Bus Milan to Messina: Compare prices and save money

Compare all timetables for the bus from Milan to Messina

Here is a selection of the cheapest bus trips from the schedule from Milan to Messina from various bus operators like Itabus, FlixBus or Autoservizi Salemi for the next days.

today

$44

tomorrow

$33

Saturday

$42

Sunday

$47

Monday

$41

Tuesday

$37

Wednesday

$47

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	19h 40m	11:30 PM	Milan	San Donato Bus Station	7:10 PM	Messina	Central Station	Premium Economy	$44	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/10/2026 11:30:00 PM to Central Station, Messina (Italy) arriving at 9/11/2026 7:10:00 PM. 50 Premium Economy ticket for $44 per person are available. Travel duration is 19h 40m
Itabus	22h 50m	8:00 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Central Station	Premium Economy	$58	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/10/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/11/2026 6:50:00 AM. 50 Premium Economy ticket for $58 per person are available. Travel duration is 22h 50m
Itabus	19h 20m	11:50 PM	Milan	Lampugnano Bus Station	7:10 PM	Messina	Central Station	Premium Economy	$58	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 9/10/2026 11:50:00 PM to Central Station, Messina (Italy) arriving at 9/11/2026 7:10:00 PM. 50 Premium Economy ticket for $58 per person are available. Travel duration is 19h 20m
FlixBus	18h 30m	4:40 PM	Milan	Lampugnano Bus Station	11:10 AM	Messina	Piazza della Repubblica	Economy	$67	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/10/2026 4:40:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/11/2026 11:10:00 AM. 50 Economy ticket for $67 per person are available. Travel duration is 18h 30m
FlixBus	20h 5m	5:45 PM	Milan	Lampugnano Bus Station	1:50 PM	Messina	Piazza della Repubblica	Economy	$67	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/10/2026 5:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/11/2026 1:50:00 PM. 50 Economy ticket for $67 per person are available. Travel duration is 20h 5m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $15? You can find the corresponding connections below.
- Itabus
  
  19h 45m
  
  0
  
  10:00 AM
  
  Milan
  San Donato Bus Station
  
  6:30 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $9
  
  A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/12/2026 10:00:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 9/12/2026 6:30:00 PM. 50 Premium Economy ticket for $9 per person are available. Travel duration is 8h 30m
- Itabus
  
  10h 15m
  
  0
  
  7:30 PM
  
  Rome
  Tiburtina Bus Station
  
  5:45 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $20
  
  A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 9/12/2026 7:30:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/13/2026 5:45:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 10h 15m
Travel time is 1h 15m longer, but you will save $15

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 30m	11:20 PM	Milan	San Donato Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$33	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 9/11/2026 11:20:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/12/2026 7:50:00 PM. 50 Economy ticket for $33 per person are available. Travel duration is 20h 30m
FlixBus	22h 0m	8:20 AM	Milan	Lampugnano Bus Station	6:20 AM	Messina	Piazza della Repubblica	Economy	$41	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/11/2026 8:20:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/12/2026 6:20:00 AM. 50 Economy ticket for $41 per person are available. Travel duration is 22h 0m
Itabus	22h 50m	8:00 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Piazza della Repubblica	Economy	$48	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/11/2026 8:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/12/2026 6:50:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 22h 50m
Itabus	20h 10m	8:00 AM	Milan	San Donato Bus Station	4:10 AM	Messina	Central Station	Premium Economy	$52	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/11/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/12/2026 4:10:00 AM. 50 Premium Economy ticket for $52 per person are available. Travel duration is 20h 10m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Economy	$101	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 9/11/2026 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/12/2026 4:40:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 17h 55m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $4? You can find the corresponding connections below.
- Itabus
  
  19h 10m
  
  0
  
  4:00 PM
  
  Milan
  Lampugnano Bus Station
  
  11:45 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $7
  
  A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 9/12/2026 4:00:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 9/12/2026 11:45:00 PM. 50 Premium Economy ticket for $7 per person are available. Travel duration is 7h 45m
- FlixBus
  
  9h 50m
  
  0
  
  1:20 AM
  
  Rome
  Tiburtina Bus Station
  
  11:10 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $22
  
  A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 9/13/2026 1:20:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/13/2026 11:10:00 AM. 50 Economy ticket for $22 per person are available. Travel duration is 9h 50m
Travel time is 1h 15m longer, but you will save $4

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	20h 10m	8:00 AM	Milan	San Donato Bus Station	4:10 AM	Messina	Central Station	Premium Economy	$42	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/12/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/13/2026 4:10:00 AM. 50 Premium Economy ticket for $42 per person are available. Travel duration is 20h 10m
Itabus	19h 45m	10:00 AM	Milan	San Donato Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$42	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/12/2026 10:00:00 AM to Central Station, Messina (Italy) arriving at 9/13/2026 5:45:00 AM. 50 Premium Economy ticket for $42 per person are available. Travel duration is 19h 45m
FlixBus	20h 30m	11:20 PM	Milan	San Donato Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$43	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 9/12/2026 11:20:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/13/2026 7:50:00 PM. 50 Economy ticket for $43 per person are available. Travel duration is 20h 30m
Itabus	22h 50m	8:00 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Central Station	Premium Economy	$52	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/12/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/13/2026 6:50:00 AM. 50 Premium Economy ticket for $52 per person are available. Travel duration is 22h 50m
FlixBus	21h 5m	10:45 PM	Milan	Lampugnano Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$60	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/12/2026 10:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/13/2026 7:50:00 PM. 50 Economy ticket for $60 per person are available. Travel duration is 21h 5m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $14? You can find the corresponding connections below.
- Itabus
  
  26h 0m
  
  0
  
  9:10 AM
  
  Milan
  Lampugnano Bus Station
  
  6:30 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 9/13/2026 9:10:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 9/13/2026 6:30:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 9h 20m
- FlixBus
  
  9h 50m
  
  0
  
  1:20 AM
  
  Rome
  Tiburtina Bus Station
  
  11:10 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $20
  
  A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 9/14/2026 1:20:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/14/2026 11:10:00 AM. 50 Economy ticket for $20 per person are available. Travel duration is 9h 50m
Travel time is 6h 15m longer, but you will save $14

Cheapest bus trips Sunday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	20h 10m	8:00 AM	Milan	San Donato Bus Station	4:10 AM	Messina	Central Station	Premium Economy	$47	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/13/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/14/2026 4:10:00 AM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 20h 10m
FlixBus	21h 40m	8:50 AM	Milan	San Donato Bus Station	6:30 AM	Messina	Piazza della Repubblica	Economy	$53	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 9/13/2026 8:50:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/14/2026 6:30:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 21h 40m
Itabus	19h 45m	10:00 AM	Milan	San Donato Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$55	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/13/2026 10:00:00 AM to Central Station, Messina (Italy) arriving at 9/14/2026 5:45:00 AM. 50 Premium Economy ticket for $55 per person are available. Travel duration is 19h 45m
Itabus	22h 50m	8:00 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Central Station	Premium Economy	$58	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/13/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/14/2026 6:50:00 AM. 50 Premium Economy ticket for $58 per person are available. Travel duration is 22h 50m
FlixBus	21h 5m	10:45 PM	Milan	Lampugnano Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$69	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/13/2026 10:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/14/2026 7:50:00 PM. 50 Economy ticket for $69 per person are available. Travel duration is 21h 5m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $21? You can find the corresponding connections below.
- Itabus
  
  25h 10m
  
  0
  
  10:00 AM
  
  Milan
  San Donato Bus Station
  
  6:30 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $7
  
  A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/14/2026 10:00:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 9/14/2026 6:30:00 PM. 50 Premium Economy ticket for $7 per person are available. Travel duration is 8h 30m
- FlixBus
  
  9h 50m
  
  0
  
  1:20 AM
  
  Rome
  Tiburtina Bus Station
  
  11:10 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $19
  
  A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 9/15/2026 1:20:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/15/2026 11:10:00 AM. 50 Economy ticket for $19 per person are available. Travel duration is 9h 50m
Travel time is 5h 25m longer, but you will save $21

Cheapest bus trips Monday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	20h 5m	5:45 PM	Milan	Lampugnano Bus Station	1:50 PM	Messina	Piazza della Repubblica	Economy	$41	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/14/2026 5:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/15/2026 1:50:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 20h 5m
FlixBus	21h 20m	8:35 PM	Milan	Lampugnano Bus Station	5:55 PM	Messina	Piazza della Repubblica	Economy	$41	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/14/2026 8:35:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/15/2026 5:55:00 PM. 50 Economy ticket for $41 per person are available. Travel duration is 21h 20m
Itabus	19h 45m	10:00 AM	Milan	San Donato Bus Station	5:45 AM	Messina	Piazza della Repubblica	Economy	$42	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/14/2026 10:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/15/2026 5:45:00 AM. 50 Economy ticket for $42 per person are available. Travel duration is 19h 45m
Itabus	22h 50m	8:00 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Piazza della Repubblica	Economy	$53	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/14/2026 8:00:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/15/2026 6:50:00 AM. 50 Economy ticket for $53 per person are available. Travel duration is 22h 50m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Economy	$101	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 9/14/2026 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/15/2026 4:40:00 AM. 50 Economy ticket for $101 per person are available. Travel duration is 17h 55m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $16? You can find the corresponding connections below.
- Itabus
  
  21h 5m
  
  0
  
  10:45 PM
  
  Milan
  Lampugnano Bus Station
  
  8:10 AM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Economy
  
  $9
  
  A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 9/15/2026 10:45:00 PM to Tiburtina Bus Station, Rome (Italy) arriving at 9/16/2026 8:10:00 AM. 50 Economy ticket for $9 per person are available. Travel duration is 9h 25m
- FlixBus
  
  10h 55m
  
  0
  
  8:55 AM
  
  Rome
  Tiburtina Bus Station
  
  7:50 PM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $16
  
  A Bus from FlixBus goes from Tiburtina Bus Station, Rome (Italy) at 9/16/2026 8:55:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/16/2026 7:50:00 PM. 50 Economy ticket for $16 per person are available. Travel duration is 10h 55m
Travel time is 3h 10m longer, but you will save $16

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	19h 45m	10:00 AM	Milan	San Donato Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$37	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/15/2026 10:00:00 AM to Central Station, Messina (Italy) arriving at 9/16/2026 5:45:00 AM. 50 Premium Economy ticket for $37 per person are available. Travel duration is 19h 45m
Itabus	22h 50m	8:00 AM	Milan	San Donato Bus Station	6:50 AM	Messina	Central Station	Premium Economy	$38	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/15/2026 8:00:00 AM to Central Station, Messina (Italy) arriving at 9/16/2026 6:50:00 AM. 50 Premium Economy ticket for $38 per person are available. Travel duration is 22h 50m
FlixBus	20h 45m	9:10 PM	Milan	San Donato Bus Station	5:55 PM	Messina	Piazza della Repubblica	Economy	$44	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 9/15/2026 9:10:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/16/2026 5:55:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 20h 45m
FlixBus	20h 30m	11:20 PM	Milan	San Donato Bus Station	7:50 PM	Messina	Piazza della Repubblica	Economy	$44	A Bus from FlixBus goes from San Donato Bus Station, Milan (Italy) at 9/15/2026 11:20:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/16/2026 7:50:00 PM. 50 Economy ticket for $44 per person are available. Travel duration is 20h 30m
FlixBus	21h 20m	8:35 PM	Milan	Lampugnano Bus Station	5:55 PM	Messina	Piazza della Repubblica	Economy	$45	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/15/2026 8:35:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/16/2026 5:55:00 PM. 50 Economy ticket for $45 per person are available. Travel duration is 21h 20m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $15? You can find the corresponding connections below.
- Itabus
  
  19h 45m
  
  0
  
  10:00 AM
  
  Milan
  San Donato Bus Station
  
  6:30 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $7
  
  A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/16/2026 10:00:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 9/16/2026 6:30:00 PM. 50 Premium Economy ticket for $7 per person are available. Travel duration is 8h 30m
- Itabus
  
  10h 15m
  
  0
  
  7:30 PM
  
  Rome
  Tiburtina Bus Station
  
  5:45 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $15
  
  A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 9/16/2026 7:30:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/17/2026 5:45:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 10h 15m
Travel time is the same as the direct connection, but you will save $15

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Itabus	19h 45m	10:00 AM	Milan	San Donato Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$47	A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/16/2026 10:00:00 AM to Central Station, Messina (Italy) arriving at 9/17/2026 5:45:00 AM. 50 Premium Economy ticket for $47 per person are available. Travel duration is 19h 45m
FlixBus	18h 30m	4:40 PM	Milan	Lampugnano Bus Station	11:10 AM	Messina	Piazza della Repubblica	Economy	$48	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/16/2026 4:40:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/17/2026 11:10:00 AM. 50 Economy ticket for $48 per person are available. Travel duration is 18h 30m
FlixBus	20h 5m	5:45 PM	Milan	Lampugnano Bus Station	1:50 PM	Messina	Piazza della Repubblica	Economy	$48	A Bus from FlixBus goes from Lampugnano Bus Station, Milan (Italy) at 9/16/2026 5:45:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/17/2026 1:50:00 PM. 50 Economy ticket for $48 per person are available. Travel duration is 20h 5m
Itabus	19h 5m	10:40 AM	Milan	Lampugnano Bus Station	5:45 AM	Messina	Central Station	Premium Economy	$58	A Bus from Itabus goes from Lampugnano Bus Station, Milan (Italy) at 9/16/2026 10:40:00 AM to Central Station, Messina (Italy) arriving at 9/17/2026 5:45:00 AM. 50 Premium Economy ticket for $58 per person are available. Travel duration is 19h 5m
Autoservizi Salemi	17h 55m	10:45 AM	Milan	San Donato Bus Station	4:40 AM	Messina	Piazza della Repubblica	Economy	$102	A Bus from Autoservizi Salemi goes from San Donato Bus Station, Milan (Italy) at 9/16/2026 10:45:00 AM to Piazza della Repubblica, Messina (Italy) arriving at 9/17/2026 4:40:00 AM. 50 Economy ticket for $102 per person are available. Travel duration is 17h 55m

Did you know that if you travel from Milan to Messina via Rome, you can save more than $25? You can find the corresponding connections below.
- Itabus
  
  19h 45m
  
  0
  
  10:00 AM
  
  Milan
  San Donato Bus Station
  
  6:30 PM
  
  Rome
  Tiburtina Bus Station
  
  0
  
  Premium Economy
  
  $7
  
  A Bus from Itabus goes from San Donato Bus Station, Milan (Italy) at 9/16/2026 10:00:00 AM to Tiburtina Bus Station, Rome (Italy) arriving at 9/16/2026 6:30:00 PM. 50 Premium Economy ticket for $7 per person are available. Travel duration is 8h 30m
- Itabus
  
  10h 15m
  
  0
  
  7:30 PM
  
  Rome
  Tiburtina Bus Station
  
  5:45 AM
  
  Messina
  Piazza della Repubblica
  
  0
  
  Economy
  
  $15
  
  A Bus from Itabus goes from Tiburtina Bus Station, Rome (Italy) at 9/16/2026 7:30:00 PM to Piazza della Repubblica, Messina (Italy) arriving at 9/17/2026 5:45:00 AM. 50 Economy ticket for $15 per person are available. Travel duration is 10h 15m
Travel time is 1h 50m longer, but you will save $25

Best Price Offer: The price for the cheapest bus from Milan to Messina is $22 on 9/28/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between Milan and Messina

See here how frequent the connections between Milan and Messina are, during different times and days of the week.

Friday is the busiest day, with more than 40 daily buses from Milan to Messina. Wednesday has instead the fewest connections, with only 17 daily coaches between Milan and Messina.

The busiest time of the day is the Morning, with 101 buses from Milan to Messina, while Night sees the fewest connections between Milan and Messina, with 14 offers.

Facts about the bus from Milan to Messina

Compare all providers like Itabus, FlixBus and Autoservizi Salemi that travel 27 times every day by bus from Milan to Messina in one click! Book your bus ticket from Milan to Messina starting from $22!

Cheapest Bus	$22
Fastest Bus	17h 15m
Earliest Bus	8:00 AM
Latest Bus	10:00 PM
Daily Bus Routes	27 Ø
Distance	599.7 miles
Bus Companies	Itabus, FlixBus and Autoservizi Salemi

Cheapest bus connections from Milan to Messina

Every day, 27 buses from 3 bus companies leave Milan for Messina: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 09/10/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 09/06

Monday 09/07

Tuesday 09/08

Wednesday 09/09

Thursday 09/10

$67

Friday 09/11

$52

Saturday 09/12

$60

Sunday 09/13

$69

Monday 09/14

$74

Tuesday 09/15

$37

Wednesday 09/16

$48

Thursday 09/17

$47

Friday 09/18

$38

Saturday 09/19

$74

Sunday 09/20

$35

Monday 09/21

$42

Tuesday 09/22

$38

Wednesday 09/23

$44

Thursday 09/24

$48

Friday 09/25

$38

Saturday 09/26

$45

Sunday 09/27

$56

Monday 09/28

$22

Tuesday 09/29

$49

Wednesday 09/30

$55

Thursday 10/01

$54

Friday 10/02

$59

Saturday 10/03

The cheapest time to travel from Milan to Messina

See here on which day and which time of the day you can find the cheapest bus ticket from Milan to Messina, for the next 30 days.

With a price starting from $22, Monday is the cheapest day for a bus from Milan to Messina. Thursday instead is the most expensive day with prices starting from $44.

Night is the cheapest day time for bus tickets from Milan to Messina, with $22. Afternoon is the most expensive time of the day with prices starting from $41.

How to save money travelling from Milan to Messina

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from Milan to Messina in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from Milan to Messina, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from Milan to Messina are also emptier.

All bus stations and stops in Milan and Messina

In the map below, you can see where to find all bus stations in Milan and Messina.

Lampugnano Bus Station

Via Giulio Natta Lampugnano

Rogoredo Bus Station

Via Cassinis Giovanni Battista 76

San Donato Bus Station

Via Giuseppe Impastato 25

Central Bus Station

Duomo Bus Stop

Piazza del Duomo

Piazza della Repubblica

Piazza della Repubblica 25

Via Taormina - Policlinico Bus Stop

V. Nazionale; 56 - S. Margherita Bus Stop

Viale Gazzi Bus Stop

SS114 Orientale Sicula Bus Stop

Service and Comfort on the bus from Milan to Messina

Want to know which seat classes are available on the buses from Milan to Messina? Or which bus companies serve the route Milan to Messina? Below you will find answers to your questions.

FAQs about the Milan to Messina bus

How much does a Milan Messina bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $22 and takes 20h 30m to reach Messina. Compare offers to save money!

How much could I save by comparing buses from Milan to Messina?

This route is offered by 3 companies with a range of ticket prices between $22 and $154. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Messina.

On average, how many connections are available from Milan to Messina each day?

Every day, the Milan to Messina bus route is served by approximately 27 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from Milan to Messina take?

The fastest bus from Milan to Messina is offered by FlixBus and takes 17h 15m. Bus tickets for this connection cost $48. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from Milan to Messina?

The earliest bus arriving in Messina from Milan starts at 8:00 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from Milan to Messina?

The latest bus trip departing from Milan for Messina starts at 10:00 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the Milan Messina route?

When traveling by bus from Milan to Messina, passengers can travel with Itabus, FlixBus and Autoservizi Salemi. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between Milan and Messina?

You can check all the direct connections between Milan and Messina by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: Itabus, FlixBus and Autoservizi Salemi.

What can I take with me on the Milan to Messina bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the Milan Messina bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the Milan Messina bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from Milan to Messina on your planned travel date.

How does CheckMyBus find the best bus deals from Milan to Messina?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 27 daily trips between Milan and Messina. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from Milan to Messina?

Prices and availability for 27 trips between Milan and Messina change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route Milan to Messina

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

Premium Economy

A mix between Economy and Business, it offers extra legroom, WI-FI and possible snacks.

More bus routes to Milan and to Messina

Here’s an overview of the most popular bus routes to Milan and to Messina. Simply click on the connection of your choice, and you will find all the details about your bus route!