the day you can find the cheapest bus ticket from Isernia to Rome, for the next 30 days.

With a price starting from $19, Tuesday is the cheapest day for a bus from Isernia to Rome. Sunday instead is the most expensive day with prices starting from $38.

Afternoon is the cheapest day time for bus tickets from Isernia to Rome, with $19. Morning is the most expensive time of the day with prices starting from $36.

How to save money travelling from Isernia to Rome

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Isernia to Rome in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Isernia to Rome, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Isernia to Rome are also emptier.

All bus stations and stops in Isernia and Rome

In the map below, you can see where to find all bus stations in Isernia and Rome.

Central Bus Station

Train Station

Anagnina Bus Station

Piazzale della Stazione Anagnina

Termini Bus Station

Piazza dei Cinquecento 64

Tiburtina Bus Station

Tiburtina Partenze

Vatican City

Via Crescenzio 19

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Isernia to Rome? Compare all modes of transports from Isernia to Rome.

Service and Comfort on the bus from Isernia to Rome

Want to know which seat classes are available on the buses from Isernia to Rome? Or which bus companies serve the route Isernia to Rome? Below you will find answers to your questions.

FAQs about the Isernia to Rome bus

How much does a Isernia Rome bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $19 and takes 7h 5m to reach Rome. Compare offers to save money!

How much could I save by comparing buses from Isernia to Rome?

This route is offered by 1 companies with a range of ticket prices between $19 and $43. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Rome.

On average, how many connections are available from Isernia to Rome each day?

Every day, the Isernia to Rome bus route is served by approximately 1 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Isernia to Rome take?

The fastest bus from Isernia to Rome is offered by FlixBus and takes 6h 55m. Bus tickets for this connection cost $27. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Isernia to Rome?

The earliest bus arriving in Rome from Isernia starts at 11:25 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Isernia to Rome?

The latest bus trip departing from Isernia for Rome starts at 3:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Isernia Rome route?

When traveling by bus from Isernia to Rome, passengers can travel with FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Isernia and Rome?

You can check all the direct connections between Isernia and Rome by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus.

What can I take with me on the Isernia to Rome bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Isernia Rome bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Isernia Rome bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Isernia to Rome on your planned travel date.

How does CheckMyBus find the best bus deals from Isernia to Rome?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 1 daily trips between Isernia and Rome. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Isernia to Rome?

Prices and availability for 1 trips between Isernia and Rome change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Isernia to Rome

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Isernia and to Rome

Here’s an overview of the most popular bus routes to Isernia and to Rome. Simply click on the connection of your choice, and you will find all the details about your bus route!