Bus Santander to Madrid: Compare prices and save money

Compare all timetables for the bus from Santander to Madrid

Here is a selection of the cheapest bus trips from the schedule from Santander to Madrid from various bus operators like ALSA or FlixBus for the next days.

today

$41

tomorrow

$38

Sunday

$37

Monday

$42

Tuesday

$38

Wednesday

$38

Thursday

$37

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 30m	5:30 PM	Santander	Bus Station	11:00 PM	Madrid	Avenida de Aragon	Basic	$41	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/5/2025 5:30:00 PM to Avenida de Aragon, Madrid (Spain) arriving at 12/5/2025 11:00:00 PM. 50 Basic ticket for $41 per person are available. Travel duration is 5h 30m
ALSA	6h 45m	4:00 PM	Santander	Bus Station	10:45 PM	Madrid	Intercambiador de Moncloa	Economy	$42	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/5/2025 4:00:00 PM to Intercambiador de Moncloa, Madrid (Spain) arriving at 12/5/2025 10:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 45m
ALSA	5h 50m	8:00 AM	Santander	Bus Station	1:50 PM	Madrid	Avenida de América Bus Station	Economy	$46	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/5/2025 8:00:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/5/2025 1:50:00 PM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 50m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$93	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/5/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/6/2025 1:20:00 PM. 50 Economy ticket for $93 per person are available. Travel duration is 18h 30m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$94	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/5/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/6/2025 7:10:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 21h 45m

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 45m	12:00 PM	Santander	Bus Station	5:45 PM	Madrid	Avenida de América Bus Station	Economy	$38	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/6/2025 12:00:00 PM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/6/2025 5:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 45m
ALSA	5h 30m	5:30 PM	Santander	Bus Station	11:00 PM	Madrid	Avenida de América Bus Station	Economy	$38	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/6/2025 5:30:00 PM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/6/2025 11:00:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 30m
ALSA	6h 45m	4:00 PM	Santander	Bus Station	10:45 PM	Madrid	Intercambiador de Moncloa	Economy	$42	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/6/2025 4:00:00 PM to Intercambiador de Moncloa, Madrid (Spain) arriving at 12/6/2025 10:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 45m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$65	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/6/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/7/2025 1:20:00 PM. 50 Economy ticket for $65 per person are available. Travel duration is 18h 30m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$94	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/6/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/7/2025 7:10:00 AM. 50 Economy ticket for $94 per person are available. Travel duration is 21h 45m

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 30m	5:30 PM	Santander	Bus Station	11:00 PM	Madrid	Avenida de América Bus Station	Economy	$37	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/7/2025 5:30:00 PM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/7/2025 11:00:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 5h 30m
ALSA	5h 45m	12:00 PM	Santander	Bus Station	5:45 PM	Madrid	Avenida de América Bus Station	Economy	$38	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/7/2025 12:00:00 PM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/7/2025 5:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 5h 45m
ALSA	6h 15m	10:30 AM	Santander	Bus Station	4:45 PM	Madrid	Avenida de América Bus Station	Economy	$41	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/7/2025 10:30:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/7/2025 4:45:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 6h 15m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$93	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/7/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/8/2025 7:10:00 AM. 50 Economy ticket for $93 per person are available. Travel duration is 21h 45m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$106	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/7/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/8/2025 1:20:00 PM. 50 Economy ticket for $106 per person are available. Travel duration is 18h 30m

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	6h 45m	4:00 PM	Santander	Bus Station	10:45 PM	Madrid	Intercambiador de Moncloa	Economy	$42	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/8/2025 4:00:00 PM to Intercambiador de Moncloa, Madrid (Spain) arriving at 12/8/2025 10:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 45m
ALSA	5h 30m	5:30 PM	Santander	Bus Station	11:00 PM	Madrid	Avenida de América Bus Station	Economy	$45	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/8/2025 5:30:00 PM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/8/2025 11:00:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 5h 30m
ALSA	5h 30m	1:00 AM	Santander	Bus Station	6:30 AM	Madrid	Avenida de América Bus Station	Economy	$46	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/8/2025 1:00:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/8/2025 6:30:00 AM. 50 Economy ticket for $46 per person are available. Travel duration is 5h 30m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$113	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/8/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/9/2025 1:20:00 PM. 50 Economy ticket for $113 per person are available. Travel duration is 18h 30m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$170	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/8/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/9/2025 7:10:00 AM. 50 Economy ticket for $170 per person are available. Travel duration is 21h 45m

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	6h 15m	10:30 AM	Santander	Bus Station	4:45 PM	Madrid	Avenida de América Bus Station	Economy	$38	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/9/2025 10:30:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/9/2025 4:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 15m
ALSA	5h 30m	1:00 AM	Santander	Bus Station	6:30 AM	Madrid	Avenida de América Bus Station	Economy	$41	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/9/2025 1:00:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/9/2025 6:30:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 30m
ALSA	6h 45m	4:00 PM	Santander	Bus Station	10:45 PM	Madrid	Intercambiador de Moncloa	Economy	$42	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/9/2025 4:00:00 PM to Intercambiador de Moncloa, Madrid (Spain) arriving at 12/9/2025 10:45:00 PM. 50 Economy ticket for $42 per person are available. Travel duration is 6h 45m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$76	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/9/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/10/2025 1:20:00 PM. 50 Economy ticket for $76 per person are available. Travel duration is 18h 30m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$99	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/9/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/10/2025 7:10:00 AM. 50 Economy ticket for $99 per person are available. Travel duration is 21h 45m

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	6h 15m	10:30 AM	Santander	Bus Station	4:45 PM	Madrid	Avenida de América Bus Station	Economy	$38	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/10/2025 10:30:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/10/2025 4:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 15m
ALSA	5h 30m	1:00 AM	Santander	Bus Station	6:30 AM	Madrid	Avenida de América Bus Station	Economy	$41	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/10/2025 1:00:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/10/2025 6:30:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 30m
ALSA	5h 30m	5:30 PM	Santander	Bus Station	11:00 PM	Madrid	Avenida de Aragon	Basic	$41	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/10/2025 5:30:00 PM to Avenida de Aragon, Madrid (Spain) arriving at 12/10/2025 11:00:00 PM. 50 Basic ticket for $41 per person are available. Travel duration is 5h 30m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$67	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/10/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/11/2025 7:10:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 21h 45m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$68	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/10/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/11/2025 1:20:00 PM. 50 Economy ticket for $68 per person are available. Travel duration is 18h 30m

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
ALSA	5h 30m	5:30 PM	Santander	Bus Station	11:00 PM	Madrid	Avenida de América Bus Station	Economy	$37	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/11/2025 5:30:00 PM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/11/2025 11:00:00 PM. 50 Economy ticket for $37 per person are available. Travel duration is 5h 30m
ALSA	6h 15m	10:30 AM	Santander	Bus Station	4:45 PM	Madrid	Avenida de América Bus Station	Economy	$38	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/11/2025 10:30:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/11/2025 4:45:00 PM. 50 Economy ticket for $38 per person are available. Travel duration is 6h 15m
ALSA	5h 30m	1:00 AM	Santander	Bus Station	6:30 AM	Madrid	Avenida de América Bus Station	Economy	$41	A Bus from ALSA goes from Bus Station, Santander (Spain) at 12/11/2025 1:00:00 AM to Avenida de América Bus Station, Madrid (Spain) arriving at 12/11/2025 6:30:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 5h 30m
FlixBus	21h 45m	9:25 AM	Santander	Bus Station	7:10 AM	Madrid	Sur Bus Station	Economy	$65	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/11/2025 9:25:00 AM to Sur Bus Station, Madrid (Spain) arriving at 12/12/2025 7:10:00 AM. 50 Economy ticket for $65 per person are available. Travel duration is 21h 45m
FlixBus	18h 30m	6:50 PM	Santander	Bus Station	1:20 PM	Madrid	Sur Bus Station	Economy	$79	A Bus from FlixBus goes from Bus Station, Santander (Spain) at 12/11/2025 6:50:00 PM to Sur Bus Station, Madrid (Spain) arriving at 12/12/2025 1:20:00 PM. 50 Economy ticket for $79 per person are available. Travel duration is 18h 30m

Best Price Offer: The price for the cheapest bus from Santander to Madrid is $37 on 11/30/2025. Flexible travelers save on ticket prices.

Frequency of bus connections between Santander and Madrid

See here how frequent the connections between Santander and Madrid are, during different times and days of the week.

Thursday is the busiest day, with more than 29 daily buses from Santander to Madrid. Monday has instead the fewest connections, with only 16 daily coaches between Santander and Madrid.

The busiest time of the day is the Afternoon, with 62 buses from Santander to Madrid, while Evening sees the fewest connections between Santander and Madrid, with 9 offers.

Facts about the bus from Santander to Madrid

Compare all providers like ALSA and FlixBus that travel 22 times every day by bus from Santander to Madrid in one click! Book your bus ticket from Santander to Madrid starting from $37!

Cheapest Bus	$37
Fastest Bus	4h 40m
Earliest Bus	12:45 AM
Latest Bus	6:50 PM
Daily Bus Routes	22 Ø
Distance	210.6 miles
Bus Companies	ALSA and FlixBus

Cheapest bus connections from Santander to Madrid

Every day, 22 buses from 2 bus companies leave Santander for Madrid: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/05/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 11/30

Monday 12/01

Tuesday 12/02

Wednesday 12/03

Thursday 12/04

Friday 12/05

$42

Saturday 12/06

$41

Sunday 12/07

$41

Monday 12/08

$45

Tuesday 12/09

$43

Wednesday 12/10

$38

Thursday 12/11

$65

Friday 12/12

$41

Saturday 12/13

$38

Sunday 12/14

$38

Monday 12/15

$38

Tuesday 12/16

$38

Wednesday 12/17

$38

Thursday 12/18

$38

Friday 12/19

$37

Saturday 12/20

$41

Sunday 12/21

$107

Monday 12/22

$41

Tuesday 12/23

$37

Wednesday 12/24

$46

Thursday 12/25

$41

Friday 12/26

$106

Saturday 12/27

The cheapest time to travel from Santander to Madrid

See here on which day and which time of the day you can find the cheapest bus ticket from Santander to Madrid, for the next 30 days.

With a price starting from $37, Sunday is the cheapest day for a bus from Santander to Madrid. Wednesday instead is the most expensive day with prices starting from $38.

Afternoon is the cheapest day time for bus tickets from Santander to Madrid, with $37. Evening is the most expensive time of the day with prices starting from $65.

How to save money travelling from Santander to Madrid

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santander to Madrid in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santander to Madrid, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santander to Madrid are also emptier.

Beloved bus companies from Santander to Madrid

These are the most booked bus companies between Santander to Madrid from our users.

ALSA from Santander to Madrid

Here you will find the key facts about the ALSA bus route Santander to Madrid:

Cheapest Price	$37
Fastest Bus	4h 40m
Earliest Bus	12:45 AM
Last Bus	6:00 PM
Daily Connections	20 Ø
Found on	12/4/2025

All bus stations and stops in Santander and Madrid

In the map below, you can see where to find all bus stations in Santander and Madrid.

Bus Station

Plaza Las Estaciones

Bus Stop

Peñacastillo

Calle Camarreal-Ojaiz 65

Sardinero

Calle Real Racing Club

UIMP Bus Stop

Avenida de América Bus Station

Avenida de América 13

Bus Stop

Calle de Tiziano 40

Intercambiador de Moncloa

Calle de la Princesa 89n

Plaza de Castilla

Sur Bus Station

Calle de Méndez Álvaro 83

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Santander to Madrid? Compare all modes of transports from Santander to Madrid.

Service and Comfort on the bus from Santander to Madrid

Want to know which seat classes are available on the buses from Santander to Madrid? Or which bus companies serve the route Santander to Madrid? Below you will find answers to your questions.

FAQs about the Santander to Madrid bus

How much does a Santander Madrid bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $37 and takes 5h 30m to reach Madrid. Compare offers to save money!

How much could I save by comparing buses from Santander to Madrid?

This route is offered by 2 companies with a range of ticket prices between $37 and $170. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Madrid.

On average, how many connections are available from Santander to Madrid each day?

Every day, the Santander to Madrid bus route is served by approximately 22 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santander to Madrid take?

The fastest bus from Santander to Madrid is offered by ALSA and takes 4h 40m. Bus tickets for this connection cost $46. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santander to Madrid?

The earliest bus arriving in Madrid from Santander starts at 12:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santander to Madrid?

The latest bus trip departing from Santander for Madrid starts at 6:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santander Madrid route?

When traveling by bus from Santander to Madrid, passengers can travel with ALSA and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santander and Madrid?

You can check all the direct connections between Santander and Madrid by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ALSA and FlixBus.

What can I take with me on the Santander to Madrid bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santander Madrid bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santander Madrid bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santander to Madrid on your planned travel date.

Available seat classes which are offered on the bus route Santander to Madrid

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santander and to Madrid

Here’s an overview of the most popular bus routes to Santander and to Madrid. Simply click on the connection of your choice, and you will find all the details about your bus route!