Bus Karlsruhe to Madrid - Compare all Companies

Compare all timetables for the bus from Karlsruhe to Madrid

Here is a selection of the cheapest bus trips from the schedule from Karlsruhe to Madrid from various bus operators like FlixBus or BlaBlaCar Bus for the next days.

today

$100

tomorrow

$93

Saturday

$163

Sunday

$72

Monday

Tuesday

$61

Wednesday

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	27h 40m	6:35 AM	Karlsruhe	Central Station	10:15 AM	Madrid	Sur Bus Station	Economy	$100	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 4/30/2026 6:35:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/1/2026 10:15:00 AM. 50 Economy ticket for $100 per person are available. Travel duration is 27h 40m
FlixBus	33h 0m	11:40 PM	Karlsruhe	Central Station	8:40 AM	Madrid	Sur Bus Station	Economy	$102	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 4/30/2026 11:40:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/2/2026 8:40:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 33h 0m
FlixBus	26h 20m	6:35 AM	Karlsruhe	Central Station	8:55 AM	Madrid	Sur Bus Station	Economy	$118	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 4/30/2026 6:35:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/1/2026 8:55:00 AM. 50 Economy ticket for $118 per person are available. Travel duration is 26h 20m
BlaBlaCar Bus	27h 35m	9:05 PM	Karlsruhe	Central Station	12:40 AM	Madrid	Sur Bus Station	Economy	$175	A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 4/30/2026 9:05:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/2/2026 12:40:00 AM. 50 Economy ticket for $175 per person are available. Travel duration is 27h 35m

Cheapest bus trips tomorrow
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	BlaBlaCar Bus	26h 50m	11:15 AM	Karlsruhe	Central Station	2:05 PM	Madrid	Sur Bus Station		Economy	$93	A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/1/2026 11:15:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/2/2026 2:05:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 26h 50m
	BlaBlaCar Bus	27h 35m	9:05 PM	Karlsruhe	Central Station	12:40 AM	Madrid	Sur Bus Station		Economy	$157	A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/1/2026 9:05:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/3/2026 12:40:00 AM. 50 Economy ticket for $157 per person are available. Travel duration is 27h 35m

Did you know that if you travel from Karlsruhe to Madrid via Lyon, you can save more than $19? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  36h 50m
  
  0
  
  9:05 PM
  
  Karlsruhe
  Central Station
  
  5:10 AM
  
  Lyon
  Perrache Train Station
  
  0
  
  Economy
  
  $23
  
  A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/1/2026 9:05:00 PM to Perrache Train Station, Lyon (France) arriving at 5/2/2026 5:10:00 AM. 50 Economy ticket for $23 per person are available. Travel duration is 8h 5m
- ALSA
  
  17h 25m
  
  0
  
  4:30 PM
  
  Lyon
  Perrache Bus Stop
  
  9:55 AM
  
  Madrid
  Mendez Alvaro Train Station
  
  0
  
  Economy
  
  $50
  
  A Bus from ALSA goes from Perrache Bus Stop, Lyon (France) at 5/2/2026 4:30:00 PM to Mendez Alvaro Train Station, Madrid (Spain) arriving at 5/3/2026 9:55:00 AM. 50 Economy ticket for $50 per person are available. Travel duration is 17h 25m
Travel time is 10h 0m longer, but you will save $19

Cheapest bus trips Saturday
Mode of Transport	BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Logo	Seat classes	Price
	BlaBlaCar Bus	27h 35m	9:05 PM	Karlsruhe	Central Station	12:40 AM	Madrid	Sur Bus Station		Economy	$163	A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/2/2026 9:05:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/4/2026 12:40:00 AM. 50 Economy ticket for $163 per person are available. Travel duration is 27h 35m

Did you know that if you travel from Karlsruhe to Madrid via Lyon, you can save more than $91? You can find the corresponding connections below.
- BlaBlaCar Bus
  
  36h 50m
  
  0
  
  9:05 PM
  
  Karlsruhe
  Central Station
  
  5:10 AM
  
  Lyon
  Perrache Train Station
  
  0
  
  Economy
  
  $26
  
  A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/3/2026 9:05:00 PM to Perrache Train Station, Lyon (France) arriving at 5/4/2026 5:10:00 AM. 50 Economy ticket for $26 per person are available. Travel duration is 8h 5m
- ALSA
  
  17h 25m
  
  0
  
  4:30 PM
  
  Lyon
  Lyon Avenue Tony Garnier Bus Stop
  
  9:55 AM
  
  Madrid
  Mendez Alvaro Train Station
  
  0
  
  Economy
  
  $47
  
  A Bus from ALSA goes from Lyon Avenue Tony Garnier Bus Stop, Lyon (France) at 5/4/2026 4:30:00 PM to Mendez Alvaro Train Station, Madrid (Spain) arriving at 5/5/2026 9:55:00 AM. 50 Economy ticket for $47 per person are available. Travel duration is 17h 25m
Travel time is 9h 15m longer, but you will save $91

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	26h 15m	11:05 AM	Karlsruhe	Central Station	1:20 PM	Madrid	Sur Bus Station	Economy	$72	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/3/2026 11:05:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/4/2026 1:20:00 PM. 50 Economy ticket for $72 per person are available. Travel duration is 26h 15m
FlixBus	32h 45m	11:10 PM	Karlsruhe	Central Station	7:55 AM	Madrid	Sur Bus Station	Economy	$72	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/3/2026 11:10:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/5/2026 7:55:00 AM. 50 Economy ticket for $72 per person are available. Travel duration is 32h 45m
FlixBus	33h 0m	11:40 PM	Karlsruhe	Central Station	8:40 AM	Madrid	Sur Bus Station	Economy	$75	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/3/2026 11:40:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/5/2026 8:40:00 AM. 50 Economy ticket for $75 per person are available. Travel duration is 33h 0m
BlaBlaCar Bus	26h 50m	11:15 AM	Karlsruhe	Central Station	2:05 PM	Madrid	Sur Bus Station	Economy	$128	A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/3/2026 11:15:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/4/2026 2:05:00 PM. 50 Economy ticket for $128 per person are available. Travel duration is 26h 50m
BlaBlaCar Bus	27h 35m	9:05 PM	Karlsruhe	Central Station	12:40 AM	Madrid	Sur Bus Station	Economy	$157	A Bus from BlaBlaCar Bus goes from Central Station, Karlsruhe (Germany) at 5/3/2026 9:05:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/5/2026 12:40:00 AM. 50 Economy ticket for $157 per person are available. Travel duration is 27h 35m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	31h 45m	12:55 AM	Karlsruhe	Central Station	8:40 AM	Madrid	Sur Bus Station	Economy	$61	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/5/2026 12:55:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/6/2026 8:40:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 31h 45m
FlixBus	30h 45m	3:30 AM	Karlsruhe	Central Station	10:15 AM	Madrid	Sur Bus Station	Economy	$61	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/5/2026 3:30:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/6/2026 10:15:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 30h 45m
FlixBus	32h 45m	11:10 PM	Karlsruhe	Central Station	7:55 AM	Madrid	Sur Bus Station	Economy	$61	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/5/2026 11:10:00 PM to Sur Bus Station, Madrid (Spain) arriving at 5/7/2026 7:55:00 AM. 50 Economy ticket for $61 per person are available. Travel duration is 32h 45m
FlixBus	31h 20m	12:35 AM	Karlsruhe	Central Station	7:55 AM	Madrid	Sur Bus Station	Economy	$73	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/5/2026 12:35:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/6/2026 7:55:00 AM. 50 Economy ticket for $73 per person are available. Travel duration is 31h 20m
FlixBus	26h 15m	11:05 AM	Karlsruhe	Central Station	1:20 PM	Madrid	Sur Bus Station	Economy	$77	A Bus from FlixBus goes from Central Station, Karlsruhe (Germany) at 5/5/2026 11:05:00 AM to Sur Bus Station, Madrid (Spain) arriving at 5/6/2026 1:20:00 PM. 50 Economy ticket for $77 per person are available. Travel duration is 26h 15m

Best Price Offer: The price for the cheapest bus from Karlsruhe to Madrid is $61 on 5/5/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Karlsruhe and Madrid

See here how frequent the connections between Karlsruhe and Madrid are, during different times and days of the week.

Sunday is the busiest day, with more than 7 daily buses from Karlsruhe to Madrid. Saturday has instead the fewest connections, with only 1 daily coaches between Karlsruhe and Madrid.

The busiest time of the day is the Evening, with 9 buses from Karlsruhe to Madrid, while Night sees the fewest connections between Karlsruhe and Madrid, with 5 offers.

Facts about the bus from Karlsruhe to Madrid

Compare all providers like FlixBus and BlaBlaCar Bus that travel 4 times every day by bus from Karlsruhe to Madrid in one click! Book your bus ticket from Karlsruhe to Madrid starting from $61!

Cheapest Bus	$61
Fastest Bus	26h 15m
Earliest Bus	6:35 AM
Latest Bus	11:10 PM
Daily Bus Routes	4 Ø
Distance	838.4 miles
Bus Companies	FlixBus and BlaBlaCar Bus

Cheapest bus connections from Karlsruhe to Madrid

Every day, 4 buses from 2 bus companies leave Karlsruhe for Madrid: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/30/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 04/26

Monday 04/27

Tuesday 04/28

Wednesday 04/29

Thursday 04/30

$175

Friday 05/01

$93

Saturday 05/02

$163

Sunday 05/03

$128

Monday 05/04

Tuesday 05/05

$61

Wednesday 05/06

Thursday 05/07

Friday 05/08

$93

Saturday 05/09

$175

Sunday 05/10

$117

Monday 05/11

$65

Tuesday 05/12

Wednesday 05/13

$113

Thursday 05/14

$128

Friday 05/15

$82

Saturday 05/16

$181

Sunday 05/17

$117

Monday 05/18

$76

Tuesday 05/19

Wednesday 05/20

$70

Thursday 05/21

$117

Friday 05/22

$93

Saturday 05/23

The cheapest time to travel from Karlsruhe to Madrid

See here on which day and which time of the day you can find the cheapest bus ticket from Karlsruhe to Madrid, for the next 30 days.

With a price starting from $61, Tuesday is the cheapest day for a bus from Karlsruhe to Madrid. Saturday instead is the most expensive day with prices starting from $128.

Night is the cheapest day time for bus tickets from Karlsruhe to Madrid, with $61. Morning is the most expensive time of the day with prices starting from $72.

How to save money travelling from Karlsruhe to Madrid

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Karlsruhe to Madrid in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Karlsruhe to Madrid, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Karlsruhe to Madrid are also emptier.

All bus stations and stops in Karlsruhe and Madrid

In the map below, you can see where to find all bus stations in Karlsruhe and Madrid.

Central Bus Station

Central Station

Hinterm Hauptbahnhof 6

Durlach Train Station

Knielingen Train Station

Durlach Auer Str./Dr.Willmar Schwabe Bus Stop

Avenida de América Bus Station

Avenida de América 13

Bus Stop

Calle de Tiziano 40

Intercambiador de Moncloa

Calle de la Princesa 89n

Plaza de Castilla

Sur Bus Station

Calle de Méndez Álvaro 83

Service and Comfort on the bus from Karlsruhe to Madrid

Want to know which seat classes are available on the buses from Karlsruhe to Madrid? Or which bus companies serve the route Karlsruhe to Madrid? Below you will find answers to your questions.

FAQs about the Karlsruhe to Madrid bus

How much does a Karlsruhe Madrid bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $61 and takes 31h 45m to reach Madrid. Compare offers to save money!

How much could I save by comparing buses from Karlsruhe to Madrid?

This route is offered by 2 companies with a range of ticket prices between $61 and $175. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Madrid.

On average, how many connections are available from Karlsruhe to Madrid each day?

Every day, the Karlsruhe to Madrid bus route is served by approximately 4 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Karlsruhe to Madrid take?

The fastest bus from Karlsruhe to Madrid is offered by FlixBus and takes 26h 15m. Bus tickets for this connection cost $138. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Karlsruhe to Madrid?

The earliest bus arriving in Madrid from Karlsruhe starts at 6:35 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Karlsruhe to Madrid?

The latest bus trip departing from Karlsruhe for Madrid starts at 11:10 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Karlsruhe Madrid route?

When traveling by bus from Karlsruhe to Madrid, passengers can travel with FlixBus and BlaBlaCar Bus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Karlsruhe and Madrid?

You can check all the direct connections between Karlsruhe and Madrid by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and BlaBlaCar Bus.

What can I take with me on the Karlsruhe to Madrid bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Karlsruhe Madrid bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Karlsruhe Madrid bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Karlsruhe to Madrid on your planned travel date.

How does CheckMyBus find the best bus deals from Karlsruhe to Madrid?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 4 daily trips between Karlsruhe and Madrid. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Karlsruhe to Madrid?

Prices and availability for 4 trips between Karlsruhe and Madrid change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Karlsruhe to Madrid

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Karlsruhe and to Madrid

Here’s an overview of the most popular bus routes to Karlsruhe and to Madrid. Simply click on the connection of your choice, and you will find all the details about your bus route!