Bus Milan to Messina: Compare prices and save money

Compare all timetables for the bus from Milan to Messina

Here is a selection of the cheapest bus trips from the schedule from Milan to Messina from various bus operators like FlixBus, Itabus or Autoservizi Salemi for the next days.

today

$94

tomorrow

$90

Saturday

$94

Sunday

$84

Monday

$94

Tuesday

$86

Wednesday

$64

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	18h 30m	11:15 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$94	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/18/2025 11:15:00 AM to Central Station, Messina (Italy) arriving at 12/19/2025 5:45:00 AM. 50 Premium Economy ticket for $94 per person are available. Travel duration is 18h 30m
Itabus	19h 25m	10:20 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Piazza della Repubblica	Economy	$96	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/18/2025 10:20:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/19/2025 5:45:00 AM. 50 Economy ticket for $96 per person are available. Travel duration is 19h 25m
Autoservizi Salemi	18h 40m	10:00 AM	Milan	Lampugnano Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$126	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 12/18/2025 10:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/19/2025 4:40:00 AM. 50 Basic ticket for $126 per person are available. Travel duration is 18h 40m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$126	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 12/18/2025 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/19/2025 4:40:00 AM. 50 Basic ticket for $126 per person are available. Travel duration is 17h 55m
FlixBus	20h 30m	11:20 PM	Milan	San Donato Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$129	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 12/18/2025 11:20:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/19/2025 7:50:00 PM. 50 Economy ticket for $129 per person are available. Travel duration is 20h 30m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $17? You can find the corresponding connections below.
- FlixBus
  
  23h 25m
  
  0
  
  5:15 AM
  
  Milan
  Lampugnano Bus Station
  
  1:50 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Economy
  
  $32
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 5:15:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/19/2025 1:50:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 8h 35m
- Bookaway
  
  9h 55m
  
  0
  
  6:45 PM
  
  Rome
  Tiburtina Bus Station
  
  4:40 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Basic
  
  $45
  
  A Bus from Bookaway goes from Tiburtina Bus Station, Rome (Italy) at 12/19/2025 6:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 4:40:00 AM. 50 Basic ticket for $45 per person are available. Travel duration is 9h 55m
Travel time is 5h 30m longer, but you will save $17

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	24h 50m	6:00 AM	Milan	Lampugnano Bus Station	6:50 AM	Messina	Central Station	Premium Economy	$90	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 6:00:00 AM to Central Station, Messina (Italy) arriving at 12/20/2025 6:50:00 AM. 50 Premium Economy ticket for $90 per person are available. Travel duration is 24h 50m
Itabus	19h 15m	9:25 AM	Milan	Lampugnano Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$92	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 9:25:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 4:40:00 AM. 50 Basic ticket for $92 per person are available. Travel duration is 19h 15m
Autoservizi Salemi	18h 40m	10:00 AM	Milan	Lampugnano Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$128	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 10:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 4:40:00 AM. 50 Basic ticket for $128 per person are available. Travel duration is 18h 40m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$128	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 12/19/2025 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 4:40:00 AM. 50 Basic ticket for $128 per person are available. Travel duration is 17h 55m
FlixBus	21h 5m	8:50 PM	Milan	Lampugnano Bus Station	5:55 PM	Messina	Piazza della Repubblica	Economy	$154	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 8:50:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 5:55:00 PM. 50 Economy ticket for $154 per person are available. Travel duration is 21h 5m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $13? You can find the corresponding connections below.
- FlixBus
  
  23h 25m
  
  0
  
  5:15 AM
  
  Milan
  Lampugnano Bus Station
  
  1:50 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Economy
  
  $32
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 5:15:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/19/2025 1:50:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 8h 35m
- Bookaway
  
  9h 55m
  
  0
  
  6:45 PM
  
  Rome
  Tiburtina Bus Station
  
  4:40 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Basic
  
  $45
  
  A Bus from Bookaway goes from Tiburtina Bus Station, Rome (Italy) at 12/19/2025 6:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 4:40:00 AM. 50 Basic ticket for $45 per person are available. Travel duration is 9h 55m
Travel time is 5h 30m longer, but you will save $13

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	18h 30m	11:15 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$94	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/20/2025 11:15:00 AM to Central Station, Messina (Italy) arriving at 12/21/2025 5:45:00 AM. 50 Premium Economy ticket for $94 per person are available. Travel duration is 18h 30m
Itabus	24h 0m	6:50 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Piazza della Repubblica	Basic	$95	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 12/20/2025 6:50:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/21/2025 6:50:00 AM. 50 Basic ticket for $95 per person are available. Travel duration is 24h 0m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$109	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 12/20/2025 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/21/2025 4:40:00 AM. 50 Basic ticket for $109 per person are available. Travel duration is 17h 55m
Autoservizi Salemi	18h 40m	10:00 AM	Milan	Lampugnano Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$120	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 12/20/2025 10:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/21/2025 4:40:00 AM. 50 Basic ticket for $120 per person are available. Travel duration is 18h 40m
FlixBus	21h 20m	8:35 PM	Milan	Lampugnano Bus Station	5:55 PM	Messina	Piazza della Repubblica	Economy	$152	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/20/2025 8:35:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/21/2025 5:55:00 PM. 50 Economy ticket for $152 per person are available. Travel duration is 21h 20m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $17? You can find the corresponding connections below.
- FlixBus
  
  23h 25m
  
  0
  
  5:15 AM
  
  Milan
  Lampugnano Bus Station
  
  1:50 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Economy
  
  $32
  
  A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/19/2025 5:15:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/19/2025 1:50:00 PM. 50 Economy ticket for $32 per person are available. Travel duration is 8h 35m
- Bookaway
  
  9h 55m
  
  0
  
  6:45 PM
  
  Rome
  Tiburtina Bus Station
  
  4:40 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Basic
  
  $45
  
  A Bus from Bookaway goes from Tiburtina Bus Station, Rome (Italy) at 12/19/2025 6:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/20/2025 4:40:00 AM. 50 Basic ticket for $45 per person are available. Travel duration is 9h 55m
Travel time is 5h 30m longer, but you will save $17

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	24h 50m	6:00 AM	Milan	Lampugnano Bus Station	6:50 AM	Messina	Piazza della Repubblica	Basic	$84	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/21/2025 6:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/22/2025 6:50:00 AM. 50 Basic ticket for $84 per person are available. Travel duration is 24h 50m
Itabus	24h 0m	6:50 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Piazza della Repubblica	Basic	$84	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 12/21/2025 6:50:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/22/2025 6:50:00 AM. 50 Basic ticket for $84 per person are available. Travel duration is 24h 0m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$132	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 12/21/2025 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/22/2025 4:40:00 AM. 50 Basic ticket for $132 per person are available. Travel duration is 17h 55m
FlixBus	19h 15m	12:35 AM	Milan	Lampugnano Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$155	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/21/2025 12:35:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/21/2025 7:50:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 19h 15m
FlixBus	17h 25m	12:55 PM	Milan	Lampugnano Bus Station	6:20 AM	Messina	Piazza della Repubblica	Economy	$155	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/21/2025 12:55:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/22/2025 6:20:00 AM. 50 Economy ticket for $155 per person are available. Travel duration is 17h 25m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $13? You can find the corresponding connections below.
- Distribusion
  
  24h 0m
  
  0
  
  6:50 AM
  
  Milan
  San Donato Bus Station
  
  3:00 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $27
  
  A Bus from Distribusion goes from San Donato Bus Station, Milan (Italy) at 12/22/2025 6:50:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/22/2025 3:00:00 PM. 50 Premium Economy ticket for $27 per person are available. Travel duration is 8h 10m
- Bookaway
  
  14h 25m
  
  0
  
  4:25 PM
  
  Rome
  Tiburtina Bus Station
  
  6:50 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Basic
  
  $44
  
  A Bus from Bookaway goes from Tiburtina Bus Station, Rome (Italy) at 12/22/2025 4:25:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/23/2025 6:50:00 AM. 50 Basic ticket for $44 per person are available. Travel duration is 14h 25m
Travel time is 6h 35m longer, but you will save $13

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	18h 30m	11:15 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$94	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/22/2025 11:15:00 AM to Central Station, Messina (Italy) arriving at 12/23/2025 5:45:00 AM. 50 Premium Economy ticket for $94 per person are available. Travel duration is 18h 30m
Itabus	19h 25m	10:20 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Piazza della Repubblica	Economy	$109	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/22/2025 10:20:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/23/2025 5:45:00 AM. 50 Economy ticket for $109 per person are available. Travel duration is 19h 25m
Autoservizi Salemi	18h 40m	10:00 AM	Milan	Lampugnano Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$125	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 12/22/2025 10:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/23/2025 4:40:00 AM. 50 Basic ticket for $125 per person are available. Travel duration is 18h 40m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$125	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 12/22/2025 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/23/2025 4:40:00 AM. 50 Basic ticket for $125 per person are available. Travel duration is 17h 55m
FlixBus	19h 15m	12:35 AM	Milan	Lampugnano Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$155	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/22/2025 12:35:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/22/2025 7:50:00 PM. 50 Economy ticket for $155 per person are available. Travel duration is 19h 15m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $23? You can find the corresponding connections below.
- Distribusion
  
  24h 0m
  
  0
  
  6:50 AM
  
  Milan
  San Donato Bus Station
  
  3:00 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $27
  
  A Bus from Distribusion goes from San Donato Bus Station, Milan (Italy) at 12/22/2025 6:50:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/22/2025 3:00:00 PM. 50 Premium Economy ticket for $27 per person are available. Travel duration is 8h 10m
- Bookaway
  
  14h 25m
  
  0
  
  4:25 PM
  
  Rome
  Tiburtina Bus Station
  
  6:50 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Basic
  
  $44
  
  A Bus from Bookaway goes from Tiburtina Bus Station, Rome (Italy) at 12/22/2025 4:25:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/23/2025 6:50:00 AM. 50 Basic ticket for $44 per person are available. Travel duration is 14h 25m
Travel time is 6h 5m longer, but you will save $23

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	24h 50m	6:00 AM	Milan	Lampugnano Bus Station	6:50 AM	Messina	Central Station	Premium Economy	$86	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/23/2025 6:00:00 AM to Central Station, Messina (Italy) arriving at 12/24/2025 6:50:00 AM. 50 Premium Economy ticket for $86 per person are available. Travel duration is 24h 50m
Itabus	18h 30m	11:15 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$94	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/23/2025 11:15:00 AM to Central Station, Messina (Italy) arriving at 12/24/2025 5:45:00 AM. 50 Premium Economy ticket for $94 per person are available. Travel duration is 18h 30m
Autoservizi Salemi	18h 40m	10:00 AM	Milan	Lampugnano Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$116	A Bus from Autoservizi Salemi goes from Lampugnano Bus Station, Milan (Italy) at 12/23/2025 10:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/24/2025 4:40:00 AM. 50 Basic ticket for $116 per person are available. Travel duration is 18h 40m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Basic	$116	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 12/23/2025 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/24/2025 4:40:00 AM. 50 Basic ticket for $116 per person are available. Travel duration is 17h 55m
FlixBus	19h 15m	12:35 AM	Milan	Lampugnano Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$164	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/23/2025 12:35:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/23/2025 7:50:00 PM. 50 Economy ticket for $164 per person are available. Travel duration is 19h 15m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $30? You can find the corresponding connections below.
- Bookaway
  
  24h 0m
  
  0
  
  6:50 AM
  
  Milan
  San Donato Bus Station
  
  3:00 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Basic
  
  $32
  
  A Bus from Bookaway goes from San Donato Bus Station, Milan (Italy) at 12/24/2025 6:50:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/24/2025 3:00:00 PM. 50 Basic ticket for $32 per person are available. Travel duration is 8h 10m
- INFOBUS
  
  14h 25m
  
  0
  
  4:25 PM
  
  Rome
  Tiburtina Bus Station
  
  6:50 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $24
  
  A Bus from INFOBUS goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 4:25:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 6:50:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 14h 25m
Travel time is 6h 5m longer, but you will save $30

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	24h 0m	6:50 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Piazza della Repubblica	Basic	$64	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 12/24/2025 6:50:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 6:50:00 AM. 50 Basic ticket for $64 per person are available. Travel duration is 24h 0m
Itabus	18h 30m	11:15 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Piazza della Repubblica	Basic	$71	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/24/2025 11:15:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 5:45:00 AM. 50 Basic ticket for $71 per person are available. Travel duration is 18h 30m
Itabus	24h 50m	6:00 AM	Milan	Lampugnano Bus Station	6:50 AM	Messina	Piazza della Repubblica	Basic	$76	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 12/24/2025 6:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 6:50:00 AM. 50 Basic ticket for $76 per person are available. Travel duration is 24h 50m
FlixBus	21h 50m	10:00 PM	Milan	Lampugnano Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$133	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/24/2025 10:00:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 7:50:00 PM. 50 Economy ticket for $133 per person are available. Travel duration is 21h 50m
FlixBus	24h 10m	5:45 PM	Milan	Lampugnano Bus Station	5:55 PM	Messina	Piazza della Repubblica	Economy	$139	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 12/24/2025 5:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 5:55:00 PM. 50 Economy ticket for $139 per person are available. Travel duration is 24h 10m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $8? You can find the corresponding connections below.
- Bookaway
  
  24h 0m
  
  0
  
  6:50 AM
  
  Milan
  San Donato Bus Station
  
  3:00 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Basic
  
  $32
  
  A Bus from Bookaway goes from San Donato Bus Station, Milan (Italy) at 12/24/2025 6:50:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 12/24/2025 3:00:00 PM. 50 Basic ticket for $32 per person are available. Travel duration is 8h 10m
- INFOBUS
  
  14h 25m
  
  0
  
  4:25 PM
  
  Rome
  Tiburtina Bus Station
  
  6:50 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $24
  
  A Bus from INFOBUS goes from Tiburtina Bus Station, Rome (Italy) at 12/24/2025 4:25:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 12/25/2025 6:50:00 AM. 50 Economy ticket for $24 per person are available. Travel duration is 14h 25m
Travel time is 5h 30m longer, but you will save $8

Best Price Offer: The price for the cheapest bus from Milan to Messina is $33 on 1/9/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Milan and Messina

See here how frequent the connections between Milan and Messina are, during different times and days of the week.

Friday is the busiest day, with more than 40 daily buses from Milan to Messina. Thursday has instead the fewest connections, with only 12 daily coaches between Milan and Messina.

The busiest time of the day is the Morning, with 101 buses from Milan to Messina, while Night sees the fewest connections between Milan and Messina, with 12 offers.

Facts about the bus from Milan to Messina

Compare all providers like FlixBus, Itabus and Autoservizi Salemi that travel 23 times every day by bus from Milan to Messina in one click! Book your bus ticket from Milan to Messina starting from $33!

Cheapest Bus	$33
Fastest Bus	17h 25m
Earliest Bus	9:40 AM
Latest Bus	10:00 PM
Daily Bus Routes	23 Ø
Distance	599.7 miles
Bus Companies	FlixBus, Itabus and Autoservizi Salemi

Cheapest bus connections from Milan to Messina

Every day, 23 buses from 3 bus companies leave Milan for Messina: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 12/18/2025 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 12/14

Monday 12/15

Tuesday 12/16

Wednesday 12/17

Thursday 12/18

$129

Friday 12/19

$130

Saturday 12/20

$94

Sunday 12/21

$90

Monday 12/22

$94

Tuesday 12/23

$87

Wednesday 12/24

$76

Thursday 12/25

$85

Friday 12/26

$99

Saturday 12/27

$95

Sunday 12/28

$80

Monday 12/29

$65

Tuesday 12/30

$87

Wednesday 12/31

$73

Thursday 01/01

$39

Friday 01/02

$81

Saturday 01/03

$46

Sunday 01/04

$42

Monday 01/05

$47

Tuesday 01/06

$46

Wednesday 01/07

$57

Thursday 01/08

$41

Friday 01/09

$33

Saturday 01/10

The cheapest time to travel from Milan to Messina

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Messina, for the next 30 days.

With a price starting from $26, Monday is the cheapest day for a bus from Milan to Messina. Wednesday instead is the most expensive day with prices starting from $57.

Night is the cheapest day time for bus tickets from Milan to Messina, with $26. Afternoon is the most expensive time of the day with prices starting from $130.

How to save money travelling from Milan to Messina

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Messina in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Messina, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Messina are also emptier.

All bus stations and stops in Milan and Messina

In the map below, you can see where to find all bus stations in Milan and Messina.

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Duomo Bus Stop

Piazza del Duomo

Central Bus Station

Piazza della Repubblica

Piazza della Repubblica 25

Via Taormina - Policlinico Bus Stop

SS114 Orientale Sicula Bus Stop

V. Nazionale; 56 - S. Margherita Bus Stop

Viale Gazzi Bus Stop

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from Milan to Messina? Compare all modes of transports from Milan to Messina.

Service and Comfort on the bus from Milan to Messina

Want to know which seat classes are available on the buses from Milan to Messina? Or which bus companies serve the route Milan to Messina? Below you will find answers to your questions.

FAQs about the Milan to Messina bus

How much does a Milan Messina bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $33 and takes 24h 0m to reach Messina. Compare offers to save money!

How much could I save by comparing buses from Milan to Messina?

This route is offered by 3 companies with a range of ticket prices between $33 and $223. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Messina.

On average, how many connections are available from Milan to Messina each day?

Every day, the Milan to Messina bus route is served by approximately 23 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Messina take?

The fastest bus from Milan to Messina is offered by FlixBus and takes 17h 25m. Bus tickets for this connection cost $155. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Messina?

The earliest bus arriving in Messina from Milan starts at 9:40 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Messina?

The latest bus trip departing from Milan for Messina starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Messina route?

When traveling by bus from Milan to Messina, passengers can travel with FlixBus, Itabus and Autoservizi Salemi. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Messina?

You can check all the direct connections between Milan and Messina by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus, Itabus and Autoservizi Salemi.

What can I take with me on the Milan to Messina bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Messina bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Messina bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Messina on your planned travel date.

How does CheckMyBus find the best bus deals from Milan to Messina?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 23 daily trips between Milan and Messina. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Milan to Messina?

Prices and availability for 23 trips between Milan and Messina change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Milan to Messina

Basic

Name referring to the typical seat you will find with companies that don’t distinguish between different classes.

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Milan and to Messina

Here’s an overview of the most popular bus routes to Milan and to Messina. Simply click on the connection of your choice, and you will find all the details about your bus route!