Bus from Messina to Milan from $49

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Compare all timetables for the bus from Messina to Milan

Here is a selection of the cheapest bus trips from the schedule from Messina to Milan from various bus operators like FlixBus, Autoservizi Salemi or Itabus for the next days.
today
from $49
tomorrow
from $70
Sunday
from $85
Monday
from $77
Tuesday
from $55
Wednesday
from $61
Thursday
from $60

Cheapest bus trips today

Prices are for one way and one person
  • Itabus
    18h 55m
    0
    10:15 PM
    Messina
    Central Station
    5:10 PM
    Milan
    Lampugnano Bus Station
    0
    Itabus
    Premium Economy
    $49
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $86
  • Autoservizi Salemi
    16h 5m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:10 PM
    Milan
    San Donato Bus Station
    0
    Autoservizi Salemi
    Economy
    $92
  • Itabus
    22h 0m
    0
    10:15 PM
    Messina
    Central Station
    8:15 PM
    Milan
    Lampugnano Bus Station
    0
    Itabus
    Premium Economy
    $96
  • FlixBus
    18h 20m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    2:35 PM
    Milan
    San Donato Bus Station
    0
    FlixBus
    Economy
    $99
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $2? You will find the corresponding connections below.
    • Save more than 4%
      19h 50m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Central Station
      3:10 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Premium Economy
      $47

Cheapest bus trips tomorrow

Prices are for one way and one person
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $70
  • FlixBus
    17h 25m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    1:40 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $89
  • FlixBus
    19h 0m
    0
    10:55 AM
    Messina
    Piazza della Repubblica
    5:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $91
  • Autoservizi Salemi
    16h 5m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:10 PM
    Milan
    San Donato Bus Station
    0
    Autoservizi Salemi
    Economy
    $92
  • Autoservizi Salemi
    16h 45m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:50 PM
    Milan
    Lampugnano Bus Station
    0
    Autoservizi Salemi
    Economy
    $92
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $27? You will find the corresponding connections below.
    • Save more than 39%
      19h 50m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Central Station
      3:10 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Premium Economy
      $43
  • Did you know that if you travel from Messina to Milan via Rome, you can save more than $23? You can find the corresponding connections below.
    • FlixBus
      19h 50m
      0
      10:55 AM
      Messina
      Piazza della Repubblica
      9:30 PM
      Rome
      Tiburtina Bus Station
      0
      FlixBus
      Economy
      $36
      • Waiting Time 1h 30m
    • Distribusion
      7h 45m
      0
      11:00 PM
      Rome
      Tiburtina Bus Station
      6:45 AM
      Milan
      San Donato Bus Station
      0
      Distribusion
      Premium Economy
      $11
    Travel time is 3h 45m longer, but you will save $23

Cheapest bus trips Sunday

Prices are for one way and one person
  • FlixBus
    17h 25m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    1:40 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $85
  • Autoservizi Salemi
    16h 5m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:10 PM
    Milan
    San Donato Bus Station
    0
    Autoservizi Salemi
    Economy
    $90
  • Autoservizi Salemi
    16h 45m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:50 PM
    Milan
    Lampugnano Bus Station
    0
    Autoservizi Salemi
    Economy
    $90
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $94
  • Itabus
    18h 55m
    0
    10:15 PM
    Messina
    Piazza della Repubblica
    5:10 PM
    Milan
    Lampugnano Bus Station
    0
    Itabus
    Economy
    $98
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $53? You will find the corresponding connections below.
    • Save more than 62%
      19h 25m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Central Station
      2:45 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Premium Economy
      $32
  • Did you know that if you travel from Messina to Milan via Rome, you can save more than $44? You can find the corresponding connections below.
    • FlixBus
      21h 35m
      0
      10:55 AM
      Messina
      Piazza della Repubblica
      9:30 PM
      Rome
      Tiburtina Bus Station
      0
      FlixBus
      Economy
      $26
      • Waiting Time 2h 20m
    • FlixBus
      8h 40m
      0
      11:50 PM
      Rome
      Tiburtina Bus Station
      8:30 AM
      Milan
      San Donato Bus Station
      0
      FlixBus
      Economy
      $16
    Travel time is 5h 30m longer, but you will save $44

Cheapest bus trips Monday

Prices are for one way and one person
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $77
  • FlixBus
    17h 25m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    1:40 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $85
  • FlixBus
    18h 20m
    0
    10:55 AM
    Messina
    Piazza della Repubblica
    5:15 AM
    Milan
    San Donato Bus Station
    0
    FlixBus
    Economy
    $93
  • FlixBus
    19h 0m
    0
    10:55 AM
    Messina
    Piazza della Repubblica
    5:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $93
  • FlixBus
    19h 45m
    0
    9:30 PM
    Messina
    Piazza della Repubblica
    5:15 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $98
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $39? You will find the corresponding connections below.
    • Save more than 51%
      19h 25m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Central Station
      2:45 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Premium Economy
      $38
  • Did you know that if you travel from Messina to Milan via Rome, you can save more than $41? You can find the corresponding connections below.
    • FlixBus
      21h 45m
      0
      9:25 PM
      Messina
      Piazza della Repubblica
      7:00 AM
      Rome
      Tiburtina Bus Station
      0
      FlixBus
      Economy
      $27
      • Waiting Time 2h 15m
    • FlixBus
      9h 55m
      0
      9:15 AM
      Rome
      Tiburtina Bus Station
      7:10 PM
      Milan
      Lampugnano Bus Station
      0
      FlixBus
      Economy
      $9
    Travel time is 4h 20m longer, but you will save $41

Cheapest bus trips Tuesday

Prices are for one way and one person
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $55
  • FlixBus
    19h 50m
    0
    9:25 PM
    Messina
    Piazza della Repubblica
    5:15 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $56
  • Autoservizi Salemi
    16h 45m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:50 PM
    Milan
    Lampugnano Bus Station
    0
    Autoservizi Salemi
    Economy
    $92
  • Sais Trasporti
    20h 35m
    0
    10:20 PM
    Messina
    Central Station
    6:55 PM
    Milan
    Lampugnano Bus Station
    0
    Sais Trasporti
    Economy
    $99
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $17? You will find the corresponding connections below.
    • Save more than 31%
      19h 25m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Central Station
      2:45 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Premium Economy
      $38
  • Did you know that if you travel from Messina to Milan via Rome, you can save more than $19? You can find the corresponding connections below.
    • FlixBus
      21h 45m
      0
      9:25 PM
      Messina
      Piazza della Repubblica
      7:00 AM
      Rome
      Tiburtina Bus Station
      0
      FlixBus
      Economy
      $27
      • Waiting Time 2h 15m
    • FlixBus
      9h 55m
      0
      9:15 AM
      Rome
      Tiburtina Bus Station
      7:10 PM
      Milan
      Lampugnano Bus Station
      0
      FlixBus
      Economy
      $9
    Travel time is 5h 0m longer, but you will save $19

Cheapest bus trips Wednesday

Prices are for one way and one person
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $61
  • FlixBus
    17h 25m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    1:40 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $78
  • FlixBus
    18h 20m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    2:35 PM
    Milan
    San Donato Bus Station
    0
    FlixBus
    Economy
    $80
  • Autoservizi Salemi
    16h 5m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:10 PM
    Milan
    San Donato Bus Station
    0
    Autoservizi Salemi
    Economy
    $89
  • Autoservizi Salemi
    16h 45m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:50 PM
    Milan
    Lampugnano Bus Station
    0
    Autoservizi Salemi
    Economy
    $89
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $29? You will find the corresponding connections below.
    • Save more than 48%
      19h 50m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Via Caprera / Piazza Giuseppe Garibaldi
      3:10 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Economy
      $32
  • Did you know that if you travel from Messina to Milan via Rome, you can save more than $25? You can find the corresponding connections below.
    • FlixBus
      21h 45m
      0
      9:25 PM
      Messina
      Piazza della Repubblica
      7:00 AM
      Rome
      Tiburtina Bus Station
      0
      FlixBus
      Economy
      $27
      • Waiting Time 2h 15m
    • FlixBus
      9h 55m
      0
      9:15 AM
      Rome
      Tiburtina Bus Station
      7:10 PM
      Milan
      Lampugnano Bus Station
      0
      FlixBus
      Economy
      $9
    Travel time is 5h 40m longer, but you will save $25

Cheapest bus trips Thursday

Prices are for one way and one person
  • FlixBus
    19h 45m
    0
    4:10 PM
    Messina
    Piazza della Repubblica
    11:55 AM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $60
  • FlixBus
    17h 25m
    0
    8:15 PM
    Messina
    Piazza della Repubblica
    1:40 PM
    Milan
    Lampugnano Bus Station
    0
    FlixBus
    Economy
    $67
  • Itabus
    22h 0m
    0
    10:15 PM
    Messina
    Central Station
    8:15 PM
    Milan
    Lampugnano Bus Station
    0
    Itabus
    Premium Economy
    $68
  • Itabus
    18h 55m
    0
    10:15 PM
    Messina
    Central Station
    5:10 PM
    Milan
    Lampugnano Bus Station
    0
    Itabus
    Premium Economy
    $68
  • Autoservizi Salemi
    16h 5m
    0
    9:05 PM
    Messina
    Piazza della Repubblica
    1:10 PM
    Milan
    San Donato Bus Station
    0
    Autoservizi Salemi
    Economy
    $92
  • Did you know that if you travel from Messina to Milan via Reggio Calabria, you can save more than $20? You will find the corresponding connections below.
    • Save more than 33%
      19h 50m
      Messina
      8 mi
      7:20 PM
      Reggio Calabria
      Central Station
      3:10 PM
      Milan
      Lampugnano Bus Station
      0 mi
      Premium Economy
      $40
  • Did you know that if you travel from Messina to Milan via Rome, you can save more than $24? You can find the corresponding connections below.
    • FlixBus
      21h 45m
      0
      9:25 PM
      Messina
      Piazza della Repubblica
      7:00 AM
      Rome
      Tiburtina Bus Station
      0
      FlixBus
      Economy
      $27
      • Waiting Time 2h 15m
    • FlixBus
      9h 55m
      0
      9:15 AM
      Rome
      Tiburtina Bus Station
      7:10 PM
      Milan
      Lampugnano Bus Station
      0
      FlixBus
      Economy
      $9
    Travel time is 5h 40m longer, but you will save $24

Frequency of bus connections between Messina and Milan

See here how frequent the connections between Messina and Milan are, during different times and days of the week.
Sunday is the busiest day, with more than 15 daily buses from Messina to Milan. Monday has instead the fewest connections, with only 8 daily coaches between Messina and Milan.
The busiest time of the day is the Evening, with 57 buses from Messina to Milan, while Afternoon sees the fewest connections between Messina and Milan, with 7 offers.

Facts about the bus from Messina to Milan

Compare all providers like FlixBus, Autoservizi Salemi and Itabus that travel 11 times every day by bus from Messina to Milan in one click! Book your bus ticket from Messina to Milan starting from $49!

Cheapest Bus $49
Fastest Bus 16h 5m
Earliest Bus 10:55 AM
Latest Bus 10:50 PM
Daily Bus Routes 11 Ø
Distance 599.7 miles
Bus Companies FlixBus, Autoservizi Salemi, Itabus and Sais Trasporti

Cheapest bus connections from Messina to Milan

Every day, 11 buses from 4 bus companies leave Messina for Milan: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 06/13/2025 and for the following days.

Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Sunday 06/08
Monday 06/09
Tuesday 06/10
Wednesday 06/11
Thursday 06/12
Friday 06/13
$49
Saturday 06/14
$70
Sunday 06/15
$85
Monday 06/16
$77
Tuesday 06/17
$55
Wednesday 06/18
$61
Thursday 06/19
$60
Friday 06/20
$66
Saturday 06/21
$68
Sunday 06/22
$78
Monday 06/23
$77
Tuesday 06/24
$62
Wednesday 06/25
$58
Thursday 06/26
$83
Friday 06/27
$63
Saturday 06/28
$66
Sunday 06/29
$66
Monday 06/30
$55
Tuesday 07/01
$66
Wednesday 07/02
$58
Thursday 07/03
$66
Friday 07/04
$61
Saturday 07/05

The cheapest time to travel from Messina to Milan

See here on which day and which time of the day you can find the cheapest bus ticket from Messina to Milan, for the next 30 days.
With a price starting from $49, Friday is the cheapest day for a bus from Messina to Milan. Sunday instead is the most expensive day with prices starting from $85.
Evening is the cheapest day time for bus tickets from Messina to Milan, with $49. Morning is the most expensive time of the day with prices starting from $91.

How to save money travelling from Messina to Milan

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Messina to Milan in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Messina to Milan, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Messina to Milan are also emptier.

Beloved bus companies from Messina to Milan

These are the most booked bus companies between Messina to Milan from our users.

FlixBus from Messina to Milan

FlixBus

Here you will find the key facts about the FlixBus bus route Messina to Milan:

Cheapest Price $55
Fastest Bus 17h 25m
Earliest Bus 10:55 AM
Last Bus 10:50 PM
Daily Connections 7 Ø
Found on 6/11/2025

Autoservizi Salemi from Messina to Milan

Autoservizi Salemi

Here you will find the key facts about the Autoservizi Salemi bus route Messina to Milan:

Cheapest Price $89
Fastest Bus 16h 5m
Earliest Bus 9:05 PM
Last Bus 9:05 PM
Daily Connections 2 Ø
Found on 5/19/2025

Itabus from Messina to Milan

Itabus

Here you will find the key facts about the Itabus bus route Messina to Milan:

Cheapest Price $49
Fastest Bus 18h 55m
Earliest Bus 10:15 PM
Last Bus 10:15 PM
Daily Connections 3 Ø
Found on 6/11/2025

All bus stations and stops in Messina and Milan

In the map below, you can see where to find all bus stations in Messina and Milan.

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Messina to Milan? Compare all modes of transports from Messina to Milan.

Service and Comfort on the bus from Messina to Milan

Want to know which seat classes are available on the buses from Messina to Milan? Or which bus companies serve the route Messina to Milan? Below you will find answers to your questions.

FAQs about the Messina to Milan bus

How much does a Messina Milan bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $49 and takes 18h 55m to reach Milan. Compare offers to save money!

How much could I save by comparing buses from Messina to Milan?

This route is offered by 4 companies with a range of ticket prices between $49 and $152. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Milan.

On average, how many connections are available from Messina to Milan each day?

Every day, the Messina to Milan bus route is served by approximately 11 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Messina to Milan take?

The fastest bus from Messina to Milan is offered by Autoservizi Salemi and takes 16h 5m. Bus tickets for this connection cost $92. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Messina to Milan?

The earliest bus arriving in Milan from Messina starts at 10:55 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Messina to Milan?

The latest bus trip departing from Messina for Milan starts at 10:50 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Messina Milan route?

When traveling by bus from Messina to Milan, passengers can travel with FlixBus, Autoservizi Salemi and Itabus. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Messina and Milan?

You can check all the direct connections between Messina and Milan by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Autoservizi Salemi and Itabus.

What can I take with me on the Messina to Milan bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Messina Milan bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Messina Milan bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Messina to Milan on your planned travel date.

Available seat classes which are offered on the bus route Messina to Milan

Economy
Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy
PremiumEconomy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Messina and to Milan

Here’s an overview of the most popular bus routes to Messina and to Milan. Simply click on the connection of your choice, and you will find all the details about your bus route!
Bus Taormina - Messina Bus Taormina - Messina
Buses Palermo to Messina Buses Palermo to Messina
Buses from Catania to Messina Buses from Catania to Messina
Buses from Bari to Messina Buses from Bari to Messina
From Florence to Milan bus From Florence to Milan bus
Bus to Milan from Amsterdam Bus to Milan from Amsterdam
Buses from Turin to Milan Buses from Turin to Milan
Geneva to Milan bus Geneva to Milan bus
Popular Airport Shuttles to Messina and to Milan
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