Bus from Santander to Madrid from $36

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Compare all timetables for the bus from Santander to Madrid

Here is a selection of the cheapest bus trips from the schedule from Santander to Madrid from various bus operators like ALSA or FlixBus for the next days.

today
$40
tomorrow
$44
Friday
$43
Saturday
$40
Sunday
$43
Monday
$44
Tuesday
$41

Cheapest bus trips today

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 5h 45m 12:45 AM Santander Bus Station 6:30 AM Madrid Avenida de América Bus Station  Economy $40
ALSA 6h 15m 10:30 AM Santander Bus Station 4:45 PM Madrid Avenida de América Bus Station  Economy $42
ALSA 6h 45m 4:00 PM Santander Bus Station 10:45 PM Madrid Intercambiador de Moncloa  Economy $43
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $146
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $159

Cheapest bus trips tomorrow

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 6h 15m 10:30 AM Santander Bus Station 4:45 PM Madrid Avenida de América Bus Station  Economy $44
ALSA 6h 45m 4:00 PM Santander Bus Station 10:45 PM Madrid Intercambiador de Moncloa  Economy $44
ALSA 5h 30m 5:30 PM Santander Bus Station 11:00 PM Madrid Avenida de América Bus Station  Economy $47
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $156
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $198

Cheapest bus trips Friday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 6h 45m 4:00 PM Santander Bus Station 10:45 PM Madrid Intercambiador de Moncloa  Economy $43
ALSA 5h 30m 5:30 PM Santander Bus Station 11:00 PM Madrid Avenida de América Bus Station  Economy $46
ALSA 5h 30m 1:00 AM Santander Bus Station 6:30 AM Madrid Avenida de América Bus Station  Economy $48
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $108
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $139

Cheapest bus trips Saturday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 5h 45m 12:45 AM Santander Bus Station 6:30 AM Madrid Avenida de América Bus Station  Economy $40
ALSA 5h 50m 8:00 AM Santander Bus Station 1:50 PM Madrid Avenida de América Bus Station  Economy $42
ALSA 6h 45m 4:00 PM Santander Bus Station 10:45 PM Madrid Intercambiador de Moncloa  Economy $43
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $139
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $177

Cheapest bus trips Sunday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 6h 45m 4:00 PM Santander Bus Station 10:45 PM Madrid Intercambiador de Moncloa  Economy $43
ALSA 5h 30m 5:30 PM Santander Bus Station 11:00 PM Madrid Avenida de América Bus Station  Economy $46
ALSA 5h 30m 1:00 AM Santander Bus Station 6:30 AM Madrid Avenida de América Bus Station  Economy $48
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $150
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $198

Cheapest bus trips Monday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 6h 45m 4:00 PM Santander Bus Station 10:45 PM Madrid Intercambiador de Moncloa  Economy $44
ALSA 5h 30m 5:30 PM Santander Bus Station 11:00 PM Madrid Avenida de América Bus Station  Economy $47
ALSA 5h 30m 1:00 AM Santander Bus Station 6:30 AM Madrid Avenida de América Bus Station  Economy $49
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $113
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $117
  • Did you know that if you travel from Santander to Madrid via Burgos, you can save more than $4? You can find the corresponding connections below.
    • ALSA
      5h 50m
      0
      8:00 AM
      Santander
      Bus Station
      11:00 AM
      Burgos
      Bus Station
      0
      ALSA
      Economy
      $19
      • Waiting Time 0h 15m
    • ALSA
      2h 35m
      0
      11:15 AM
      Burgos
      Bus Station
      1:50 PM
      Madrid
      Avenida de América Bus Station
      0
      ALSA
      Economy
      $21
    Travel time is 0h 20m longer, but you will save $4

Cheapest bus trips Tuesday

Mode of Transport BertCompanyCountOneCompanyName Duration Departure time From Departure Arrival time To Destination Logo Seat classes Price
ALSA 5h 45m 12:45 AM Santander Bus Station 6:30 AM Madrid Avenida de América Bus Station  Economy $41
ALSA 5h 50m 8:00 AM Santander Bus Station 1:50 PM Madrid Avenida de América Bus Station  Economy $44
ALSA 6h 15m 10:30 AM Santander Bus Station 4:45 PM Madrid Avenida de América Bus Station  Economy $44
FlixBus 18h 30m 6:50 PM Santander Bus Station 1:20 PM Madrid Sur Bus Station  Economy $78
FlixBus 21h 45m 9:25 AM Santander Bus Station 7:10 AM Madrid Sur Bus Station  Economy $89

Best Price Offer: The price for the cheapest bus from Santander to Madrid is $36 on 5/2/2026. Flexible travelers save on ticket prices.


Frequency of bus connections between Santander and Madrid

See here how frequent the connections between Santander and Madrid are, during different times and days of the week.
Friday is the busiest day, with more than 29 daily buses from Santander to Madrid. Monday has instead the fewest connections, with only 16 daily coaches between Santander and Madrid.
The busiest time of the day is the Afternoon, with 64 buses from Santander to Madrid, while Evening sees the fewest connections between Santander and Madrid, with 9 offers.

Facts about the bus from Santander to Madrid

Compare all providers like ALSA and FlixBus that travel 22 times every day by bus from Santander to Madrid in one click! Book your bus ticket from Santander to Madrid starting from $36!

Cheapest Bus $36
Fastest Bus 5h 15m
Earliest Bus 12:45 AM
Latest Bus 6:50 PM
Daily Bus Routes 22 Ø
Distance 210.6 miles
Bus Companies ALSA and FlixBus

Cheapest bus connections from Santander to Madrid

Every day, 22 buses from 2 bus companies leave Santander for Madrid: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 04/29/2026 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 04/26
Monday 04/27
Tuesday 04/28
Wednesday 04/29
$40
Thursday 04/30
$44
Friday 05/01
$50
Saturday 05/02
$36
Sunday 05/03
$46
Monday 05/04
$44
Tuesday 05/05
$45
Wednesday 05/06
$42
Thursday 05/07
$71
Friday 05/08
$45
Saturday 05/09
$42
Sunday 05/10
$39
Monday 05/11
$95
Tuesday 05/12
$42
Wednesday 05/13
$40
Thursday 05/14
$40
Friday 05/15
$43
Saturday 05/16
$42
Sunday 05/17
$43
Monday 05/18
$42
Tuesday 05/19
$42
Wednesday 05/20
$40
Thursday 05/21
$40
Friday 05/22
$42
Saturday 05/23

The cheapest time to travel from Santander to Madrid

See here on which day and which time of the day you can find the cheapest bus ticket from Santander to Madrid, for the next 30 days.
With a price starting from $12, Saturday is the cheapest day for a bus from Santander to Madrid. Monday instead is the most expensive day with prices starting from $42.
Night is the cheapest day time for bus tickets from Santander to Madrid, with $12. Evening is the most expensive time of the day with prices starting from $78.

How to save money travelling from Santander to Madrid

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Santander to Madrid in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Santander to Madrid, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Santander to Madrid are also emptier.

Beloved bus companies from Santander to Madrid

These are the most booked bus companies between Santander to Madrid from our users.

ALSA from Santander to Madrid

ALSA

Here you will find the key facts about the ALSA bus route Santander to Madrid:

Cheapest Price $40
Fastest Bus 5h 15m
Earliest Bus 12:45 AM
Last Bus 5:30 PM
Daily Connections 20 Ø
Found on 4/28/2026

All bus stations and stops in Santander and Madrid

In the map below, you can see where to find all bus stations in Santander and Madrid.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Santander to Madrid? Compare all modes of transports from Santander to Madrid.

Service and Comfort on the bus from Santander to Madrid

Want to know which seat classes are available on the buses from Santander to Madrid? Or which bus companies serve the route Santander to Madrid? Below you will find answers to your questions.

FAQs about the Santander to Madrid bus

How much does a Santander Madrid bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $36 and takes 5h 45m to reach Madrid. Compare offers to save money!

How much could I save by comparing buses from Santander to Madrid?

This route is offered by 2 companies with a range of ticket prices between $36 and $198. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Madrid.

On average, how many connections are available from Santander to Madrid each day?

Every day, the Santander to Madrid bus route is served by approximately 22 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Santander to Madrid take?

The fastest bus from Santander to Madrid is offered by ALSA and takes 5h 15m. Bus tickets for this connection cost $71. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Santander to Madrid?

The earliest bus arriving in Madrid from Santander starts at 12:45 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Santander to Madrid?

The latest bus trip departing from Santander for Madrid starts at 6:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Santander Madrid route?

When traveling by bus from Santander to Madrid, passengers can travel with ALSA and FlixBus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Santander and Madrid?

You can check all the direct connections between Santander and Madrid by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: ALSA and FlixBus.

What can I take with me on the Santander to Madrid bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Santander Madrid bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Santander Madrid bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Santander to Madrid on your planned travel date.

How does CheckMyBus find the best bus deals from Santander to Madrid?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 22 daily trips between Santander and Madrid. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Santander to Madrid?

Prices and availability for 22 trips between Santander and Madrid change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Santander to Madrid

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to Santander and to Madrid

Here’s an overview of the most popular bus routes to Santander and to Madrid. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Vivar del Cid to Santander Bus Vivar del Cid to Santander
Bus from Los Corrales de Buelna to Santander Bus from Los Corrales de Buelna to Santander
Bus Torrelavega to Santander Bus Torrelavega to Santander
Buses to Santander from Llanes Buses to Santander from Llanes
From Lille to Madrid bus From Lille to Madrid bus
Sofia to Madrid bus Sofia to Madrid bus
From Tordesillas to Madrid bus From Tordesillas to Madrid bus
Cáceres‎‎ (ES) to Madrid bus Cáceres‎‎ (ES) to Madrid bus
Popular Airport Shuttles to Santander and to Madrid
CheckMyBus › Buses in Spain › Bus to Santander › Bus to Madrid

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