Bus San Diego to Mexico City: Compare prices and save money

Compare all timetables for the bus from San Diego to Mexico City

Here is a selection of the cheapest bus trips from the schedule from San Diego to Mexico City from various bus operators like FlixBus or Greyhound US for the next days.

today

$228

tomorrow

$219

Tuesday

$220

Wednesday

$222

Thursday

$227

Friday

$221

Saturday

$221

Cheapest bus trips today
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	64h 10m	12:40 PM	San Diego	San Ysidro Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$228	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/22/2026 12:40:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/25/2026 5:50:00 AM. 50 Economy ticket for $228 per person are available. Travel duration is 64h 10m
FlixBus	63h 45m	12:40 PM	San Diego	San Ysidro Transit Center	5:25 AM	Mexico City	Fórum Buenavista	Economy	$228	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/22/2026 12:40:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/25/2026 5:25:00 AM. 50 Economy ticket for $228 per person are available. Travel duration is 63h 45m
Greyhound US	60h 15m	9:15 AM	San Diego	San Ysidro Transit Center	10:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$271	A Bus from Greyhound US goes from San Ysidro Transit Center, San Diego (USA) at 3/22/2026 9:15:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/24/2026 10:30:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 60h 15m
Greyhound US	59h 50m	9:15 AM	San Diego	San Ysidro Transit Center	10:05 PM	Mexico City	Fórum Buenavista	Economy	$271	A Bus from Greyhound US goes from San Ysidro Transit Center, San Diego (USA) at 3/22/2026 9:15:00 AM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/24/2026 10:05:00 PM. 50 Economy ticket for $271 per person are available. Travel duration is 59h 50m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $111? You can find the corresponding connections below.
- Tufesa International
  
  44h 35m
  
  0
  
  6:45 AM
  
  San Diego
  San Ysidro Transit Center
  
  7:45 AM
  
  Tijuana, BC
  Central Bus Station
  
  0
  
  Economy
  
  $11
  
  A Bus from Tufesa International goes from San Ysidro Transit Center, San Diego (USA) at 3/23/2026 6:45:00 AM to Central Bus Station, Tijuana, BC (Mexico) arriving at 3/23/2026 7:45:00 AM. 50 Economy ticket for $11 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/23/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/25/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 16h 15m shorter, and you will save $111

Cheapest bus trips tomorrow
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	70h 55m	3:55 PM	San Diego	Old Town Transit Center	3:50 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$219	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/23/2026 3:55:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/26/2026 3:50:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 70h 55m
FlixBus	70h 35m	3:55 PM	San Diego	Old Town Transit Center	3:30 PM	Mexico City	Fórum Buenavista	Economy	$219	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/23/2026 3:55:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/26/2026 3:30:00 PM. 50 Economy ticket for $219 per person are available. Travel duration is 70h 35m
FlixBus	61h 55m	7:35 AM	San Diego	Old Town Transit Center	10:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$220	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/23/2026 7:35:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/25/2026 10:30:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 61h 55m
Greyhound US	59h 40m	9:50 AM	San Diego	Old Town Transit Center	10:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$221	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/23/2026 9:50:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/25/2026 10:30:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 59h 40m
Greyhound US	59h 15m	9:50 AM	San Diego	Old Town Transit Center	10:05 PM	Mexico City	Fórum Buenavista	Economy	$221	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/23/2026 9:50:00 AM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/25/2026 10:05:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 59h 15m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $105? You can find the corresponding connections below.
- Greyhound Lines Mexico
  
  56h 5m
  
  0
  
  7:15 PM
  
  San Diego
  San Ysidro Transit Center
  
  8:15 PM
  
  Tijuana, BC
  Cross Border Xpress CBX Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Greyhound Lines Mexico goes from San Ysidro Transit Center, San Diego (USA) at 3/24/2026 7:15:00 PM to Cross Border Xpress CBX Bus Station, Tijuana, BC (Mexico) arriving at 3/24/2026 8:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/25/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 4h 10m shorter, and you will save $105

Cheapest bus trips Tuesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	70h 5m	6:45 AM	San Diego	Old Town Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$220	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/24/2026 6:45:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 5:50:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 70h 5m
Greyhound US	64h 45m	7:35 PM	San Diego	Old Town Transit Center	1:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$220	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/24/2026 7:35:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 1:20:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 64h 45m
Greyhound US	64h 20m	7:35 PM	San Diego	Old Town Transit Center	12:55 PM	Mexico City	Fórum Buenavista	Economy	$220	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/24/2026 7:35:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/27/2026 12:55:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 64h 20m
FlixBus	61h 55m	7:35 AM	San Diego	Old Town Transit Center	10:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$220	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/24/2026 7:35:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/26/2026 10:30:00 PM. 50 Economy ticket for $220 per person are available. Travel duration is 61h 55m
FlixBus	64h 35m	12:15 PM	San Diego	Old Town Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$220	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/24/2026 12:15:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 5:50:00 AM. 50 Economy ticket for $220 per person are available. Travel duration is 64h 35m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $106? You can find the corresponding connections below.
- Greyhound Lines Mexico
  
  56h 5m
  
  0
  
  7:15 PM
  
  San Diego
  San Ysidro Transit Center
  
  8:15 PM
  
  Tijuana, BC
  Cross Border Xpress CBX Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Greyhound Lines Mexico goes from San Ysidro Transit Center, San Diego (USA) at 3/24/2026 7:15:00 PM to Cross Border Xpress CBX Bus Station, Tijuana, BC (Mexico) arriving at 3/24/2026 8:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/25/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 6h 50m shorter, and you will save $106

Cheapest bus trips Wednesday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	62h 35m	6:55 AM	San Diego	San Ysidro Transit Center	10:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$222	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/25/2026 6:55:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 10:30:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 62h 35m
FlixBus	62h 10m	6:55 AM	San Diego	San Ysidro Transit Center	10:05 PM	Mexico City	Fórum Buenavista	Economy	$222	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/25/2026 6:55:00 AM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/27/2026 10:05:00 PM. 50 Economy ticket for $222 per person are available. Travel duration is 62h 10m
FlixBus	63h 45m	12:40 PM	San Diego	San Ysidro Transit Center	5:25 AM	Mexico City	Fórum Buenavista	Economy	$226	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/25/2026 12:40:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/28/2026 5:25:00 AM. 50 Economy ticket for $226 per person are available. Travel duration is 63h 45m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $108? You can find the corresponding connections below.
- Greyhound Lines Mexico
  
  56h 5m
  
  0
  
  7:15 PM
  
  San Diego
  San Ysidro Transit Center
  
  8:15 PM
  
  Tijuana, BC
  Cross Border Xpress CBX Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Greyhound Lines Mexico goes from San Ysidro Transit Center, San Diego (USA) at 3/24/2026 7:15:00 PM to Cross Border Xpress CBX Bus Station, Tijuana, BC (Mexico) arriving at 3/24/2026 8:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/25/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 7h 5m shorter, and you will save $108

Cheapest bus trips Thursday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	61h 15m	9:15 AM	San Diego	San Ysidro Transit Center	11:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$227	A Bus from Greyhound US goes from San Ysidro Transit Center, San Diego (USA) at 3/26/2026 9:15:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/28/2026 11:30:00 PM. 50 Economy ticket for $227 per person are available. Travel duration is 61h 15m
Greyhound US	59h 50m	9:15 AM	San Diego	San Ysidro Transit Center	10:05 PM	Mexico City	Fórum Buenavista	Economy	$229	A Bus from Greyhound US goes from San Ysidro Transit Center, San Diego (USA) at 3/26/2026 9:15:00 AM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/28/2026 10:05:00 PM. 50 Economy ticket for $229 per person are available. Travel duration is 59h 50m
FlixBus	64h 10m	12:40 PM	San Diego	San Ysidro Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$232	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/26/2026 12:40:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/29/2026 5:50:00 AM. 50 Economy ticket for $232 per person are available. Travel duration is 64h 10m
FlixBus	63h 45m	12:40 PM	San Diego	San Ysidro Transit Center	5:25 AM	Mexico City	Fórum Buenavista	Economy	$232	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/26/2026 12:40:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/29/2026 5:25:00 AM. 50 Economy ticket for $232 per person are available. Travel duration is 63h 45m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $113? You can find the corresponding connections below.
- Greyhound Lines Mexico
  
  56h 5m
  
  0
  
  7:15 PM
  
  San Diego
  San Ysidro Transit Center
  
  8:15 PM
  
  Tijuana, BC
  Cross Border Xpress CBX Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Greyhound Lines Mexico goes from San Ysidro Transit Center, San Diego (USA) at 3/24/2026 7:15:00 PM to Cross Border Xpress CBX Bus Station, Tijuana, BC (Mexico) arriving at 3/24/2026 8:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/25/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 4h 45m shorter, and you will save $113

Cheapest bus trips Friday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
Greyhound US	59h 40m	9:50 AM	San Diego	Old Town Transit Center	10:30 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$221	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/27/2026 9:50:00 AM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/29/2026 10:30:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 59h 40m
Greyhound US	59h 15m	9:50 AM	San Diego	Old Town Transit Center	10:05 PM	Mexico City	Fórum Buenavista	Economy	$221	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/27/2026 9:50:00 AM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/29/2026 10:05:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 59h 15m
FlixBus	64h 35m	12:15 PM	San Diego	Old Town Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$222	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/27/2026 12:15:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/30/2026 5:50:00 AM. 50 Economy ticket for $222 per person are available. Travel duration is 64h 35m
FlixBus	64h 10m	12:15 PM	San Diego	Old Town Transit Center	5:25 AM	Mexico City	Fórum Buenavista	Economy	$222	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/27/2026 12:15:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/30/2026 5:25:00 AM. 50 Economy ticket for $222 per person are available. Travel duration is 64h 10m
FlixBus	64h 10m	12:40 PM	San Diego	San Ysidro Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$222	A Bus from FlixBus goes from San Ysidro Transit Center, San Diego (USA) at 3/27/2026 12:40:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/30/2026 5:50:00 AM. 50 Economy ticket for $222 per person are available. Travel duration is 64h 10m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $107? You can find the corresponding connections below.
- Greyhound Lines Mexico
  
  56h 5m
  
  0
  
  7:15 PM
  
  San Diego
  San Ysidro Transit Center
  
  8:15 PM
  
  Tijuana, BC
  Cross Border Xpress CBX Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Greyhound Lines Mexico goes from San Ysidro Transit Center, San Diego (USA) at 3/24/2026 7:15:00 PM to Cross Border Xpress CBX Bus Station, Tijuana, BC (Mexico) arriving at 3/24/2026 8:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/25/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 4h 10m shorter, and you will save $107

Cheapest bus trips Saturday
BertCompanyCountOneCompanyName	Duration	Departure time	From	Departure	Arrival time	To	Destination	Seat classes	Price
FlixBus	64h 35m	12:15 PM	San Diego	Old Town Transit Center	5:50 AM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$221	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/28/2026 12:15:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/31/2026 5:50:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 64h 35m
FlixBus	68h 25m	3:55 PM	San Diego	Old Town Transit Center	1:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$221	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/28/2026 3:55:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/31/2026 1:20:00 PM. 50 Economy ticket for $221 per person are available. Travel duration is 68h 25m
FlixBus	64h 10m	12:15 PM	San Diego	Old Town Transit Center	5:25 AM	Mexico City	Fórum Buenavista	Economy	$221	A Bus from FlixBus goes from Old Town Transit Center, San Diego (USA) at 3/28/2026 12:15:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/31/2026 5:25:00 AM. 50 Economy ticket for $221 per person are available. Travel duration is 64h 10m
Greyhound US	64h 45m	7:35 PM	San Diego	Old Town Transit Center	1:20 PM	Mexico City	San Pedro Santa Clara Bus Stop	Economy	$223	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/28/2026 7:35:00 PM to San Pedro Santa Clara Bus Stop, Mexico City (Mexico) arriving at 3/31/2026 1:20:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 64h 45m
Greyhound US	64h 20m	7:35 PM	San Diego	Old Town Transit Center	12:55 PM	Mexico City	Fórum Buenavista	Economy	$223	A Bus from Greyhound US goes from Old Town Transit Center, San Diego (USA) at 3/28/2026 7:35:00 PM to Fórum Buenavista, Mexico City (Mexico) arriving at 3/31/2026 12:55:00 PM. 50 Economy ticket for $223 per person are available. Travel duration is 64h 20m

Did you know that if you travel from San Diego to Mexico City via Tijuana, BC, you can save more than $107? You can find the corresponding connections below.
- Greyhound Lines Mexico
  
  56h 5m
  
  0
  
  7:15 PM
  
  San Diego
  San Ysidro Transit Center
  
  8:15 PM
  
  Tijuana, BC
  Cross Border Xpress CBX Bus Station
  
  0
  
  Economy
  
  $8
  
  A Bus from Greyhound Lines Mexico goes from San Ysidro Transit Center, San Diego (USA) at 3/24/2026 7:15:00 PM to Cross Border Xpress CBX Bus Station, Tijuana, BC (Mexico) arriving at 3/24/2026 8:15:00 PM. 50 Economy ticket for $8 per person are available. Travel duration is 1h 0m
- ACN Autobuses
  
  41h 40m
  
  0
  
  9:40 AM
  
  Tijuana, BC
  Centro Bus Stop
  
  4:20 AM
  
  Mexico City
  Instituto Politécnico Nacional Bus Stop
  
  0
  
  Economy
  
  $106
  
  A Bus from ACN Autobuses goes from Centro Bus Stop, Tijuana, BC (Mexico) at 3/25/2026 9:40:00 AM to Instituto Politécnico Nacional Bus Stop, Mexico City (Mexico) arriving at 3/27/2026 4:20:00 AM. 50 Economy ticket for $106 per person are available. Travel duration is 41h 40m
Travel Time is 9h 5m shorter, and you will save $107

Best Price Offer: The price for the cheapest bus from San Diego to Mexico City is $213 on 4/14/2026. Flexible travelers save on ticket prices.

Frequency of bus connections between San Diego and Mexico City

See here how frequent the connections between San Diego and Mexico City are, during different times and days of the week.

Monday is the busiest day, with more than 16 daily buses from San Diego to Mexico City. Wednesday has instead the fewest connections, with only 3 daily coaches between San Diego and Mexico City.

The busiest time of the day is the Afternoon, with 35 buses from San Diego to Mexico City, while Evening sees the fewest connections between San Diego and Mexico City, with 8 offers.

Facts about the bus from San Diego to Mexico City

Compare all providers like FlixBus and Greyhound US that travel 10 times every day by bus from San Diego to Mexico City in one click! Book your bus ticket from San Diego to Mexico City starting from $213!

Cheapest Bus	$213
Fastest Bus	60h 15m
Earliest Bus	9:15 AM
Latest Bus	7:35 PM
Daily Bus Routes	10 Ø
Distance	1,443.3 miles
Bus Companies	FlixBus and Greyhound US

Cheapest bus connections from San Diego to Mexico City

Every day, 10 buses from 2 bus companies leave San Diego for Mexico City: in the table below, you will find the cheapest prices for a bus ticket for this route, starting from 03/22/2026 and for the following days.

Sunday

Monday

Tuesday

Wednesday

Thursday

Friday

Saturday

Sunday 03/22

$228

Monday 03/23

$239

Tuesday 03/24

$223

Wednesday 03/25

$222

Thursday 03/26

$227

Friday 03/27

$222

Saturday 03/28

$226

Sunday 03/29

$224

Monday 03/30

$221

Tuesday 03/31

$220

Wednesday 04/01

$249

Thursday 04/02

$220

Friday 04/03

$224

Saturday 04/04

$219

Sunday 04/05

$217

Monday 04/06

$223

Tuesday 04/07

$217

Wednesday 04/08

$222

Thursday 04/09

$217

Friday 04/10

$218

Saturday 04/11

$219

Sunday 04/12

$215

Monday 04/13

$215

Tuesday 04/14

$213

Wednesday 04/15

$213

Thursday 04/16

$218

Friday 04/17

Saturday 04/18

The cheapest time to travel from San Diego to Mexico City

See here on which day and which time of the day you can find the cheapest bus ticket from San Diego to Mexico City, for the next 30 days.

With a price starting from $213, Tuesday is the cheapest day for a bus from San Diego to Mexico City. Saturday instead is the most expensive day with prices starting from $219.

Afternoon is the cheapest day time for bus tickets from San Diego to Mexico City, with $219. Evening is the most expensive time of the day with prices starting from $220.

How to save money travelling from San Diego to Mexico City

Travel can be expensive, but it doesn't need to be! Do you want to avoid paying a terrible price for your trip? Then follow these quick steps to save money:

Book the ticket from San Diego to Mexico City in advance! The earlier you book, the cheaper usually the price is. Also, you will be sure to have a place on the bus from San Diego to Mexico City, compared instead if you buy it at the last moment, or directly at the station.

If you can, avoid travelling at peak times. Instead of weekend, try travelling during the week. Travelling in the evening or at night it’s also cheaper, and later buses from San Diego to Mexico City are also emptier.

All bus stations and stops in San Diego and Mexico City

In the map below, you can see where to find all bus stations in San Diego and Mexico City.

Old Town Transit Center

Congress Street 2727

San Ysidro Transit Center

E San Ysidro Blvd 723

Santa Fe Depot

Kettner Blvd 1050

Seaport Village

W Harbor Dr 789

La Jolla Village

Hyatt Regency

Norte Bus Station

Eje Central Lázaro Cárdenas

Terminal de Autobuses de Oriente (TAPO)

Calz. Ignacio Zaragoza 200

Terminal del Sur

Av. Taxqueña 1320

Observatorio Central Bus Station

Av Río de Tacubaya 122 232

Eje Central Bus Stop

Avenida Lázaro Cárdenas & Calle Poniente 112 Avenida Lázaro Cárdenas & Calle Poniente 112

Compare the bus with other modes of transport

The bus is often the cheapest mode of transport, while other modes like train or flight are faster. Looking for quicker alternatives to travel from San Diego to Mexico City? Compare all modes of transports from San Diego to Mexico City.

Service and Comfort on the bus from San Diego to Mexico City

Want to know which seat classes are available on the buses from San Diego to Mexico City? Or which bus companies serve the route San Diego to Mexico City? Below you will find answers to your questions.

FAQs about the San Diego to Mexico City bus

How much does a San Diego Mexico City bus trip cost?

This depends on, among other things, the day and time of travel. The cheapest trip is available from $213 and takes 71h 55m to reach Mexico City. Compare offers to save money!

How much could I save by comparing buses from San Diego to Mexico City?

This route is offered by 2 companies with a range of ticket prices between $213 and $271. Thus, we recommend booking your ticket as early as possible to make sure you get the cheapest bus ticket to Mexico City.

On average, how many connections are available from San Diego to Mexico City each day?

Every day, the San Diego to Mexico City bus route is served by approximately 10 connections. With our search, you can compare bus times to find the perfect trip.

How long does a bus journey from San Diego to Mexico City take?

The fastest bus from San Diego to Mexico City is offered by Greyhound US and takes 60h 15m. Bus tickets for this connection cost $221. In this context, bear in mind that the journey can take longer due to traffic.

What time is the first bus from San Diego to Mexico City?

The earliest bus arriving in Mexico City from San Diego starts at 9:15 AM. However, information regarding departure times may differ on weekends and holidays. Simply use our search to find exact times for your planned travel date.

What time is the last bus from San Diego to Mexico City?

The latest bus trip departing from San Diego for Mexico City starts at 7:35 PM. Please note that departure times may differ on weekends and holidays. So just use our search to find the exact times for your planned travel date.

Which bus companies operate the San Diego Mexico City route?

When traveling by bus from San Diego to Mexico City, passengers can travel with FlixBus and Greyhound US. With our search, you can compare all available bus tickets to book the one that works for you.

Is there a direct bus between San Diego and Mexico City?

You can check all the direct connections between San Diego and Mexico City by using our search and looking at the Changes section in our filters. These are some of the companies which offer a direct bus: FlixBus and Greyhound US.

What can I take with me on the San Diego to Mexico City bus route?

Depending on which provider you travel with, what you're allowed to bring with you can vary. Generally, you can take a suitcase and hand luggage with you on the San Diego Mexico City bus route free of charge. Simply use our search to find a bus that is best suited to your needs for your planned travel date.

What equipment is available for the San Diego Mexico City bus route?

The equipment on board differs depending on the provider. However, many long-distance buses have WiFi so you can tell your friends your exact location during the journey. To make traveling even more pleasant, air conditioning systems provide ventilation. It is best to use our search to get precise information about the equipment of the bus from San Diego to Mexico City on your planned travel date.

How does CheckMyBus find the best bus deals from San Diego to Mexico City?

CheckMyBus collaborates directly with companies around the world to provide you with the best options when searching for a trip. We retrieve their first-hand data to show you real-time prices, schedules, and seat availability for 10 daily trips between San Diego and Mexico City. With the most up-to-date information from verified sources, you can fairly compare all available options and choose the trip that suits you best.

How does CheckMyBus technology work for trips from San Diego to Mexico City?

Prices and availability for 10 trips between San Diego and Mexico City change constantly. To provide you with the most up-to-date information, we connect directly with bus operators, Online Travel Agencies (OTAs), and Global Distribution Systems (GDS) via real-time interfaces (APIs). The data collected from these sources undergoes strict quality checks, is processed within our infrastructure, and is then presented to you on our search results pages. Visit our About Us page to learn more.

Available seat classes which are offered on the bus route San Diego to Mexico City

Economy

The cheapest option available for your ticket, it usually comes with reclinable seats and AC.

More bus routes to San Diego and to Mexico City

Here’s an overview of the most popular bus routes to San Diego and to Mexico City. Simply click on the connection of your choice, and you will find all the details about your bus route!